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30篇 您的检索式:作者名="LU Mingyang"
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1Side Effects during Treatment of Advanced Gastric Carcinoma by Chemotherapy Combined with CIK-cell Transfusion in Elderly People显示文摘OBJECTIVE To study the side effects and therapeutic results of autologous cytokine-induced killer(CIK)cell treatment in elderly patients with advanced gastric cancer. METHODS CIK cells were induced and cultured using biotechnics in vitro,and then the cells were infused back into the patients.Sixty elderly gastric cancer patients treated by chemotherapy(FOLFOX4 protocol)were followed-up.Among them,29 patients were treated with CIK cells during application of chemotherapy.Short-term curative effects and adverse events from the CIK transfusion and chemotherapy were observed. RESULTS Eight cases developed partial remission(PR),9 cases moderate remission(MR),7 cases stable disease(SD)and 5 cases progressive disease(PD).Out of a total of 29 patients who received chemotherapy combined with autologous CIK therapy, the total remission rate(PR+MR)was 58.6%.The total remission rate following chemotherapy alone was 45.2%,including 5 PR cases,9 MR cases,7 SD cases,and 10 PD cases.There was a relatively lower rate of severe chemotherapic toxicities in the CIK- cell transfusion group.Side e?ects of autologous CIK transfusion included chills(13 cases),fever(9 cases),nausea and vomiting (1 case)and general malaise(3 cases).Side effects were treated with conventional therapy resulting in their amelioration.No patients developed shock,blood capillary leakage syndrome,or abnormalities in routine blood,urine,liver and renal function tests. CONCLUSION Adoptive immunotherapy with autologous CIK cells may decrease the clinical signs and symptoms of elderly patients who suffer from advanced gastric cancer.Adverse reactions of patients can be alleviated by conventional therapy. Autologous CIK-cell transfusion may improve endurance to chemotherapy.Jingting Jiang Changping Wu Liangrong Shi Ning Xu Haifeng Deng Mingyang Lu Mei Ji Hbei Zhu Xueguang Zhang 2008Chinese Journal of Clinical Oncology2008,5,2:10
2Facile electrodeposition of 3D concentration-gradient Ni-Co hydroxide nanostructures on nickel foam as high performance electrodes for asymmetric supercapacitors显示文摘小说三维(3D ) 集中坡度 Ni 公司氢氧化物 nanostructures (3DCGNC ) 被一个灵巧的逐步的电气化学的免职方法直接在镍泡沫上种了并且强烈地为 supercapacitors 调查同样没有文件夹、没有售票员的电极。基于一种三电极的电气化学的描述技术,获得的 3DCGNC 电极表明了 1,760 F 的一个高特定的电容 ????Mingyang Yang Hua Cheng Yingying Gu Zhifang Sun Jing Hu Lujie Cao Fucong Lv Minchan Li Wenxi Wang Zhenyu Wang Shaofei Wu Hongtao Liu Zhouguang Lu 2015Nano Research2015,8,8:8
3Rational design of palladium single-atoms and clusters supported on silicoaluminophosphate-31 by a photochemical route for chemoselective hydrodeoxygenation of vanillin显示文摘Chemoselective hydrodeoxygenation of vanillin is of great importance in converting biomass into high value-added chemicals.Herein,we describe a facile photochemical route to access palladium single atoms and clusters supported on silicoaluminophosphate-31(SAPO-31)as a highly active,chemoselective,and reusable catalyst for hydrodeoxygenation of vanillin.Characterizations by aberration-corrected high-angle annular dark-field scanning transmission electron microscopy,extended X-ray absorption fine structure measurement,and CO-absorbed diffuse reflectance infrared Fourier transform spectroscopy reveal the atomically dispersed palladium single atoms and clusters are loosely bonded and randomly dispersed,without forming strong palladium-palladium metallic bonding,over the SAPO-31 support.This catalyst,with a full metal availability to the reactants,exhibits exceptional catalytic activity(TOF:3,000 h^(−1),Yield:>99%)in the hydrodeoxygenation of vanillin toward 2-methoxy-4-methylphenol(MMP)under mild conditions(1 atm,80°C,30 min),along with excellent stability,scalability(up to 100-fold),and wide substrate scope.The superior catalytic performance can be attributed to the synergistic effect of the positively charged palladium single atoms and fully exposed clusters,as well as the strong metal-support interactions.This work may offer a new avenue for the design and synthesis of fully exposed metal catalysts with targeted functionalities.Xiaowen Lu Chunmu Guo Mingyang Zhang Leipeng Leng J.Hugh Horton Wei Wu Zhijun Li 2021Nano Research2021,14,11:3
4Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART.Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu 2021Cell Research2021,31,8:2
