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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Incidence and in-hospital mortality of acute aortic dissection in China: analysis of China Health Insurance Research (CHIRA) Data 2011显示文摘ObjectiveAcute 大动脉的解剖(AAD ) 是有高早的死亡率的一个灾难的事件,但是迄今为止,在大陆中国的 AAD 的发生上的数据都不是可得到的。这研究试图在中国估计 AAD 的发生并且描绘临床的侧面,这脉管的 event.MethodsWe 的管理和在里面医院结果使用了中国健康保险研究数据( CHIRA 数据) 2011 它从 25 个城市在到 3,335,000 个随机取样的受益人( 1,718,500 个男人和 1,616,500 个女人)的2011年12月31日的1月一日 2011 的经期期间包括所有住院病人医院记录( 300,886 )并且在大陆中国的不同经济地理的区域的县。有尖锐大动脉的解剖的病人根据疾病 10 I71.0 的 th 修订(ICD-10 ) 。AAD 的估计的发生用方程被计算:估计的发生 = 2.0 ×( 40%×医院承认率)+60%×医院承认 rate.ResultsThe 医院承认率是 2.0/100,000 (65/3,325,000, 95% CI:1.2-2.8 ) 。AAD 的估计的年度发生是 2.8/100,000 (95% CI:1.9-3.6 ) 并且比在女性在男性是更高的(3.7 对 1.5, P <0.001 ) 。吝啬的年龄是 58.9 ±13.4 年。在 23 ± 的吝啬的医院停留期间;6 天,全面在里面医院死亡是 13.9%(9/65 ).ConclusionsOur 学习在中国的大陆显示出相对更低然而并非可以忽略的发生和 AAD 的在里面医院死亡。有用汉语的 AAD 的病人的吝啬的年龄比从西方国家由研究报导了的年轻,当到女发生比率的男性类似于另外的研究报导的那些时。 | Lei XIA Jing-Hu LI Kun ZHAO Hai-Yun WU | 2015 | Journal of Geriatric Cardiology2015，12，5： | 49 |
| 3 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 4 | Effects of Active Modified Atmosphere Packaging on Postharvest Quality of Shiitake Mushrooms (Lentinula edodes) Stored at Cold Storage显示文摘The effects of active modified atmosphere packaging (MAP) on the postharvest quality of shiitake mushrooms stored at cold temperature (4°C) were investigated.The gas components were 2% O 2 +7% CO 2 (MAP1),2% O 2 +10% CO 2 (MAP2) and 2% O 2 +13% CO 2 (MAP3),respectively.The results showed that active MAP could extend the shelf-life of shiitake mushrooms to 17 d and the concentration of carbon dioxide could influence the postharvest quality of shiitake mushrooms.MAP2 treatment inhibited the increase in respiration rate and malondinaldehyde (MDA) contents,delayed the decrease in firmness,soluble sugar and vitamin C,and obviously reduced the activity of polyphenol oxidase (PPO) and the degree of browning,therefore maintaining better quality. | YE Jing-jun LI Jian-rong HAN Xiao-xiang ZHANG Lei JIANG Tian-jia XIA Miao | 2012 | Journal of Integrative Agriculture2012，11，3： | 39 |
| 5 | 2000–2020年中国氮氧化物排放清单及排放趋势(英文)显示文摘研究目的:建立2000–2020年中国氮氧化物排放清单,了解中国主要行业和省份氮氧化物的排放情况,为评估氮氧化物的环境影响和制定相关减排政策提供依据。创新要点:分析了中国主要省份产业结构对氮氧化物排放量的影响;根据不同情景分析,预测2020年中国氮氧化物的排放量。研究方法:1.基于自底向上法,根据不同类型化石燃料的氮氧化物排放因子,结合化石燃料消耗量,建立中国2000–2010年氮氧化物排放清单;2.基于IPAT方程,并以中国2000–2010年的国内生产总值增长数据和氮氧化物排放量为依据,分三种情景,分析2011–2020年中国能源消耗和氮氧化物排放趋势。重要结论:2010年中国氮氧化物的排放量约是2000年的两倍;自2009年起,中国氮氧化物总排放量超过了二氧化硫总排放量;主要由于产业结构和地区生产总值的不同,中国东部和西部氮氧化物排放量有明显差异;制造业、电力行业和交通运输业是中国氮氧化物的主要排放源,其中交通运输业氮氧化物排放量呈现逐年增长趋势;预计2020年中国氮氧化物排放量为19.7 Mt。 | Yun SHI Yin-feng XIA Bi-hong LU Nan LIU Lei ZHANG Su-jing LI Wei LI | 2014 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2014，15，6： | 34 |
| 6 | A comprehensive classification method for VOC emission sources to tackle air pollution based on VOC species reactivity and emission amounts显示文摘In China, volatile organic compound(VOC) control directives have been continuously released and implemented for important sources and regions to tackle air pollution. The corresponding control requirements were based on VOC emission amounts(EA), but never considered the significant differentiation of VOC species in terms of atmospheric chemical reactivity. This will adversely influence the effect of VOC reduction on air quality improvement. Therefore,this study attempted to develop a comprehensive classification method for typical VOC sources in the Beijing–Tianjin–Hebei region(BTH), by combining the VOC emission amounts with the chemical reactivities of VOC species. Firstly, we obtained the VOC chemical profiles by measuring 5 key sources in the BTH region and referencing another 10 key sources, and estimated the ozone formation potential(OFP) per ton VOC emission for these sources by using the maximum incremental reactivity(MIR) index as the characteristic of source reactivity(SR). Then, we applied the data normalization method to