|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation显示文摘AIM:To investigate the effects of intravenous administration of the antioxidant glutathione (GSH) on reperfusion injury following liver transplantation.METHODS:Livers of male Lewis rats were transplanted after 24 h of hypothermic preservation in University of Wisconsin solution in a syngeneic setting. During a 2-h reperfusion period either saline (controls,n=8) or GSH (50 or 100μmol/(h·kg),n=5 each) was continuously administered via the jugular vein.RESULTS:Two hours after starting reperfusion plasma ALT increased to 1 457±281U/L (mean±SE) in controls but to only 908_+187 U/L (P<0.05) in animals treated with 100μmol GSH/(h·kg).No protection was conveyed by 50μmol GSH/(h·kg).Cytoprotection was confirmed by morphological findings on electron microscopy:GSH treatment prevented detachment of sinusoidal endothelial cells (SECs) as well as loss of microvilli and mitochondrial swelling of hepatocytes. Accordingly, postischemic bile flow increased 2-fold. Intravital fluorescence microscopy revealed a nearly complete restoration of sinusoidal blood flow and a significant reduction of leukocyte adherence to sinusoids and postsinusoidal venules. Following infusion of 50μmol and 100 μmol GSH/(h·kg),plasma GSH increased to 65±7mol/L and 97±18μmol/L,but to only 20±3mol/L in untreated recipients.Furthermore, plasma glutathione disulfide (GSSG) increased to 7.5±1.0mol/L in animals treated with 100μmol/(h·kg) GSH but infusion of 50μmol GSH/(h·kg) did not raise levels of untreated controls (1.8±0.5mol/L vs 2.2±0.2mol/L).CONCLUSION:Plasma GSH levels above a critical level may act as a “sink” for ROS produced in the hepatic vasculature during reperfusion of liver grafts.Therefore, GSH can be considered a candidate antioxidant for the prevention of reperfusion injury after liver transplantation, in particular since it has a low toxicity in humans. | RolfJ.Schauer SinanKalmuk Alexander L.Gerbes Rosemarie Leiderer Herbert Meissner Friedrich W.Schildberg Konrad Messmer Manfred Bilzer | 2004 | World Journal of Gastroenterology2004，10，6： | 9 |
| 2 | 双叶背阔肌肌皮瓣修复大面积深部组织缺损显示文摘目的介绍一种新的背阔肌设计切取方法,修复大面积深部组织缺损。方法 6例大面积深部组织缺损患者,其中头顶部创面缺损4例,下肢创面缺损2例,创面宽度均>8 cm。采用双叶背阔肌肌皮瓣设计,在患者一侧背部远近端切取两个依靠深部肌肉相连的较小的背阔肌肌皮瓣,两叶皮瓣在受区进行拼接修复较大的缺损,而供区直接拉拢缝合。结果术后6例患者的移植皮瓣全部成活,最大皮瓣切取面积为18 cm×16 cm。所有皮瓣供区直接拉拢缝合,仅遗留线性瘢痕。随访3~6个月后,移植皮瓣成活良好、柔软、色泽佳,供区的外形和功能满意。结论应用双叶背阔肌肌皮瓣设计可以最大限度减少供区的数目和损伤,并能获得最佳的供区术后外观。 | 王朝阳 章一新 王丹茹 濮哲铭 罗先平 苏薇洁 钱云良 Caroline Messmer | 2012 | 上海交通大学学报(医学版)2012，32，5： | 7 |
| 3 | Silk fibroin microtubes for blood vessel engineering显示文摘 | Michael Lovett Christopher Cannizzaro Laurence Daheron Brady Messmer Gordana Vunjak-Novakovic David L. Kaplan | 2007 | Biomaterials2007，，35： | 2 |
| 4 | Freeway ramp metering: an overview显示文摘 | PAPAGEORGIOU M MESSMER A | 2002 | IEEE Transactions on Intelligent Transportation Systems2002，3，4： | 1 |
| 5 | Unexpected high complication rate following internal fixation of unstable proximal humerus fractures with an angled blade plate显示文摘 | Meier RA Messmer P Regazzoni P | 2006 | J Orthop Trauma2006，20，7： | 1 |
| 6 | Induction of tyrosine hydroxylase expression by the transcription factor pitx3显示文摘 | Messmer K Remington M P Skidmore F | 2007 | Int J Dev Neurosci2007，25，1： | 1 |
| 7 | New stabilization techniques for fixation of proximal tibial fractures ( LISS/LCP)显示文摘 | Messmer P Regazzoni P Gross T | 2003 | Ther Umsch2003，60，： | 1 |
| 8 | High-mobility group box 1 (HMGB1) protein: friend and foe 显示文摘 | Ulloa L Messmer D | 2006 | Cytokine Growth Factor Rev2006，17，3： | 1 |
| 9 | In vivo confocal microscopy of corneal small fiber damage in diabetes melhtus 显示文摘 | Messmer EM Schmid-Tannwald C Zapp D | 2010 | Graefes Arch Clin Exp Ophthalmol2010，248，9： | 1 |
| 10 | Freeway ramp metering:An overview显示文摘 | Papageorgiou M Messmer A | 2002 | IEEE Transactions on Intelligent Transportation Systems2002，3，4： | 1 |
| 11 | Analysis of stickies in deinked pulp,part II:distribution of stickies in deinked pulp显示文摘 | Sarja T MacNeil D Messmer M | 2006 | Professional Papermaking2006，，1： | 1 |
| 12 | Unexpected high com- plication rate following internal fixation of unstable proximal humerus fractures with an angled blade pate显示文摘 | Meier R A Messmer P Regazzoni P | 2006 | J Orthop Trauma2006，20，4： | 1 |
| 13 | Loss of a primordial identity element for a mammalian mitochondrial aminoacylation system显示文摘 | Fender A Sauter C Messmer M | 2006 | J Biol Chem2006，281，15： | 1 |
| 14 | An Adaptive Freeway Traffic State Estimator 显示文摘 | WANG Y PAPAGEORGIOU M MESSMER A | 2009 | Automatica2009，45，1： | 1 |
| 15 | Genetic diversity among progenitors and elite lines from the Iowa Stiff Stalk Synthetic (BSSS) maize population: Comparison of allozyme and RFLP data显示文摘 | Messmer M M Melchinger A E Woodman W L | 1991 | Theoretical and Applied Genetics1991，83，： | 1 |
| 16 | Resolution of diabetic maeular edema after surgical removal of the posterior hyaloids and the inner limiting membrane 显示文摘 | Gandorfer A messmer EM Ulbig MW | 2000 | Retia2000，20，2： | 1 |
| 17 | In vivo confocal microscopy of normal conjunctiva and conjunctivitls显示文摘 | Messmer E M Mackert M J Zapp DM | 2006 | Cornea2006，25，： | 1 |
| 18 | Hemdilution显示文摘 | MESSMER K SUNDER-PLASSMANN L | 1974 | Prog Surg1974，13，： | 1 |
| 19 | The interferon gamma induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF alpha) induction of matrix metalloproteinase 9 (MMP-9) by inhibiting NF kappaB and Rac protein显示文摘 | Balasubramanian S Fan M Messmer Blust AF | 2011 | J Biol Chem2011，286，20： | 1 |
| 20 | Can the Proximal Femoral Nail be Improved?显示文摘 | Inger B. 1 8 Phone Fax e-mail: Schipper MD PhD Roger K. J. Simmermacher Tobias Hüttl R?bi Frigg Peter Messmer Michael Schütz Andreas Lenich Chris Werken | 2005 | European Journal of Trauma2005，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员