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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Chronotropic incompetence:ready for prime time显示文摘 | Lauer M S | 2004 | J Am Coil Cardiol2004，44，2： | 1 |
| 3 | Napsin A expression in smallcell carcinoma of the lung: a cytologic study with review of difTerenti-als显示文摘 | Hookim K Kavuri S Lauer SR | 2014 | JASC2014，3，1： | 1 |
| 4 | Dynamic site index equation for thinned stands of even-aged natural longleaf pine 显示文摘 | Lauer D K Kush J S | 2010 | Southern Journal of Applied Forestry2010，34，1： | 1 |
| 5 | Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regu- lation of tissue inhibitor of matrix metalloproteinase 1/matrix metaUopro- teinase 9 axis and transforming growth factor betal in the rat heart显示文摘 | Lauer D Slavic S Sommerfeld M | 2014 | Hypertension2014，63，3： | 1 |
| 6 | Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septicrats显示文摘 | Lauer S Freise H Westphal M | 2009 | CritCare2009，13，4： | 1 |
| 7 | Solu- tion of large scale optimal unit commitment problems显示文摘 | Lauer G S Sandell Jr N R Bertsekas N R | 1982 | IEEE Trans on power apparatus1982，101，1： | 1 |
| 8 | Short-term protein loading in assessment of patients with renal disease显示文摘 | Bosch JP Lauer A Glabman S | 1984 | Am J Med1984，77，： | 1 |
| 9 | Impaired heart rate response to graded exercise:Prognostic implications of Chronotropic incompetence in the Framingham heart study显示文摘 | LAUER M S OKIN P M LARSON M G | 1996 | Circulation1996，93，8： | 1 |
| 10 | Left ventricular hypertrophy, the next treatable, silent killer显示文摘 | GARDIN J M LAUER M S | 2004 | JAMA2004，292，19： | 1 |
| 11 | Situation Outlook Questionnaire: measure of the climate for creativity and change显示文摘 | Isaksen S G Lauer K J Ekvall G | 1999 | Psychological Report1999，85，： | 1 |
| 12 | Repeatability of and relation- ship between potential COPD biomarkers in bronchoalveolar lay- age, bronchial biopsies, serum, and induced sputum显示文摘 | Ropcke S Holz O Lauer G | 2012 | PLoS One2012，7，46： | 1 |
| 13 | Generation of a novel proteolysis resistant vascular endothelial growth factor165 variant by a site-directed mutation at the plasmin sensitive cleavage site显示文摘 | Lauer G Sollberg S Cole M | 2002 | FEBS Lett2002，531，： | 1 |
| 14 | Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (An American Ophthalmological Society Thesis)显示文摘 | Flaxel CJ Yeh S Lauer AK | 2013 | Trans Am Ophthalmol Soc2013，111，： | 1 |
| 15 | Tumor necrosis factor- stimulated gene-6 (TSG-6) amplifies hyaluronan synthesis by airway smooth muscle cells 显示文摘 | Lauer ME Cheng G Swaidani S | 2013 | J Biol Chem2013，288，42： | 1 |
| 16 | Translational research for cardiovascular diseases at the National Heart, Lung, and Blood Institute: moving from bench to bedside and from bedside to community 显示文摘 | Lauer MS Skarlatos S | 2010 | Circulation2010，121，7： | 1 |
| 17 | Random Survival Forests 显示文摘 | Ishwaran H Kogalur U B Blackstone E H Lauer M S | 2008 | The Annals of Applied Statis- tics2008，2，3： | 1 |
| 18 | Expression and characterization of three important panallergens from hazelnut显示文摘 | Lauer I Alessandri S Pokoj S | | 0，，： | 1 |
| 19 | Increased EEG power density in alpha and theta bands in adult ADHD patients显示文摘 | KOEHLER S LAUER P SCHREPPEL T | 2009 | J NeuralTransm2009，116，1： | 1 |
| 20 | Situational outlook questionnaire : a measure of the climate for creativity and change显示文摘 | Isaksen S G Lauer K J Ekvall G | 1999 | Psychological Reports1999，，85： | 1 |
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