respectively convert EA and SR to normalized EA(NEA) and normalized SR(NSR) for various sources in the BTH region.Finally, the control index(CI) was calculated, and these sources were further classified into four grades based on the normalized CI(NCI). The study results showed that in the BTH region,furniture coating, automobile coating, and road vehicles are characterized by high NCI and need to be given more attention; however, the petro-chemical industry, which was designated as an important control source by air quality managers, has a lower NCI. | Guohao Li Wei Wei Xia Shao Lei Nie Hailin Wang Xiao Yan Rui Zhang | 2018 | Journal of Environmental Sciences2018，30，5： | 32 |
| 7 | Current cancer burden in China: epidemiology, etiology, and prevention显示文摘Cancer has become the most common cause of death in China.Owing to rapid economic development,improved livelihood,and shifts in risk factors,cancer epidemiology has experienced substantial changes during the past several decades.In this review,we aim to describe the current cancer epidemiology of the main types of cancer in China,report major risk factors associated with cancer development,and summarize the contributions of the Chinese government to controlling the cancer burden.A total of 4,064,000 new cases were diagnosed in China in 2016.The most frequent types are lung cancer(828,100;20.4%),colorectal cancer(408,000;10.0%),and gastric cancer(396,500;9.8%).Lung(657,000;27.2%),liver(336,400,13.9%),and stomach(288,500;12.0%)cancers are the 3 most deadly cancers in the general population.The 5-year survival rate for cancer has dramatically increased in recent decades.However,liver and particularly pancreatic cancers still have the poorest prognosis.The main modifiable risk factors associated with cancer development include infectious agents,smoking,alcohol consumption,obesity,unhealthful dietary habits,and inadequate physical activity.The Chinese government has made unremitting efforts to decrease the cancer burden,including cancer education and investment in cancer screening programs. | Maomao Cao He Li Dianqin Sun Siyi He Xinxin Yan Fan Yang Shaoli Zhang Changfa Xia Lin Lei Ji Peng Wanqing Chen | 2022 | Cancer Biology & Medicine2022，19，8： | 33 |
| 8 | Precise Modifications of Both Exogenous and Endogenous Genes in Rice by Prime Editing显示文摘Dear Editor,Harnessing genetic diversity and the introduction of elite alleles from wild relatives or landraces into commercial cultivars has been a major goal in crop breeding programs.Precise modification of the plant genome through clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated protein(Cas)(CRISPR/Cas)-mediated homology-directed repair(HDR)offers a great promise to introduce elite alleles from wild relatives or landraces into commercialized cultivars in the short term. | Huiyuan Li Jingying Li Jilin Chen Lei Yan Lanqin Xia | 2020 | Molecular Plant2020，13，5： | 30 |
| 9 | Engineering application of membrane bioreactor for wastewater treatment in China: Current state and future prospect显示文摘中国是大规模膜生物反应器(MBR ) 的 forerunner 申请。自从第一大规模 MBR (10 000 m < 啜 class= “ a-plus-plus ” > 3 湩朠潯 ? 慦瑩? | Kang XIAO Ying XU Shuai LIANG Ting LEI Jianyu SUN Xianghua WEN Hongxun ZHANG Chunsheng CHEN Xia HUANG | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 26 |
| 10 | Early nasogastric enteral nutrition for severe acute pancreatitis: A systematic review显示文摘AIM: To evaluate the effectiveness and safety of early nasogastric enteral nutrition (NGEN) for patients with severe acute pancreatitis (SAP). METHODS: We searched Cochrane Central Register of Controlled Trials (Issue 2, 2006), Pub-Medline (1966-2006), and references from relevant articles. We included randomized controlled trials (RCTs) only, which reported the mortality of SAP patients at least. Two reviewers assessed the quality of each trial and collected data independently. The Cochrane Collaboration’s RevMan 4.2.9 software was used for statistical analysis. RESULTS: Three RCTs were