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| 1 | 散发型克罗伊茨费尔特-雅各布病患者的睡眠-觉醒紊乱显示文摘Background: The prevalence and characteristics of sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease (sCJD) are poorly understood. Methods: Seven consecutive patients with definite sCJD underwent a systematic assessment of sleep-wake disturbances, including clinical history, videopolysomnography, and actigraphy. Extent and distribution of neurodegeneration was estimated by brain autopsy in six patients. Western blot analyses enabling classification and quantification of the protease-resistant isoform of the prion protein, PrPSc, in thalamus and occipital cortex was available in four patients. Results: Sleep-wake symptoms were observed in all patients, and were prominent in four of them. All patients had severe sleep EEG abnormalities with loss of sleep spindles, very low sleep efficiency, and virtual absence of REM sleep. The correlation between different methods to assess sleep-wake functions (history, polysomnography, actigraphy, videography) was generally poor. Brain autopsy revealed prominent changes in cortical areas, but only mild changes in the thalamus. No mutation of the PRNP gene was found. Conclusions: This study demonstrates in sporadic Creutzfeldt-Jakob disease, first, the existence of sleep-wake disturbances similar to those reported in fatal familial insomnia in the absence of prominent and isolated thalamic neuronal loss, and second, the need of a multimodal approach for the unambiguous assessment of sleep-wake functions in these patients. | Landolt H.-P Glatzel M. Blttler T. C.L. Bassetti 张嘉靖 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 2 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | High-Density Lipoprotein Transport Through Aortic Endothelial Cells Involves Scavenger Receptor BI and ATP-Binding Cassette Transporter G1显示文摘 | Lucia Rohrer Pascale M. Ohnsorg Marc Lehner Franziska Landolt Franz Rinninger Arnold von Eckardstein | 2009 | Circulation Research2009，，10： | 2 |
| 4 | Electrochimica acta显示文摘 | Datta M landolt D | 1981 | Electrochemical machining under pulsed current conditions1981，26，7： | 1 |
| 5 | Binary floral lure attractive to velvetbean caterpillar adults (Lepidoptera: noctuidae)显示文摘 | Meagher R L Landolt P J | 2010 | Florida Entomologist2010，93，1： | 1 |
| 6 | Electrochemical micromachining, polishing and surface structuring of metals: fundamental aspects and new developments 显示文摘 | LANDOLT D CHAUVY P F ZINGER O | 2003 | Electrochimica Acta2003，，48： | 1 |
| 7 | Insufficient non- REM sleep intensity in narcolepsy cataplexy 显示文摘 | Khatami R Landolt HP Achermann P | 2007 | Sleep2007，30，8： | 1 |
| 8 | Mating frequency of the papaya fruit fly (Diptera: Tephritidae) with and without host fruit显示文摘 | Landolt P J | 1994 | Florida Ento- mologist1994，，： | 1 |
| 9 | A concept for the introduction of cerebral microdialysis in neurointensive care显示文摘 | Landolt H Langemann H Alessandri B | 1996 | Acta Neurochir Suppl1996，67，： | 1 |
| 10 | Evaluation of corrosion protection properties of additives for waterborne epoxy coatings on steel 显示文摘 | F Galliano D Landolt | 2002 | Progress in Organic Coatings2002，44，： | 1 |
| 11 | Attraction of pest moths (Lepidoptera: Noctuidae, Crambidae) to floral lures on the island of Hawaii显示文摘 | Landolt P Jang E Carvalho L | 2011 | Hawaiian Entomological Society Proceedings2011，43，： | 1 |
| 12 | Psychosocial adjustment,health-related quality of life,and psychosexual development of boys with hypospadias:a systematic review显示文摘 | Sch nbucher VB Weber DM Landolt MA | | 0，，05： | 1 |
| 13 | The role of passive oxide films on the degradation of steel in tribocorrosion systems显示文摘 | Mischler S Spiegel A Landolt D | 1999 | Wear1999，，： | 1 |
| 14 | Atmospheric oxidation of a Nb-Zr alloy studied with XPS显示文摘 | OLSSON C O A LANDOLT D | 2004 | Corrosion Science2004，46，： | 1 |
| 15 | Effect of dispersion agent on the degradation of a water bome paint on steel studied by scanning acoustic microscopy and impedance 显示文摘 | V guillaumin D Landolt | 2002 | Corrosion Science2002，44，： | 1 |
| 16 | Intrinsic and heat-induced exchange coupling through amorphous silicon显示文摘 | Briner B Landolt M | 1994 | Phys Rev Lett1994，73，： | 1 |
| 17 | Pulse-reverse plating of nanocomposite thin fihns显示文摘 | Podlaha E J Landolt D | 1997 | J Electrochem Soc1997，144，7： | 1 |
| 18 | How wind affects the photosynthetic performance of trees:quantified with chlorophyll a fluorescence and open-top chambers显示文摘 | Clark AJ Landolt W Bucher JB Strasser RJ | | 0，，： | 1 |
| 19 | In vitro toxicity of eight mutagens/carcinogens for three fish ceil lines显示文摘 | Richard M. Kocan Marsha L. Landolt Kathleen M. Sabo | 1979 | Bulletin of Environmental Contamination and Toxicology1979，，1： | 1 |
| 20 | The influence of gallic acid on the reduction of rust on painted steel surfaces显示文摘 | LANDOLT D | 1993 | Corrosion Science1993，34，9： | 1 |
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