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| 1 | Inflammation and retinal degenerative diseases显示文摘Vision is an ability that depends on the precise structure and functioning of the retina.Any kind of stress or injury can disrupt the retinal architecture and leads to vision impairment,vision loss,and blindness.Immune system and immune response function maintain homeostasis in the microenvironment.Several genetic,metabolic,and environmental factors may alter retinal homeostasis,and these events may initiate various inflammatory cascades.The prolonged inflammatory state may contribute to the initiation and development of retinal disorders such as glaucoma,age-related macular degeneration,diabetic retinopathy,and retinitis pigmentosa,which pose a threat to vision.In the current review,we attempted to provide sufficient evidence on the role of inflammation in these retinal disorders.Moreover,this review paves the way to focus on therapeutic targets of the disease,which are found to be promising. | Geetika Kaur Nikhlesh K.Singh | 2023 | Neural Regeneration Research2023，18，3： | 3 |
| 2 | Immunofluorescence on paraffin embedded renal biopsies:Experience of a tertiary care center with review of literature显示文摘AIM To describe the technique of immunofluorescence on paraffin embedded tissue sections and discuss the potential pitfalls with an in depth review of literature.METHODS Immunofluorescence is integral to diagnostic renal pathology. Immunofluorescence on paraffin embedded renal biopsies(IF-P) after enzyme treatment has been described in literature, however has not found widespread use in renal pathology laboratories. In our laboratory proteinase K digestion of paraffin embedded renal biopsy material was standardized and applied prospectively in cases where immunofluorescence on fresh frozen tissue was non contributory or not possible. Diagnostic utility was assessed and in a cohort of cases comparison of intensity of staining with routine immunofluorescence was performed. RESULTS Over the 5-year study period, of the 3141 renal biopsies received IF-P was performed on 246 cases(7.7%) and was interpretable with optimal digestion in 214 cases(6.8%). It was of diagnostic utility in the majority of cases, which predominantly included glomerular disease. Nondiagnostic IF-P was found in membranous nephropathy(2 of 11 cases), membranoproliferative glomerulonephritis(2 of 32 cases), lupus nephritis(1 of 25 cases), post infectious glomerulonephritis(1 of 11 cases) and chronic glomerulonephritis(3 of 8 cases). Comparing cases with both routine IF and IF-P, 35 of 37 showed either equal intensity or a minor difference in intensity of staining(1+) for the diagnostic immunoglobulin/complement. Technically assessment of immunofluorescence on the paraffin embedded tissue was found to be easier with clearly observed morphology, however a false positive staining pattern was observed in under-digested tissue. CONCLUSION As a 'salvage' technique, immunofluorescence on paraffin embedded renal biopsies is of great diagnostic utility, however not without pitfalls. | Geetika Singh Lavleen Singh Ranajoy Ghosh Devajit Nath Amit Kumar Dinda | 2016 | World Journal of Nephrology2016，5，5： | 3 |
| 3 | Disaster Risk Reduction Including Climate Change Adaptation Over South Asia: Challenges and Ways Forward显示文摘South Asia is vulnerable to a variety of hydrometeorological hazards, which are often crossboundary in nature. Climate change is expected to influence many of these hazards. Thus, climate-related risks over South Asia make disaster risk reduction(DRR) and climate change adaptation(CCA) key policy goals.Recently there is an increasing consensus that DRR including CCA should be embedded in development planning. Disaster risk reduction including CCA has progressively gained importance in global governance. Across South Asia, however, such integration is only in a preliminary stage. This review was to assess the existing status and scope of DRR including CCA in development projects across South Asia, so that an effective and achievable deliberation may be made to regional policymakers. A total of 371 projects relevant to CCA and DRR were reviewed.The project inventory was diverse in nature with respect to location, scale, sectoral focus, and strategic importance.Bangladesh, India, and Bhutan were observed to be proactive in implementing DRR-and CCA-related projects.Meta-analysis of the project inventory suggests an urgent need for an individual and collaborative convergence of processes for DRR and CCA through policies,plans, strategies, and programs. | Rajesh K.Mall Ravindra K.Srivastava Tirthankar Banerjee Om Prakash Mishra Diva Bhatt Geetika Sonkar | 2019 | International Journal of Disaster Risk Science2019，10，1： | 2 |
