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| 1 | A survey of numerical algorithms for trajectory optimization of flight vehicles显示文摘As one of the important components of computational flight mechanics and control,numerical algorithms of trajectory optimization for flight vehicles are currently studied by many researchers in aerospace engineering to completely solve these difficult problems,but few papers on the survey of this research field have been published recently.Based on the investigation of more than one hundred literatures,considering the application perspectives of computational flight mechanics and recent developments of trajectory optimization,the numerical algorithms of trajectory optimizations for aerospace vehicles are summarized and systematically analyzed.This paper summarized the basic principle,characteristics and application for all kinds of current trajectory optimization algorithms;and introduced some new methods and theories appearing in recent years.Finally,collaborative trajectory optimization for many flight vehicles,and hypersonic vehicle trajectory optimization were mainly reviewed in this paper.In the conclusion of this paper,the future research properties are presented regarding to numerical algorithms of trajectory optimization and control for flight vehicles as follows:collaboration and antagonization for many flight vehicles and multiple targets,global,real-time online,high accuracy of 7-D trajectory,considering all kinds of unknown random disturbances in trajectory optimization,and so on. | HUANG GuoQiang LU YuPing NAN Ying | 2012 | Science China(Technological Sciences)2012，55，9： | 32 |
| 2 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 3 | The complete mitochondrial genome of the Chinese oak silkmoth, Antheraea pernyi (Lepidoptera: Saturniidae)显示文摘我们从中国橡树丝绸蛾决定了 mitogenome 的完全的核苷酸顺序, Antheraea pernyi (鳞翅目:Saturniidae ) 。15,566 bp 通报染色体为鳞翅类的 mitogenomes 包含不正常的基因组织和顺序。mitogenome 在已知的鳞翅类的 mitogenome 序列之中包含最低 A+T 内容(80.16%) 。一个不平常的特征比作为是更多的 T 的出现,与一在偏斜度(−0.021 ) 稍微否定,在主要染色体海滨的作文。所有编码蛋白质的基因被 ATN 鳕鱼 ons 开始,除了细胞色素 oxidase 子单元我,它被在另外的 lepidopterans 观察了的 TTAG 顺序建议。所有转移 RNA (tRNAs ) 有 mitochondrial tRNA 的典型四叶苜蓿形的立体道路交叉点结构,除了 tRNA 重量的单位 (AGN), 哪个不能形成稳定的茎环结构的 DHU 手臂。二与一段超过 50 bp 排列了顺序块, 90% 顺序身份在 Saturniidae 和 Bombycoidae 种类的 A+T 富有的区域被识别。 | Yanqun Liu Yuping Li Minhui Pan Fangyin Dai Xuwei Zhu Cheng Lu Zhonghuai Xiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 21 |
| 4 | Prediction of Primary Climate Variability Modes at the Beijing Climate Center显示文摘Climate variability modes, usually known as primary climate phenomena, are well recognized as the most important predictability sources in subseasonal–interannual climate prediction. This paper begins by reviewing the research and development carried out, and the recent progress made, at the Beijing Climate Center(BCC) in predicting some primary climate variability modes. These include the El Ni?o–Southern Oscillation(ENSO), Madden–Julian Oscillation(MJO), and Arctic Oscillation(AO), on global scales, as well as the sea surface temperature(SST) modes in the Indian Ocean and North Atlantic, western Pacific subtropical high(WPSH), and the East Asian winter and summer monsoons(EAWM and EASM, respectively), on regional scales. Based on its latest climate and statistical models, the BCC has established a climate phenomenon prediction system(CPPS) and completed a hindcast experiment for the period 1991–2014. The performance of the CPPS in predicting such climate variability modes is systematically evaluated. The results show that skillful predictions have been made for ENSO, MJO, the Indian Ocean basin mode, the WPSH, and partly for the EASM, whereas less skillful predictions were made for the Indian Ocean Dipole(IOD) and North Atlantic SST Tripole, and no clear skill at all for the AO, subtropical IOD, and EAWM. Improvements in the prediction of these climate variability modes with low skill need to be achieved by improving the BCC's climate models, developing physically based statistical models as well as correction methods for model predictions.Some of the monitoring/prediction products of the BCC-CPPS are also introduced in this paper. | Hong-Li REN Fei-Fei JIN Lianchun SONG Bo LU Ben TIAN Jinqing ZUO Ying LIU Jie WU Chongbo ZHAO Yu NIE Peiqun ZHANG Jin BA Yujie WU Jianghua WAN Yuping YAN Fang ZHOU | 2017 | Journal of Meteorological Research2017，31，1： | 13 |
