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| 1 | Tat-functionalized Ag-Fe_3O_4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery显示文摘In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide(Tat), producing Tat-modified Ag-Fe_3O_4 nanocomposites(Tat-FeAgNPs). To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin(Dox) in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC_(50) of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor(6.772.4% ID of Tat-FeAgNPs).Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%(P ? 0.009), which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles. | Ergang Liu Meng Zhang Hui Cui Junbo Gong Yongzhuo Huang Jianxin Wang Yanna Cui Weibing Dong Lu Sun Huining He Victor C.Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 2 | Porosity Prediction from Well Logs Using Back Propagation Neural Network Optimized by Genetic Algorithm in One Heterogeneous Oil Reservoirs of Ordos Basin, China显示文摘A reliable and effective model for reservoir physical property prediction is a key to reservoir characterization and management.At present,using well logging data to estimate reservoir physical parameters is an important means for reservoir evaluation.Based on the characteristics of large quantity and complexity of estimating process,we have attempted to design a nonlinear back propagation neural network model optimized by genetic algorithm(BPNNGA)for reservoir porosity prediction.This model is with the advantages of self-learning and self-adaption of back propagation neural network(BPNN),structural parameters optimizing and global searching optimal solution of genetic algorithm(GA).The model is applied to the Chang 8 oil group tight sandstone of Yanchang Formation in southwestern Ordos Basin.According to the correlations between well logging data and measured core porosity data,5 well logging curves(gamma ray,deep induction,density,acoustic,and compensated neutron)are selected as the input neurons while the measured core porosity is selected as the output neurons.The number of hidden layer neurons is defined as 20 by the method of multiple calibrating optimizations.Modeling results demonstrate that the average relative error of the model output is 10.77%,indicating the excellent predicting effect of the model.The predicting results of the model are compared with the predicting results of conventional multivariate stepwise regression algorithm,and BPNN model.The average relative errors of the above models are 12.83%,12.9%,and 13.47%,respectively.Results show that the predicting results of the BPNNGA model are more accurate than that of the other two,and BPNNGA is a more applicable method to estimate the reservoir porosity parameters in the study area. | Lin Chen Weibing Lin Ping Chen Shu Jiang Lu Liu Haiyan Hu | 2021 | Journal of Earth Science2021，32，4： | 3 |
| 3 | Experimental research of flow patterns and pressure signals in horizontal dense phase pneumatic conveying of pulverized coal显示文摘 | Cong Xingliang Guo Xiaolei Gong Xin Lu Haifeng Dong Weibing | 2011 | Powder Technology2011，208，3： | 1 |
| 4 | A planar electromagnetic 'black hole' based on graphene 显示文摘 | JIANG Yun LU Weibing XU Hongju | 2012 | Physics Letters A2012，376，17： | 1 |
| 5 | An Improved MOM Model for Line-Fed Patch Antennas and Printed Circuits 显示文摘 | Qian Zhiguo Cui Tiejun Lu Weibing | 2005 | IEEE Trans on Antenna and Propagation2005，53，9： | 1 |
| 6 | Experimental research of flow patterns and pressure signals in horizontal dense phase pneumatic conveying of pulverized coal 显示文摘 | Cong Xingliang Guo Xiaolei Gong Xin Lu Haifeng Dong Weibing | 2011 | Pozoder Technology2011，208，60： | 1 |
| 7 | Accurateanalysis of large-scale periodic structures using an effi-cient sub-entire-domain basis function method显示文摘 | Lu Weibing Cui Tiejun Qian Zhiguo | 2004 | IEEE Transactions on Antennas and Propagation2004，52，11： | 1 |
| 8 | Fast algo-rithms for large-scale periodic structures显示文摘 | Lu Weibing Cui Tiejun Qian Zhiguo | 2004 | IEEE An-tennas and Propagation Society Symposium2004，4，： | 1 |
| 9 | Fast algorithms for large-scale periodic structures using subentire domain basis functions 显示文摘 | Lu Weibing Cui Tiejun Yin Xiaoxing | 2005 | IEEE Transactions on Antennas and Propagation2005，53，3： | 1 |
| 10 | 1-MCP delayed soften- ing and affected expression of XET and EXP genes in harvested cherimoya fruit显示文摘 | LI Cairong SHEN Weibing LU Wangjin | 2009 | Postharvest Biology and Technology2009，52，3： | 1 |
