|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Pneumoniae of Swines Cost and Value of Control显示文摘 | Leman A D T Stein B Straw H D Hilley | 1982 | Mod Vet Pract1982，63，： | 1 |
| 3 | Polymer indentation: numerical analysis and comparison with a spherical cavity model显示文摘 | TVERGAARD V LEMAN A | 2011 | Jour- nalof the Mechanics and Physics of Solids2011，59，9： | 1 |
| 4 | Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal显示文摘 | Surget A Saxe M Leman S | | 0，，： | 1 |
| 5 | Toward Communicating Expressiveness and Affect in Multimodal Interactive Systems for Performing Arts and Cultural Applications显示文摘 | A Camurri G De Poli M Leman | 2005 | IEEE Multimedia2005，12，1： | 1 |
| 6 | Signal-averaged P-wave analysis of normal controls and patients with paroxysmal atrial fibrillation: a study in gender differences, age dependence,and reproducibility显示文摘 | Dhala A Underwood D Leman R | 2002 | Clin Cardiol2002，25，： | 1 |
| 7 | Toward communicating expressiveness and affect in multimodal interactive systems for performing arts and cultural applications显示文摘 | Camurri A Poli G D Leman M | 2005 | IEEE Multimedi- a2005，12，1： | 1 |
| 8 | Experimental inoculation of plants and animals with Ebola virus显示文摘 | Swanepoel R Leman P A Burt F J | 1996 | Emerg Infect Dis1996，2，4： | 1 |
| 9 | Kidney in early atherosclerosis显示文摘 | Leman A Leman LO | 2005 | Hypertension2005，45，： | 1 |
| 10 | Treat ment of severe psoriasis wish infliximab显示文摘 | Leman J Burden A | | 0，，06： | 1 |
| 11 | Antibody responses of guiued- pigs, rabbits and pigs to inactivated porcine parvovirus vaccines 显示文摘 | Joo H S Molitor T W Leman A D | 1984 | Vet Microbiol1984，9，1： | 1 |
| 12 | Circalating, Cend tissue endothelin immunoreactivity in advanced atherosdevosis显示文摘 | Leman A Edward BS Halletjw | 1991 | WEang Jmed1991，，325： | 1 |
| 13 | Effects of a physical activity behavior change intervention on inflammation and related health outcomes in breastcancer survivors : pilot randomized trial 显示文摘 | Rogers LQ Fog leman A | 2013 | Integr Cancer T-her2013，12，4： | 1 |
| 14 | Antibody responses of guinea - pigs,rabbits and pigs to inactivated porcine parvovirus vaccine显示文摘 | JOO H S MOUTOR T W LEMAN A D | 1984 | Vet Microbiol1984，9，1： | 1 |
| 15 | Phylogenetic relationships of southern African West Nile virus isolates显示文摘 | Burt F J Grobbelaar A A Leman P A | 2002 | Emerging Infectious Diseases2002，，8： | 1 |
| 16 | Factors that influence litter size in pigs显示文摘 | Clark L K Leman A D Morris R | 1986 | Pig News and Information1986，73，： | 1 |
| 17 | Seasonal influence on the fertility of sows and gilts显示文摘 | Hurtgen J P Leman A D | 1980 | J Am Vet Ned Assoc1980，177，7： | 1 |
| 18 | Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis显示文摘 | Leman A Edwards B S | 1991 | N Eng J Med1991，235，： | 1 |
| 19 | Boar management显示文摘 | Leman A D Rodeffer H E | 1976 | The Veterinary Record1976，，23： | 1 |
| 20 | Coarctation of aorta repair at the National Heart Institute(1983-1994)显示文摘 | Adeeb SM Leman H Sallehuddin A | 2004 | Med J Malaysia2004，59，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员