| 5 | A hybrid quantum-based PIO algorithm for global numerical optimization显示文摘A novel hybrid quantum-based pigeon-inspired optimization(PIO) algorithm for global numerical optimization is proposed to perceive deceptiveness and preserve diversity. In the proposed algorithm,the current best solution is regarded as a linear superposition of two probabilistic states, namely positive and deceptive. Through a quantum rotation gate, the positive probability is either enhanced or reset to balance exploration and exploitation. Simulation results reveal that the hybrid quantum-based PIO algorithm demonstrates an outstanding performance in global optimization owing to preserving diversity in the early evolution. As a result, the stability of the algorithm is enhanced so that the precision of optimization is improved statistically. The proposed algorithm is demonstrated to be effective for solving multimodal and non-convex problems in higher dimension with a smaller population size. | Boyi CHEN Hao LEI Haidong SHEN Yanbin LIU Yuping LU | 2019 | Science China(Information Sciences)2019，62，7： | 7 |
| 6 | An experiment-library least-squares method on on-line coal element contents analysis显示文摘A new experiment-library least-squares(experiment-LLs) method used in the neutron inelastic-scattering and thermal-capture analysis(NITA) technique for on-line coal analysis was developed,which has significantly decreased the non-linear radiation effects.In this method,sixty samples with preset elemental contents were made,from whose experimental spectra twenty single-element spectrum libraries corresponding to twenty kinds of coal were built using the least-squares method.The spectrum of the unknown sample was analyzed based on these twenty libraries to estimate its element contents.With the initial estimated result,the procedure of developing library and analysis was iterated to build a new library with the closest element contents to the unknown sample.Hence the experiment-LLs method can reduce non-linear radiation effects.The experiment-LLs method was performed on an improved coal analysis system which was equipped with a long-life 14 MeV pulsed-neutron generator,a bulk BGO detector with a temperature controller,a moisture meter and coal-smoothing device.The precisions of this system for ash content,water content,volatile content and calorific value have reached 1.0wt%,0.5wt%,1.0wt%,350 kJ/kg,respectively. | WANG HuiDong LU JingBin LU YuPing YANG Dong MA KeYan YANG Kang LIU YuMin CHENG DaoWen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 6 |
| 7 | Global 4-D trajectory optimization for spacecraft显示文摘Global 4-D trajectory(x,y,z,t)is optimized for a spacecraft,which is launched from the Earth to fly around the Sun,just as star-drift of 1437 asteroids in the solar system.The spacecraft trajectory is controlled by low thrust.The performance index of optimal trajectory is to maximize the rendezvous times with the intermediate asteroids,and also maximize the final mass.This paper provides a combined algorithm of global 4-D trajectory optimization.The algorithm is composed of dynamic programming and two-point-boundary algorithm based on optimal control theory.The best 4-D trajectory is obtained:the spacecraft flies passing 55 asteroids,and rendezvous with(following or passing again)asteroids for 454 days,and finally rendezvous with the asteroid 2005SN25 on the day 60521(MJD),the final mass of the spacecraft is 836.53 kg. | NAN Ying ,HUANG GuoQiang,LU YuPing&GONG Ping School of Astronautics,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China | 2010 | Science China(Technological Sciences)2010，53，8： | 6 |
