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| 1 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 2 | Surface roughness of zirconia for full-contour crowns after clinically simulated grinding and polishing显示文摘The aim of this study was to evaluate the effect of controlled intraoral grinding and polishing on the roughness of full-contour zirconia compared to classical veneered zirconia. Thirty bar-shaped zirconia specimens were fabricated and divided into two groups(n515). Fifteen specimens(group 1) were glazed and 15 specimens(group 2) were veneered with feldspathic ceramic and then glazed. Prior to grinding,maximum roughness depth(Rmax) values were measured using a profilometer, 5 times per specimen. Simulated clinical grinding and polishing were performed on the specimens under water coolant for 15 s and 2 N pressure. For grinding, NTI diamonds burs with grain sizes of 20 mm, 10 mm, and 7.5 mm were used sequentially. The ground surfaces were polished using NTI kits with coarse, medium and fine polishers. After each step, Rmaxvalues were determined. Differences between groups were examined using one-way analysis of variance(ANOVA). The roughness of group 1 was significantly lower than that of group 2. The roughness increased significantly after coarse grinding in both groups. The results after glazing were similar to those obtained after fine grinding for non-veneered zirconia. However, fine-ground veneered zirconia had significantly higher roughness than venerred, glazed zirconia. No significant difference was found between fine-polished and glazed zirconia, but after the fine polishing of veneered zirconia, the roughness was significantly higher than after glazing.It can be concluded that for full-contour zirconia, fewer defects and lower roughness values resulted after grinding and polishing compared to veneered zirconia. After polishing zirconia, lower roughness values were achieved compared to glazing; more interesting was that the grinding of glazed zirconia using the NTI three-step system could deliver smooth surfaces comparable to untreated glazed zirconia surfaces. | Rim Hmaidouch Wolf-Dieter Mller Hans-Christoph Lauer Paul Weigl | 2014 | International Journal of Oral Science2014，6，4： | 2 |
| 3 | Chronotropic incompetence:ready for prime time显示文摘 | Lauer M S | 2004 | J Am Coil Cardiol2004，44，2： | 1 |
| 4 | Efficacy of computerassited surgery in secondary orbital reconstruction显示文摘 | LAUER G PRADEL W SCHNEIDER M | 2006 | J Craniomaxillofac Surg2006，34，5： | 1 |
| 5 | Role of family history and family testing in cardiovascular risk assessment显示文摘 | LAUER R M | 1999 | Am J Med1999，107，2： | 1 |
| 6 | Does childhood obesity track into adulthood 显示文摘 | Clarke W R R M Lauer | 1993 | Critical Reviews in Food Science & Nutrition1993，33，45： | 1 |
| 7 | Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regu- lation of tissue inhibitor of matrix metalloproteinase 1/matrix metaUopro- teinase 9 axis and transforming growth factor betal in the rat heart显示文摘 | Lauer D Slavic S Sommerfeld M | 2014 | Hypertension2014，63，3： | 1 |
| 8 | Rates of caesarean section: analysis of global, regional and national estimates 显示文摘 | Betran AP Merialdi M Lauer JA et a1 | 2007 | Paediatr Perinat Epidemiol2007，2，2： | 1 |
| 9 | The synthesis of micrometer-and submicrometer-size spheres of ordered mesoporous oxide MCM-41显示文摘 | LAUER I UNGER K K | 1997 | Adv Mater1997，9，3： | 1 |
| 10 | Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septicrats显示文摘 | Lauer S Freise H Westphal M | 2009 | CritCare2009，13，4： | 1 |
| 11 | Hemodynamic contsequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1998 | Am J Kidney Dis1998，12，： | 1 |
| 12 | Impaired heart rate response to graded exercise:Prognostic implications of Chronotropic incompetence in the Framingham heart study显示文摘 | LAUER M S OKIN P M LARSON M G | 1996 | Circulation1996，93，8： | 1 |
| 13 | Left ventricular hypertrophy, the next treatable, silent killer显示文摘 | GARDIN J M LAUER M S | 2004 | JAMA2004，292，19： | 1 |
| 14 | Hepatitis C virus infection显示文摘 | Lauer G M Walker B D | 2001 | New England Journal of Medicine2001，345，1： | 1 |
| 15 | Rates of caesarean section:analysis of global,regional and national estimates显示文摘 | Betrán AP Merialdi M Lauer JA | 2007 | Paediatr Perinat Epidemiol2007，21，2： | 1 |
| 16 | Generation of a novel proteolysis resistant vascular endothelial growth factor165 variant by a site-directed mutation at the plasmin sensitive cleavage site显示文摘 | Lauer G Sollberg S Cole M | 2002 | FEBS Lett2002，531，： | 1 |
| 17 | Random Survival Forests 显示文摘 | Ishwaran H Kogalur U B Blackstone E H Lauer M S | 2008 | The Annals of Applied Statis- tics2008，2，3： | 1 |
| 18 | The proteasome inhibitor bortezomib enhances the susceptibility to viral infection显示文摘 | Basler M Lauer C Beck U | | 0，，： | 1 |
| 19 | Incidence and predictors of pericardial effusion after permanent heart rhythm device implantation:prospective evaluation of 968 consecutive patients 显示文摘 | Ohlow MA Lauer B Brunelli M | 2013 | Circ J2013，，4： | 1 |
| 20 | Impairments of the medial olivocochlear system increase the risk of noise-induced autory neuropathy in laboratory mice 显示文摘 | MAY B J LAUER A M ROOS M J | 2011 | Otology and neurotology2011，32，9： | 1 |
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