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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 3 | Freeze-thaw Effects on Sorption/Desorption of Dissolved Organic Carbon in Wetland Soils显示文摘The effects of freeze-thaw cycles on sorption/desorption of dissolved organic carbon (DOC) in two wetland soils and one reclaimed wetland soil were investigated. DOC concentrations added were 0-600 mg/L. Laboratory incubations of sorption/desorption of DOC had been carried out at -15℃ for 10 h, and then at +5℃ for 13 h. Soil samples were refrozen and thawed subsequently for 5 cycles. Initial Mass model was used to describe sorption behavior of DOC. The results indicate that freeze-thaw cycles can significantly increase the sorption capacity of DOC and reduce the desorption capacity of DOC in the three soils. The freeze-thaw effects on desorption of DOC in soils increase with the increasing freeze-thaw cycles. The conversion of natural wetlands to soybean farmland can decrease the sorption capacity and increase the desorption capacity of DOC in soils. Global warming and reclamation may increase DOC release, and subsequently increase the loss of carbon and the emission of greenhouse gas. | YU Xiaofei ZHANG Yuxia ZHAO Hongmei LU Xianguo WANG Guoping | 2010 | Chinese Geographical Science2010，20，3： | 12 |
| 4 | Aqueous Chemistry of Typical Geothermal Springs with Deep Faults in Xinyi and Fengshun in Guangdong Province,China显示文摘This paper investigated aqueous chemistry for two geothermal spring groups responsive and sensitive to flow fluctuations induced by earthquakes. Quake monitorings are favored for their being in residential areas with well-preserved natural flow systems in Xinyi City's Xijiang Hot Springs and Fengshun County's Shihu Hot Spring. The hot springs are typical in temperatures and flow rates in southern China's Guangdong Province. Physical and chemical conditions deep down in the heat sources are important constraints on earthquake,fluid flow,reactive solute transport and heat transfer,but remain challenging to address via field observations and numerical experiments. In this paper,we made daily and annual observations on flow rates,temperature,and/or aqueous chemistry. We employed strontium isotopes as tracers for the water sources,equilibrium phase diagram for K-feldspar and albite stability,and Na-K-Mg diagram for heat reservoir temperatures. The abundant sulfite content in Xi- jiang Hot Springs is discussed. Our main finding are that the deep fault springs are characterized by low reduction-oxidation potential at around-200–-150 m V and relatively large daily flow variations. The results provide scientific background features on the field sites regarding earthquake monitoring and predictions and geothermal reservoir. | Guoping Lu Runfang Liu | 2015 | Journal of Earth Science2015，26，1： | 10 |
| 5 | The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment显示文摘 | Jiezuan Yang Guoping Sheng Dangsheng Xiao Haiyan Shi Wei Wu Haifeng Lu Ping Yi Hongcui Cao Lanjuan Li | 2016 | Cellular & Molecular Immunology2016，13，5： | 9 |
| 6 | New Nodosaurid Dinosaur from the Late Cretaceous of Lishui, Zhejiang Province, China显示文摘nodosaurid 恐龙的一个新类和种:Zhejiangosaurus lishuiensisgen。et sp。nov。此处被树立。它被由至少三真骶的 vertebrae,熔化形成 presacral 杆的 5 尾的背面的 vertebrae,从身体的中间的线的肠骨的长苗条的 preacetabular 过程的宽分叉,和定位在的 fourthtrochanter 组成的骶骨描绘大腿骨中间长度。 | LU Junchang JIN Xingsheng SHENG Yiming LI Yihong WANG Guoping Yoichi AZUMA | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 8 |
| 7 | Mesozoic lithofacies palaeogeography and petroleum prospectivity in North Carnarvon Basin,Australia显示文摘The North Carnarvon Basin, which lies in the North West Shelf of Australia, is highly rich in gas resources. As a typical passive marginal basin, it experienced the pre-rifting, early rifting, main rifting, late rifting, post-rifting sagging and passive margin stages. The basin was mainly filled with thick Mesozoic-Cenozoic sediments, of which the Mesozoic hosts the principal source, reservoir and seal intervals. Mesozoic palaeogeography has an important control on the oil and gas distribution. Triassic gas-prone source rocks of deltaic origin deter-mine the high endowment of natural gases in the North Carnarvon Basin. The more restricted distribution of oil accumulations is controlled by oil source rocks in the Upper Jurassic Dingo Claystone. The Muderong Shale deposited in the Early Cretaceous marine transgression provides the effective regional seal for the underlying oil and gas reservoirs. | Tao Chongzhi Bai Guoping Liu Junlan Deng Chao Lu Xiaoxin Liu Houwu Wang Dapeng | 2013 | Journal of Palaeogeography2013，2，1： | 7 |