| 8 | U-Pb dating of zircon grains from the ore-bearing plagioclase amphibolite in the Dashuigou Te deposit显示文摘The Dashuigou Te deposit is a unique independent one found in the world, and hosted in the plagioclase amphibolite. The upper intercept age of single zircon from the amphibolite can be considered to be the crystallization age of the source-rock of the amphibolite (tholeiitic basalt), while the lower intercept is nearly consistent with the time of the tectono-thermal event. | Shijin Xu Weizhou Shen Rucheng Wang Jianjun Lu Xiaoming Chen Yuping Lin | 1998 | Chinese Science Bulletin1998，43，17： | 5 |
| 9 | Chromatographic Resolution of a-Amino Acids by (R)-(3,3'-Halogen Substituted-l,l'-binaphthyl)-20-crown-6 Stationary Phase in HPLC显示文摘三新 chiral 为高效的液体层析的静止阶段(CSP ) 从 R-(3,3 卤素 substituted-1,1-binaphthyl ) 被准备 -20-crown-6 (卤素 = Cl, Br 并且我) 。试验性的结果证明 R-(3,3-dibromo-1,1-binaphthyl )-20-crown-6 (CSP-1 ) 比二另外的代替卤素的王冠醚衍生物拥有更突出的 enantioselectivity。所有 21 氨基酸在房间温度在 R-(3,3-dibromo-1,1-binaphthyl )-20-crown-6-based CSP-1 上有分离的不同的度。CSP-1 的 enantioselectivity 也比一些商业 R-(1,1-binaphthyl )-20-crown-6 衍生物的那些好。两分离因素()并且决定( R s )比商业王冠的那些好基于醚的 CSP [从 Daicel 的 CROWNPAK CR (+)]在为天门冬素, threonine ,脯氨酸,精氨酸,丝氨酸, histidine 和缬氨酸的一样的条件下面,它不能被商业 CR (+)分开。这研究证明 R-(3,3-dibromo-1,1-binaphthyl )-20-crown-6 chiral 的商业实用性是静止阶段。 | Peng Wu Yuping Wu JunhuiZhang Zhenyu Lu Mei Zhang Xuexian Chen Liming Yuan | 2017 | Chinese Journal of Chemistry2017，35，7： | 4 |
| 10 | Design of longitudinal predictive re-entry guidance law based on variable universe fuzzy-PI composite control显示文摘This paper studies the longitudinal predictive re-entry guidance law based on the variable universe fuzzy-PI composite control to overcome the inaccuracy of the reference trajectory re-entry guidance for re-entry vehicles. The variable universe fuzzy controller is used to obtain a satisfactory dynamic response when the downrange error is large, and the PI controller is utilized to eliminate the steady-state error when the downrange error is small. Simulation results show that the proposed guidance law is very robust to the initial errors and can achieve better accuracy, and is also able to handle the effect of the stochastic errors in re-entry processes. | Yin WANG 1 , Yuping LU 2 1.College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing Jiangsu 210016, China 2.College of Astronautics, Nanjing University of Aeronautics and Astronautics, Nanjing Jiangsu 210016, China | 2012 | 控制理论与应用(英文版)2012，10，2： | 4 |
| 11 | Preparation of an anti-diethylstilbestrol monoclonal antibody and development of an indirect competitive ELISA to detect diethylstilbestrol in biological samples显示文摘Based on the preparation of an anti-diethylstilbestrol(DES) monoclonal antibody,a simple and convenient indirect competitive enzyme-linked immunosorbent assay(ELISA) method for DES detection has been developed.The monoclonal antibody demonstrated high sensitivity to DES with an IC50 value of 275 pg mL-1 and detection limit(LOD) of 90 pg mL-1.The specificity of the assay was studied by measuring cross-reactivity of the antibody with structurally related compounds of ethinyl estradiol(<7%),estrone(<0.1%),estriol(<0.1%),and diethylstilbestrol benzoate(<0.1%).Chicken,fish,shrimp,urine and bile spiked with different concentration of DES were detected by the developed method,and the recovery rates were greater than 79.5%.Intra-and inter-assay variations were about 6%.This method exhibited high stability with a coefficient of variation less than 10% in buffer and in real samples.The LODs in fish/shrimp,liver,feed and urine spiked with DES were 600,600,4800 and 600 pg mL-1,respectively.These results confirmed that the antibody to DES was successfully produced and could be used to establish ELISA methods for DES detection in food producing animals. | LI WeiHua MENG Meng HE FangYang WAN YuPing XUE HuYin LIU Wei YIN WeiWei XU Jing FENG CaiWei WANG ShanLiang LU Xiao LIU JinTing XI RiMo | 2011 | Chinese Science Bulletin2011，56，8： | 4 |
