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| 1 | Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection显示文摘AIM:To investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H. pylori ) infection. METHODS:This open randomized trial recruited 234 H. pylori positive gastritis patients from seven local centers. The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid , clarithromycin 500 mg bid , and amoxicillin 1000 mg bid ; OCA group, n = 79); two weeks of pre-treatment with probiotics, containing 3 × 107 Lactobacillus acidophilus per day, prior to one week of triple therapy (POCA group, n = 78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group, n = 77). Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy. Patients were asked to report associated symptoms at baseline and during follow-up, and side effects related to therapy were recorded. Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods. RESULTS:PP analysis involved 228 patients, 78 in the OCA, 76 in the POCA and 74 in the OCAP group. Successful eradication was observed in 171 patients; by PP analysis, the eradication rates were significantly higher (P = 0.007 each) in the POCA (62/76; 81.6%, 95% CI 72.8%-90.4%) and OCAP (61/74; 82.4%, 95% CI 73.6%-91.2%) groups than in the OCA group (48/78; 61.5%, 95% CI 50.6%-72.4%). ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5%, 95% CI 70.4%-88.6%) and OCAP (61/77; 79.2%, 95% CI 70%-88.4%) groups than in the OCA group (48/79; 60.8%, 95% CI 49.9%-71.7%), (P = 0.014 and P = 0.015). The symptom relieving rates in the POCA, OCAP and OCA groups were 85.5%, 89.2% and 87.2%, respectively. Only one of the 228 patients experienced an adverse reaction. CONCLUSION:Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates. | Yi-Qi Du Tun Su Jian-Gao Fan Yu-Xia Lu Ping Zheng Xing-Hua Li Chuan-Yong Guo Ping Xu Yan-Fang Gong Zhao-Shen Li | 2012 | World Journal of Gastroenterology2012，18，43： | 54 |
| 2 | Thermal lens determination of end-pumped solid-state laser by a simple direct approach显示文摘 | Liu Jun hai Lu Jian ren Lu Tun hua | 1999 | Chin Phys Lett1999，16，3： | 2 |
| 3 | Achieving transparent&real-time collaborationin Co-AutoCAD application显示文摘 | GAN Li-ping LU Tun | 2011 | Journal of Universal ComputerScience2011，17，14： | 1 |
| 4 | Intrapleural hyperthermic perfusion chemotherapy in subjects with metastatic pleural malignancies显示文摘 | Ahmet Feridun I??k Maruf ?anl? Miray Y?lmaz Fatih Metero?lu ?ner Dikensoy Alper Sevin? Celaletdin Camc? Bülent Tun??zgür Levent Elbeyli | 2013 | Respiratory Medicine2013，，： | 1 |
| 5 | Reconfigurable and nonvolatile terahertz lithography-free photonic devices based on phase change films显示文摘High-performance terahertz(THz)devices with reconfigurable features are highly desirable in many promising THz applications.However,most of the existing reconfigurable THz elements are still limited to volatile responses,single functionality,and time-consuming multistep manufacturing procedures.In this paper,we report a lithography-free approach to create reconfigurable and nonvolatile THz components by exploring the reversible,nonvolatile,and continuous THz modulation capability of the phase change material Ge_(2)Sb_(2)Te_(5).As a proof of concept,THz gratings with significant Rayleigh anomalies and diffraction as well as ultrathin THz flat lenses with subwavelength and ultra-broadband focusing capabilities are designed and fabricated on ultrathin Ge_(2)Sb_(2)Te_(5)films using the presented photo-imprint strategy.Moreover,such a method can also be adopted to create more complex THz devices,such as Pancharatnam–Berry phase metasurfaces and grayscale holographic plates.With these findings,the proposed method will provide a promising solution to realize reconfigurable and nonvolatile THz elements. | XIEYU CHEN SHOUJUN ZHANG KUAN LIU YUEHONG XU XIAOHAN JIANG HAIYANG LI XI FENG QINGWEI WANG YONGCHANG LU KEMENG WANG TUN CAO ZHEN TIAN | 2023 | Photonics Research2023，11，4： | 1 |
| 6 | The expansion coefficient and elastic modulus of crystal with FCC structure 显示文摘 | Lu Chao Zhou Tie Zheng Rui - tun | 2005 | Journal of Southwest China Normal University (Natural Science Edition)2005，5，： | 1 |
| 7 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 8 | Severe vitreous hemorrhage associated with closed-globe injury显示文摘 | Ling Yeung Tun Lu Chen Ya Hui Kuo An Ning Chao Wei Chi Wu Kuan Jen Chen Yih Shiou Hwang Yen Po Chen Chi Chun Lai | 2006 | Graefe’s Archive for Clinical and Experimental Ophthalmology2006，，1： | 1 |