| 8 | A Review of Technical Advances,Barriers,and Solutions in the Power to Hydrogen(P2H)Roadmap显示文摘Power to hydrogen(P2H)provides a promising solution to the geographic mismatch between sources of renewable energy and the market,due to its technological maturity,flexibility,and the availability of technical and economic data from a range of active demonstration projects.In this review,we aim to provide an overview of the status of P2H,analyze its technical barriers and solutions,and propose potential opportunities for future research and industrial demonstrations.We specifically focus on the transport of hydrogen via natural gas pipeline networks and end-user purification.Strong evidence shows that an addition of about 10%hydrogen into natural gas pipelines has negligible effects on the pipelines and utilization appliances,and may therefore extend the asset value of the pipelines after natural gas is depleted.To obtain pure hydrogen from hydrogen-enriched natural gas(HENG)mixtures,end-user separation is inevitable,and can be achieved through membranes,adsorption,and other promising separation technologies.However,novel materials with high selectivity and capacity will be the key to the development of industrial processes,and an integrated membrane-adsorption process may be considered in order to produce high-purity hydrogen from HENG.It is also worth investigating the feasibility of electrochemical separation(hydrogen pumping)at a large scale and its energy analysis.Cryogenics may only be feasible when liquefied natural gas(LNG)is one of the major products.A range of other technological and operational barriers and opportunities,such as water availability,byproduct(oxygen)utilization,and environmental impacts,are also discussed.This review will advance readers’understanding of P2H and foster the development of the hydrogen economy. | Guoping Hu Chao Chen Hiep Thuan Lu Yue Wu Congmin Liu Lefu Tao Yuhan Men Guangli He Kevin Gang Li | 2020 | Engineering2020，6，12： | 7 |
| 9 | A single circular chromosome yeast显示文摘Dear editor,Most of the prokaryotic cells contain a single circular chromosome.In contrast, the eukaryotic cells usually contain multiple linear chromosomes. Recently, we artificially created a single linear chromosome yeast strain SY14 from native 16 chromosomes in a haploid Saccharomyces cerevisiae, which displays minor fitness defects.^1 In this study, we have created a new yeast strain which contains a single circular chromosome and apparently has not been found in nature. | Yangyang Shao Ning Lu Chen Cai Fan Zhou Shanshan Wang Zhihu Zhao Guoping Zhao Jin-Qiu Zhou Xiaoli Xue Zhongjun Qin | 2019 | Cell Research2019，29，1： | 5 |
| 10 | Nutrient maximums related to low oxygen concentrations in the southern Canada Basin显示文摘The phenomenon of nutrient maximums at 70~200 m occurred only in the region of the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injection of the low-temperature high-nutrient brines from the Chukchi Sea shelf (<50 m) in winter provided the nutrient maximums. However, we found that there are five problems in the direct injection process. Formerly Jin et al. considered that the formation of nutrient maximums can be a process of locally long-term regeneration. Here we propose a regeneration-mixture process. Data of temperature, salinity, oxygen and nutrients were collected at three stations in the southern Canada Basin during the summer 1999 cruise. We identified the cores of the surface, near-surface, potential temperature maximum waters and Arctic Bottom Water by the diagrams and vertical profiles of salinity, potential temperature, oxygen and nutrients. The historical 129I data indicated that the surface and near-surface waters were Pacific-origin, but the waters below