| 12 | Pseudo-noise preamble based joint frame and frequency synchronization algorithm in OFDM communication systems显示文摘Frame and frequency synchronization are essential for orthogonal frequency division multiplexing(OFDM) systems. The frame offset owing to incorrect start point position of the fast Fourier transform(FFT) window, and the carrier frequency offset(CFO) due to Doppler frequency shift or the frequency mismatch between the transmitter and receiver oscillators, can bring severe intersymbol interference(ISI) and intercarrier interference(ICI) for the OFDM system. Relying on the relatively good correlation characteristic of the pseudonoise(PN) sequence, a joint frame offset and normalized CFO estimation algorithm based on PN preamble in time domain is developed to realize the frame and frequency synchronization in the OFDM system. By comparison, the performances of the traditional algorithm and the improved algorithm are simulated under different conditions. The results indicate that the PN preamble based algorithm both in frame offset estimation and CFO estimation is more accurate, resourcesaving and robust even under poor channel condition, such as low signaltonoise ratio(SNR) and large normalized CFO. | Qingfeng Jing Ming Cheng Yuping Lu Weizhi Zhong Hongwei Yao | 2014 | Journal of Systems Engineering and Electronics2014，25，1： | 4 |
| 13 | Performance limitations in trajectory tracking control for air-breathing hypersonic vehicles显示文摘An integrated approach that considers the performance limitations of tracking control systems for air-breathing hypersonic vehicles is proposed. First, a set of ascent trajectories is obtained as candidates for tracking control through a trajectory design method that considers the available acceleration. Second, the basic theory of performance limitations, which is adopted to calculate the limits on control performance through the trajectory, is integrated. The openloop dynamics of air-breathing hypersonic vehicles is responsible for these limits on the control system. Comprehensive specifications on stability, tracking accuracy, and robustness are derived, and the flight envelope with constraints and control specifications is identified. Simulation results suggest that trajectory design should consider restrictions on control performance to obtain reliable solutions. | Boyi CHEN Yanbin LIU Haidong SHEN Hao LEI Yuping LU | 2019 | Chinese Journal of Aeronautics2019，32，1： | 4 |
| 14 | Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction显示文摘Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson's disease(PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots(QDs) that can induce autophagy in a cellular model of Parkinson's disease. Cd Te/Cd S/Zn S QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of α-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases. | Lu Wang Xiaoming Li Yuping Han Ting Wang Yun Zhao Aldalbahi Ali Nahed Nasser El-Sayed Jiye Shi Wenfeng Wang Chunhai Fan Nan Chen | 2016 | Science China Chemistry2016，59，11： | 3 |
| 15 | Preparation of P(St-NMA)microsphere inks and their application in photonic crystal patterns with brilliant structural colors显示文摘Patterned photonic crystals with structural colors on textile substrates have attracted a special attention due to the great advantages in application,which currently become a research hot-spot.This study utilized an ink-jet printing technology to prepare high-quality photonic crystal patterns with structural colors on polyester substrates.The self-assembly temperature of poly(styrene-N-methylol acrylamide)(P(St-NMA))microspheres set to construct photonic crystals were deeply optimized.Moreover,the structural colors of prepared photonic crystal patterns were characterized and evaluated.When the mass fraction of P(St-NMA)microspheres was 1.0 wt.%,the pH value ranged from 5 to 7,and the surface tension was in the range of 63.79 to 71.20 mN/m,inks could present the best print performance.At 60°C,prepared P(St-NMA)microsphere inks were good for printing to obtain patterned photonic crystals with regular arrangement and beautiful structural colors.Specifically,photonic crystals with different colors could be constructed by regulating the diameter of microspheres in inks,and prepared structural colors exhibited distinct iridescent phenomenon.The present results could provide a theoretical basis for the industrial realization of patterned photonic crystals by ink-jet printing technology. | Guojin Liu Pengshuai Han Liqin Chai Peng Lu Yuping He Lan Zhou | 2020 | Frontiers of Materials Science2020，14，1： | 3 |