included, involving 131 patients. The baselines of each trial were comparable. Meta-analysis showed no significant differences in mortality rate of SAP patients between nasogastric and conventional routes (RR = 0.76, 95% CI = 0.37 and 1.55, P = 0.45), and in other outcomes, including time of hospital stay (weighted mean difference = -5.87, 95% CI = -20.58 and 8.84, P = 0.43), complication rate of infection (RR = 1.41, 95% CI = 0.62 and 3.23, P = 0.41) or multiple organ defi ciency syndrome (RR = 0.97, 95% CI = 0.27 and 3.47, P = 0.97), rate of admission to ICU (RR = 1.00, 95% CI = 0.48 and 2.09, P = 0.99) or conversion to surgery (RR = 0.66, 95% CI = 0.12 and 3.69, P = 0.64), as well as recurrence of re-feeding pain and adverse events associated with nutrition. CONCLUSION: Early NGEN is a breakthrough in the management of SAP. Based on current studies, early NGEN appears effective and safe. Since the available evidence is poor in quantity, it is hard to make an accurate evaluation of the role of early NGEN in SAP.Before recommendation to clinical practice, further high qualified, large scale, randomized controlled trials are needed. | Kun Jiang Xin-Zu Chen Qing Xia Wen-Fu Tang Lei Wang | 2007 | World Journal of Gastroenterology2007，13，39： | 21 |
| 11 | Effect of Chaiqinchengqi decoction on sarco/endoplasmic reticulum Ca^(2+)-ATPase mRNA expression of pancreatic tissues in acute pancreatitis rats显示文摘AIM: To investigate the effect of Chaiqinchengqi decoction (CQCQD) on sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) mRNA expression of pancreatic tissues in acute pancreatitis (AP) rats. METHODS: Thirty Sprague-Dawley (SD) rats were randomized into control group, AP group and CQCQD group (n = 3 × 10). The rats in the CQCQD group were intragastrically administered with CQCQD (10 mL/kg every 2 h) after induction of AP by intraperitoneal injection of caerulein (50 μg/kg.h × 5) within 4 h. At 6 h after the induction of AP model, pancreatic tissues were collected for the pathological observation, mRNA extraction for determination of SERCA1 and SERCA2 mRNA expression or pancreatic acinar cell isolation for measurement of fluorescence intensity (FI) of intracellular calcium ion concentration [Ca2+]i. RESULTS: There was no expression of pancreatic SERCA1 mRNA in the control group and the AP group. The expression of pancreatic SERCA2 mRNA in the AP group was down-regulated (expression ratio = 0.536; P = 0.001) compared with the control group, while that in the CQCQD group was up-regulated (expression ratio= 2.00; P = 0.012) compared with AP group. The FI of intracellular [Ca2+] of pancreatic acinar cells in the AP group (138.2 ± 23.1) was higher than the C group (111.0 ± 18.4) and the CQCQD group (118.7 ± 15.2 ) (P < 0.05) and the pancreatic pathological score in the CQCQD group was lower than that in the AP group (5.7 ± 1.9 vs 9.2 ± 2.7, P < 0.05).CONCLUSION: CQCQD can up-regulate the expression of SERCA2 mRNA of pancreatic tissues, reduce intracellular calcium overload and relieve pancreatic tissue lesions. | Ping Xue Li-Hui Deng Zhao-Da Zhang Xiao-Nan Yang Qing Xia Da-Kai Xiang Lei Huang Mei-Hua Wan | 2008 | World Journal of Gastroenterology2008，14，15： | 20 |
| 12 | Safflower yellow injection combined with conventional therapy in treating unstable angina pectoris:a meta-analysis显示文摘OBJECTIVE:To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS:We searched online databases:Chinese journal full-text database,China National Knowledge Infrastructure,Wanfang database,Chinese journal full-text database,Pubmed,ScienceDirect,Embase,and the Cochrane Library with manual-screening of relevant literature.Eligible randomized controlled trials(RCT)on angina pectoris were included.We conducted meta-analysis using the RevMan 5.1 software from The Cochrane Collaboration.We treated the relief rate of angina symptoms and electrocardiograph(ECG)as evaluation.RESULTS:Seven articles,including in 1134 patients,were enrolled after the evaluation.Therewas no