the potential temperature maximum core depth was Atlantic-origin. Along with the correlation of nutrient maximums and very low oxygen contents in the near-surface water, we hypothesize that, the putative organic matter was decomposed to inorganic nutrients; and the Pacific water was mixed with the Atlantic water in the transition zone. The idea of the regeneration-mixture process agrees with the historical observations of no apparent seasonal changes, the smooth nutrient profiles, the lowest saturation of CaCO3 above 400 m, low rate of CFC-11 ventilation and 3H-3He ages of 8~18 a around the nutrient maximum depths. | JIN Ming-ming SHI Jiuxin LU Yong CHEN Jianfang GAO Guoping WU Jingfeng ZHANG Haisheng | 2005 | Acta Oceanologica Sinica2005，24，6： | 5 |
| 11 | Wetland Definitions:Creation,Evolution and Application显示文摘In this paper,we review the creation,evolution and application of wetland definitions.Varying wetlands are found from the tundra to the tropics and on every continent except Antarctica in the planet.Wetlands have many distinguishing features,the most notable of which are water presence,unique soil conditions,and biota that are adapted to or tolerant of saturated soils.Many wetland definitions have been developed by scientists,U.S.federal agencies,and the Ramsar Convention for both scientific and regulatory purposes.Wetlands are not easily defined but a well-conceived,science-based definition of wetlands is important for scientists and resource managers to understand the nature of wetlands and/or to use and protect wetlands.A scientific definition is the basis for wetland classification.Developing an effective wetland classification system requires a well-conceived,science-based definition and clearly explicit guidance on the appropriate use of various wetland indicators to verify the presence of wetlands on the ground.Based on a well-accepted wetland definition,both wetland classification and inventory further provide needed information and a working frame for wise use and management of wetlands. | CHEN Hongjun WANG Guoping LU Xianguo | 2010 | 湿地科学2010，8，3： | 4 |
| 12 | Selecting pinning nodes to control complex networked systems显示文摘One of the fundamental problems in pinning control of complex networks is selecting appropriate pinning nodes, such that the whole system is controlled. This is particularly useful for complex networks with huge numbers of nodes. Recent research has yielded several pinning node selection strategies, which may be efficient. However, selecting a set of pinning nodes and identifying the nodes that should be selected first remain challenging problems. In this paper, we present a network control strategy based on left Perron vector. For directed networks where nodes have the same in-and out-degrees, there has so far been no effective pinning node selection strategy, but our method can find suitable nodes. Likewise, our method also performs well for undirected networks where the nodes have the same degree. In addition, we can derive the minimum set of pinning nodes and the order in which they should be selected for given coupling strengths. Our proofs of these results depend on the properties of non-negative matrices and M-matrices. Several examples show that this strategy can effectively select appropriate pinning nodes, and that it can achieve better results for both directed and undirected networks. | CHENG ZunShui XIN YouMing CAO JinDe YU XingHuo LU GuoPing | 2018 | Science China(Technological Sciences)2018，61，10： | 4 |
| 13 | Reversible Histone Acetylation Involved in Transcriptional Regulation of WT1 Gene显示文摘验证参与可逆嘘在人的 Wilm 的肿瘤的 transcriptional 规定的一 acetylation 1 基因(WT1 ) ,我们分析了角色嘘一 deacetylases (HDAC ) 并且嘘在这个 epigenetic 过程的一 acetyltransferase。检验的六 HDAC (HDAC1-6 ) , HDAC4 和 HDAC5 被发现有重要镇压在 WT1 记者基因的活动完成,由酶记者试金和量的即时反向的抄写聚合酶链反应揭示了试金。酶记者试金证明一 acetyltransferase p300 能在 WT1 记者的激活与转录因子 Sp1, c-Myb,和 Ets-1 抵抗 HDAC4/HDAC5-mediated 压抑和那 p300/CBP synergized 的 hist。染色质免疫降水实验证明 p300 支持 acetylation 水平嘘在 WT1 intronic 增强子的一 H3。把数据基于这些,我们为参与建议了一个假想模型可逆嘘在 WT1 基因的 transcriptional 规定的一 acetylation。这研究提供进一步的卓见进联系的 WT1 基因和 WT1 的 transcriptional 规定的机制疾病处理。 | Yangguang SHAO Jun LU Cao CHENG Liguo CUI Guoping ZHANG Baiqu HUANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 4 |
