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173篇 您的检索式：作者名="Lauer A"

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	题名	作者	年代	出处	被引量
1	Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.	Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o\|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer	2005	World Journal of Gastroenterology2005，11，44：	2
2	Perils of Rib Fractures显示文摘	Sharma Om P Oswanski Michael F Jolly Shashank Lauer Sherry K Dressel Rhonda Stombaugh Heather A	2008	The American Surgeon2008，，4：	2
3	Renal functional reserve in hmans:effects of protein intake on glomerular filtration rate显示文摘	Bosch JP Saccaggi A Lauer A	1983	Am J Med1983，75，：	1
4	Application of col- lagen-model triple-helical peptide-amphiphiles for CD44-Targeted drug delivery systems显示文摘	Ndinguri MW Zheleznyak A Lauer JL	2012	J Drug Deliv2012，，：	1
5	Microleakage of various cementing agents for full cast crowns显示文摘	Piwowarczyk A Lauer HC Sorensen JA	2005	Dent Mater2005，21，5：	1
6	Possible venlafaxine withdrawal syndrome显示文摘	Farah A Lauer TE	1996	Am J Psychiatry1996，153，：	1
7	Short-term protein loading in assessment of patients with renal disease显示文摘	Bosch JP Lauer A Glabman S	1984	Am J Med1984，77，：	1
8	Hemodynamic contsequences of continuous arteriovenous hemofiltration显示文摘	Lauer A Alvis R Avram M	1998	Am J Kidney Dis1998，12，：	1
9	Association of fasting plasma glu- cose with heart rate recovery in healthy adults: a population - based study 显示文摘	Panzer C Lauer MS Brieke A	2002	Diabetes2002，51，：	1
10	Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals 显示文摘	Kleinbongard P Dejam A Lauer T	2003	Free Radic Biol Med2003，35，：	1
11	Defective complement control of Factor H (Y402H) and FHL-1 in age-related macular degeneration显示文摘	SKERKA C LAUER N WEINBERGER A A	2007	Mol Immunol2007，44，13：	1
12	The electrical resistivity of con- crete with emphasis on the use of electrical resistance for measuring moisture content显示文摘	WOELFL G A LAUER K	1991	Cement Concrete and Aggre- gates1991，1，2：	1
13	In vitro shear bond strength of cementing agents to fixed prosthodontic restorative materials显示文摘	Piwowarczyk A Lauer HC Sorensen JA	2004	J Prosthet Dent2004，92，3：	1
14	Impairments of the medial olivocochlear system increase the risk of noise-induced autory neuropathy in laboratory mice 显示文摘	MAY B J LAUER A M ROOS M J	2011	Otology and neurotology2011，32，9：	1
15	RF artifacts caused by metallic implants or instruments which get more prominent at 3 T: an in vitro study显示文摘	Graf H Lauer UA Berger A	2005	Magn Reson lmag2005，23，3：	1
16	Thoracic epidural analgesia with low concentration of bupivacaine induces thoracic and lumbar sympathetic block: a randomized, double blind clinical trial 显示文摘	Freise H Meissner A Lauer S	2008	Anesthesiology2008，109，6：	1
17	Association of fasting plasma glu- cose with heart rate recovery in healthy adults : a population - based stffdy显示文摘	Panzer C Lauer MS Brieke A	2002	Diabetes2002，51，：	1
18	Next steps for the grand cooperative driving challenge: ITS Events 显示文摘	Lauer M Gerrits A	2009	IEEE Intelligent Transportation Sys- tems Magazine2009，1，4：	1
19	Corpecipitation of microalgal biomass with calcium and phosphate ions显示文摘	SUKENIK A SCHRODER W LAUER J	1985	Water Research1985，19，1：	1
20	Zygomatio-orbital fractures:historical perspective and current surgical management显示文摘	Adamo A Pollick SA Lauer SA	1997	J Cranio-Maxillofac Traum1997，3，3：	1

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