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| 1 | Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study显示文摘Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis. | Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu | 2019 | Science China(Life Sciences)2019，62，12： | 16 |
| 2 | V2O5 Nanospheres with Mixed Vanadium Valences as High Electrochemically Active Aqueous Zinc-Ion Battery Cathode显示文摘AV4+-V2O5 cathode with mixed vanadium valences was prepared via a novel synthetic method using VOOH as the precursor,and its zinc-ion storage performance was evaluated.The products are hollow spheres consisting of nanoflakes.The V4+-V2O5 cathode exhibits a prominent cycling performance,with a specific capacity of 140 mAhg-1 after 1000 cycles at 10 A g.1,and an excellent rate capability.The good electrochemical performance is attributed to the presence of V4+,which leads to higher electrochemical activity,lower polarization,faster ion diffusion,and higher electrical conductivity than V2O5 without V4+.This engineering strategy of valence state manipulation may pave the way for designing high-performance cathodes for elucidating advanced battery chemistry. | Fei Liu Zixian Chen Guozhao Fang Ziqing Wang Yangsheng Cai Boya Tang Jiang Zhou Shuquan Liang | 2019 | Nano-Micro Letters2019，11，2： | 12 |
| 3 | Magnesium Acetate Used as an Effective Catalyst for Synthesizing Aliphatic Polycarbonates via Melt Transesterification Process显示文摘 | WANG Ziqing YANG Xiangui LIU Shaoying ZHANG Hua WANG Gongying | 2016 | Chemical Research in Chinese Universities2016，32，3： | 7 |
| 4 | Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity显示文摘Implant-related infection and early bone integration are the main risk factors of implants for long-term service,to overcome these difficulties,SLA-TiCu surface was prepared by sandblasting and large-grits etching(SLA)treatment on a novel antibacterial titanium-copper alloy(TiCu),which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants.Effects of SLA-TiCu surface on the adhesion,proliferation,apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen(Staphylococcus aureus)were studied.Compared to the following surfaces:sandblasting and large-grits etched pure titanium(SLATi),mechanically ground pure titanium and TiCu alloy(M-Ti and M-TiCu),these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions(alkaline phosphates(ALP),collagen typeⅠ(COLⅠ),Runt-related transcription factor 2(RUN x 2),and osteopontin(OPN)).Moreover,SLA-TiCu surface could maintain a sustainable release of Cu2+ions and effectively inhibited the viability of bacteria.This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity,making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants. | Hui Liu Rui Liu Ihsan Ullah Shuyuan Zhang Ziqing Sun Ling Ren Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，13： | 6 |
| 5 | Molecular cloning and expression under abiotic stresses and hormones of the ethylene response factor Ⅶ gene FmRAP2.12 from Fraxinus mandshurica显示文摘RELATED TO AP2.12(RAP2.12)is one of the Ethylene Response Factors(ERF)transcription factor and plays a key role in controlling plant root bending and responding to multiple abiotic stresses including hypoxia stress.In this study,FmRAP2.12 gene was isolated and characterized from Fraxinus mandshurica Rupr.The open reading frame(ORF)of FmRAP2.12 was 1170 bp and encoded a protein of 389 amino acids.The conserved domains,three-dimensional phylogenetic relationship of FmRAP2.12 was also investigated.Quantitative real-time(qRT-PCR)analyzed the expression of FmRAP2.12 in different tissues.The expression level of FmRAP2.12 was highest in roots followed by leaves,and lowest in male flowers.Abiotic stress and hormone signal-induced expression was established using qRT-PCR.Salt stress induced FmRAP2.12 to a double peak pattern:the first peak value was at 6 h and the second at 72 h.Drought stress also induced FmRAP2.12 to a double peak pattern:the first at6 h and the second at 48 h.FmRAP2.12 was up-regulated after initiation of gibberellic acid(GA3)treatment,with a one peak pattern at 24 h.FmRAP2.12 may not respond to cold stress and Abscisic acid(ABA)treatment.The transient overexpression of FmRAP2.12 caused the up-expression of downstream key genes of abiotic stress response and gibberellin pathway.Our research reveals the molecular characteristic and expression patterns under abiotic stress and hormone condition of FmRAP2.12,providing support for the genetic improvement of F.mandshurica at a molecular level. | Nansong Liang Lei Yu Chunhao Liu Ziqing Wang Xingtang Zhao Yaguang Zhan | 2019 | Journal of Forestry Research2019，30，4： | 3 |
