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| 1 | p53/microRNA-214/ULK1信号通路调控的自噬在糖尿病肾病中的作用机制显示文摘目前有多个研究证实糖尿病肾病中存在自噬失调,但其潜在的病理机制并不清楚。该研究通过对糖尿病小鼠及糖尿病患者肾脏组织分析发现,自噬反应在肾脏中均明显被抑制。特异性敲除小鼠肾脏近端小管的自噬相关基因Atg6后可抑制自噬作用,导致糖尿病小鼠肾脏肥大,加重小管损伤、炎症反应及纤维化,最终导致蛋白尿增加,说明自噬在糖尿病肾病中起保护作用。与此同时,研究发现糖尿病组织中小RNA214(miR-214)表达上调,从而抑制下游unc-51样自噬相关激活酶(ULK1)的表达,最终导致自噬表达降低。特异性沉默肾脏近端小管miR-214的表达可减少对ULK1的抑制,阻止了糖尿病肾病肾脏体积的增大,降低了蛋白尿水平。 | Ma Z Li L Livingston MJ 梅淑钦(编译) | 2021 | 中华医学杂志2021，101，42： | 2 |
| 2 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 3 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 4 | Induction of antibodies against GD3 ganglioside in melanoma patients by vaccination with GD3-1actone-KLH conjugate plus immunological adjuvant QS-21 显示文摘 | Ragupathi G Meyers M Adluri S Howard L Musselli C Livingston PO | 2000 | Int J Cancer2000，85，5： | 1 |
| 5 | Genital mycoplasmas stimulate tumor necrosis factor-alpha and inducible nitric oxide synthase production from a murine macrophage cell line显示文摘 | Crouse DT English BK Livingston L | 1998 | Pediatr Res1998，44，： | 1 |
| 6 | The effectiveness of problembased learning compared to traditional teaching inundergraduate psy-chiatry 显示文摘 | McParland M Noble L M Livingston G | 2004 | Med Educ2004，38，8： | 1 |
| 7 | Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells显示文摘 | Song L Coppola D Livingston S | 2005 | Cancer Biol Ther2005，4，3： | 1 |
| 8 | Vinorelbine plus cisplatin vs observation in resected non-small cell lung cancer Intergroup显示文摘 | Winton T L Livingston R Johnson D | 2005 | N Engl J Med2005，25，352： | 1 |
| 9 | Tectonostratigraphic development of the Interior Sudan Rifts,Central Africa显示文摘 | TIM R Mchargue TOM L Heidrick JACK E Livingston | 1992 | Tectonophysics1992，21，3： | 1 |
| 10 | Autophagy in acute kidney injury andrepair显示文摘 | He L Livingston M J Dong Z | 2014 | Nephron Clin Pract2014，127，1234： | 1 |
| 11 | Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensit stabilization of its alpha subunit显示文摘 | HUANG L E ARAMY I LIVINGSTON D M | 1996 | J Biol Chem1996，271，32： | 1 |
| 12 | Tectonostratigraphic development of the interior Sudan rifts, Central Africa显示文摘 | McHargue T R Heidrick T L and Livingston J K | 1992 | Tectonophysics1992，213，： | 1 |
| 13 | Pathogensis of Mycoplasmal pneumoniaein swine显示文摘 | LIVINGSTON C W STAIR E L MEBUS C A | 1972 | Am J Vet Res1972，33，： | 1 |
| 14 | DoD′s Medical Radi-obiology Advisory Team:experts on the ground显示文摘 | VanHorne-Sealy J Livingston B Alleman L | | 0，，5： | 1 |
| 15 | Obesity and inflammation:the effects of weight loss显示文摘 | Forsythe L Wallace J Livingstone M | 2008 | Nutr Res Rev2008，21，2： | 1 |
| 16 | Cost effectiveness of a manual based coping strategy programme in promoting the mental health of family carers of people with dementia (the START (STrAtegies for RelaTives) study): a pragmatic randomised controlled trial显示文摘 | Martin Knapp Derek King Renee Romeo Barbara Schehl Julie Barber Mark Griffin Penny Rapaport Debbie Livingston Cath Mummery Zuzana Walker Juanita Hoe Elizabeth L Sampson Claudia Cooper Gill Livingston | 2013 | BMJ (oct )2013，，252： | 1 |
| 17 | Mc1-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lungcancer cells 显示文摘 | Song L Coppola D Livingston S | 2005 | Cancer Biol Ther2005，4，3： | 1 |
| 18 | Coagulation dysfunction in sepsis and multiple organ system failure显示文摘 | Calligan L Livingstone W Volkov Y | 2003 | Critcare Clin2003，19，7： | 1 |
| 19 | The effectiveness of Problem-based Learning compared to traditonal teaching in undergraduate psychiatry显示文摘 | MCPARLAND M NOBLE L M LIVINGSTON G | 2004 | Med Edu2004，38，8： | 1 |
| 20 | Coagulation dysfunction in sepsis and multiple organ system failure显示文摘 | Galligan L Livingstone W Volkov Y | 2003 | Crit Care Clin2003，19，： | 1 |
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