5Effects of surface roughness on the aerodynamic performance of a high subsonic compressor airfoil at low Reynolds number显示文摘The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact of surface roughness on the profile loss of a high subsonic compressor airfoil at Re=1.5×10^(5).Four roughness locations,covering 10%,30%,50%and 100%of the suction surface from the leading edge and seven roughness magnitudes(Ra)ranging from 52 to525 lm were selected.Results showed that the surface roughness mainly determined the loss generation process by influencing the structure of the Laminar Separation Bubble(LSB)and the turbulence level near the wall.For all the roughness locations,the variation trend for the profile loss with the roughness magnitude was similar.In the transitionally rough region,the negative displacement effect of the LSB was suppressed with the increase of roughness magnitude,leading to a maximum decrease of 14.6%,16.04%,16.45%and 10.20%in the profile loss at Ra=157 lm for the four roughness locations,respectively.However,with a further increase of the roughness magnitude in the fully rough region,the stronger turbulent dissipation enhanced the growth rate of the turbulent boundary layer and increased the profile loss instead.By comparison,the leading edge roughness played a dominant role in the boundary layer development and performance variation.To take fully advantage of the surface roughness reducing profile loss at low Re,the effects of roughness on suppressing LSB and inducing strong turbulent dissipation should be balanced effectively.Mingyang WANG Chengwu YANG Ziliang LI Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU 2021Chinese Journal of Aeronautics2021,34,3:2
6In situ assembly of magnetic nanocrystals/graphene oxide nanosheets on tumor cells enables efficient cancer therapy显示文摘Owing to the stimulus-responsive and dynamic properties,magnetism-driven assembly of building blocks to form ordered structures is always a marvelous topic.While abundant magnetic assemblies have been developed in ideal physical and chemical conditions,it remains a challenge to realize magnetic assembly in complicated biological systems.Herein,we report a kind of biomacromolecule-modified magnetic nanosheets,which are mainly composed of superparamagnetic graphene oxide(Y-Fe2O3@GO),the tumor-targeting protein transferrin(TF),and the mitochondrion-targeting peptide(MitP).Such large-size nanosheets(0.5-1μm),noted as L-Fe2O3@GO-MitP-TF,can successfully in s itu assemble on the surface of tumor cells in a size-dependent and tumor cell-specific way,leading to severe inhibition of nutrient uptake for the tumor cells.More significantly,the nanostructures could efficiently confine the tumor cells,preventing both invasion and metastasis of tumor cells both in vitro and in vivo.Moreover,the 2D assemblies could remarkably disrupt the mitochondria and induce apoptosis,remarkably eradicating tumors under near-infrared(NIR)irradiation.This study sheds light on the development of new nano-systems for efficient cancer therapy and other biomedical applications.Mingyang Liu Yang Lu Qilin Yu Shu-Hong Yu 2020Nano Research2020,13,4:1
7Effect of heavy metals on the stabilization of mercury(II) by DTCR in desulfurization solutions显示文摘Jiaai Hou Rongjie Lu Mingyang Sun Shams Ali Baig Tingmei Tang Lihua Cheng Xinhua Xu 2012Journal of Hazardous Materials2012,,:1
8Stabilization of mercury in flue gas desulfurization gypsum from coal-fired electric power plants with additives显示文摘Mingyang Sun Jiaai Hou Tingmei Tang Rongjie Lu Lihua Cheng Xinhua Xu 2012Fuel Processing Technology2012,,:1
9Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride显示文摘Taoguang Huo Shuang Cai Xiumei Lu Yi Sha Mingyang Yu Famei Li 2009Journal of Pharmaceutical and Biomedical Analysis2009,,4:1
10Preparation of hybrid perovskite-type Li_(0.33)La_(0.56)TiO_(3)by adding ionic liquids显示文摘Perovs kite-type Li_(0.33)La_(0.56)TiO_(3)(LLTO)shows greate r advantages than organic liquid electrolytes to be used in all-so lid-state lithium-ion batteries with high energy densities.Ionic liquid[BMIM][BF4]was used to improve the properties of Li_(0.33)La_(0.56)TiO_(3)by attrition milling in this study.The microstructure,crystallinity and lithium-ion conductivity of the samples were measured by scanning electron microscopy(SEM),X-ray diffraction(XRD),and impedance spectroscopy(IS).The total ionic conductivities of the samples LLTO+x wt%[BMIM][BF4]increase upon adding[BMIM][BF4]and the maximum conductivity reaches4.71×10^(-4)S/cm when x=12.5 wt%.The enhancement of the total conductivity is ascribed to the bridging role of the ionic liquid among grains,as evidenced by the low activation energy of 0.17-0.25 eV and the SEM observation.The Li+transference numbers of the hybrid samples are all lower than that of the pure LLTO,indicating the existence of electronic conductions.The hybrid mate rial with a mixed conductivity and good stability in the atmosphere can find uses in all-solid-state lithium-ion batteries to improve the interface contact between electrolytes and electrodes.Xiaojuan Lu Xinyu Li Mingyang Duan Jiankang Hai Songtao Liu 2023Journal of Rare Earths2023,41,5:1
