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| 1 | Knockdown of S-phase Kinase-associated Protein-2 Expression in MCF-7 Inhibits Cell Growth and Enhances the Cytotoxic Effects of Epirubicin显示文摘S 阶段联系 kinase 的 protein-2 (Skp2 ) 在调停 ubiquitin 的解朊作用起一个关键作用,导致房间从的前进一对一个 proliferative 状态静止。Skp2 完了在许多肿瘤表示了并且相反地与 p27 表示相关,包括乳癌。在这研究,我们使用了小介入的 RNA (siRNAs ) 在人的乳癌 MCF-7 细胞禁止 Skp2 表示并且如果击倒,从而由 RNA 干扰(RNAi ) Skp2 调查将禁止乳癌细胞生长并且在 MCF-7 细胞上影响 epirubicin 的效果。三 Skp2 siRNA 构造被重新结合并且短暂地 transfected 人乳癌 MCF-7 房间。Skp2 的下面规定被反向的抄写聚合酶链反应和蛋白质印迹分析证实。我们证明 Skp2 siRNA 转染减少了 Skp2 蛋白质并且在 MCF-7 房间导致了 p27 蛋白质的累积。Skp2 siRNA 在 vitro 并且在 vivo 禁止了房间增长。由 RNAi 的 Skp2 击倒在 vitro 的增加的细胞的 apoptosis。有治疗进一步与 epirubicin 跟随的 Skp2 siRNA 的治疗禁止了癌症房间线的增长,与 epirubicin 跟随的控制 siRNA 相比。因此, Skp2 击倒由 RNAi 的表示禁止乳癌细胞生长并且提高 epirubicin 的效果。Skp2 的调停 siRNA 的基因 silencing 能是为在规定下面的 p27 的抑制的新奇癌症基因治疗。 | Lichun SUN Li CAI Yan YU Qingwei MENG Xuesong CHENG Yanbin ZHAO Guangjie SUI Fengmin ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 2 | Extraction of Hemicellulose from Acacia Wood via Autohydrolysis and Ethanol Precipitation显示文摘Isolation and utilization of hemicellulose are important processes in the pulp mill-based biorefinery. Considering the potential end use of the hemicellulose,this study investigated the concentration of monomeric and oligomeric sugars in the hydrolysate derived from autohydrolysis of acacia wood and the obtainment of these sugars via ethanol precipitation. The rate of generation of monomers and oligomers increased dramatically with an increase of the temperature from 160℃ to 180℃. The maximum content of oligomers and total sugars was achieved under conditions of 180℃ and 10 min,170℃ and 85 min,respectively. Interestingly,the maximum yield of hemicellulose via ethanol precipitation was achieved in a much shorter time,compared with the maximum yield of oligomer from the hydrolysate by autohydrolysis. A 6. 66 g / L quantity of hemicellulose was obtained by intensifying the conditions of ethanol precipitation. The hemicellulose characteristics were analyzed by Fourier transform infrared,nuclear magnetic resonance,and ultraviolet spectroscopy,and the molecular weight was determined by gel permeation chromatography and thermal analysis. | HaiQiang Shi KaiYuan Guo YanNing Sun Na Li Jian Zhang MeiHong Niu QingWei Ping | 2016 | Paper And Biomaterials2016，1，1： | 4 |
| 3 | Precise synthesis of discrete and dispersible carbon- protected magnetic nanoparticles for efficient magnetic resonance imaging and photothermal therapy显示文摘保护碳的磁性的 nanoparticles 展览在酸或碱的媒介,好 biocompatibility,和高浸透磁化的长期的稳定性。作为结果,他们为磁性的回声成像保持大诺言, photothermal 治疗,等等。自从热分解,它是经常要求了把碳先锋变换成碳,不管多么典型地导致 nanoparticles 的结合,获得的保护碳的磁性的 nanoparticles 通常作为非可分散的聚集是 sintered。我们成功地综合了经由一条精确表面 / 接口 nano 工程途径的分离、可分散、一致的保护碳的磁性的 nanoparticles。显著地, nanoparticles 拥有优秀水可分散性, biocompatibility,一个高 T 2 relaxivity 系数(384 公里 -1 捡潲祣汣?? 乐 ?? 鳦銺? 鎽 ? 鎻黦貒鳦 ? 鷦鮊髧 ? 苧蒚? ⑼ O?蒚渠湡灯牯獥胣?? | An-Hui Lu Xiang-Qian Zhang Qiang Sun Yan Zhang Qingwei Song Ferdi Schuth Fang Cheng | 2016 | Nano Research2016，9，5： | 3 |
| 4 | Historical Evolution of Mariculture in China During Past 40 Years and Its Impacts on Eco-environment显示文摘The rapid development of mariculture in China in recent decades has satisfied people's demand of seafood, and has made a great contribution to economic development. However, mariculture has also caused some negative impacts on the eco-environment. By statistically analyzing national data(as well as data for four main provinces) regarding the mariculture area and cultivation species in China since reform and opening up, the historical evolution of mariculture during the past 40 years was analyzed, the driving factors related to policy, market and technology innovation were discussed, and the