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| 1 | Endoscopic balloon catheter dilatation via retrograde or static technique is safe and effective for cricopharyngeal dysfunction显示文摘AIM To evaluate the safety and efficacy of upper esophageal sphincter(UES) dilatation for cricopharyngeal(CP) dysfunction. To determine if:(1) indication for dilatation; or(2) technique of dilatation correlated with symptom improvement.METHODS All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success. Dilatation technique was separated into static(stationary balloon distention) and retrograde(brusque pull-back of a fully distended balloon across the UES).RESULTS Four hundred and eighty-eight dilatations were reviewed. Thirty-one patients were identified who underwent UES dilatation. Median age was 63 years(range 27-81)and 55% of patients were male. Indications included dysphagia(28 patients), globus sensation with evidence of UES dysfunction(2 patients) and obstruction to echocardiography probe with cricopharyngeal(CP)bar(1 patient). There was evidence of concurrent oropharyngeal dysfunction in 16 patients(52%) and a small Zenker's diverticula(≤ 2 cm) in 7 patients(23%). Dilator size ranged from 15 mm to 20 mm. Of the 31 patients, 11 had dilatation of other esophageal segments concurrently with UES dilatation and 20 had UES dilatation alone.Follow-up was available for 24 patients for a median of 2.5 mo(interquartile range 1-10 mo), of whom 19 reported symptomatic improvement(79%). For patients undergoing UES dilatation alone, follow-up was available for 15 patients, 12 of whom reported improvement(80%).Nineteen patients underwent retrograde dilatation(84%response) while 5 patients had static dilatation(60%response); however, there was no significant difference in symptom improvement between the techniques(P = 0.5).Successful symptom resolution was also not significantly affected by dilator size, oropharyngeal dysfunction,Zenker's diverticulum, age or gender(P > 0.05). The only complication noted was uvular edema and a shallow ulcer after static dilatation in one patient, which resolved spontaneously and did not require hospital admission.CONCLUSION UES dilatation with a through-the-scope balloon by either static or retrograde technique is safe and effective for the treatment of dysphagia due to CP dysfunction. To our knowledge, this is the first study evaluating retrograde balloon dilatation of the UES. | Vinay Chandrasekhara Joyce Koh Lakshmi Lattimer Kerry B Dunbar William J Ravich John O Clarke | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 6 |
| 2 | The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer显示文摘 | Craig P. Carden Adam Stewart Parames Thavasu Emma Kipps Lorna Pope Mateus Crespo Susana Miranda Gerhardt Attard Michelle D. Garrett Paul A. Clarke Paul Workman Johann S. de Bono Martin Gore Stan B Kaye Udai Banerji | 2012 | Molecular Cancer Therapeutics2012，，7： | 2 |
| 3 | Structure and Properties of plain and alloyed ultrahigh carbon steel wire rod显示文摘 | Clarke B D Mclvor I D | 1991 | Ironmaking and Steelmaking1991，18，： | 2 |
| 4 | Thermal degradation of Nicalon SiC fiber 显示文摘 | CLARK T J ARONS R M STAMATOFF J B | 1985 | Ceram Eng Sci Proc1985，6，78： | 2 |
| 5 | 减少条片缺陷的结晶器保护渣设计,改进与应用显示文摘 | Clark,B 刘戈 | 1994 | 湘钢译丛1994，，4： | 2 |
| 6 | Bevacizumab in combination with oxaliplatin - based chemotherapy as first - line therapy in metastatic colorectal cancer: a randomized phase Ⅲ study显示文摘 | SALTZ L B CLARKE S DIAZ -RUBIO E | 2008 | J Clin Oncol2008，26，12： | 1 |
| 7 | Vaginal childbirth and bladder neck mobility显示文摘 | Dietz HP Clarke B Vancaillie TG | 2002 | Aust N Z J Obstet Gynaecol2002，42，5： | 1 |
| 8 | Origins of breast cancer subtypes and therapeutic implications 显示文摘 | Sims AH Howell A Howell S J Clarke R B | 2007 | Nature Clin Pract Oncol2007，4，12： | 1 |
| 9 | Project Scope and Project Performance: The Effect of Parts Strategy and Supplier Involvement on Product Development 显示文摘 | Clark K B | 1989 | Management Science1989，35，10： | 1 |
| 10 | Decreased incidence of prostate cancer with selenium supplementation:results of a double-blind cancer prevention trial显示文摘 | Dalkin B Krongrad A | 1998 | Br J Urol1998，81，5： | 1 |
| 11 | Fixed abrasive diamond wire machining-part Ⅰ:process monitoring and wire tension force显示文摘 | Shih A J Hardin C W Lemaster R L McSpadden S B | 2003 | International Journal Machine Tools & Manufacture2003，43，： | 1 |
| 12 | Oxidative renaturation of lysozyme at high concentrations显示文摘 | Hevehan D L Clark E D B | 1997 | Biotech and Bioeng1997，54，3： | 1 |
| 13 | Managing in an Age of Modularity显示文摘 | Baldwin C Y Clark K B | 1997 | Harvard Business Review1997，75，5： | 1 |
| 14 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 15 | Use of a peptide rather than free amino acid nitrogen source in chemically defined 'elemental' diets显示文摘 | SILK D B A FAIRCLOUGH P D CLARK M L | 1980 | Journal of Parenteral and Enteral Nutrition1980，4，： | 1 |
| 16 | In vitro and in vivo activities of a novel cephaiosporin,BMS-247243,against organisms other than staphylococci显示文摘 | Clark J Fung-Tomc J C Minassian B | 2002 | Antimicrob Agents Chemother2002，46，4： | 1 |
| 17 | Labeling of mesenchymal stem cells by bioconjugated quantum dots 显示文摘 | SHAH B S CLARK P A MOIOLI E K | 2007 | Nano Lett2007，7，10： | 1 |
| 18 | Form and function of arabinogalactans and arabinogalactanproteins显示文摘 | Clarke A E Anderson R L Stone B A | 1979 | Phytochemistry1979，18，： | 1 |
| 19 | Human pappillomavirus types and localization in adenocarcinoma and adenosquamous carcinoma of the uterine cervix:A study by in situ hybridization显示文摘 | TASE T OKAGAKI T CLARK B A | 1988 | Cancer Res1988，48，： | 1 |
| 20 | The split-cavity oscillator: a high-power e-beam modulator and microwave source显示文摘 | Marder B M Clark M C Bacon L D | 1992 | IEEE Trans on Plasma Science1992，20，3： | 1 |
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