| 6 | A Stiffness Adjustment Mechanism Based on Negative Work for High-efficient Propulsion of Robotic Fish显示文摘 | Dong Xu Haining Zeng Xiang Peng Ziqing Zhao Jingmeng Liu | 2018 | Journal of Bionic Engineering2018，15，2： | 3 |
| 7 | Up-conversion fluorescence biosensor for sensitive detection of CA-125 tumor markers显示文摘Sensitive and specific bioassays of tumor markers are critical for early cancer detection and treatment.In recent years,lanthanide(Ln3+)doped upconversion nanoparticles(UCNPs)have attracted wide attentions in tumor markers detectio n.Herein,we co mbined NaYF4:Yb,Tm and silver nanoparticles,serving as energy donor and receptor,respectively,to form an up-conversion fluorescence based inhibitory tumor marker biosensor system.The tumor marker CA-125 molecules are labeled with silver NPs,and the energy transfer fluorescent signal can be detected between the UCNPs and the silver NP receptors.The biosensor shows good stability,high sensitivity and selectivity in the tumor marker concentration range from 5 to 100 ng/mL,as well as a detection limit of 120 pg/mL.Due to the advantage of ease of fabrication and operation,low cost and high information capacity,this technology holds great potential for the clinical applications. | Jingshi Liu Sai Xu Liheng Sun Songtao Hu Jiao Sun Min Liu Cui Ma Haipeng Liu Ziqing Wang Ying Yang Biao Dong Decheng Hong | 2019 | Journal of Rare Earths2019，37，9： | 3 |
| 8 | Chemical synthesis of Ub-AMC via ligation of peptide hydrazides显示文摘The C-terminal conjugate of ubiquitin with 7-amino-4-methylcoumarin (Ub-AMC) is an important probe for fluorescencebased analysis of deubiquitinating enzyme (DUB) activity. It is important to develop more efficient methods for the preparation of Ub-AMC because the currently available technology is still expensive for scaled-up production. In the present work we report an efficient strategy for total chemical synthesis of Ub-AMC through ligation of peptide hydrazides. Three peptide segments are assembled via N-to-C sequential ligation and the resulting product is converted to Ub-AMC via TCEP-mediated desulfurization. The synthetic Ub-AMC is shown to have expected biological functions | LIANG Jun FANG GeMin HUANG XiuLiang MEI ZiQing LI Juan TIAN ChangLin LIU Lei | 2013 | Science China Chemistry2013，56，9： | 2 |
| 9 | Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats显示文摘 | Pinjie Huang Dezhao Liu Xiaoliang Gan Rui Zhang Wanling Gao Zhengyuan Xia Ziqing Hei | 2012 | Injury2012，，8： | 1 |
| 10 | The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma显示文摘Objective:Patients with non–small cell lung cancer(NSCLC)respond differently to cytokine-induced killer cell(CIK)treatment.Therefore,potential prognostic markers to identify patients who would benefit from CIK treatment must be elucidated.The current research aimed at identifying predictive prognostic markers for efficient CIK treatment of patients with NSCLC.Methods:Patients histologically diagnosed with NSCLC were enrolled from the Tianjin Medical University Cancer Institute and Hospital.We performed whole-exome sequencing(WES)on the tumor tissues and paired adjacent benign tissues collected from 50 patients with NSCLC,and RNA-seq on tumor tissues of 17 patients with NSCLC before CIK immunotherapy treatment.Multivariate Cox proportional hazard regression analysis was used to analyze the association between clinical parameters and prognostic relevance.WES and RNA-seq data between lung squamous cell carcinoma(SCC)and adenocarcinoma(Aden)were analyzed and compared.Results:The pathology subtype of lung cancer was the most significantly relevant clinical parameter associated with DFS,as analyzed by multivariate Cox proportional hazard regression(P=0.031).The patients with lung SCC showed better CIK treatment efficacy and extended DFS after CIK treatment.Relatively low expression of HLA class II genes and checkpoint molecules,and less immunosuppressive immune cell infiltration were identified in the patients with lung SCC.Conclusions:Coordinated suppression of the expression of HLA class II genes and checkpoint molecules,as well as less immune suppressive cell infiltration together contributed to the better CIK treatment efficacy in lung SCC than lung Aden. | Jian Wang Fan Yang Qian Sun Ziqing Zeng Min Liu Wenwen Yu Peng Zhang Jinpu Yu Lili Yang Xinwei Zhang Xiubao Ren Feng Wei | 2021 | Cancer Biology & Medicine2021，18，4： | 1 |