potential impacts of mariculture on the coastal eco-environment were also illustrated. The statistical results indicated that the maricultural area increased radically during the past 40 years, from 1979(116.47 × 10~3 ha) to 2012(2205.65 × 10~3 ha), with an increase of nearly 20-fold. Shandong Province represented the fastest-growing region, with an increase of 31-fold. Moreover, the cultivated species had gradually become diversified. Initially, shellfish and algae were major species, and then it developed to various species including fish, and currently shellfish and crustaceans were the major species. The development of mariculture was driven by government policies, market economy and technology innovation. Rapid development of mariculture also caused significantly adverse impacts on the eco-environment of the coastal regions. For example, the sea reclamation for mariculture decreased the area and function of coastal wetlands and the contaminants originating from mariculture destroyed the coastal aquatic environment. Fortunately, the implementation of ‘13 th Five-Year Fisheries Planning' is expected to help both improve the seafood quality and reduce the contamination in coastal aquatic environment. This current study will provide reference for management and structure adjustment of mariculture in the future. | LIANG Yinxiu CHENG Xianwei ZHU Hui Brian SHUTES YAN Baixing ZHOU Qingwei YU Xiangfei | 2018 | Chinese Geographical Science2018，28，3： | 3 |
| 5 | Studies of the Geodesic Acoustic Mode Zonal Flow in HL-2A Tokamak Plasmas显示文摘 | ZHAO Kaijun DONG Jiaqi YAN Longwen HONG Wenyu QIAN Jun CHENG Jun YU Deliang YANG Qingwei DING Xuantong LIU Yong PAN Chuanhong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 2 |
| 6 | Detecting Non-Stationarity for Auscultation Signal of Traditional Chinese Medicine显示文摘The information about the nonstationarity of the aus-cultation signal is utilized in this paper to objectively and auto-matically identify healthy people and patients with qi-deficiency or yin-deficiency. In order to characterize the nonstationarity of the sound signal,the nonlinear cross-prediction method is used to extract features from the signal. A feature selection method based on conditional mutual information maximization criterion (CMIM) is implemented to find an optimal feature set. By means of the support vector machine (SVM) classifier,three common states (healthy,qi-deficiency and yin-deficiency) in traditional Chinese medicine are distinguished using the feature set,and a satisfactory classification accuracy of 80% is achieved in the experiment. In conclusion,the analysis based on the nonstationarity of the sound signal provides an alternative and outstanding approach to the objective auscultation of traditional Chinese medicine (TCM). | YAN Jianjun SHEN Qingwei WANG Yiqin LI Fufeng GUO Rui CHEN Chunfeng SHEN Yong | 2011 | Wuhan University Journal of Natural Sciences2011，16，1： | 1 |
| 7 | New Diagnostic Systems on HL-2A Tokamak显示文摘 | DING Xuantong ZHOU Yan DENG Zhongchao XIAO Weiwen LIU Zetian SHI Zhongbing YAN Longwen HONG Wenyu YANG Qingwei | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 1 |
| 8 | The Pellet Enhanced Performance on the HL-2A Tokamak显示文摘 | DING Xuantong YANG Qingwei YAN Longwen ZHU Genliang CAO Zeng XIAO Zhenggui GAO Qingdi LONG Yongxing LIU Dequan LIU Yi ZHOU Yan PAN Yudong CUI Zhengying HUANG Yuan LIU Zetian SHI Zhongbing JI Xiaoquan XIAO Weiwen LIU Yong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 1 |
