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| 1 | PBPK modeling and simulation in drug research and development显示文摘Physiologically based pharmacokinetic(PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data.It can also explore the effects of various physiologic parameters such as age,ethnicity,or disease status on human pharmacokinetics,as well as guide dose and dose regiment selection and aid drug–drug interaction risk assessment.PBPK modeling has developed rapidly in the last decade within both the field of academia and the pharmaceutical industry,and has become an integral tool in drug discovery and development.In this mini-review,the concept and methodology of PBPK modeling are briefly introduced.Several case studies were discussed on how PBPK modeling and simulation can be utilized through various stages of drug discovery and development.These case studies are from our own work and the literature for better understanding of the absorption,distribution,metabolism and excretion(ADME) of a drug candidate,and the applications to increase efficiency,reduce the need for animal studies,and perhaps to replace clinical trials.The regulatory acceptance and industrial practices around PBPK modeling and simulation is also discussed. | Xiaomei Zhuang Chuang Lu | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 21 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | Species composition and distribution of marine nematode community in the North Taiwan Strait显示文摘Marine free-living nematodes were investigated at 13 sampling stations divided into three transects in the northern Taiwan Strait in February 1998. One hundred species of marine nematodes belonging to 91 Genera 28 Families 3 Orders were identified and were first recorded in the northern Taiwan Strait. The dominant species were Vasostoma sp., Sabatieria sp. 1, Linhystera sp. 1, Spilophorella sp., Daptonema sp., Halalaimus sp. and Dorylaimopsis variabilis. Their main densities were all over 4 950 ind./m2. According to mean density at transects, marine nematode density decreased from coastal Weitou to off Minjiang Estuary, which was similar to polychaete distribution in northern Taiwan Strait. The selective deposit feeder (1A) was the dominant food type of marine nematodes in the northern Taiwan Strait, but non-selective deposit feeders (1B) and epigrowth feeders (2A) occupied high proportion, indicating diverse feeding types of marine nematodes in the northern Taiwan Strait. Some environmental factors such as currents are discussed. | Cai Lizhe, Hong Huasheng, Zou Chaozhong, Fang Shaohua, Lu Xiaomei, Zhang Yueping (1. Key Laboratory of SEDC of Marine Environmental Science/Environmental Science Research Center, Xiamen Universi- ty, Xiamen 361005, China 2. Department of Biology, Xiamen | 2001 | Acta Oceanologica Sinica2001，20，2： | 12 |
| 4 | Aquaculture area extraction and vulnerability assessment in Sanduao based on richer convolutional features network model显示文摘Sanduao is an important sea-breeding bay in Fujian,South China and holds a high economic status in aquaculture.Quickly and accurately obtaining information including the distribution area,quantity,and aquaculture area is important for breeding area planning,production value estimation,ecological survey,and storm surge prevention.However,as the aquaculture area expands,the seawater background becomes increasingly complex and spectral characteristics differ dramatically,making it difficult to determine the aquaculture area.In this study,we used a high-resolution remote-sensing satellite GF-2 image to introduce a deep-learning Richer Convolutional Features(RCF)network model to extract the aquaculture area.Then we used the density of aquaculture as an assessment index to assess the vulnerability of aquaculture areas in Sanduao.The results demonstrate that this method does not require land and water separation of the area in advance,and good extraction can be achieved in the areas with more sediment and waves,with an extraction accuracy>93%,which is suitable for large-scale aquaculture area extraction.Vulnerability assessment results indicate that the density of aquaculture in the eastern part of Sanduao is considerably high,reaching a higher vulnerability level than other parts. | LIU Yueming YANG Xiaomei WANG Zhihua LU Chen LI Zhi YANG Fengshuo | 2019 | Journal of Oceanology and Limnology2019，37，6： | 4 |