| 11 | Optically transparent graphene-based cognitive metasurface for adaptive frequency manipulation显示文摘Optically transparent microwave absorbing metasurfaces have shown great potential and are needed in multiple applications environments containing optical windows owing to their ability to reduce backscattering electromagnetic(EM)signals while keeping continuous optical observation.Meanwhile,they are also required to have adaptive EM manipulation capability to cope with complex and capricious EM environments.As a general approach,distributed circuit components,including positive-intrinsic-negative diodes and varactors and sensing components,are integrated with passive absorbing metasurfaces to realize adaptive control of microwave absorption.However,these circuit elements generally require bulky electrical wires and complex control circuits to regulate the operating state,resulting in the absorbing structures being optically opaque.Hence,it is a great challenge to realize self-operating absorbers while maintaining optical transparency.Here,we report an optically transparent cognitive metasurface made of patterned graphene sandwich structures and a radio frequency detector,which can achieve adaptive frequency manipulation to match incident EM waves.As a proof-of-principle application example,we realize a closed-loop automatic absorber system prototype of the proposed graphene metasurface with self-adaptive frequency variation,without any human intervention.The approach may facilitate other adaptive metadevices in microwave regime with high-level recognition and manipulation and,more generally,promote the development of intelligent stealth technologies. | MINGYANG GENG XIAOLU YANG HAO CHEN XINZHI BO MENGZI LI ZHENGUO LIU WEIBING LU | 2023 | Photonics Research2023，11，1： | 0 |
| 12 | Physical vapor deposited 2D bismuth for CMOS technology显示文摘Two-dimensional(2D)bismuth,bismuthene,is an emerging pnictogen family member that has received increasing research attention in the past few years,which could yield exotic electrical,thermal,and optical properties due to unique band structure.This review provides a holistic view of recent research advances on 2D bismuth material synthesis and device applications in complementary metal oxide semiconductor(CMOS)technology.Firstly,the atomic and band structure of bismuthene is reviewed as the fundamental understanding of its physical properties.Then,it highlights material synthesis of 2D bismuth atomic sheets with emphasis on physical vapor deposition method with accurate layer controllability and process compatibility with CMOS technology.Moreover,it will survey latest applications of 2D bismuth in terms of electronic,optic,thermoelectric,spintronic and magnetic nanodevices.2D bismuth derivatives(Bi-X,X=Sb,Te,Se)will also be mentioned as a promising strategy to further improve device performance.At last,it concludes with a brief summary on the current challenges and future prospects in 2D bismuth and its derivatives for innovative electronics,sensors and other devices compatible with CMOS techniques. | Hanliu Zhao Xinghao Sun Zhengrui Zhu Wen Zhong Dongdong Song Weibing Lu Li Tao | 2020 | Journal of Semiconductors2020，41，8： | 0 |
| 13 | Analysis of DNA Methylation Level of Portunus trituberculatus Subjected to Low Salinity with Methylation-Sensitive Amplification Polymorphism显示文摘In this study,the methylation-sensitive amplification polymorphism(MSAP)was used to compare the genomic DNA methylation level of muscle,gill and hepatopancreas of Portunus trituberculatus subjected to salinity 12 for 30 days to illustrate the epigenetic mechanism of osmoregulation.Thirty primers were used to analyze the difference of methylation level of different tissues.The results showed that the baseline methylation level of muscle,hepatopancreas and gill was 47.31%,22.94%and 17.69%,respectively.After exposed to low salinity stress,the methylation epiloci changed in the three tissues.Both demethylation and methylation processes occurred under low salinity stress.The methylation ratio decreased in muscle and gill but increased in hepatopancreas.These results indicated that DNA methylation is tissue-specific when P.trituberculatus responds to low salinity. | LU Shaokun LI Ronghua GAO Tianlong WANG Chunlin ZHENG Weibing MU Changkao SONG Weiwei | 2019 | Journal of Ocean University of China2019，18，5： | 0 |
