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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Even and Odd Q-coherent State Representations of the Q-deformed Heisenberg-Weyl Algebra显示文摘We construct explicitly even and odd q-coherent states.These q-coherent states are introduced in terms of the q-functions defined in the paper.It is shown that the even and odd q-coherent states form a kind of representations of the q-deformed Heisenberg-Weyl algebra which is realized in the form of matrix q-differential operators in the even and odd q-coherent state space.We also analyse some different between the even and odd q-CSs and the usual even and odd CSs. | WANG Fabo KUANG Leman | 1992 | Chinese Physics Letters1992，9，12： | 4 |
| 3 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 4 | Coherent State of N Components and Cycle Representation显示文摘In this paper,we construct a type of coherent state with N components,and use it to span cycle representations of the Lie algebras SU(2),SU(1,l)and the Lit:superalgebra OSP(1,2).The method for constructing cycle representation may be generalized to other Lie algebras and Lie superalgebras. | ZENG Gaojian KUANG Leman LI Jinhui | 1995 | Chinese Physics Letters1995，12，3： | 3 |
| 5 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 6 | Pneumoniae of Swines Cost and Value of Control显示文摘 | Leman A D T Stein B Straw H D Hilley | 1982 | Mod Vet Pract1982，63，： | 1 |
| 7 | Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury显示文摘 | Leman P Kapadia Y Herington J | 2003 | Emerg Med2003，20，6： | 1 |
| 8 | Polymer indentation: numerical analysis and comparison with a spherical cavity model显示文摘 | TVERGAARD V LEMAN A | 2011 | Jour- nalof the Mechanics and Physics of Solids2011，59，9： | 1 |
| 9 | Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal显示文摘 | Surget A Saxe M Leman S | | 0，，： | 1 |
| 10 | Spy: A Windows CE API interceptor 显示文摘 | LEMAN D | 2003 | Doctor Dobbs Journal2003，28，10： | 1 |
| 11 | Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury 显示文摘 | Leman P Kapadia Y Herington J | 2003 | Emerg Med J2003，20，6： | 1 |
| 12 | Mahogenic amylase has a non- typical impact on the molecular and rheological properties of starch 显示文摘 | Leman P Goesaert H Vandeputte G E | 2005 | Carbohydrate Polymers2005，62，3： | 1 |
| 13 | Initial analyses ofcolon cancer-specific antigen ( CCSA )-3 and CCSA-4 ascolorectal cancer-associated serum markers 显示文摘 | Leman ES Schoen RE Weivssfeld JL | 2007 | Cancer Res2007，67，12： | 1 |
| 14 | Inhibition of constitutively activated stat3 signaling pathway suppresses growth of prostate cancer cells 显示文摘 | Lou W Leman ES | 2000 | Cancer Res2000，60，： | 1 |
| 15 | Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes 显示文摘 | Ramsey PS Leman JM Brumfield CG | 2005 | Am J Obstet Gynecol2005，192，4： | 1 |
| 16 | EPCA-2: a highly specific serum marker for prostate cancer显示文摘 | LEMAN ES CANNON GW TROCK BJ | 2007 | Urology2007，69，4： | 1 |
| 17 | Inhibition of constitute activated Stat3 signaling pathway suppresses growth of prostate cancer cells 显示文摘 | Lou W Leman ZS | 2000 | Cancer Res2000，60，5： | 1 |
| 18 | Statin effects beyond lipid lowering are they clinically relevant显示文摘 | Bonetti PO Leman LO Napolic C | 2003 | Eur Heart J2003，24，3： | 1 |
| 19 | Activation of Ventrolateral Medullary Neurons Projecting to Spinal Autonomic Areas After Chemical Stimulation of the Central Nucleus of Amygdala: A Neuroanatomical Study in the Rat 显示文摘 | SALOME N VILTART O LEMAN S | 2001 | Brain Res2001，890，2： | 1 |
| 20 | EPCA-2: A Highly Specific Serum Marker for Prostate Cancer显示文摘 | Eddy S. Leman Grant W. Cannon Bruce J. Trock Lori J. Sokoll Daniel W. Chan Leslie Mangold Alan W. Partin Robert H. Getzenberg | 2007 | Urology2007，，4： | 1 |
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