| 5 | Star-shaped conjugated oligoelectrolyte for bioimaging in living cells显示文摘A new star-shaped oligoelectrolyte (TEFCOONa) with triphenylamine as the core, acetylene as linkage and anionic fluorenes as arms was obtained and used for direct imaging in living PANC-1 cells. Because of the hydrophobic conjugated groups of the oli-goelectrolyte, TEFCOONa can form nanospheres with an average diameter of^75 nm in 10 mmol/L PBS. These nanospheres possess a relatively high absolute quantum yield (16.5% in PBS), low cytotoxicity and can penetrate into the nucleus through the cytoplasm, which is essential for living cellular imaging. Collectively, these results validate our rational design of conjugated oligoelectrolyte and even hyper branched polymers-copolyelectrolyte as effective nanovectors for bioimaging and other clinical applications. | SONG WenLi JIANG RongCui YUAN Yan LU XiaoMei HU WenBo FAN QuLi HUANG Wei | 2013 | Chinese Science Bulletin2013，58，21： | 4 |
| 6 | Hydrolysis of cellobiose catalyzed by zeolites—the role of acidity and micropore structure显示文摘The roles of acidity and micropore structure of zeolite were studied in the hydrolysis of the model oligosaccharide of cellulose–cellobiose. HZSM-5, HY, HMOR and Hβ zeolites were selected as model catalysts for the hydrolysis of cellobiose. The effect of acidity of zeolite, including the strength, type and location, on its catalytic activity was investigated. The strong Br?nsted acid sites located in micropores are the active sites for the hydrolysis of cellobiose to glucose. Meanwhile, the catalytic performance of zeolite is also dependent on the micropore size of zeolite. | Lipeng Zhou Zhen Liu Yuqi Bai Tianliang Lu Xiaomei Yang Jie Xu | 2016 | Journal of Energy Chemistry2016，25，1： | 4 |
| 7 | An in situ ATR-FTIR study of mixed collectors BHA/DDA adsorption in ilmenite-titanaugite flotation system显示文摘This paper researched the enhanced flotation separation performance of ilmenite and titanaugite using the mixed collector benzhydroxamic acid/dodecylamine(BHA/DDA).The interface assembly mechanism was mainly investigated through in situ attenuated total reflectance Fourier transform infrared(ATRFTIR)spectroscopy combined with the two-dimensional correlation spectroscopy(2D-COS)and X-ray photoelectron spectroscopy(XPS).It has been found that BHA/DDA mixed collectors successfully separate ilmenite from titanaugite at a molar ratio of 8:1.Zeta potential experiments suggested that,in the presence of mixed collector system,the BHA-DDA complex adsorbed on the ilmenite surface via the chemically adsorbed BHA and the electrostatically adsorbed DDA,however,the complex adsorbed on the surface of titanaugite unstably.According to in situ ATR-FTIR combined with 2D-COS and XPS results,the interface assembly mechanism of BHA/DDA is summarized as:the function group of BHA molecules first binds to the metal sites on minerals to form bidentate ligand,then DDA co-adsorbed with BHA on the surface of minerals through hydrogen bonding.DDA may change the adsorption modes of some BHA on the ilmenite surface from four-membered ring to five-membered ring,while the modes on the titanaugite surface is true opposite.Finally,recommended adsorption configurations of the BHA/DDA complex on the two mineral surfaces are proposed. | Liping Luo Houqin Wu Longhua Xu Jinping Meng Jiahui Lu Huan Zhou Xiaomei Huo Lingyun Huang | 2021 | International Journal of Mining Science and Technology2021，31，4： | 4 |
| 8 | Synthesis of Mesoporous Anatase TiO2 Sphere with High Surface Area and Enhanced Photocatalytic Activity显示文摘Mesoporous anatase TiO_2 spheres with high surface area(119 m^2g^(-1)) were successfully synthesized via a facile and green template-free method. The prepared TiO_2 was characterized by X-ray diffraction(XRD),N_2 adsorption, scanning electron microscopy(SEM), transmission electron microscopy(TEM) and UV–vis absorbance spectra. It was found that the prepared TiO_2 is characterized by pure anatase phase, which shows uniform spheres and has a typical mesostructure with a high specific surface area and a large pore volume. The effects of complexant(acetylacetone) amount, crystallization temperature and calcination temperature were also investigated. Based on the results, a sketch for the preparation of mesoporous TiO_2 was proposed. First, complex formed between tetrabutyl titanate and acetylacetone in ethanol. After introduction of aqueous of ammonia sulfate and urea, hydrolysis of tetrabutyl titanate would occur slowly,and sol of TiO_2 was formed. Then, crystallization proceeded under hydrothermal conditions. Calcination process favored the formation of bigger TiO_2 crystal through combining of the small crystals in TiO_2.This led to the formation of bigger mesopores between TiO_2 crystals. Photocatalytic activity of the prepared TiO_2 was evaluated by decomposition of methyl orange. | Tianliang Lu Youqiang Wang Yingli Wang Lipeng Zhou Xiaomei Yang Yunlai Su | 2017 | Journal of Materials Science & Technology2017，33，3： | 3 |
