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| 1 | Tai Ji Quan as antihypertensive lifestyle therapy:A systematic review and meta-analysis显示文摘Background:Professional health organizations are not currently recommending Tai Ji Quan alongside aerobic exercise to treat hypertension.We aimed to examine the efficacy of Tai Ji Quan as antihypertensive lifestyle therapy.Methods:Tai Ji Quan interventions published in English and Chinese were included when they involved healthy adults,reported pre-and postintervention blood pressure(BP),and had a non-exercise/non-diet control group.We systematically searched 11 electronic databases for studies published through July 31,2018,yielding 31 qualifying controlled trials.We(1)evaluated the risk of bias and methodological study quality,(2)performed meta-regression analyses following random-effects assumptions,and(3)generated additive models representing the largest possible clinically relevant BP reductions.Results:Participants(n=3223)were middle-aged(56.6±15.1 years of age,mean±SD)adults with prehypertension(systolic BP(SBP)=136.9±15.2 mmHg,diastolic BP(DBP)=83.4±8.7 mmHg).Tai Ji Quan was practiced 4.0±1.4 sessions/week for 54.0§10.6 min/session for 22.3±20.2 weeks.Overall,Tai Ji Quan elicited significant reductions in SBP(-11.3 mmHg,95%CI:-14.6 to-8.0;d+=-0.75)and DBP(-4.8 mmHg,95%CI:-6.4 to-3.1;d+=-0.53)vs.control(p<0.001).Controlling for publication bias among samples with hypertension,Tai Ji Quan trials published in English elicited SBP reductions of 10.4 mmHg and DBP reductions of 4.0 mmHg,which was half the magnitude of trials published in Chinese(SBP reductions of 18.6 mmHg and DBP reductions of 8.8 mmHg).Conclusion:Our results indicate that Tai Ji Quan is a viable antihypertensive lifestyle therapy that produces clinically meaningful BP reductions(i.e.,10.4 mmHg and 4.0 mmHg of SBP and DBP reductions,respectively)among individuals with hypertension.Such magnitude of BP reductions can lower the incidence of cardiovascular disease by up to 40%. | Yin Wu Blair T.Johnson Shiqi Chen Yiyang Chen Jill Livingston Linda S.Pescatello | 2021 | Journal of Sport and Health Science2021，10，2： | 11 |
| 2 | 中加两国精神障碍患者无责任能力评定跨文化比较研究显示文摘目的 :对中国湖南省和加拿大BC省两地无责任能力精神障碍患者人口学等资料进行比较 ,探讨不同的法律体系中无责任能力的精神障碍患者的基本特点。方法 :对两地已有的精神障碍患者责任能力评定数据库进行整合 ;共提取年龄、性别、婚姻、教育、犯罪史、精神病史、鉴定时案型、诊断 8个变量进行统计处理 ;BC组和湖南组入组病例数分别为 2 73例和 35 4例。结果 :除性别和精神病史外 ,其他各变量差异显著。BC组的离婚率、犯罪史、最高教育程度明显高于湖南组 ,评估时年龄明显大于湖南组 ;而湖南组的严重犯罪和精神分裂症的诊断比例明显高于BC组 (P均 <0 .0 1)。结论 :不同的法律体系。 | 王小平 Murphy E Brink J Livingston JD | 2004 | 中国临床心理学杂志2004，12，4： | 4 |
| 3 | Valgus osteotomy for nonunion and neglected neck of femur fractures显示文摘Nonunion neck of femur can be a difficult problem to treat, particularly in the young, and is associated with high complication rates of avascular necrosis due to the precarious blood supply and poor biomechanics.The various treatment options that have been described can be broadly divided according to the aim of improving either biology or biomechanics. Surgeries aimed at improving the biology, such as vascularized fibula grafting, have good success rates but require high levels of expertise and substantial resources. A popular surgical treatment aimed at improving the biomechanics-valgus intertrochanteric osteotomyoptimizes conditions for fracture healing by converting shear forces across the fracture site into compressive forces. Numerous variations of this surgical procedure have been developed and successfully applied in clinical practice. As a result, the proximal femoral orientation for obtaining a good functional outcome has evolved over the years, and the present concept of altering the proximal femoral anatomy as little as possible has arisen. This technical objective supports attaining union as well as a good functional outcome, since excessive valgus can lead to increased joint reaction forces. This review summarizes the historical and current literature on valgus intertrochanteric osteotomy treatment of nonunion neck of femur, with a focus on factors predictive of good functional outcome and potential pitfalls to be avoided as well as controversies surrounding this procedure. | Viju Daniel Varghese Abel Livingston P R Boopalan Thilak S Jepegnanam | 2016 | World Journal of Orthopedics2016，7，5： | 4 |