| 9 | Mechanisms of Pb(Ⅱ) coprecipitation with natrojarosite and its behavior during acid dissolution显示文摘Lead(Pb) coprecipitation with jarosite is common in natural and engineered environments,such as acid mine drainage(AMD) sites and hydrometallurgical industry. Despite the high relevance for environmental impact, few studies have examined the exact interaction of Pb with jarosite and the dissolution behavior of each phase. In the present work, we demonstrate that Pb mainly interacts with jarosite in four modes, namely incorporation, occlusion,physically mixing, and chemically mixing. For comparison, the four modes of Pb-bearing natrojarosite were synthesized and characterized separately. Batch dissolution experiments were undertaken on these synthetic Pb-bearing natrojarosites under pH_(2) to simulate the AMD environments. The introduction of Pb decreases the final Fe releasing efficiency of jarosite-type compounds from 18.18% to 3.45%-5.01%, showing a remarkable inhibition of their dissolution. For Pb releasing behavior, PbSO_(4) dissolves in preference to Pb-substituted natrojarosite, i.e.,(Na, Pb)-jarosite, which primarily results in the sharp increase of Pb releasing concentration(> 40 mg/L). PbSO_(4) occlusion by jarosite-type compounds can significantly reduce the release of Pb. The results of this study could provide useful information regarding Fe and Pb cycling in acidic natural and engineered environments. | Meiqing Shi Xiaobo Min Chen Tian Taixu Hao Sijie Zhu Yun Ge Qingwei Wang Xu Yan Zhang Lin | 2022 | Journal of Environmental Sciences2022，34，12： | 1 |
| 10 | Im- proved Lattice-based Confidence Measure for Speech Rec- ognition via a Lattice Cut off Procedure 显示文摘 | Jie Gao Qingwei Zhao Ran Xu and Yonghong Yan | 2009 | IEEE Com- puter Science2009，，： | 1 |
| 11 | Numerical Investigations on Transient Behaviours of Two 3-D Freely Floating Structures by Using a Fully Nonlinear Method显示文摘在靠近的最近的二漂浮结构很通常在近海的设计被看见。他们经常受到陡峭的波浪并且因此,他们的水动力学特征上的短暂效果担心大。这份报纸使用伪任意的 Lagrangian-Eulerian 有限元素方法(QALE女性)基于充分非线性的潜在的理论( FNPT ),组织自由( DOF )的度数字地调查在二 3-D 漂浮之间的相互作用,它与 6 经历运动,并且与不同事件角度受到波浪。漂浮的结构,伴随的结构的效果,和运动和波浪上的非线性的短暂行为结构上的负担是学习的主要焦点。调查揭示一引起更加更大的结构的重要短暂效果处于稳定的状态比那打手势。结果也显示在靠近的最近的伴随的结构在引起第二顺序部件具有到基本的类似的意义的更强壮的非线性提高在不同运动模式和结果之间的相互作用。 | Shiqiang Yan Qingwei Ma Xiaoming Cheng | 2012 | Journal of Marine Science and Application2012，11，1： | 1 |
| 12 | Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction: A preliminary randomized controlled study显示文摘 | Qifeng Tang Yanning Qian Qingwei Zhang Jianjun Yang Zhongyun Wang | 2010 | Upsala Journal of Medical Sciences2010，，2： | 1 |
| 13 | Efficient System Combination for Chinese Spoken Term Detection显示文摘 | GAO Jie SHAO Jian ZHAO Qingwei YAN Yonghong | 2010 | Chinese Journal of Electronics2010，19，3： | 1 |
| 14 | Single-Molecule Sequencing Assists Genome Assembly Improvement and Structural Variation Inference显示文摘 | Yan, Jun Lv, Shuwei Hu, Min Gao, Zhaoxu He, Hang Ma, Qingwei Deng, Xing Wang Zhu, Zuofeng Wang, Xiangfeng | 2016 | Molecular Plant2016，9，7： | 1 |
| 15 | Overview of HL-2A Experiment Results显示文摘 | YANG Qingwei LIU Yong DING Xuantong YAN Longwen LIU Dequan XUAN Weiming CHEN Liaoyuan RAO Jun SONG Xianming CAO Zeng ZHANG Jinhua DUAN Xuru MAO Weicheng ZHOU Caipin PAN Chuanhong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 1 |
| 16 | HMGB1 is necessary for the development of lamprey显示文摘High mobility group box protein 1(HMGB1)with a highly conserved structure in chromatin is an abundant nonhistone protein,which is involved in nucleosome folding and assembly,chromatin formation,DNA binding,V(D)J recombination,DNA replication,gene transfer,cell differentiation,cell migration,neurotransmitters,cell death,immune response,and other important processes[1–4].So,it has important biological functions in animals.The function of hmgb1 has been extensively studied in jawed vertebrates but little in lampreys.Lampreys are members of the living agnathans,the most basal group of vertebrates.Lamprey is a considerable model