| 16 | Nanoparticle-free and self-healing amphiphobic membrane for anti-surfactant-wetting membrane distillation显示文摘In membrane distillation(MD),complicated feed water with amphiphilic contaminants induces fouling/wetting of the MD membrane and can even lead to process failure.This study reports a facile approach to fabricate robust and self-healing hybrid amphiphobic membranes for anti-surfactant-wetting MD based on the ultra-low surface energy of fluorinated polyhedral oligomeric silsesquioxanes(F-POSS)and its thermal induced motivation and rotation.The thermal treatment makes the membranes achieving amphiphobicity at a very low cost of F-POSS(13.04 wt.%),which is about 1/3 of without thermal treatment.The prepared membrane exhibits excellent amphiphobicity,i.e.ethanol contact angle of 120.3°,without using environmentally toxic fluorinated nanoparticles.Robust MD performance was observed for the amphiphobic membrane in concentrated sodium dodecyl sulfate(SDS)feed solutions.Furthermore,the fabricated membrane exhibited stable amphiphobicity even in extreme environments,including strong acid or alkaline solutions.In the event of a damaged or abraded membrane surface where the F-POSS can be removed,the amphiphobic membrane exhibits self-healing ability with additional thermal treatment.This simple approach without the use of nanoparticles provides an environmentally friendly way for fabrication of amphiphobic membranes for anti-surfactant-wetting membrane distillation. | Chun Lu Chunlei Su Hongbin Cao Thomas Horseman Feng Duan Yuping Li | 2021 | Journal of Environmental Sciences2021，33，2： | 3 |
| 17 | cDNA cloning and expression pattern of two enolase genes from the Chinese oak silkworm, Antheraea pernyi显示文摘在这研究,二 enolase 基因从中国橡树蚕被孤立并且描绘, Antheraea perny,它被指定为 enolase 我和 II 分别地。enolase 我 cDNA 顺序是有编码 433 氨基酸的 1302 bp 的一个开的读物框架(ORF ) 的 1712 bp。enolase II cDNA 顺序是有编码 431 氨基酸的 1296 bp 的 ORF 的 1549 bp。二基因的氨基酸序列分享 enolase 的几个保存特征 / 地点。我显示出的 Antheraea pernyi enolase 93%97% 顺序身份到迄今为止可得到的 lepidopterans 的 enolases,到另外的无脊椎动物的 enolases 的 75%82% 身份,到包括脊椎动物的另外的有机体的 enolases 的 60%72% 身份,植物,和真菌。Antheraea pernyi enolase II 显示出 84% 身份到 Bombyx mori enolase II,而是 60% 身份到 A。pernyi enolase 我。在种系发生的树上, enolase II 从 A 定序。pernyi 和 B。mori 清楚地包括 A 与更高的有机体的 enolase 序列的多数被分开。pernyi 和 B。我定序的 mori enolase。由顺序比较和种系发生的分析,我们从 A 建议那 enolase II。pernyi 和 B。mori 可以是 enolase 总科的一个新成员。Antheraea pernyi enolase 我而 enolase II mRNA 在睾丸和卵巢明确地被表示, mRNA 在所有测试纸巾被发现,建议 enolase II 基因的产品可能与复制有关。抄本许多 A。pernyi enolase 我基因在冷吃惊以后并且显著地是显著地下面调整的在热吃惊以后起来调整,建议那 A。pernyi enolase 我基因可能由温度应力是可诱导的。 | Yanqun Liu Yuping Li Huan Wang Runxi Xia Xisheng Li Haolei Wan Li Qin Defu Jiang Cheng Lu Zhonghuai Xiang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 2 |
| 18 | Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo显示文摘Corydalis yanhusuo W.T.Wang is a classic herb that is frequently used in traditional Chinese medicine and is efficacious in promoting blood circulation,enhancing energy,and relieving pain.Benzylisoquinoline alkaloids(BIAs)are the main bioactive ingredients in Corydalis yanhusuo.However,few studies have investigated the BIA biosynthetic pathway in C.yanhusuo,and the biosynthetic pathway of species-specific chemicals such as tetrahydropalmatine remains unclear.We performed full-length transcriptomic and metabolomic analyses to identify candidate genes that might be involved in BIA biosynthesis and identified a total of 101 full-length transcripts and 19 metabolites involved in the BIA biosynthetic pathway.Moreover,the contents of 19 representative BIAs in