| 4 | Gastroenterology service in a teaching hospital in rural New Zealand, 1991-2003显示文摘AIM: To retrospectively collect inpatient and outpatient data and to assess the use of endoscopic procedures during the years 1991, 1997 and 2003 to analyse for trends. METHODS: This retrospective survey was conducted in a University-associated Gastroenterology Unit offering secondary and tertiary health care services for a population of approximately 182 000 people in Southern New Zealand. Data collected included patient contacts (inand outpatients), gastroscopic and colonoscopic investigations. RESULTS: We observed a significant increase in the absolute numbers of patient contacts over the years (1991: 2308 vs 1997: 2022 vs 2003: 2783, P < 0.0001) with inflammatory bowel disease, other diseases of the colon, anus and rectum and iron studies related disorders decreasing significantly but liver disease and constipation increasing linearly over time. The use of endoscopy services remained relatively stable but colonoscopic investigations for a positive family history of colorectal cancer increased significantly while more gastroscopies were performed for unexplained anaemia. CONCLUSION: The whole spectrum of gastroenterology contacts was studied. A substantial proportion of colonoscopies and outpatient consultations were undertaken to screen for colorectal cancer. This proportion is likely to grow further. Our fi ndings have implications for the recruitment and training of the next generation of gastroenterologists. | Michael Schultz Andrew Davidson Sarah Donald Bogna Targonska Angus Turnbull Susan Weggery Vicki Livingstone John D Dockerty | 2009 | World Journal of Gastroenterology2009，15，5： | 3 |
| 5 | p53/microRNA-214/ULK1信号通路调控的自噬在糖尿病肾病中的作用机制显示文摘目前有多个研究证实糖尿病肾病中存在自噬失调,但其潜在的病理机制并不清楚。该研究通过对糖尿病小鼠及糖尿病患者肾脏组织分析发现,自噬反应在肾脏中均明显被抑制。特异性敲除小鼠肾脏近端小管的自噬相关基因Atg6后可抑制自噬作用,导致糖尿病小鼠肾脏肥大,加重小管损伤、炎症反应及纤维化,最终导致蛋白尿增加,说明自噬在糖尿病肾病中起保护作用。与此同时,研究发现糖尿病组织中小RNA214(miR-214)表达上调,从而抑制下游unc-51样自噬相关激活酶(ULK1)的表达,最终导致自噬表达降低。特异性沉默肾脏近端小管miR-214的表达可减少对ULK1的抑制,阻止了糖尿病肾病肾脏体积的增大,降低了蛋白尿水平。 | Ma Z Li L Livingston MJ 梅淑钦(编译) | 2021 | 中华医学杂志2021，101，42： | 2 |
| 6 | Colorectal cancer in the young显示文摘 | Jessica B O’Connell Melinda A Maggard Edward H Livingston Cifford K Yo | 2004 | The American Journal of Surgery2004，，： | 2 |
| 7 | The role of streamline curvature in sand dune dynamics: evidence from field and wind tunnel measurements显示文摘 | Giles F.S. Wiggs Ian Livingstone Andrew Warren | 1996 | Geomorphology1996，，1： | 2 |
| 8 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 9 | Person-environment fit and creativity: An examination of supply-value and demand-ability versions of fit显示文摘 | Linda P. Livingstone | 1997 | Journal of Management1997，，2： | 2 |
| 10 | Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center 1 1 No competing interests declared.显示文摘 | Arie Regev K.Rajender Reddy Mariana Berho Dan Sleeman Joe U Levi Alan S Livingstone David Levi Unzila Ali Enrique G Molina Eugene R Schiff | 2001 | Journal of the American College of Surgeons2001，，1： | 2 |
| 11 | Contaminant-stimulated Reactive Oxygen Species Production and Oxidative Damage in Aquatic Organisms显示文摘 | D.R. Livingstone | 2001 | Marine Pollution Bulletin2001，，8： | 2 |
| 12 | Minimally invasive spleen-preserving distal pancreatectomy: Does splenic vessel preservation have better postoperative outcomes? A systematic review and meta-analysis显示文摘BACKGROUND: Minimally invasive spleen-preserving distal pancreatectomy(SPDP) can be performed with either splenic vessel preservation(SVP) or resection [Warshaw procedure(WP)]. The aim of this study was to evaluate the postoperative clinical outcomes of patients undergoing both methods.DATA SOURCES: Database search of PubM ed, Embase, Scopus,Cochrane, and Google Scholar was performed(2000-2014); key bibliographies were reviewed. Qualified studies comparing patients undergoing SPDP with either SVP or WP, and assessing postoperative complications were included. Calculated pooled risk ratio(RR) with the corresponding 95% confidence