| 9 | Preparation of synthetic rutile via selective sulfation of ilmenite with(NH4)2SO4 followed by targeted removal of impurities显示文摘This paper describes a novel, facile chemical pathway for preparing synthetic rutile from ilmenite. The pathway consists of two primary units, i.e., selectively sulfating ilmenite, which was realized via roasting ilmenite with(NH_4)_2SO_4followed by selective thermal decomposition of the sulfated ilmenite, and targeted leaching of the impurities. The effects of the process parameters were systematically investigated. The results showed that the optimum sulfation conditions were a mass ratio of(NH_4)_2SO_4to ilmenite of 14, temperature of 360 °C, and time of 120 min with a sulfation ratio of ~ 95%. The optimum thermal decomposition conditions were480 °C in N_2 atmosphere, and nearly all Ti OSO_4 were decomposed with co-decomposition of Fe SO_4 of 23%. For acid leaching, the optimum conditions were 2.5 wt% HCl, 98 °C and 120 min. Under those conditions, 94.2% iron was removed with a Ti O_2 dissolution loss b 1%. For alkali leaching, 67% Si O_2 was removed in 5 wt% Na OH at102 °C for 1 h. A synthetic rutile with a Ti O_2 content N 92 wt% and total Mg O + Ca O b 1.5 wt% was obtained.Based on these results, a schematic flowsheet was proposed. Additionally, it was found that the decomposition of Fe SO_4 mixed with Ti OSO_4 under N_2was inhibited due to its oxidation to a higher thermal stability Fe_2(SO_4)_3by oxygen emitted from the decomposition of Ti OSO_4. At the same time, Ti OSO_4 decomposition was promoted due to the immediate in situ consumption of oxygen by Fe SO_4. The synergetic effect might be responsible for the enhanced selectivity of sulfated ilmenite thermal decomposition. | Weizao Liu Xiaomei Wang Zhenpu Lu Hairong Yue Bin Liang Li Lü Chun Li | 2017 | Chinese Journal of Chemical Engineering2017，25，6： | 3 |
| 10 | Stochastic stability of networked control systems with network-induced delay and data dropout显示文摘This paper deals with the stochastic stability of networked control systems with the presence of network-induced delay and transmitted data dropout. Based on the Lyapunov approach, sufficient conditions for the mean-square stability of the networked control system are derived subject that the sequence of transmission interval is driven by an identically independently distributed sequence and by a finite state Markov chain, respectively. Stabilization controllers are constructed in terms of linear matrix inequalities correspondingly. An example is provided to illustrate our results. | Xiaomei ZHANG Yufan ZHENG Guoping LU | 2008 | 控制理论与应用(英文版)2008，6，4： | 3 |
| 11 | Numerical Simulation of 2D Supersonic Magnetohydrodynamic Channel and Study on Hall Effect显示文摘In this research effort,numerical simulation of two-dimensional magnetohydrodynamic(MHD) channel is performed and Hall effect is studied.The computational model consists of the Navier-Stokes(N-S) equations coupled with electrical-magnetic source terms,Maxwell equations and the generalized Ohm's law.Boundary conditions for the electrical potential equation considering Hall effect are derived.To start with,the MHD channel with single-pair electrodes is studied and flow of the electric current is in accordance with physical principle.Then the MHD channel with five-pair electrodes is numerically simulated.The results show that the electrical current concentrates on the downstream of the anode and the upstream of the cathode due to Hall effect,and the flow field becomes asymmetrical.At the current value of the magnetic interaction parameter,the electrical-magnetic force affects the flow remarkably,decreasing the outlet Mach number and increasing the outlet pressure;what's more,the flow structure in the channel becomes extremely complex.Performances of MHD channels with continual electrodes and segmented electrodes are compared.The results show that performance of the MHD channel with segmented electrodes is better than that with continual electrodes with the increase of Hall parameter. | ZHENG Xiaomei LU Haoyu XU Dajun CAI Guobiao | 2011 | Chinese Journal of Aeronautics2011，24，2： | 3 |
| 12 | Water-soluble light-emitting nanoparticles prepared by non-covalent bond self-assembly of a hydroxyl group functionalized oligo(p-phenyleneethynylene) with different water-soluble polymers显示文摘Water-soluble light-emitting nanoparticles were prepared from hydroxyl group functionalized oligos(p-phenyleneethynylene) (OHOPEL) and water-soluble polymers(PEG,PAA,and PG) by non-covalent bond self-assembly.Their structure and optoelectronic properties were investigated through dynamic light scattering(DLS) ,UV and PL spectroscopy.The optical properties of OHOPEL-based water-soluble nanoparticles exhibited the same properties as that found in OHOPEL films,indicating the existence of interchain-aggregation of OHOPELs in the nanoparticles.OHOPEL-based nanoparticles prepared from conjugated oligomers show smaller size and lower dispersity than nanoparticles from conjugated polymers,which means that the structures of water-soluble nanoparticles are linked to the conjugated length.Furthermore,the OHOPEL/PG and OHOPEL/PAA systems produced smaller particles and lower polydispersity than the OHOPEL/PEG system,indicating that there may exist influence of the strength of non-covalent bonds on the size and degree of dispersity of the nanoparticles. | Lu XiaoMei Fan QuLi Zhang GuangWei Pu KanYi Huang Wei | 2010 | Science China Chemistry2010，53，5： | 3 |