C.yanhusuo were quantified by classical targeted metabolomic approaches.Their accumulation in the tuber was consistent with the expression patterns of identified BIA biosynthetic genes in tubers and leaves,which reinforces the validity and reliability of the analyses.Full-length genes with similar expression or enrichment patterns were identified,and a complete BIA biosynthesis pathway in C.yanhusuo was constructed according to these findings.Phylogenetic analysis revealed a total of ten enzymes that may possess columbamine-O-methyltransferase activity,which is the final step for tetrahydropalmatine synthesis.Our results span the whole BIA biosynthetic pathway in C.yanhusuo.Our full-length transcriptomic data will enable further molecular cloning of enzymes and activity validation studies. | Dingqiao Xu Hanfeng Lin Yuping Tang Lu Huang Jian Xu Sihui Nian Yucheng Zhao | 2021 | Horticulture Research2021，8，1： | 2 |
| 19 | VPS4B mutation impairs the osteogenic differentiation of dental follicle cells derived from a patient with dentin dysplasia type I显示文摘A splicing mutation in VPS4B can cause dentin dysplasia type I(DD-I),a hereditary autosomal-dominant disorder characterized by rootless teeth,the etiology of which is genetically heterogeneous.In our study,dental follicle cells(DFCs)were isolated and cultured from a patient with DD-I and compared with those from an age-matched,healthy control.In a previous study,this DD-I patient was confirmed to have a loss-of-function splicing mutation in VPS4B(IVS7+46C>G).The results from this study showed that the isolated DFCs were vimentin-positive and CK14-negative,indicating that the isolated cells were derived from the mesenchyme.DFCs harboring the VPS4B mutation had a significantly higher proliferation rate from day 3 to day 8 than control DFCs,indicating that VPS4B is involved in cell proliferation.The cells were then replenished with osteogenic medium to investigate how the VPS4B mutation affected osteogenic differentiation.Induction of osteogenesis,detected by alizarin red and alkaline phosphatase staining in vitro,was decreased in the DFCs from the DD-I patient compared to the control DFCs.Furthermore,we also found that the VPS4B mutation in the DD-I patient downregulated the expression of osteoblast-related genes,such as ALP,BSP,OCN,RUNX2,and their encoded proteins.These outcomes confirmed that the DD-I-associated VPS4B mutation could decrease the capacity of DFCs to differentiate during the mineralization process and may also impair physiological root formation and bone remodeling.This might provide valuable insights and implications for exploring the pathological mechanisms underlying DD-I root development. | Qiang Li Fangli Lu Tianxuan Chen Ke Zhang Yuping Lu Xiaocong Li Yingying Wang Ling Liu Qing Tian Fu Xiong Dong Chen | 2020 | International Journal of Oral Science2020，12，3： | 2 |
| 20 | Effective femtosecond laser shock peening on a Mg-3Gd alloy at low pulse energy 430 μJ of 1 kHz显示文摘In this paper,microstructure evolution and hardness of Mg-3 Gd alloy treated by femtosecond(fs)laser shock peening(LSP)with direct and confined ablation m odes were investigated in detail.Under a relatively low pulse energy of 430μJ with a repetition of 1 kHz,the surface hardness of sample has been enhanced by 70%effectively.Comp a r e d with ns-LSP with pulse fluence of 71.7J/cm2,fs-LSP with pulse fluence of 34.2 J/cm2 is superior in the hardness increment,both of which are in the same order of magnitude.A distinct grain refinement of surface layer has been discovered and results in the increase of hardness.Nonuse of absorption and confining layers and the employment of the industry commercial fs laser with high repetition can inspire big potential L S P application in special metal material.©2019 Published by Elsevier B.V.on behalf of Chongqing University. | Chenghao Lu Licheng Ge Bing Zhu Yangxin Li Xianfeng Chen Xiaoqin Zeng Yuping Chen | 2019 | Journal of Magnesium and Alloys2019，7，3： | 2 |
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