11African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-βpathway activation by degrading TBK1显示文摘African swine fever virus(ASFV)is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers the global swine industry.As ASFV is structurally complex and encodes a large number of functional proteins,no effective vaccine has been developed to date.Thus,dissecting the mechanisms of immune escape induced by ASFV proteins is crucial.A previous study showed that the ASFV-encoded protein is an important factor in host immunity.In this study,we identified a negative regulator,MGF505-3R,that significantly downregulated cGAS/STING-and poly(dG:dC)-mediated IFN-βand interferon stimulation response element(ISRE)reporter activity and suppressed IFNB1 and IFIT2 mRNA levels.In addition,TBK1,IRF3 and IκBαphosphorylation levels were also inhibited.Mechanistically,MGF505-3R interacted with cGAS/TBK1/IRF3 and targeted TBK1 for degradation,thereby disrupting the cGAS-STING-mediated IFN-βsignaling pathway,which appears to be highly correlated with autophagy.Knockdown MGF505-3R expression enhanced IFN-βand IL-1βproduction.Taken together,our study revealed a negative regulatory mechanism involving the MGF505-3R-cGAS-STING axis and provided insights into an evasion strategy employed by ASFV that involves autophagy and innate signaling pathways.Mingyang Cheng Jiawei Luo Yuetong Duan Yu Yang Chunwei Shi Yu Sun Yiyuan Lu Junhong Wang Xiaoxu Li Jianzhong Wang Nan Wang Wentao Yang Yanlong Jiang Guilian Yang Yan Zeng Chunfeng Wang Xin Cao 2022Animal Diseases2022,2,3:1
12Crystal structure of unliganded influenza B virus hemagglutinin 显示文摘Qinghua Wang Feng Cheng Mingyang Lu 2008J Virol2008,82,6:1
13Vortex dynamics and entropy generation in separated transitional flow over a compressor blade at various incidence angles显示文摘The transition process within a Laminar Separation Bubble(LSB)that formed on a compressor blade surface was investigated using Large Eddy Simulations(LESs)at a Reynolds number of 1.5×10;and incidence angles of 0°,+3°,and+5°.The vortex dynamics in the separated shear layers were compared at various incidence angles and its effects on the loss generation were clarified through entropy analysis.Results showed that transition onset,which was accurately identified by the Linear Stability Theory(LST),was significantly promoted at the increased incidence angle.As such,the development of LSB was suppressed and the relative role of viscous instability played in the transition process was weakened.At the incidence angle of 0°,two-dimensional spanwise vortices detached from the blade surface and roiled up periodically,which were further stretched and eventually evolved into large-scale hairpin vortices.As time passed,the fully developed hairpin vortices broke down into small-scale eddies.Meanwhile,the flow near the wall reversely ejected into the outer separated shear layers and a sweeping process happened subsequently,forcing the separated shear layers to reattach and accelerating the generation of turbulent fluctuations.By comparison,the strength of vortex rolling-up was weakened at higher incidence angles,and the vortex pairing and breakdown of large-scale vortices were less pronounced.Therefore,the level of turbulent fluctuations that generated in the separated shear layers was reduced.Detailed entropy analysis showed that the turbulent dissipation effect related to the Reynolds shear stresses determined the largest amount of positive entropy generation,which declined to a lower level as the incidence angle increased from 0°to+5°.Correspondingly,the profile loss was reduced by 50.4%.Mingyang WANG Ziliang LI Ge HAN Chengwu YANG Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU 2022Chinese Journal of Aeronautics2022,35,3:1
14Time-series surface water reconstruction method(TSWR)based on spatial distance relationship of multi-stage water boundaries显示文摘Spatiotemporal continuity of surface water datasets widely known for its significance in the surface water dynamic monitoring and assessments,are faced with drawbacks like cloud influence,which hinders the direct extraction of data from time-series remote sensing images.This study proposes a Time-series Surface Water Reconstruction method(TSWR).The initial stage of this method involves the effective use of remote sensing images to automatically construct multi-stage surface water boundaries based on Google Earth Engine(GEE).Then,we reconstructed regions the reconstruction of regions with missing water pixels using the distance relationship between the multi-stage water