| 9 | Construction of a single chain variable fragment antibody (scFv) against tetrodotoxin (TTX) and its interaction with TTX显示文摘 | Rongzhi Wang Ailing Huang Licai Liu Shuangshuang Xiang Xiufeng Li Sumei Ling Lei Wang Tun Lu Shihua Wang | 2014 | Toxicon2014，，： | 1 |
| 10 | The effect of heme oxygenase-1 induction by octreotide on radiation enteritis显示文摘 | Semra Do?ru Abbaso?lu Ye?im Erbil Tun? Eren Murat Giri? Umut Barbaros Rifat Yücel Vakur Olga? Müjdat Uysal Gül?in Toker | 2005 | Peptides2005，，6： | 1 |
| 11 | CLAF:solving intention violation of step-wise operations in CAD groupware显示文摘 | GAO Li-ping LU Tun GU Ning | 2010 | Advanced Enginee-ring Informatics2010，24，2： | 1 |
| 12 | Achieving transparent and real-time collaboration in Co-AutoCAD application显示文摘 | Gao Liping Lu Tun | 2011 | Journal of Universal Computer Science2011，17，14： | 1 |
| 13 | FGSM:A Framework for Grid Service Mining显示文摘 | Lu Tun Li Zhishu Xu Chunlin | 2005 | Journal of Sichuan University2005，37，2： | 1 |
| 14 | Thoracic interstitial injection of drug-liposomes in mice for treating atherosclerosis显示文摘Intervaginal space injection(ISI)is a novel mode of administration investigated over the last decade.After injecting nanoparticles into the intervaginal space,they can be transported along low flow resistance channels into the interstitial space.This transport has a certain delivery direction,and site-specific injection can work on specific organs or tissues.In this study,the thorax,a new ISI site in the interstitial surrounding the internal thoracic artery named the thoracic interstitial injection(tISI)was investigated.To prove the targeting ability of the tISI,two sizes of gold nanoparticles(AuNPs)(47 and 87 nm)were administered to mice.After 1 h,the biodistribution of AuNPs in the tissues was measured via single particle inductively coupled plasma mass spectrometry(spICP-MS).The results showed that the concentration of AuNPs in the aorta after tISI injection was significantly higher than that after intravenous injection.Moreover,fewer nanoparticles with larger particle sizes were observed to have entered the blood and were better targeted to the aorta.Thereafter,tanshinone IIa sodium sulfonate liposomes were administered for the treatment of aortic atherosclerosis.The proportion of aortic plaques in atherosclerotic Apoe-/-mice administered via tISI was significantly lower than that in other model animals(P<0.001).Furthermore,the proteoglycan content and CD68-positive cell count in the plaques were significantly reduced.The vascular elastic fibers at the plaque site were thickened,and fractures were reduced.tISI was,therefore,determined to be an effective strategy for the treatment of atherosclerotic aortic plaques. | Tun Yan Huizhen Sun Yahong Shi Ya Gao Xi Lu Kai Li Yuting Zhu Qiang Zhang Tingting Li Zhongxian Li Xiaohan Zhou Yuting Guo Yinglu Ji Xiaoli Shi Dong Han | 2023 | Nano Research2023，16，4： | 0 |
| 15 | A blockchain-enabled wiki framework based on participatory design显示文摘The 5G mobile Internet facilitates contents generation for online communities and platforms through human-to-human collaboration.Wikipedia,a well-known online community,uses wiki technology to build an encyclopedia through collective intelligence and collaboration.Mainstream wiki systems adopt a centralized implementation,and while existing studies have optimized the efficiency of the wiki systems'centralized implementation,these systems still suffer from a lot of problems,for example,opacity and distrust.Over the years,blockchain has brought a flurry of fervour and decentralization to the system architecture,meanwhile giving users a sense of trust and participation.Thus,an innovative blockchain-enabled wiki framework called DecWiki is proposed to build one transparent,truthful,collaborative and autonomous encyclopedia.After several participatory design iterations,we present DecWiki's detailed architecture and its implementation in the form of a smart contract and use the interplanetary file system to complement the big data storage.Meanwhile,we use the trusted execution environment to secure sensitive information in the wireless scenario.Finally,the system overhead and the acceptance of the prototype are evaluated.Extensive experiments present its significant performance. | Zheng Xu Chaofan Liu Peng Zhang Tun Lu Ning Gu | 2022 | Digital Communications and Networks2022，8，6： | 0 |
| 16 | The Massage Therapy of Balancing the Mechanism of the Body显示文摘TheMassageTherapyofBalancingtheMechanismoftheBody￥LiJun;XinLu(Kuitunbuildingarmyteacherstrainingschool,Xinjiang)Themassagethe... | Li Jun Xin Lu(Kui tun building army teachers training school, Xinjiang) | 1995 | 中国针灸1995，15，S2： | 0 |
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