significant heterogeneity among the studies(χ2=1.08,df=6,P=0.98,I2=0%).The safflower yellow injection with conventional therapy has a higher effective rate than the control group in relieving the symptoms of angina pectoris[odds ratio(OR)=2.95,95%(CI)(1.81,4.81)]and improving ischemic ECG[OR=2.85,95%CI(1.67,4.86)].The difference was statistically significant in the'80 mg dosage'and'100 mg dosage'subgroups(P<0.05)for improving clinical symptoms and ECG.The funnel graphic was nearly symmetrical.Sensitivity analysis suggested that the results were stable.CONCLUSION:Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone.However,the conclusions should be interpreted with care until more high-quality RCTs are reported.2013 JTCM.All rights reserved. | Dezhao Kong Wei Xia Zhe Zhang Lei Xiao Dongchao Yuan Yue Liu Guanlin Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 13 | Portosplenomesenteric vein thrombosis in patients with early-stage severe acute pancreatitis显示文摘AIM To investigate the incidence and risk factors of portosplenomesenteric vein thrombosis(PSMVT) in the early stage of severe acute pancreatitis(SAP).METHODS Patients with SAP in a tertiary care setting from January 2014 to December 2016 were retrospectively reviewed. All contrast-enhanced computed tomography(CT) studies were reassessed and reviewed. Clinical outcome measures were compared between SAP patients with and without PSMVT in the early stage of the disease. Univariate and multivariate logistic regression analyses were sequentially performed to assess potential risk factors for the development of PSMVT in SAP patients. A receiver operating characteristic(ROC) curve was generated for the qualifying independent risk factors.RESULTS Twenty-five of the one hundred and forty(17.86%) SAP patients developed PSMVT 6.19 ± 2.43 d after acute pancreatitis(AP) onset. PSMVT was confirmed by contrast-enhanced CT. Multivariate stepwise logistic regression analyses showed that Balthazar's CT severity index(CTSI) scores [odds ratio(OR): 2.742; 95% confidence interval(CI): 1.664-4.519; P = 0.000], hypoalbuminemia(serum albumin level < 25 g/L)(OR: 32.573; 95%CI: 2.711-391.353; P = 0.006) and gastrointestinal wall thickening(OR: 4.367, 95%CI: 1.218-15.658; P = 0.024) were independent risk factors for PSMVT developed in patients with SAP. The area under the ROC curve for Balthazar's CTSI scores was 0.777(P = 0.000), the sensitivity was 52%, and the specificity was 93% at a cut-off value of 5.5.CONCLUSION High Balthazar's CTSI scores, hypoalbuminemia and gastrointestinal wall thickening are independent risk factors for PSMVT developed in the early stage of SAP. | Ling Ding Feng Deng Chen Yu Wen-Hua He Liang Xia Mi Zhou Xin Huang Yu-Peng Lei Xiao-Jiang Zhou Yin Zhu Nong-Hua Lu | 2018 | World Journal of Gastroenterology2018，24，35： | 20 |
| 14 | YAP promotes osteogenesis and suppresses adipogenic differentiation by regulatingβ-catenin signaling显示文摘YAP(yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis.YAP is selectively expressed in osteoblast(OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs(bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis. | Jin-Xiu Pan Lei Xiong Kai Zhao Peng Zeng Bo Wang Fu-Lei Tang Dong Sun Hao-han Guo Xiao Yang Shun Cui Wen-Fang Xia Lin Mei Wen-Cheng Xiong | 2018 | Bone Research2018，6，2： | 19 |
| 15 | Theoretical Analysis and Experimental Verification on Flow Field of Piezoelectric Pump with Unsymmetrical Slopes Element显示文摘Regular valveless piezoelectric pumps have rectifying elements outside their chambers to produce net flow.These rectifying elements outside the chamber will increase the overall volume of the pump and prevent its minimization.Valveless piezoelectric pump with unsymmetrical slopes elements(USE),proposed in this paper,differs from other valveless pumps in that it is easy to be minimized by developing the chamber bottom as such a rectifying element.In this research,the working principle of the proposed pump was analyzed