interval(CI) by random effects methods were used in the meta-analyses. RESULTS: The search yielded 215 studies, of which only 14 observational studies met our selection criteria. The studies included 943 patients in total; 652(69%) underwent SVP and 291(31%) underwent WP. Overall, there was a lower incidence of splenic infarction(RR=0.17; 95% CI: 0.09-0.33; P<0.001),gastric varices(RR=0.16; 95% CI: 0.05-0.51; P=0.002), and intra/postoperative splenectomy(RR=0.20; 95% CI: 0.08-0.49; P<0.001) in the SVP group. There was no difference in incidence of pancreatic fistula(WP vs SVP, 23.6% vs 22.9%;P=0.37), length of hospital stay, operative time or blood loss. There was moderate cross-study heterogeneity.CONCLUSIONS: SVP is a safe, efficient and feasible technique that may be used to preserve the spleen. WP may be more suitable for large tumors close to the splenic hilum or those associated with splenomegaly. Randomized clinical trials are justified to examine the long-term benefits of SVP-SPDP. | Fady Elabbasy Rahul Gadde Mena M Hanna Danny Sleeman Alan Livingstone Danny Yakoub | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 2 |
| 13 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 14 | Defining the Role of Surgery for Primary Gastrointestinal Tract Melanoma显示文摘 | Michael C. Cheung Eduardo A. Perez Manuel A. Molina Xiaoling Jin Juan C. Gutierrez Dido Franceschi Alan S. Livingstone Leonidas G. Koniaris | 2008 | Journal of Gastrointestinal Surgery2008，，4： | 2 |
| 15 | Percutaneous Irreversible Electroporation for Downstaging and Control of Unresectable Pancreatic Adenocarcinoma显示文摘 | Govindarajan Narayanan Peter J. Hosein Geetika Arora Katuzka J. Barbery Tatiana Froud Alan S. Livingstone Dido Franceschi Caio M. Rocha Lima Jose Yrizarry | 2012 | Journal of Vascular and Interventional Radiology2012，，12： | 2 |
| 16 | Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)显示文摘Background:There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease(PD-MCI)and the coping strategies used by these caregivers.Methods:To investigate this relationship,we examined levels of burden,depression,anxiety,coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD patients.The PD patients were classified using MDS-Task Force Level II criteria as showing either normal cognition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased significantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing clinically significant levels of burden(ZBI score≥21)also increased as the patients’cognitive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing amount of time spent providing care by the caregivers.Caregiver ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that caregivers spent caregiving.Caregiver use of different coping strategies increased with worsening cognition.However,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping mediated the association between patient cognitive status and caregiver burden,because the inverse models that used caregiver burden as the mediator were also significant.Conclusions:The study highlights the impact of Parkinson’s disease on those providing care when the patient’s cognition is poor,including those with MCI.Caregiver well-being has important implications for caregiver support,nursing home placement and disease course. | Ann J.Jones Roeline G.Kuijer Leslie Livingston Daniel Myall Kyla Horne Michael MacAskill Toni Pitcher Paul T.Barrett Tim J.Anderson John C.Dalrymple-Alford | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 17 | Human ICE/CED-3 Protease Nomenclature显示文摘 | Emad S Alnemri David J Livingston Donald W Nicholson Guy Salvesen Nancy A Thornberry Winnie W Wong Junying Yuan | 1996 | Cell1996，，2： | 2 |
| 18 | Postoperative ileus显示文摘 | Livingston EH | 1990 | Dig Dis Sci1990，35，： | 1 |
| 19 | Right middle lobe syndrome in children显示文摘 | Livingston GL Holinger LD Luck SR | 1987 | Int J Pediatr Otorhinolaryngol1987，13，1： | 1 |
| 20 | The effectiveness of problem-based learning compared to traditional teaching in undergraduate psychiatry显示文摘 | Noble LM Livingston G | 2004 | Med Educ2004，38，8： | 1 |
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