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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 3 | Comparison between hepaticojejunostomy and hepaticoduodenostomy after excision of choledochal cyst in children:a cohort study显示文摘Objective Hepaticojejunostomy(HJ)and hepaticoduodenostomy(HD)are commonly used biliary reconstruction techniques after choledochal cyst excision.HD has been suggested to be a more physiologic alternative during reconstruction.The objective of this study is to compare operative time,hospital stay,morbidity(leak,cholangitis,ileus,and obstruction),and mortality between HJ and HD after cyst excision.Methods This is a 14-year retrospective cohort study of pediatric patients(≤18 years old)who underwent choledochal cyst excision and subsequent biliary reconstruction at the Philippine Children’s Medical Center.Data were taken from inpatient charts,operative technique,OPD logbook,readmission,and OPD charts.results There were 122 patients:56%HD and 44%HJ.Majority were female(72%),with 1:2.6 male to female ratio.The average age was 36.1 months,with a mean follow-up of 32.8 months(range 6 months-14 years).The most common cyst was type I(87%).Operative time was longer for HJ compared with HD(321.3 vs 203.6 min;p=0.000).Hospital stay was longer with HJ compared with HD(7.7 vs 6.8 days;p=0.002).Mortality rate was low at 1.6%while morbidity was at 13.9%in both groups.Although morbidity was higher among those who underwent HD,there was no significant difference between the two procedures.Anastomotic leak(4%)and cholangitis(7.4%)were observed in HD,and ileus(7.4%)was observed in the HJ group.Conclusions In our series,HD provided less operative time and hospital stay than with HJ.We did not observe bile gastritis after HD as compared with others.It is suggested that longer follow-up is needed to confirm such findings. | Johann Paulo Suico Guzman Leandro L Resurreccion III Marcus Lester R Suntay Renato G Bernaldez | 2019 | World Journal of Pediatric Surgery2019，2，2： | 2 |
| 4 | The effect of colchicine on liver function tests and hepatic fibrosis in patients with chronic active hepatitis:a study of 3 cases(author's transl)显示文摘 | Leandro P Ade O e Silva A BrandSo J F Saldanha L B Pontes J F | 2013 | Arquivos de Gastroenterologia2013，15，3： | 1 |
| 5 | Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal - cell carcinoma treated with first - line sunitinib : a muhicentre, observational, prospective study 显示文摘 | GARCIA - DONAS J ESTEBAN E LEANDRO - GARCIA L J | 2011 | Lancet Oncol2011，12，12： | 1 |
| 6 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009，，9： | 1 |
| 7 | Effects of Bacillus subtilis in the Dynamics of Infiltration of Immunological Cells in the Intestinal Mucosa of Chickens Challenged with Salmonella Minnesota显示文摘 | Camargo L M Leandro K N Patrick W | 2012 | Int J Poult Sci2012，11，5： | 1 |
| 8 | Land-use and land- cover change in Alantic Forest landscapes显示文摘 | Paula K L Leandro R T Robert M E | 2012 | Forest Ecology and Management2012，278，： | 1 |
| 9 | Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children 显示文摘 | Gatta L Vakil N Leandro G | 2009 | Am J Gastroenterol2009，104，： | 1 |
| 10 | Physiological, Disease Control and Yield Effects of Kresoxim-methyl显示文摘 | CLARK B LEANDRO L | 1998 | The Agronomist1998，2，： | 1 |
| 11 | Effect of soil temperature and plant age at time of inoculation on progress of root rot and foliar symptoms of soybean sudden death syn- drome显示文摘 | GONGORA-CANUL C C LEANDRO L F S | 2011 | Plant Disease2011，95，4： | 1 |
| 12 | Physiological, disease control and yield effects of kresoxim-methyl显示文摘 | CLARK B Leandro L | 1998 | The Agrono- mist1998，2，： | 1 |
| 13 | Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis显示文摘 | Spahr L Negro F Leandro G | | 0，，01： | 1 |
| 14 | Sequential therapy or triple therapy for Helicohacter pylori infection:systematic re-view and meta-analysis of randomized controlled trials in adults and children 显示文摘 | Gatta L Vakil N Leandro G | 2009 | Am J Gastr-nterol2009，104，12： | 1 |
| 15 | Sequential therapy or triple therapyfor Helicobacter pylori infection:systematic review and meta-analysis of randomized controlled trials in adults and children显示文摘 | Gatta L Vakil N Leandro G | 2009 | Am J Gastroenterol2009，104，12： | 1 |
| 16 | Towards Improving Clustering Ants: Aal Adaptive Ant Clustering Algorithm显示文摘 | Vizinel A L Leandro N Eduardo R | 2005 | Informatics2005，，29： | 1 |
| 17 | Population dynamics of Trichoderma in fumigated and compost-amended soil and on strawberry roots 显示文摘 | L F S Leandro T Guzman | 2007 | Applied Soil Ecology2007，35，： | 1 |
| 18 | 3D intergrated circuit layout visualization using VRML显示文摘 | Ricardo A da L R | 2001 | Future Generation Computer Systems2001，17，5： | 1 |
| 19 | Land-use and land cover change in Alantic Forest landscapes显示文摘 | Paula K L Leandro R T Robert M E | 2012 | Forest Ecology and Management2012，278，： | 1 |
| 20 | Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children 显示文摘 | Gatta L Vakil N Leandro G | 2009 | Am Gastroenterol2009，104，： | 1 |
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