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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | 横向激光光热偏转相位法测量金刚石薄片的热扩散率显示文摘本文介绍横向激光光热偏转装置的优化设计及其利用相位信息测量 CVD金刚石薄片的热扩散率 。 | 施柏煊 殷浩 王聪和 黄元华 谭家麟 Lo K L | 2000 | 光子学报2000，29，5： | 7 |
| 3 | Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Bas/Raf-1/ERK1/2 pathway显示文摘 | Lo L W Cheng J J Chiu J J | 2001 | J Cell Physiol2001，188，3： | 2 |
| 4 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 5 | Lead distribution in a simulated aquatic environment:effects of bacterial biofilms and iron oxide显示文摘 | Nelson Y M Lo W Lion L W | 1995 | Water Research1995，29，8： | 2 |
| 6 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 7 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 8 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 9 | Characterization of silane-modified immobilized gold colloids as a substrate for surface-enhanced Raman spectroscopy显示文摘 | Olson L G Lo Y S Beebe T P | 2001 | Analytical Chemistry2001，73，： | 1 |
| 10 | Exponents of nonnegative matrix pairs显示文摘 | Suw Lo S | 2003 | Linear Algebr APPL2003，，263： | 1 |
| 11 | Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatoeellular carcinoma cells显示文摘 | Liang J A Wu S L Lo H Y | 2009 | Mol Pharmacol2009，75，1： | 1 |
| 12 | Hysteroscopy in menopause: analysis of the techniques and accuracy of the method 显示文摘 | Costa Hde L Costa LO | 2008 | Rev Bras Ginecol Obstet2008，30，10： | 1 |
| 13 | Isolation and characterization of polymorphic microsatellites from red coral grouper(Plectropomus maculatus)显示文摘 | Zhu Z Y Lo L C Lin G | 2005 | Molecular Ecology Notes2005，5，3： | 1 |
| 14 | Synthesis of Eu3+-activated yttrium oxysulfide red phosphor by flux fusion method显示文摘 | LO C L DUH J G CHIOU B S PENG C C | 2001 | Chemistry and Physics2001，71，： | 1 |
| 15 | Real-time garbage collection for flash-memory storage systems of realtime embedded systems 显示文摘 | Chang L P Kuo T W Lo S W | 2004 | ACM Transactions on Embedded Computing Systems2004，3，4： | 1 |
| 16 | Different patterns of atrial remodeling after catheter ablation of chronic atrial fibrillation 显示文摘 | LO L W TSAO H M LIN Y J | 2011 | J Cardiovasc Electrophysiol2011，22，4： | 1 |
| 17 | MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression 显示文摘 | Scapoli L Palmieri A Lo Muzio L | 2010 | Int J Immunopathol Pharmacol2010，23，4： | 1 |
| 18 | Expression of vascular endothelial growth factor in human dysfunctional temporomandibular joint discs显示文摘 | Leonardi R Lo Muzio L Bernasconi G | | 0，，03： | 1 |
| 19 | Prevalence of myocardial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiography显示文摘 | La Grutta L Runza G Lo Re G | | 0，，： | 1 |
| 20 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
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