boundaries in previous and later periods.When applied to 10 large rivers around the world,this method yielded an overall accuracy of 98%for water extraction,an RMSE of 0.41 km2.Furthermore,time-series reconstruction tests conducted in 2020 on the Lancang and Danube rivers revealed a significant improvement in the image availability.These findings demonstrated that this method could not only be used to accurately reconstruct the surface water distribution missing water images,but also to depict a more pronounced time variation characteristic.The successful application of this method on GEE demonstrates its importance for use on large scales or in global studies.Mingyang Li Shanlong Lu Cong Du Yong Wang Chun Fang Xinru Li Hailong Tang Muhammad Hasan Ali Baig Harrison Odion Ikhumhen 2022International Journal of Digital Earth2022,15,1:0
15Research on the Problems and Countermeasures of Salary Management in Small and Medium-sized Enterprises显示文摘Small and medium-sized enterprises as the main body of Chinese enterprises should be an important driving force for China's economic development. However, the problems of salary management faced by small and medium- sized enterprises are increasingly hindering their own survival and development. Whether it is standing on the position of the enterprise or the workers, the pay problem is that they are more concerned about the problem, while the remuneration is also an indispensable modern means of competition and incentives. Salary management is not only indispensable content of enterprise human resources, but also the establishment of modern enterprise system, and optimization of the allocation of social resources requirements. Enterprise salary management operation flexibility or not, directly affect the production and operation management, which will affect the long-term development of enterprises. This paper analyzes the problems of salary management in small and medium-sized enterprises (SMEs), such as unreasonable pay system, lack of forward-looking management system, and so on, and analyzes and discusses their own countermeasures.Ke Meng Guiyao Lu Mingyang Shen 2019Human Resources Management and Services2019,1,1:0
16Boosting SN38-based oral chemotherapy to combine reductionbioactivated structured lipid-mimetic prodrug with ascorbic acid显示文摘The reduction-responsive disulfide bonds have been widely used as bioactive linkages to facilitate a rapid release of anticancer drugs into tumor cells.However,the activation can be hindered by the kinetics of the thiol-disulfide exchange reactions.Supplementing with an additional reductant is a promising strategy to further boost drug release.Herein,inspired by the specific absorption mechanism of triglyceride fat,structured lipid-mimetic oral prodrugs of 7-ethyl-10-hydroxycamptothecin(SN38)were designed to improve intestinal permeability and bypass the first-pass effect.SN38 prodrugs were prepared into lipid formulations that could self-emulsify into nano-sized particles after entering the gastrointestinal tract.Surprisingly,we found that the oral bioavailability of the prodrug lipid formulation could be up to 2.69-fold higher than that of the parent SN38,indicating an effective oral delivery.In addition,the reduction-responsive disulfide bond was used as a linker,and ascorbic acid(ASC)was coadministrated to further promote the efficient release of SN38 from the prodrug.ASC enhanced the oral antitumor effect of the reduction-responsive oral prodrug and exhibited good safety.In summary,the combination of a structured lipid-mimetic prodrug and ASC was firstly demonstrated to boost the oral chemotherapy effect of the difficult-for-oral chemotherapeutics.Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Zixuan Wang Haotian Zhang Zhonggui He Chutong Tian Jin Sun 2022Nano Research2022,15,10:0
17Optically transparent graphene-based cognitive metasurface for adaptive frequency manipulation显示文摘Optically transparent microwave absorbing metasurfaces have shown great potential and are needed in multiple applications environments containing optical windows owing to their ability to reduce backscattering electromagnetic(EM)signals while keeping continuous optical observation.Meanwhile,they are also required to have adaptive EM manipulation capability to cope with complex and capricious EM environments.As a general approach,distributed circuit components,including positive-intrinsic-negative diodes and varactors and sensing components,are integrated with passive absorbing metasurfaces to realize adaptive control of microwave absorption.However,these circuit elements generally require bulky electrical wires and complex control circuits to regulate the operating state,resulting in the absorbing structures being optically