| 4 | Percutaneous Irreversible Electroporation for Downstaging and Control of Unresectable Pancreatic Adenocarcinoma显示文摘 | Govindarajan Narayanan Peter J. Hosein Geetika Arora Katuzka J. Barbery Tatiana Froud Alan S. Livingstone Dido Franceschi Caio M. Rocha Lima Jose Yrizarry | 2012 | Journal of Vascular and Interventional Radiology2012，，12： | 2 |
| 5 | Papillary glioneuronal tumor—a rare entity: report of four cases and brief review of literature显示文摘 | Shipra Agarwal Mehar Chand Sharma Geetika Singh Vaishali Suri Chitra Sarkar Ajay Garg Rajinder Kumar P. Sharat Chandra | 2012 | Child’s Nervous System2012，，11： | 1 |
| 6 | The Influence of Zr/Ti Content on the Morphotropic Phase Boundary in the PZT-PZN System显示文摘 | Geetika Umarji A M | 2010 | Mater Sci Eng B-Solid State Mater Adv Technol2010，167，3： | 1 |
| 7 | Lattice paths and n -colour compositions显示文摘 | Geetika Narang A.K. Agarwal | 2007 | Discrete Mathematics2007，，： | 1 |
| 8 | n -Colour self-inverse compositions显示文摘 | Geetika Narang A. K. Agarwal | 2006 | Proceedings of the Indian Academy of Sciences - Mathematical Sciences2006，，： | 1 |
| 9 | Preventive Effect of Embelin from Embelia ribes on Lipid Metabolism and Oxidative Stress in High-Fat Diet-Induced Obesity in Rats显示文摘 | Hemantkumar Chaudhari Uma Bhandari Geetika Khanna | 2012 | Planta Med2012，，07： | 1 |
| 10 | p190-B, a Rho-GTPase activating protein, is differentially expressed in terminal end buds and breast cancer显示文摘 | Geetika C Deana R Maria G | 2000 | Cell Growth Differ2000，11，7： | 1 |
| 11 | The influence of Zr/Ti content on the morphotropic phase boundary in the PZT-PZN system 显示文摘 | GEETIKA UMARJI A M | 2010 | Mater Sci Eng B2010，167，： | 1 |
| 12 | Isolated popliteal tendon avulsion显示文摘 | Quan VU Geetika KH | 2009 | Pediatric Radiology2009，39，： | 1 |
| 13 | Imaging of the cranio vertebral junction oper tech显示文摘 | Geetika K Yutaka S | 2005 | Neurosurg2005，8，： | 1 |
| 14 | CH ARACTERIZATION OF LA YERED Na_(2-x-y)LixKyTi_(3)O_(7) CERAMICS BY DIELECTRIC-SPECTROSCOPIC INV ESTIG ATIONS显示文摘In this paper,we present detailed investigations on the dielectric properties of Lithium(x=0.10)and Potassium(y=0.01,0.02,0.04,0.05)mixed Sodium trititanate,Na_(2-x-y)LixKyTi_(3)O_(7) poly-crystalline ma terials synthesized by solid-state reaction.The characteristics of the pelletized samples have been studied in the temperature range from 350 to 725 K and on the frequency in the range from 10kHz to 1 MHz.The studies reveal that the chain structured Na_(2-x-y)LixKyTi_(3)O_(7) layered compound posses electronic,ionic,dipolar,and space charge polarization mechanisms over the respective temperature regions in the entire temperature range of study. | SHRIPAL RAKESH SINGH GEETIKA RAVI K.SHUKLA K.K.RAINA | 2011 | Journal of Advanced Dielectrics2011，1，4： | 0 |
| 15 | Handmade cloning:recent advances,potential and pitfalls显示文摘Handmade cloning(HMC) is the most awaited,simple and micromanipulator-free version of somatic cell nuclear transfer(SCNT).The requirement of expensive micromanipulators and skilled expertise is eliminated in this technique,proving it as a major revolution in the field of embryology.During the past years,many modifications have been incorporated in this technique to boost its efficiency.This alternative approach to micromanipulator based traditional cloning(TC) works wonder in generating comparable or even higher birth rates in addition to declining costs drastically and enabling cryopreservation.This technique is not only applicable to intraspecies nuclear transfer but also to interspecies nuclear transfer(iSCNT) thus permitting conservation of endangered species.It also offers unique possibilities for automation of SCNT which aims at production of transgenic animals that can cure certain human diseases by producing therapeutics hence,providing a healthier future for the wellbeing of humans.The present review aims at highlighting certain aspects of HMC including recent advancements in procedure and factors involved in elevating its efficiency besides covering the potentials and pitfalls of this technique. | Geetika Verma JS Arora RS Sethi CS Mukhopadhyay Ramneek Verma | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 0 |