| 14 | Grain-size Characteristics of Sediment in Daniugou Peatland in Changbai Mountains,Northeast China:Implications for Atmospheric Dust Deposition显示文摘The grain-size distribution characteristics and grain-size parameters of sediment in two vertical sections of Daniugou peatland in the Changbai Mountains were systematically investigated.A comparative analysis of the sediment granularity using a discriminative function with Hongyuan peat,red clay,loess-paleosol,fluvial deposit as well as lacustrine deposit was also conducted.It turns out that the vertical section of Daniugou peat ash is primarily constituted by clay and silt particles,and the content of sand is relatively small.Grain-size frequency curves generally show a single-peak modality while a bimodal pattern is detected in the upper layer.The grain-size component and peak pattern of grain-size frequency curves also illustrate that peat ash materials were transported to the peatland by long-range aeolian dust during the deposition process,while there existed short-distance dust influence in peat deposition of the upper layer.Comparisons of grain-size parameters and the discriminative Y-value of Daniugou peat ash with those of typical aeolian sediments show close similarities,suggesting the possibility that atmospheric dust transport processes were involved in the accumulation of peat again.Moreover,the variations of grain-size distribution suggest the local environmental deterioration which is just the driving force of local dust elevation.Grain-size analysis of peatland sediment is demonstrated to be one effective method to extract information about regional and global environmental evolution,and more attention should be paid to current local ecological environment and to seeking a balance between economic development and environmental protection in Northeast China. | BAO Kunshan | 2010 | Chinese Geographical Science2010，20，6： | 4 |
| 15 | Stochastic stability of networked control systems with network-induced delay and data dropout显示文摘This paper deals with the stochastic stability of networked control systems with the presence of network-induced delay and transmitted data dropout. Based on the Lyapunov approach, sufficient conditions for the mean-square stability of the networked control system are derived subject that the sequence of transmission interval is driven by an identically independently distributed sequence and by a finite state Markov chain, respectively. Stabilization controllers are constructed in terms of linear matrix inequalities correspondingly. An example is provided to illustrate our results. | Xiaomei ZHANG Yufan ZHENG Guoping LU | 2008 | 控制理论与应用(英文版)2008，6，4： | 3 |
| 16 | ViWoSG:A distributed scene graph of ultra-massive distributed virtual environments显示文摘An ultra-massive distributed virtual environment generally consists of ultra-massive terrain data and a large quantity of objects and their attribute data, such as 2D/3D geometric models, audio/video, images, vectors, characteristics, etc. In this paper, we propose a novel method for constructing distributed scene graphs with high extensibility. This method can support high concurrent interaction of clients and implement various tasks such as editing, querying, accessing and motion controlling. Some application experiments are performed to demonstrate its efficiency and soundness. | WANG GuoPing, LI Sheng, WANG ShaoRong, LU Bin & LI WenHang Key Lab of Machine Perception and Intelligent, MOE Department of Computer Science, Peking University, Beijing 100871, China | 2009 | Science in China(Series F)2009，52，3： | 3 |
