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| 1 | WONCA研究论文摘要汇编--老年亚临床甲状腺功能减退治疗策略的国际变化趋势:一项基于案例的调查显示文摘背景关于亚临床甲状腺功能减退治疗效果的证据十分有限,特别是对于老年患者的治疗效果。目的探讨全科医生在不同国家和针对不同类型的患者对老年亚临床甲状腺功能减退治疗的不同方式。设计和环境在荷兰、德国、英格兰、爱尔兰、瑞士和新西兰进行基于案例的全科医生调查。方法评估全科医生对于8例表现为亚临床甲状腺功能减退患者的治疗策略(治疗是/否,起始剂量甲状腺素)。患者的特征如年龄(70岁与85岁),活力状态(充满活力与脆弱)和促甲状腺激素(TSH)浓度(6 m U/L与15 m U/L)均有差异。结果共有526名全科医生参与此项研究(瑞士262名、荷兰129名、德国61名、新西兰31名、英格兰22名、爱尔兰21名,总有效率为19%)。不同国家的治疗策略会有所不同。相比较于来自德国(平均治疗比例为73%)、爱尔兰(平均治疗比例为62%)和瑞士(平均治疗比例为52%)的全科医生,来自荷兰(平均治疗比例为34%)、英格兰(平均治疗比例为40%)和新西兰(平均治疗比例为39%)的全科医生更加不倾向于实施治疗(P=0.05)。总体来讲,全科医生更倾向于对70岁的女性患者实施治疗,而不是85岁的女性患者〔比值比=0.74,95%CI(0.63,0.87)〕。TSH为15 m U/L的患者比TSH为6m U/L的患者更易于得到治疗〔比值比=9.49,95%CI(5.81,15.5)〕。结论全科医生对于不同国家和不同类型的老年亚临床甲状腺功能减退患者的治疗策略有很大差异,而这种差异说明有必要建立新一代基于初级卫生医疗随机临床试验的国际指南。 | den Elzen WP Lefèbre-van de Fliert AA Virgini V 周淑新 | 2015 | 中国全科医学2015，18，12： | 4 |
| 2 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 3 | Comparison between the SAPIEN S3 and the SAPIEN XT transcatheter heart valves:A single-center experience显示文摘AIM To investigate the clinical outcomes of transcatheter aortic valve implantation(TAVI) with the SAPIEN 3 transcatheter heart valve(S3-THV) vs the SAPIEN XT valve(XT-THV).METHODS We retrospectively analyzed 507 patients that underwent TAVI with the XT-THV and 283 patients that received the S3-THV at our institution between March 2010 and December 2015.RESULTS Thirty-day mortality(3.5% vs 8.7%:OR=0.44,P=0.21) and 1-year mortality(25.7% vs 20.1%,P=0.55) were similar in the S3-THV and the XT-THV groups.The rates of both major vascular complication and paravalvular regurgitation(PVR)>1 were almost 4 times lower in the S3-THV group than the XT-THV group(major vascular complication: 2.8% vs 9.9%,P<0.0001:PVR>1: 2.4% vs 9.7%,P<0.0001).However,the rate of new pacemaker implantation was almost twice as high in the S3-THV group(17.3% vs 9.8%,P=0.03).In the S3 group,independent predictors of new permanent pacemaker were pre-procedural RBBB(OR=4.9:P=0.001),pre-procedural PR duration(OR=1.14,P=0.05) and device lack of coaxiality(OR=1.13:P=0.05) during deployment.CONCLUSION The S3-THV is associated to lower rates of major vascular complications and PVR but higher rates of new pacemaker compared to the XT-THV.Sub-optimal visualization of the S3-THV in relation to the aortic valvular complex during deployment is a predictor of new permanent pacemaker. | Fadi J Sawaya Marco Spaziano Thierry Lefèvre Andrew Roy Phillippe Garot Thomas Hovasse Antoinette Neylon Hakim Benamer Mauro Romano Thierry Unterseeh Marie-Claude Morice Bernard Chevalier | 2016 | World Journal of Cardiology2016，8，12： | 2 |
| 4 | Chloride salinity reduces cadmium accumulation by the Mediterranean halophyte species Atriplex halimus L.显示文摘 | Isabelle Lefèvre Geoffrey Marchal Pierre Meerts Enrique Corréal Stanley Lutts | 2008 | Environmental and Experimental Botany2008，，1： | 2 |
| 5 | Extremal generators and extremal distributions for the continuous s-convex sto-chastic orderings显示文摘 | DENUIT M DE VYLDER E LEFèVRE C | | 0，，： | 1 |