first.Numerical models were thereby established and numerical simulation was conducted to the chamber flow field with the method of time-dependent velocity.The effects of the USEs on the flow field in the chamber were shown clearly in simulation.And the particular feature of flow field in the chamber was discovered.It behaves a complex flow field,in which strong turbulent occurs companying a lot of vortexes in different directions and different sizes.This feature is just opposite to what regular piezoelectric pumps expect:a moderate flow field.The turbulent flow could be used to have different liquids stirred and well mixed in the chamber to produce homogeneous solution,emulsion or turbid liquid.Meanwhile,numerical simulation also presents the effect of the angles difference of the two slopes upon the flow field,and upon the flow rate of the pump,which fits to the theoretical analysis.Experiments with the proposed pump were also conducted to verify the numerical results.In these experiments,six USEs with different slope angles were used for efficiency tests,which proved the validity and reliability of the numerical analysis.The data obtained from numerical analysis agree well with that from the experiments.The errors ranged from 4.4% to 14.8% with their weighted average error being 9.7%. | XIA Qixiao ZHANG Jianhui LEI Hong CHENG Wei | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 18 |
| 16 | Synthesis of graphitic carbon nitride through pyrolysis of melamine and its electrocatalysis for oxygen reduction reaction显示文摘Graphitic carbon nitride(g-C3N4) was synthesized via direct pyrolysis of melamine and its electrocatalysis toward oxygen reduction reaction was studied.The morphology and structures of the products were characterized by scanning electron microscope and X-ray powder diffractometer.It was found that higher pyrolysis temperature resulted in more perfect crystalline structure of the graphitic carbon nitride product.Electrochemical characterizations show that the g-C3N4 has electrocatalytic activity toward ORR through a two-step and two-electron process. | He-Sheng Zhai Lei Cao Xing-Hua Xia | 2013 | Chinese Chemical Letters2013，24，2： | 18 |
| 17 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 18 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 19 | A detailed procedure for CRISPR/Cas9-mediated gene editing in Arabidopsis thaliana显示文摘The newly developed CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats)/Cas(CRISPR-associated) system has emerged as an efficient tool for genome-editing, providing an alternative to classical mutagenesis and transgenic methods to study gene function and improve crop traits. CRISPR/Cas facilitates targeted gene editing through RNA-guided DNA cleavage followed by cellular DNA repair mechanisms that introduce sequence changes at the site of cleavage. Here we describe a detailed procedure for our previously developed and highly efficient CRISPR/Cas9 method that allows the generation of heritable-targeted gene mutations andcorrections in Arabidopsis. This protocol describes the strategies and steps for the selection of targets, design of single-guide RNA(sg RNA), vector construction and analysis of transgenic lines. We also offer a method to target two loci simultaneously using vectors containing two different sg RNAs. The principles described in this protocol can be applied to other plant species to generate stably inherited DNA modifications. | Wenshan Liu Xiaohong Zhu Mingguang Lei Qingyou Xia Jose Ramon Botella Jian-Kang Zhu Yanfei Mao | 2015 | Science Bulletin2015，60，15： | 18 |
| 20 | Transurethral seminal vesiculoscopy for recurrent hemospermia: experience from 419 cases显示文摘 | Rui Chen Lei Wang Xia Sheng Shu-Guang Piao Xin-Wen Nian Xin Cheng Tie Zhou Hui-Zhen Li Ya-Wei Liu Guang-Hua Chen Chun-Lei Zhang De-Pei Kong Guang-An Xiao Xin Lu Zhen-Yu Jia Zhi-Yong Liu Ying-Hao Sun | 2018 | Asian Journal of Andrology2018，20，5： | 18 |
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