| 16 | 韦斯特罗斯新旅游中心显示文摘韦斯特罗斯是瑞典最大的城市之一,该项目为韦斯特罗斯的新基础交通枢纽,同时也是-个充满活力的城市视觉新地标。韦斯特罗斯新旅游中心位于市中心,作为全新的公共场所,将成为铁路上的重要交通纽带,最终设计现已向公众公布,计划于2022年开始施工,于2025年完工。 | Mane Lancon Aileen Koh Allen Dennis Shakir Anders Bruntse Anders Holden Deleuraru Dalma Ujvari Federica Fogazzi Geetika Bhutani Ida Linnea Elvira Maria Lujak Laura Watte Marius Tromholt-Richter Yunus Alperen Basak 舒禹(编译) | 2021 | 现代装饰2021，，5： | 0 |
| 17 | Nanotechnology for colorectal cancer detection and treatment显示文摘Colorectal cancer(CRC)is the third most diagnosed cancer and the second leading cause of cancer-related mortality in the United States.Across the globe,people in the age group older than 50 are at a higher risk of CRC.Genetic and environmental risk factors play a significant role in the development of CRC.If detected early,CRC is preventable and treatable.Currently,available screening methods and therapies for CRC treatment reduce the incidence rate among the population,but the micrometastasis of cancer may lead to recurrence.Therefore,the challenge is to develop an alternative therapy to overcome this complication.Nanotechnology plays a vital role in cancer treatment and offers targeted chemotherapies directly and selectively to cancer cells,with enhanced therapeutic efficacy.Additionally,nanotechnology elevates the chances of patient survival in comparison to traditional chemotherapies.The potential of nanoparticles includes that they may be used simultaneously for diagnosis and treatment.These exciting properties of nanoparticles have enticed researchers worldwide to unveil their use in early CRC detection and as effective treatment.This review discusses contemporary methods of CRC screening and therapies for CRC treatment,while the primary focus is on the theranostic approach of nanotechnology in CRC treatment and its prospects.In addition,this review aims to provide knowledge on the advancement of nanotechnology in CRC and as a starting point for researchers to think about new therapeutic approaches using nanotechnology. | Purnima Gogoi Geetika Kaur Nikhlesh K Singh | 2022 | World Journal of Gastroenterology2022，28，46： | 0 |
| 18 | Incidental finding of intra-abdominal hemangioma in an infant presenting with intestinal obstruction:a case report显示文摘Hemangiomas are the most common benign vascular tumours of the pediatric age group.They originate from embryonic remnants of unipotent angioblastic cells.The liver is the most common site for hemangioma in the abdomen.1 The prevalence of hepatic hemangioma(HH)varies from 1%to 20%in the general popula-tion,and it is two to five times more common in women.HH is usually detected incidentally and shows no symptoms;therefore,most of the time it does not require any treatment.2 However,hemangioma may sometimes occur at the atypical location and present with unusual clinical manifestations within the abdominal cavity.Due to these reasons,it leads to diag-nostic confusion,resulting in their inadvertent surgical excision.12 We present here a case of intra-abdominal hemangioma in an infant who presented with the signs and symptoms of intestinal obstruction. | Parveen Kumar Arti Khatri Somshankar Chowdhury Nidhi Mahajan Geetika Mathur | 2022 | World Journal of Pediatric Surgery2022，5，1： | 0 |
| 19 | Selective inhibition of resistant bacterial pathogens using a β-lactamase-activatable antimicrobial peptide with significantly reduced cytotoxicity显示文摘The expression ofβ-lactamase,particularly metallo-β-lactamase(MBL)in bacteria has caused significant resistance to clinically importantβ-lactam antibiotics,including life-saving carbapenems.Antimicrobial peptides(AMPs)have emerged as promising therapeutic agents to combat antibiotic resistance.However,the cytotoxic AMPs has been one of the major concerns for their applications in clinical practice.Herein,we report a novel cephalosporin-caged AMP,which shows significantly reduced cytotoxicity,hemolytic activity,and antibacterial activity but turns highly active against bacteria upon specific hydrolysis by the antimicrobial resistance-causativeβ-lactamase.Further investigations demonstrate thisβ-lactamaseactivatable AMP selectively inactivates resistant bacterial pathogens over susceptible bacteria.This strategy should be applicable to other AMPs as a potential solution for the treatment of infectious diseases caused byβ-lactamase-expressing pathogenic bacteria. | Weipan Xu Zheng Ma Geetika Dhanda Jayanta Haldar Hexin Xie | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
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