organism in vertebrate evolution and developmental biology because of its special phylogenetic position and critical stage closely related to other animals.Many aspects of the hmgb1 in lampreys have not been revealed,such as evolution,distribution,and role.Therefore,in this paper,the evolution of hmgb1 was carried out,and the function of hmgb1 in lampreys was investigated by the morpholine antisense oligonucleotide(MO)technique.The data provide the foundation for the study of origins,evolution,and the function of hmgb1 in a jawless vertebrate.Linking evolution to function can shed more light on the role of the hmgb1 gene involved in development. | Jingjing Lu Jun Li Zihao Yan Xiaokun Wang Feng Lin Qinghua Ma Huaixiu Liu Haoran Guan Yueying Xun Xiaoying Kang Peijie Luan Xiao Feng Yue Pang Qingwei Li Yinglun Han | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 0 |
| 17 | Site Selection of Land Consolidation Project Based on Farmland Quality Evaluation in Yanjin County of Henan Province显示文摘In order to explore the effects of farmland quality evaluation on site selection of land consolidation projects,the methods of agricultural land use classification were used. Taking several project areas in Yanjin County of Henan Province as examples,the farmland quality before and after land consolidation projects was evaluated. The results indicate that under the conditions of reasonable site selection,the implementation of land consolidation projects can effectively improve the farmland quality and increase the grain productivity. Therefore,before the site selection for land consolidation projects,it is recommended to carry out pre-evaluation of farmland quality,and guide the project implementation according to the evaluation results. Besides,it is recommended to focus on medium and low level farmland with large centralized area,excellent original production conditions,but low level of development and use. | Peng FAN Yan TIAN Qingwei YANG Lei WANG Xihui YANG Juncheng MA | 2018 | Asian Agricultural Research2018，10，6： | 0 |
| 18 | A review on the transformation of birnessite in the environment:Implication for the stabilization of heavy metals显示文摘Birnessite is ubiquitous in the natural environment where heavy metals are retained and easily transformed.The surface properties and structure of birnessite change with the changes in external environmental conditions,which also affects the fate of heavy metals.Clarifying the effect and mechanism of the birnessite phase transition process on heavy metals is the key to taking effective measures to prevent and control heavy metal pollution.Therefore,the four transformation pathways of birnessite are summarized first in this review.Second,the relationship between transformation pathways and environmental conditions is proposed.These relevant environmental conditions include abiotic(e.g.,co-existing ions,pH,oxygen pressure,temperature,electric field,light,aging,pressure)and biotic factors(e.g.,microorganisms,biomolecules).The phase transformation is achieved by the key intermediate of Mn(Ⅲ)through interlayer-condensation,folding,neutralizationdisproportionation,and dissolution-recrystallization mechanisms.The AOS(average oxidation state)of Mn and interlayer spacing are closely correlated with the phase transformation of birnessite.Last but not least,the mechanisms of heavy metals immobilization in the transformation process of birnessite are summed up.They involve isomorphous substitution,redox,complexation,hydration/dehydration,etc.The transformation of birnessite and its implication on heavy metals will be helpful for understanding and predicting the behavior of heavy metals and the crucial phase of manganese oxides/hydroxides in natural and engineered environments. | Miao