| 6 | The fiber-optic gyroscope:Achievement and perspective显示文摘 | Lef(e)vre H C | | 0，，04： | 1 |
| 7 | Some new classes of stochastic order relations among arithmetic random variables with applications in actuarial sciences显示文摘 | DENUIT M LEFèVRE C | | 0，，： | 1 |
| 8 | On s-convex stochastic extreme for arithmetic risks显示文摘 | Denuit M Lefèvre Cl | | 0，，： | 1 |
| 9 | Transfemoral Aortic Valve Implantation显示文摘 | Kentaro Hayashida Thierry Lefèvre Bernard Chevalier Thomas Hovasse Mauro Romano Philippe Garot Darren Mylotte Jhonathan Uribe Arnaud Farge Patrick Donzeau-Gouge Erik Bouvier Bertrand Cormier Marie-Claude Morice | 2011 | JACC: Cardiovascular Interventions2011，，8： | 1 |
| 10 | On s-convex stochastic extrema for arithmetic risks显示文摘 | DENUIT M LEFèVRE C MESFIOUI M | | 0，，： | 1 |
| 11 | Variation in response to heavy metals during vegetative growth in Dorycnium pentaphyllum Scop.显示文摘 | Isabelle Lefèvre Geoffrey Marchal Enrique Corréal Andréa Zanuzzi Stanley Lutts | 2009 | Plant Growth Regulation2009，，1： | 1 |
| 12 | Intact cross-talk between insulin secretion and insulin action after postgastroplasty recovery of ideal body weight in severely obese patients显示文摘 | Letiexhe MR Desaive C Lefèbvre PJ | 2004 | Int J Obesity2004，28，： | 1 |
| 13 | What is the Incidence of Metastatic Lymph Node Involvement After Significant Pathologic Response of Primary Tumor Following Neoadjuvant Treatment for Locally Advanced Rectal Cancer?显示文摘 | Hadrien Tranchart Jérémie H. Lefèvre Magali Svrcek Jean-Fran?ois Flejou Emmanuel Tiret Yann Parc | 2013 | Annals of Surgical Oncology2013，，5： | 1 |
| 14 | One year follow-up of the multi-centre European PARTNER transcatheter heart valve study显示文摘 | Lefèvre T Kappetein AP Wolner E | 2011 | European Heart Journal2011，，02： | 1 |
| 15 | Image registration,optical flow and local rigidity显示文摘 | Lefébure Martin Cohen Laurent D | 2001 | Journal of Mathematical Imaging and Vision2001，14，2： | 1 |
| 16 | Blockade of infammation and airway hyperresponsiveness in immunesensitized mice by dominant-negative phosphoinositide 3-kinase-TAT显示文摘 | MYOU S LEF A R MRO S | 2003 | J Exp Med2003，198，： | 1 |
| 17 | Rheumatoid arthritis progression mediated by activated synovial Fibroblasts显示文摘 | Neumann E Lefèvre S Zimmermann B | 2010 | Trends in molecular medicine2010，16，10： | 1 |
| 18 | NaCl differently interferes with Cd and Zn toxicities in the wetland halophyte species Kosteletzkya virginica (L.) Presl.显示文摘 | Rui-Ming Han Isabelle Lefèvre Cheng-Jiang Ruan Pei Qin Stanley Lutts | 2012 | Plant Growth Regulation2012，，1： | 1 |
| 19 | Classical swine fever: the global situation显示文摘 | Steven Edwards Akio Fukusho Pierre-Charles Lefèvre Andrzej Lipowski Zygmunt Pejsak Paulo Roehe J?rgen Westergaard | 2000 | Veterinary Microbiology2000，，2： | 1 |
| 20 | A comparative study on multivariate mathematical morphology显示文摘 | Aptoula E Lefèvre S | 2007 | Pattern Recognition2007，40，： | 1 |
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