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| 1 | Targeting leukemic fusion proteins with small interfering RNAs:recent advances and therapeutic potentials显示文摘RNA 干扰成为了一个不可缺少的研究工具在许多有机体学习基因功能。因为他们的高功效和特性, RNA 基于干扰的途径可以也翻译成新治疗学的策略治疗人的疾病。特别地,象白血病的熔化蛋白质那样的 oncogenes,从染色体 translocations 产生,为如此的基因正在答应目标因为他们只在癌症前期、癌的纸巾被表示, silencing 来临,并且因为他们为维持恶意的显型经常是不可缺少的。这评论在指向白血病特定的基因总结最近的开发并且为可能的临床的应用讨论问题和途径。 | Maria THOMAS Johann GREIL Olaf HEIDENREICH | 2006 | Acta Pharmacologica Sinica2006，27，3： | 10 |
| 2 | Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives显示文摘The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor receptor(EGFR)signaling has improved clinical outcome of patients withmetastatic colorectal cancer(mCRC).In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC.The effects of available treatment strategies for mCRC are often temporary,with resistance and disease progression developing in most patients.Thus,new treatment strategies are urgently needed.Some GI peptides including gastrin and gastrin releasing peptide,certain growth factors such as insulin-like growth factor-ⅠandⅡand neuropeptides such as growth hormone releasing hormone(GHRH)are implicated in the growth of CRC.Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide,GHRH,and with cytotoxic peptides that can be targeted to peptide receptors on tumors,are summarized in the second part of the review. | Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally | 2014 | World Journal of Gastroenterology2014，20，20： | 3 |
| 3 | Generic principles of crack-healing ceramics显示文摘Ceramic materials able to heal manufacture or damage induced microstructure defects might trigger a change in paradigm for design and application of load bearing ceramics.This work reviews thermodynamic and kinetic aspects governing the regeneration of solid contact able to transfer stress between disrupted crack surfaces in ceramics.Major crack healing processes include perturbation of crack-like pores followed by sintering of isolated pores,as well as reaction with an environmental atmosphere and filling of the crack space with an oxidation product.Since thermally activated solid state reactions require elevated temperatures which may exceed 1000℃,processes able to trigger crack healing at lower temperatures are of particular interest for transferring into engineering applications.Generic principles of microstructure modifications able to facilitate crack repair at lower temperatures will be considered:(i)acceleration of material transport by grain boundary decoration and grain size reduction,and(ii)reduction of thermal activation barrier by repair filler activation.Examples demonstrating crack healing capability include oxidation reaction of low energy bonded intercalation metal from nano-laminate MAX phases and catalyzed surface nitridation of polymer derived ceramics containing repair fillers. | Peter GREIL | 2012 | Journal of Advanced Ceramics2012，1，4： | 3 |
| 4 | Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population显示文摘Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field. | Frances M Mitchell Sanjay K Prasad Gerald F Greil Peter Drivas Vassilios S Vassiliou Claire E Raphael | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 2 |
| 5 | Review: aqueous tape casting of ceramic powders显示文摘 | Hotza D Greil G | 1995 | Materials Science and Engineering1995，202，： | 1 |
| 6 | Three-dimensional morphological magnetic resonance imaging in infants and children with congenital heart disease显示文摘 | Fenchel M Greil GF Martirosian P | 2006 | Pediatr Radiol2006，36，12： | 1 |
| 7 | Noninvasive assessment of pul- monary artery flow and resistance by cardiac magnetic resonance in congenital heart diseases with unrestricted left-to-right shunt 显示文摘 | Bell A Beerbaum P Greil G | 2009 | JACC Cardiovasc Imaging2009，2，11： | 1 |
| 8 | 查看详情显示文摘 | Zampieri A Kullmann S Selvam T Bauer J Schwieger W Sieber H Fey T Greil P | | 0，，： | 1 |
| 9 | 显示文摘 | Greil P | 1998 | J Euro Ceram Soc1998，18，13： | 1 |
| 10 | Noninvasive assessment of pulmonary artery flow and resistance by cardiac magnetic reso-nance in congenital heart diseases with unrestricted left-to-right shunt显示文摘 | Bell A Beerbaum P Greil G | | JACC Cardiovasc Imaging0，，： | 1 |
| 11 | Three-dimensional mor- phological magnetie resonance imaging in infants and children with congenital heart disease显示文摘 | Fenchel M Greil G F Martirosian P et ol | 2006 | Pediatr Radiol2006，36，12： | 1 |
| 12 | Gadolinium-enhanced three-dimensiongal magnetic resonance angiography of pulmonary blood supply in patients with complex pulmonary stenosis or atresia:comparison with X-ray angiography显示文摘 | Geva T Greil GF Marshall AC | 2002 | Circulation2002，，106： | 1 |
| 13 | Noninvasive assessment of pulmonary artery flow and resistance by cardiac magnetic resonance in congenital heart diseases with unrestricted left-to-right shunt显示文摘 | Bell A Beerbaum P Greil G | 2009 | JACC Cardiovasc Imaging2009，2，11： | 1 |
| 14 | Randomized phase I1 study ofthe anti-epidermal growth factor receptor monoclonal antibody cetux- imab With cisplatin versus cisplatin alone in patients with metastatic triple-negative breast cancer 显示文摘 | Baselga J G6mez P Greil R | 2013 | J Clin 0ncol2013，31，20： | 1 |
| 15 | The hidden infertile infertile women 显示文摘 | Greil AL Mcquillan J Johnson K | 2010 | Fertility and Sterility2010，93，6： | 1 |
| 16 | Biomorphic cellular silicon carbide ceramics from wood:I, processing and microstnmture显示文摘 | Greil P Lifka T Kaindl A | 1998 | J Eur Ceram Soe1998，18，14： | 1 |
| 17 | Assay of synovial fluid parameters:hyaluronan concentration as a potential marker for joint diseases显示文摘 | Praest BM Greiling H Kock R | | 0，，： | 1 |
| 18 | Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki disease显示文摘 | Gerald F. Greil Achim Seeger Stephan Miller Claus D. Claussen Michael Hofbeck René M. Botnar Ludger Sieverding | 2007 | Pediatric Radiology2007，，7： | 1 |
| 19 | Neoadjuvant chemother-apy and targeted therapy in breast cancer:past, present, and future显示文摘 | Gampenrieder SP Rinnerthaler G Greil R | | 0，，： | 1 |
| 20 | Longterm outcome after haploidentical stem cell transplantation in children显示文摘 | Lang P Greil J Bader P | 2004 | Blood Cells Mol Dis2004，33，3： | 1 |
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