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| 1 | Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation显示文摘AIM:To investigate the effects of intravenous administration of the antioxidant glutathione (GSH) on reperfusion injury following liver transplantation.METHODS:Livers of male Lewis rats were transplanted after 24 h of hypothermic preservation in University of Wisconsin solution in a syngeneic setting. During a 2-h reperfusion period either saline (controls,n=8) or GSH (50 or 100μmol/(h·kg),n=5 each) was continuously administered via the jugular vein.RESULTS:Two hours after starting reperfusion plasma ALT increased to 1 457±281U/L (mean±SE) in controls but to only 908_+187 U/L (P<0.05) in animals treated with 100μmol GSH/(h·kg).No protection was conveyed by 50μmol GSH/(h·kg).Cytoprotection was confirmed by morphological findings on electron microscopy:GSH treatment prevented detachment of sinusoidal endothelial cells (SECs) as well as loss of microvilli and mitochondrial swelling of hepatocytes. Accordingly, postischemic bile flow increased 2-fold. Intravital fluorescence microscopy revealed a nearly complete restoration of sinusoidal blood flow and a significant reduction of leukocyte adherence to sinusoids and postsinusoidal venules. Following infusion of 50μmol and 100 μmol GSH/(h·kg),plasma GSH increased to 65±7mol/L and 97±18μmol/L,but to only 20±3mol/L in untreated recipients.Furthermore, plasma glutathione disulfide (GSSG) increased to 7.5±1.0mol/L in animals treated with 100μmol/(h·kg) GSH but infusion of 50μmol GSH/(h·kg) did not raise levels of untreated controls (1.8±0.5mol/L vs 2.2±0.2mol/L).CONCLUSION:Plasma GSH levels above a critical level may act as a “sink” for ROS produced in the hepatic vasculature during reperfusion of liver grafts.Therefore, GSH can be considered a candidate antioxidant for the prevention of reperfusion injury after liver transplantation, in particular since it has a low toxicity in humans. | RolfJ.Schauer SinanKalmuk Alexander L.Gerbes Rosemarie Leiderer Herbert Meissner Friedrich W.Schildberg Konrad Messmer Manfred Bilzer | 2004 | World Journal of Gastroenterology2004，10，6： | 9 |
| 2 | Optical near-field imaging and nanostructuring by means of laser ablation显示文摘In this review we consider the development of optical near-field imaging and nanostructuring by means of laser ablation since its early stages around the turn of the century.The interaction of short,intense laser pulses with nanoparticles on a surface leads to laterally tightly confined,strongly enhanced electromagnetic fields below and around the nano-objects,which can easily give rise to nanoablation.This effect can be exploited for structuring substrate surfaces on a length scale well below the diffraction limit,one to two orders smaller than the incident laser wavelength.We report on structure formation by the optical near field of both dielectric and metallic nano-objects,the latter allowing even stronger and more localized enhancement of the electromagnetic field due to the excitation of plasmon modes.Structuring with this method enables one to nanopattern large areas in a one-step parallel process with just one laser pulse irradiation,and in the course of time various improvements have been added to this technique,so that also more complex and even arbitrary structures can be produced by means of nanoablation.The near-field patterns generated on the surface can be read out with high resolution techniques like scanning electron microscopy and atomic force microscopy and provide thus a valuable tool-in conjunction with numerical calculations like finite difference time domain(FDTD)simulations-for a deeper understanding of the optical and plasmonic properties of nanostructures and their applications. | Johannes Boneberg Paul Leiderer | 2022 | Opto-Electronic Science2022，1，1： | 3 |