| 14 | Monkeypox virus 2022,gene heterogeneity and protein polymorphism显示文摘Dear Editor,Human monkeypox(MPX),an endemic disease in equatorial Africa,1 has been causing outbreaks in non-endemic countries since early May 2022.Interestingly,many confirmed cases have no history of travel to Africa.This is the first time many MPX cases have been reported concurrently in both non-endemic and endemic countries in disparate geographical areas.2 In response,we have analyzed 27 genes or sequences from 643 full-length human monkeypox virus(MPXV)genomes collected after January 1 and submitted by August 7,2022(Supplementary Table 1).We divided these 643 genomes into 24 clusters with a 95%identity threshold(Supplementary Table 2). | Yanjiao Li Jingjing Hou Zhong Sun Jingjing Hu Karuppiah Thilakavathy Yuxi Wang Zhongjun Shao Yihan Lu Weibing Wang Chenglong Xiong | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
| 15 | Constructing 2D ultrathin graphene oxide membranes with supramolecular-assembled nano-adhesives for enhancing water stability显示文摘Atomic-thick two-dimensional(2D)graphene oxide(GO)has emerged as an ideal building block in developing ultrathin 2D membranes for separating substances.However,due to the negative charge of GO sheets when hydrated,electrostatic repulsion causes GO membranes to disintegrate easily in water,limiting their wide application in aqueous solutions.Here,we introduce and apply the concept of localized gluing by designing ultra-small supramolecular-assembled nanoparticles as nanoadhesives(NPA)to construct robust GO membranes with a thickness of only 24 nm.The supramolecular-assembled NPA were synthesized by cyclodextrin(CD)and tannic acid(TA)with a uniform size distribution of about 4.5 nm,and exposed surface pyrogallols that could strongly interact with GO sheets.The physical sizing of the NPA confines the interlayer spacing and maintains the nanochannel,while the natural molecular properties of the NPA enhance the connection between adjacent layers and inhibit swelling detachment.The fabricated ultrathin 2D membranes show a remarkable two times enhancement of water permeance over pristine GO membranes and exhibit excellent durability with record-breaking stability for 720 h immersion in water.This strategy provides meaningful insights into the design and fabrication of robust ultrathin membranes for practical application. | Wei Liu Yuan Li Rujing Li Hui Xu Xinling Lu Weibing Dong Zhen Zhang Yong Wang | 2023 | Nano Research2023，16，7： | 0 |
| 16 | An Efficient Algorithm to Study the Radiation of Antennas Near to or Attached on a Large PEC Object显示文摘 | LU Weibing CUI Tiejun | 2006 | Chinese Journal of Electronics2006，15，4： | 0 |
| 17 | Small RNA sequencing revealed aberrant piRNA expression profiles in deciduas of recurrent spontaneous abortion patients显示文摘Piwi-interacting RNAs(piRNAs)is a novel class of non-coding RNAs.However,changes in piRNA expression profiles in recurrent spontaneous abortion(RSA)have not yet been investigated.The aim of this study was to identify differentially expressed piRNAs in deciduas of RSA patients.Decidua tissues were collected by curettage from recruited RSA patients and normal early pregnant(NEP)women with their informed consent.Small RNA sequencing was used to evaluate the differences in piRNA expression profiles between RSA and NEP.The present results demonstrated that the counts of total piRNA reads in RSA samples were increased compared with those in NEP samples(0.21%vs.0.11%).Differential expression analysis identified 29 upregulated piRNAs and 18 downregulated piRNAs in RSA samples.RT-qPCR further confirmed that the expression levels of uniq-109625,uniq-89328,uniq-50651 and uniq-4569 were decreased in 8 RSA tissues,compared with 13 NEP tissues.Otherwise,pi-22628 and uniq-173406 were increased in 8 RSA tissues.Based on GO term and KEGG pathway analysis,we speculate that these piRNAs regulate RSA by targeting extracellular matrix component pathway,cell adhesion pathway and focal adhesion pathway.PiRNAs may be involved in RSA pathogenesis by target genes function on adhesion and extracellular matrix component. | JIABAO WU XIAOHUA LIU LU HAN HUA NIE YUAN TANG YUNGE TANG GE SONG LIXIN ZHENG WEIBING QIN | 2022 | BIOCELL2022，46，4： | 0 |
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