Shi Qingzhu Li Qingwei Wang Xuelei Yan Bensheng Li Linhai Feng Chao Wu Rongrong Qiu Hongkai Zhang Zhihui Yang Weichun Yang Qi Liao Liyuan Chai | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 19 | A Spiral Graphene Framework Containing Highly Ordered Graphene Microtubes for Polymer Composites with Superior Through-Plane Thermal Conductivity显示文摘As the power density of electronic devices increases,there has been an urgent demand to develop highly conductive polymer composites to address the accompanying thermal management issues.Due to the ultra-high intrinsic thermal conductivity,graphene is considered a very promising filler to improve the thermal conductivity of polymers.However,graphene-based polymer composites prepared by the conventional mixing method generally have limited thermal conductivity,even under high graphene loading,due to the failure to construct efficient heat transfer pathways in the polymer matrix.Here,a spiral graphene framework(SGF)containing continuous and highly ordered graphene microtubes was developed based on a modified CVD method.After embedding into the epoxy(EP)matrix,the graphene microtubes can act as efficient heat pathways,endowing the SGF/EP composites with a high through-plane thermal conductivity of 1.35 W·m^(-1)·K^(-1) at an ultralow graphene loading of 0.86 wt%.This result gives a thermal conductivity enhancement per 1 wt%filler loading of 710%,significantly outperforming various graphene structures as fillers.In addition,we demonstrated the practical application of the SGF/EP composite as a thermal interface material for efficient thermal man-agement of the light-emitting diode(LED). | Jinrui Gong Xue Tan Qilong Yuan Zhiduo Liu Junfeng Ying Le Lv Qingwei Yan Wubo Chu Chen Xue Jinhong Yu Kazuhito Nishimura Nan Jiang Cheng-Te Lin Wen Dai | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 20 | Recent advances in high-β_(N) experiments and magnetohydrodynamic instabilities with hybrid scenarios in the HL-2A Tokamak显示文摘Over the past several years,high-β_(N) experiments have been carried out on HL-2A.The high-β_(N) is realized using double transport barriers(DTBs)with hybrid scenarios.A stationary high-β_(N) (>2)scenario was obtained by pure neutral-beam injection(NBI)heating.Transient high performance was also achieved,corresponding to β_(N)≥3,ne/ne_(G)∼0.6,H_(98)∼1.5,f_(bs)∼30%,q_(95)∼4.0,and��∼0.4.The high-β_(N) scenario was successfully modeled using integrated simulation codes,that is,the one modeling framework for integrated tasks(OMFIT).In high-����plasmas,magnetohydrodynamic(MHD)instabilities are abundant,including low-frequency global MHD oscilla-tion with n=1,high-frequency coherent mode(HCM)at the edge,and neoclassical tearing mode(NTM)and Alfvénic modes in the core.In some high-β_(N) discharges,it is observed that the NTMs with m/n=3/2 limit the growth of the plasma energy and decrease β_(N).The low-n global MHD oscillation is consistent with the coupling of destabilized internal(m/n=1/1)and external(m/n=3/1 or 4/1)modes,and plays a crucial role in triggering the onset of ELMs.Achieving high-β_(N) on HL-2A suggests that core-edge interplay is key to the plasma confinement enhancement mechanism.Experiments to enhance β_(N) will contribute to future plasma operation,such as international thermonuclear experimental reactor. | Wei Chen Liming Yu Min Xu Xiaoquan Ji Zhongbing Shi Xiaoxue He Zhengji Li Yonggao Li Tianbo Wang Min Jiang Shaobo Gong Jie Wen Peiwan Shi Zengchen Yang Kairui Fang Jia Li Lai Wei Wulv Zhong Aiping Sun Jianyong Cao Xingyu Bai Jiquan Li Xuantong Ding Jiaqi Dong Qingwei Yang Yi Liu Longwen Yan Zhengxiong Wang Xuanru Duan | 2022 | Fundamental Research2022，2，5： | 0 |
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