| 3 | The chemokine CCL5 as a poten- tial prognostic factor predicting disease progression in stage II breast cancer patients 显示文摘 | Yaal N Shina S Leider L | 2006 | Clin Cancer Res2006，12，15： | 1 |
| 4 | Melting and reentrant freezing of two-dimensional colloidal crystals in confined geometry显示文摘 | Bubeck R Bechinger C Neser S Leiderer P | 1999 | Phys Rev Lett1999，82，： | 1 |
| 5 | 显示文摘 | Karakurt I Boneberg J Leiderer P | 2006 | Appl Phys A2006，83，： | 1 |
| 6 | Directed altruism and enforced reciprocity in social networks显示文摘 | Leider S Mobius M M Rosenblat T | 2009 | The Quarter- ly Journal of Economics2009，124，4： | 1 |
| 7 | Hepatic microcirculatory perfu- sion failure is a determinant of liver dysfunction in warm ischemia- reperfusion显示文摘 | Vollmar B Glasz J Leiderer R | 1994 | Am J Pathol1994，145，6： | 1 |
| 8 | High - volume rapid HIVtesting in an urban emergency department 显示文摘 | Calderon Y Leider J Hailpem S | 2009 | AIDS Patient CareSTDS2009，23，9： | 1 |
| 9 | Phase Behavior of Two-Dimensional Colloidal Systems in the Presence of Periodic Light Fields显示文摘 | BECHINGER C BRUNNER M LEIDERER P | 2001 | Phys Rev Lett2001，86，5： | 1 |
| 10 | Radiographic characteristics of cystogenic ameloblastomg显示文摘 | Eversole LR Leider AS Strub D | 1984 | Oral Surg Oral Med Oral Pathol1984，57，5： | 1 |
| 11 | Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo显示文摘 | Massberg S Enders G Matos FC Tomic LI Leiderer R Eisenmenger S Messmer K Krombach F | 1999 | Blood 1999 Dec 11999，94，11： | 1 |
| 12 | The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells显示文摘 | Ido Nevo Orit Sagi-Assif Tsipi Meshel Adit Ben-Baruch Karin J?hrer Richard Greil Leonor E. Leider Trejo Oleg Kharenko Meora Feinmesser Ilana Yron Isaac P. Witz | 2008 | Cancer Letters2008，，1： | 1 |
| 13 | Jμmping nanodroplets显示文摘 | Habenicht A Olapinski M Burneister F Leiderer P Boneberg P | 2005 | Science2005，309，： | 1 |
| 14 | Heat-shock preconditioning protects fatty livers in genetically obese Zucker rats from microvascular perfusion failure after ischemia reperfusion显示文摘 | Kazuhiko Yamagami Georg Enders Rolf Josef Schauer Rosemarie Leiderer J?rg Hutter Yuzo Yamamoto Yoshio Yamaoka Claus Hammer Konrad Messmer | 2003 | Transplant International2003，，8： | 1 |
| 15 | Histologic evaluation of the bone/graft interface after mandibular augmentation with hydroxylapatite/ purified fibrillar collagen composite implants 显示文摘 | MEHLISCH D R LEIDER A S ROBERTS W E | 1990 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics1990，70，6： | 1 |
| 16 | MICROCIRCULATORY FAILURE AFTER RAT LIVER TRANSPLANTATION IS RELATED TO KUPFFER CELL-DERIVED OXIDANT STRESS BUT NOT INVOLVED IN EARLY GRAFT DYSFUNCTION1显示文摘 | Rolf J. Schauer Manfred Bilzer Sinan Kalmuk Alexander L. Gerbes Rosmarie Leiderer Friedrich W. Schildberg Konrad Messmer | 2001 | Transplantation2001，，10： | 1 |
| 17 | Platelet-endothelial cell interactions during ischemia/reperfusion:the role of P-selectin显示文摘 | Massberg S Enders G Leiderer R | 1998 | Blood1998，92，2： | 1 |
| 18 | 显示文摘 | Burmeister F Scha fle C Leiderer P | 1997 | Langmuir1997，13，： | 1 |
| 19 | Cystic ameloblastoma:a clinicopathological analysis显示文摘 | Eversole LR Bardin ME | 1985 | Oral Surg Oral Med Oral Pathol1985，60，： | 1 |
| 20 | Transmission increase upon switching of VO2 thin films on microstructured surfaces显示文摘 | Karakurt I Boneberg J Leiderer P | 2007 | Applied Physics Letters2007，91，09： | 1 |
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