| 13 | A Surfactant-stable Bacillus pumilus K9 α-Keratinase and Its Potential Application in Detergent Industry显示文摘 | GONG Jinsong WANG Yue ZHANG Dandan LI Heng ZHANG Xiaomei ZHANG Rongxian LU Zhenming XU Zhenghong SHI Jinsong | 2015 | Chemical Research in Chinese Universities2015，31，1： | 3 |
| 14 | A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus显示文摘To test whether amino acid mutations in the PBC and PHI loops of VP2 are involved in the replication and virulence of infectious bursal disease virus(IBDV), a pair of viruses, namely the moderately virulent IBDV(rG x-F9VP2) and the attenuated strain(rGt), were used. Residue mutations A222P(P_(BC)) and S330R(PHI), selected by sequence comparison, were introduced individually into r Gx-F9VP2 by using a reverse genetics system. In addition, the reverse mutation of either P222 A or R330 S was introduced into r Gt. The four modified viruses were then rescued and evaluated in vitro(CEF cells) and in vivo(SPF chickens). Results showed that A222 P elevated the replication efficiency of rG x-F9VP2 while P222 A reduced that of rG t in CEF cells. A mutation at residue 330 did not alter IBDV replication. In addition, animal experiments showed that a single mutation at either residue 222 or 330 did not significantly influence the virulence of IBDV. In conclusion, residue 222 in PBC of VP2 is involved in the replication efficiency of IBDV in vitro but does not affect its virulence in vivo, further facilitating our understanding of the gene-function of IBDV. | Xiaole Qi Xiang Gao Zhen Lu Lizhou Zhang Yongqiang Wang Li Gao Yulong Gao Kai Li Honglei Gao Changjun Liu Hongyu Cui Yanping Zhanga Xiaomei Wang | 2016 | Science China(Life Sciences)2016，59，7： | 2 |
| 15 | Danshen(Radix Salviae Miltiorrhizae)reverses renal injury induced by myocardial infarction显示文摘OBJECTIVE:To evaluate the protection of Danshen{Radix Salviae Miltiorrhizae)(SM) injection in myocardial infarction(Ml) induced renal damage.METHODS:Forty male C57 mice were divided into control group,Ml group and SM group.In Ml group,the left coronary artery was occluded for 8weeks;the same procedure was used for the SM group,with the additional step of SM(0.2 mL) administered intraperitoneally for 56 days.Before surgery and 8 weeks later,transthoracic echocardiography was performed and urine protein and albumin was measured.At the end of the time,all mice were killed and kidneys removed for reactive oxygen species(ROS) and fibrosis analysis,plasma was collected for blood urea nitrogen and serum creatinine determination.RESULTS:Ml slightly decreased renal function and increased production of ROS,accompanied with renal fibrosis.Administration of SM reduced production of ROS and increased renal function,it also reduced renal fibrosis.CONCLUSION:Ml plays a causal role in renal injury and SM exerts renal-protective effects,probably by its antioxidant activities. | Lu Xiaomei Jin Yunan Ma Ling Du Lili | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 2 |
| 16 | Au-catalysed free-standing wurtzite structured InAs nanosheets grown by molecular beam epitaxy显示文摘In this study,we report the growth of free-standing InAs nanosheets using Au catalysts in molecular beam epitaxy.Detailed structural characterizations suggest that wurtzite structured InAs nanosheets,with features of extensive{1120}surfaces,grown along the<1102>direction and adopted{0001}nanosheet/catalyst interfaces,are initiated from wurtzite structured[0001]nanowires as the inclined epitaxial growth due to relatively higher In concentrations in Au catalysts,and grown from these inclined nanostructures through catalyst-induced axial growth and their enhanced lateral growth under the high growth temperature.Based on the facts that the nanosheets contain large low energy{1120}surfaces and{0001}nanosheet/catalyst interfaces,the growth of our nanosheets is a thermodynamically driven process.This study provides new insights into fabricating free-standing Ⅲ-Ⅴ nanosheets for their applications in future nanoscale devices. | Qiang Sun Han Gao Xiaomei Yao Kun Zheng Pingping Chen Wei Lu Jin Zou | 2019 | Nano Research2019，12，11： | 2 |
