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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Effect of nebivolol and atenolol on brachial artery flow-mediated vasodilation in patients with coronary artery disease 显示文摘 | Lekakis JP Protogerou A Papamichael C | 2005 | Cardiovasc Drugs Ther2005，19，4： | 1 |
| 3 | Flow-mediated, endotheli- urn-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin ( TSH ) values 显示文摘 | Lekakis J Papamichael C Alevizaki M | 1997 | Thyroid1997，7，3： | 1 |
| 4 | 进食频率预测新发高血压及血压、动脉硬化和脉搏波反射进展率显示文摘普遍认为每天至少吃3餐,但现代生活方式正逐渐打破既往进食习惯。已发现每日进食频率可能影响多种心血管代谢风险因素,但尚未深入研究其临床价值。研究显示,与进食次数较少者相比,进食次数较多者通常血脂状况更好,胰岛素抵抗及代谢综合征发病风险更低。进食频率增加使空腹时间减少,平均血糖浓度及胰岛素分泌量降低。胰岛素浓度降低使羟甲基戊二酸单酰辅酶A还原酶活性降低,从而减少肝脏胆固醇合成。 | Karatzi K Georgiopoulos G Yannakoulia M Efthimiou E Voidonikola P Mitrakou A Manios E Alevizaki M Papamichael C Stamatelopoulos K 曲浥晨 | 2016 | 中华高血压杂志2016，24，5： | 1 |
| 5 | Impact of obesity in intima media thickness of carotid arteries显示文摘 | KOTSIS V T STABOULI S V PAPAMICHAEL C M | 2006 | Obesity (Silver Spring)2006，14，： | 1 |
| 6 | Enoxaparin versustinzaparin in non-ST-segment elevation acute coronary syndromes:results of the enoxaparin versus tinzaparin(EVET)trial at 6 months显示文摘 | Katsouras C Michalis LK Papamichael N | 2005 | Am Heart J2005，150，3： | 1 |
| 7 | Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness显示文摘 | Stabouil S Kotsis V Papamichael C | | 0，，05： | 1 |
| 8 | Common carotid artery intima-media thickness and the risk of stroke recurrence显示文摘 | Tsivgoulis G Vemmos K Papamichael C | 2006 | Stroke2006，37，7： | 1 |
| 9 | Common carotid artery intima-media thickness and the risk of stroke recurrence显示文摘 | Tsivgoulis G Vemmos K Papamichael C | 2006 | Stroke2006，37，7： | 1 |
| 10 | Common carotidartery intima-media thickness and the risk of stroke recurrence 显示文摘 | Tsivgoulis G Vemmos K Papamichael C | 2006 | Stroke2006，37，7： | 1 |
| 11 | Peripheral vascular endothelial dysfunction in patients with angina pectoris and normal coronary arteriograms显示文摘 | Lekakis J P Papamichael C M Vemmos C N | | 0，，3： | 1 |
| 12 | Common carotid artery intime-media thickness and the risk of stroke recurence显示文摘 | Taivgoulis G Vemmoe K Papamichael C | 2006 | Stroke2006，37，07： | 1 |
| 13 | White-coat and masked hypertension in children : association with target-organ damage显示文摘 | Stabouli S Kotsis V Toumanidis S Papamichael C Constantopoulos A Zakopoulos N | 2005 | Pediatr Nephrol2005，20，8： | 1 |
| 14 | Rapid effect of pravastatin on endothelial function and lipid peroxldation in unstableangina显示文摘 | Karatzis E Lekakis J Papamichael C | 2005 | Int JCardiol2005，101，1： | 1 |
| 15 | Treatment of the elderly colorectal cancer patient:SIOG expert recommendations显示文摘 | PAPAMICHAEL D AUDISIO R HORIOT J C | 2009 | Annals of Oncology2009，20，1： | 1 |
| 16 | Pulse pressure in normotensive: a marker of cardiovascular disease显示文摘 | Zakopoulos N A Lekakis J P Papamichael C M | 2001 | Am J Hypertens2001，14，3： | 1 |
| 17 | Rapid effect of pravastatin on endothelial function and lipid peroxidation in unstable angina 显示文摘 | Karatzis E Lekakis J Papamichael C | 2005 | Int J Cardiol2005，101，1： | 1 |
| 18 | Pulse pressure in normotensives: a marker of cardiovascular disease 显示文摘 | ZAKOPOULOS N A LEKAKIS T P PAPAMICHAEL C M | 2001 | AJH2001，14，3： | 1 |
| 19 | Common carotid artery intima-media thickness and the risk of stroke recurrence 显示文摘 | Tsivgoulis G Vemmos K Papamichael C | 2006 | Stroke2006，37，7： | 1 |
| 20 | Treatment of the elderly colorectal cancer patient:SIOG expert recommendatio- ns显示文摘 | Papamichael D Audisio R Horiot J C eta| | 2012 | Ann Onco12012，20，1： | 1 |
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