| 17 | Multi-proxy evidence of environmental change related to collapse of the Liangzhu Culture in the Yangtze Delta,China显示文摘The Liangzhu Culture(5300–4300 cal.a BP)has been regarded as the culmination of the Neolithic Age in the Yangtze Delta and as an archaic state.However,the reason behind the collapse of the Liangzhu Culture remains controversial.Some scholars attributed it to social conflicts or foreign invasions,while others suggested that environmental deterioration,such as cold episodes,inundation and palaeo-typhoon events,disrupted the civilization.Notably,the yellowish silty sediments widely overlying the Liangzhu group sites have been presumed to be one of the vital clues to resolving these issues.The process and cause of their formation are key to understanding the decline in the Liangzhu Culture.In this study,two typical profiles composed of the Liangzhu cultural layer and yellowish silty sediments were collected in Liangzhu Ancient City.Multiple proxies,including pollen,phytoliths and diatoms,along with radiocarbon and optically stimulated luminescence dating and synthesized geochemical evidence from different sediments,were applied to reconstruct ecological and hydrological changes and discuss their linkage to cultural collapse.The regional ecology was typical freshwater wetlands during 4800–4400 cal.a BP,which facilitated rice farming and large-scale architectural engineering in Liangzhu Ancient City.Evidence from microfossils and dating of the yellowish silty sediments indicated that Liangzhu Ancient City was significantly affected by seawater after abandonment during 4300–3400 cal.a BP.Furthermore,geochemical evidence,including trace element and Sr-Nd isotopic compositions,suggested that the primary provenance of the yellowish silt was a mixture of sediments from the Qiantang River,East China Sea,Yangtze River and Yellow River,which had been transported to Liangzhu Ancient City by the Yellow Sea Coastal Current and a marine transgression.Therefore,based on evidence from archaeological sites and numerical simulation in the Yangtze Delta,it was supposed that the short-term accelerated relative sea-level rise at approximately 4400 cal.a BP caused a marine transgression around Taihu Lake,formed a large range of yellowish silty sediments,destroyed rice farming production,and ultimately led to the collapse of the Liangzhu Culture. | Keyang HE Houyuan LU Guoping SUN Xiang JI Yonglei WANG Kaikai YAN Xinxin ZUO Jiangping ZHANG Bin LIU Ningyuan WANG | 2021 | Science China Earth Sciences2021，64，6： | 3 |
| 18 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 19 | The genome and gene editing system of sea barleygrass provide a novel platform for cereal domestication and stress tolerance studies显示文摘The tribe Triticeae provides important staple cereal crops and contains elite wild species with wide geneticdiversity and high tolerance to abiotic stresses. Sea barleygrass (Hordeum marinum Huds.), a wildTriticeae species, thrives in saline marshlands and is well known for its high tolerance to salinity and waterlogging. Here, a 3.82-Gb high-quality reference genome of sea barleygrass is assembled de novo, with 3.69Gb (96.8%) of its sequences anchored onto seven chromosomes. In total, 41 045 high-confidence (HC)genes are annotated by homology, de novo prediction, and transcriptome analysis. Phylogenetics, nonsynonymous/synonymous mutation ratios (Ka/Ks), and transcriptomic and functional analyses provide genetic evidence for the divergence in morphology and salt tolerance among sea barleygrass, barley, andwheat. The large variation in post-domestication genes (e.g. IPA1 and MOC1) may cause interspecies differences in plant morphology. The extremely high salt tolerance of sea barleygrass is mainly attributed tolow Na+ uptake and root-to-shoot translocation, which are mainly controlled by SOS1, HKT, and NHX transporters. Agrobacterium-mediated transformation and CRISPR/Cas9-mediated gene editing systems weredeveloped for sea barleygrass to promote its utilization for exploration and functional studies of hubgenes and for the genetic improvement of cereal crops. | Liuhui Kuang Qiufang Shen Liyang Chen Lingzhen Ye Tao Yan Zhong-Hua Chen Robbie Waugh Qi Li Lu Huang Shengguan Cai Liangbo Fu Pengwei Xing Kai Wang Jiari Shao Feibo Wu Lixi Jiang Dezhi Wu Guoping Zhang | 2022 | Plant Communications2022，3，5： | 2 |
| 20 | Neuroligin 3 R451C位点敲入小鼠前额叶皮层的gamma振荡紊乱导致其社交行为缺陷显示文摘文章简介自闭症,又称孤独症,是一种儿童先天性的严重神经发育性疾病,发病率约1%。由于自闭症的致病机制不明,因而也缺乏有效的临床治疗方法。本研究通过一个自闭症遗传模型小鼠,阐明了自闭症中引起社交缺陷的关键脑区及工作机制。 | 曹蔚 林燊 Qiang-qiang Xia Yong-lan Du Qian Yang Meng-ying Zhang Yi-qing Lu Jing Xu Shu-min Duan Jun Xia Guoping Feng 许均瑜 罗建红 | 2019 | 科学新闻2019，0，2： | 2 |
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