| 17 | Vision-Based Hand Gesture Recognition for Human-Computer Interaction——A Survey显示文摘Recently,vision-based gesture recognition(VGR)has become a hot research spot in human-computer interaction(HCI).Unlike other gesture recognition methods with data gloves or other wearable sensors,vision-based gesture recognition could lead to more natural and intuitive HCI interactions.This paper reviews the state-of-the-art vision-based gestures recognition methods,from different stages of gesture recognition process,i.e.,(1)image acquisition and pre-processing,(2)gesture segmentation,(3)gesture tracking,(4)feature extraction,and(5)gesture classification.This paper also analyzes the advantages and disadvantages of these various methods in detail.Finally,the challenges of vision-based gesture recognition in haptic rendering and future research directions are discussed. | GAO Yongqiang LU Xiong SUN Junbin TAO Xianglin HUANG Xiaomei YAN Yuxing LIU Jia | 2020 | Wuhan University Journal of Natural Sciences2020，25，2： | 2 |
| 18 | Object-based classification of cloudy coastal areas using medium-resolution optical and SAR images for vulnerability assessment of marine disaster显示文摘Efficient and accurate access to coastal land cover information is of great significance for marine disaster prevention and mitigation.Although the popular and common sensors of land resource satellites provide free and valuable images to map the land cover,coastal areas often encounter significant cloud cover,especially in tropical areas,which makes the classification in those areas non-ideal.To solve this problem,we proposed a framework of combining medium-resolution optical images and synthetic aperture radar(SAR)data with the recently popular object-based image analysis(OBIA)method and used the Landsat Operational Land Imager(OLI)and Phased Array type L-band Synthetic Aperture Radar(PALSAR)images acquired in Singapore in 2017 as a case study.We designed experiments to confirm two critical factors of this framework:one is the segmentation scale that determines the average object size,and the other is the classification feature.Accuracy assessments of the land cover indicated that the optimal segmentation scale was between 40 and 80,and the features of the combination of OLI and SAR resulted in higher accuracy than any individual features,especially in areas with cloud cover.Based on the land cover generated by this framework,we assessed the vulnerability of the marine disasters of Singapore in 2008 and 2017 and found that the high-vulnerability areas mainly located in the southeast and increased by 118.97 km2 over the past decade.To clarify the disaster response plan for different geographical environments,we classified risk based on altitude and distance from shore.The newly increased high-vulnerability regions within 4 km offshore and below 30 m above sea level are at high risk;these regions may need to focus on strengthening disaster prevention construction.This study serves as a typical example of using remote sensing techniques for the vulnerability assessment of marine disasters,especially those in cloudy coastal areas. | YANG Fengshuo YANG Xiaomei WANG Zhihua LU Chen LI Zhi LIU Yueming | 2019 | Journal of Oceanology and Limnology2019，37，6： | 2 |
| 19 | Isolation and characterization of a co-producer of fengycins and surfactins, endophytic Bacillus amyloliquefaciens ES-2, from Scutellaria baicalensis Georgi显示文摘 | Lijun Sun Zhaoxin Lu Xiaomei Bie Fengxia Lu Shengyuan Yang | 2006 | World Journal of Microbiology and Biotechnology2006，，12： | 2 |
| 20 | Dynamics and manipulation of ferroelectric domain walls in bismuth ferrite thin films显示文摘Ferroelectric domain walls differ from domains not only in their crystalline and discrete symmetry,but also in their electronic,magnetic,and mechanical properties.Although domain walls provide a degree of freedom to regulate the physical properties at the nanoscale;the relatively lower controllability prevents their practical applications in nano-devices.In this work;with the advantages of 3D domain configuration detection based on piezoresponse force microscopy;we find that the mobility of three types of domain walls(tail-to-tail,head-to-tail,head-to-head)in(001)BiFeO3 films varies with the applied electrical field.Under low voltages;head-to-tail domain walls are more mobile than other domain walls;while,under high voltages,tail-to-tail domain walls become rather active and possess relatively long average lengths.This is due to the high nucleation energy and relatively low growth energy for charged domain walls.Finally;we demonstrate the manipulation of domain walls through successive electric writings,resulting in well-aligned conduction paths as designed;paving the way for their application in advanced spintronic;memory and communication nano-devices. | Shuyu Xiao Yaming Jin Xiaomei Lu Sang-Wook Cheong Jiangyu Li Yang Li Fengzhen Huang Jinsong Zhu | 2020 | National Science Review2020，7，2： | 2 |
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