opaque.Hence,it is a great challenge to realize self-operating absorbers while maintaining optical transparency.Here,we report an optically transparent cognitive metasurface made of patterned graphene sandwich structures and a radio frequency detector,which can achieve adaptive frequency manipulation to match incident EM waves.As a proof-of-principle application example,we realize a closed-loop automatic absorber system prototype of the proposed graphene metasurface with self-adaptive frequency variation,without any human intervention.The approach may facilitate other adaptive metadevices in microwave regime with high-level recognition and manipulation and,more generally,promote the development of intelligent stealth technologies.MINGYANG GENG XIAOLU YANG HAO CHEN XINZHI BO MENGZI LI ZHENGUO LIU WEIBING LU 2023Photonics Research2023,11,1:0
18Erratum to:Boosting SN38-based oral chemotherapy to combine reduction-bioactivated structured lipid-mimetic prodrug with ascorbic acid显示文摘Erratum to Nano Research 2022,15(10):9092-9104 http://gffzzd3cc09b8251d45dfsu59fb9xxucx56xfu.ffgz.tsg.suse.edu.cn/10.1007/s12274-022-4544-7 Figure 9 was unfortunately mistakenly typeset.This error did not affect any of the conclusions from the published paper.Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Haotian Zhang Zhonggui He Zixuan Wang Chutong Tian Jin Sun 2023Nano Research2023,16,4:0
19Ultralow Interfacial Thermal Resistance of Graphene Thermal Interface Materials with Surface Metal Liquefaction显示文摘Developing advanced thermal interface materials(TIMs)to bridge heat-generating chip and heat sink for constructing an efficient heat transfer interface is the key technology to solve the thermal management issue of high-power semiconductor devices.Based on the ultra-high basal-plane thermal conductivity,graphene is an ideal candidate for preparing high-performance TIMs,preferably to form a vertically aligned structure so that the basal-plane of graphene is consistent with the heat transfer direction of TIM.However,the actual interfacial heat transfer efficiency of currently reported vertically aligned graphene TIMs is far from satisfactory.In addition to the fact that the thermal conductivity of the vertically aligned TIMs can be further improved,another critical factor is the limited actual contact area leading to relatively high contact thermal resistance(20-30 K mm^(2) W^(−1))of the“solid-solid”mating interface formed by the vertical graphene and the rough chip/heat sink.To solve this common problem faced by vertically aligned graphene,in this work,we combined mechanical orientation and surface modification strategy to construct a three-tiered TIM composed of mainly vertically aligned graphene in the middle and micrometer-thick liquid metal as a cap layer on upper and lower surfaces.Based on rational graphene orientation regulation in the middle tier,the resultant graphene-based TIM exhibited an ultra-high thermal conductivity of 176 W m^(−1) K^(−1).Additionally,we demonstrated that the liquid metal cap layer in contact with the chip/heat sink forms a“liquid-solid”mating interface,significantly increasing the effective heat transfer area and giving a low contact thermal con-ductivity of 4-6 K mm^(2) W^(−1) under packaging conditions.This finding provides valuable guidance for the design of high-performance TIMs based on two-dimensional materials and improves the possibility of their practical application in electronic thermal management.Wen Dai Xing-Jie Ren Qingwei Yan Shengding Wang Mingyang Yang Le Lv Junfeng Ying Lu Chen Peidi Tao Liwen Sun Chen Xue Jinhong Yu Chengyi Song Kazuhito Nishimura Nan Jiang Cheng-Te Lin 2023Nano-Micro Letters2023,15,1:0
20Evaluation of China Healthy Lifestyle for All Interventions Based on RE-AIM Framework — China, 2007–2020显示文摘Summary What is already known about this topic?Since the launch of China Healthy Lifestyle for All(CHLA),each action area has been evaluated at the local level and effective results have been achieved in most areas.What is added by this report?Based on the Reach,Effectiveness,Adoption,Implementation,and Maintenance(RE-AIM)model,the study found that there is an imbalance in the development of CHLA,and some of the action goals and indicators are not satisfactory.What are the implications for public health practices?A national action evaluation index system should be built to ensure the sustainability and scientific nature of this strategy.In addition,the government needs to attach great importance to CHLA to effectively help residents take health actions.Fugui Wu Lu Zhang Wenbo Guo Mingyang Wang Yang Gao Dan Liu Yamin Bai Yanfang Zhao Shengquan Mi Wenhua Zhao Zhuoqun Wang Man Li 2022China CDC weekly2022,4,19:0
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