| 11 | Current Control for Dual three- phase Permanent Magnet Synchronous Motors Ac-counting for CurrentUnbalance and Harmonics 显示文摘 | Hu Yashan Zhu Ziqing Liu Kan | 2014 | IEEE Journal of Emerging and Se- lected Topics in Power Elec-tronies2014，2，2： | 1 |
| 12 | Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats显示文摘 | Pinjie Huang Dezhao Liu Xiaoliang Gan Rui Zhang Wanling Gao Zhengyuan Xia Ziqing Hei | 2012 | Injury2012，，8： | 1 |
| 13 | Unconventional Petroleum Sedimentology:A Key to Understanding Unconventional Hydrocarbon Accumulation显示文摘The commercial exploitation of unconventional petroleum resources(e.g.,shale oil/gas and tight oil/gas)has drastically changed the global energy structure within the past two decades.Sweet-spot intervals(areas),the most prolific unconventional hydrocarbon resources,generally consist of extraordinarily high organic matter(EHOM)deposits or closely associated sandstones/carbonate rocks.The formation of sweet-spot intervals(areas)is fundamentally controlled by their depositional and subsequent diagenetic settings,which result from the coupled sedimentation of global or regional geological events,such as tectonic activity,sea level(lake level)fluctuations,climate change,bottom water anoxia,volcanic activity,biotic mass extinction or radiation,and gravity flows during a certain geological period.Black shales with EHOM content and their associated high-quality reservoir rocks deposited by the coupling of major geological events provide not only a prerequisite for massive hydrocarbon generation but also abundant hydrocarbon storage space.The Ordovician-Silurian Wufeng-Longmaxi shale of the Sichuan Basin,Devonian Marcellus shale of the Appalachian Basin,Devonian-Carboniferous Bakken Formation of the Williston Basin,and Triassic Yanchang Formation of the Ordos Basin are four typical unconventional hydrocarbon systems selected as case studies herein.In each case,the formation of sweet-spot intervals for unconventional hydrocarbon resources was controlled by the coupled sedimentation of different global or regional geological events,collectively resulting in a favorable environment for the production,preservation,and accumulation of organic matter,as well as for the generation,migration,accumulation,and exploitation of hydrocarbons.Unconventional petroleum sedimentology,which focuses on coupled sedimentation during dramatic environmental changes driven by major geological events,is key to improve the understanding of the formation and distribution of sweet-spot intervals(areas)in unconventional petroleum systems. | Caineng Zou Zhen Qiu Jiaqiang Zhang Zhiyang Li Hengye Wei Bei Liu Jianhua Zhao Tian Yang Shifa Zhu Huifei Tao Fengyuan Zhang Yuman Wang Qin Zhang Wen Liu Hanlin Liu Ziqing Feng Dan Liu Jinliang Gao Rong Liu Yifan Li | 2022 | Engineering2022，，11： | 1 |
| 14 | Mast-Cell-Releasing Tryptase Triggers Acute Lung Injury Induced by Small Intestinal Ischemia–Reperfusion by Activating PAR-2 in Rats显示文摘 | Xiaoliang Gan Dezhao Liu Pinjie Huang Wanling Gao Xinzhi Chen Ziqing Hei | 2012 | Inflammation2012，，3： | 1 |
| 15 | Distributed Gas Ignition Using Injection Strategy for High Efficiency and Clean Combustion Under Lean Condition显示文摘Jet ignition is an efficient way to achieve lean burn of the engine and a promising strategy to meet the stringent emission regulations in the future.This paper presents a distributed gas ignition(DGI)combustion concept and realizes a DGI combustion mode using a newly designed DGI igniter.The igniter integrates a fuel injector and a spark plug to achieve minimum volume and easy installation.As the mixture preparation within the jet chamber is essential for the performance of the igniter,different jet chamber injection strategies were tested with varying excess air-fuel ratio ranging from 1.4 to 2.0.By addressing the dual injection strategy,the ignition delay and combustion duration were improved evidently.Compared with the single injection strategy,dual injection strategy improves the flexibility when preparing the mixture inside the jet chamber and therefore retains more fuel.The increased energy density of the jet chamber helps to generate more energetic jets under dual injection strategy,resulting in the improvement of ignition and combustion performance with lean burn.A higher thermal efficiency and a leaner limit of the engine are attained with dual injection than that with single injection.Dual injection exhibits its potential in reducing CO and THC emissions to an acceptable level with leaner mixture.Based on dual injection strategy,the maximum indicated thermal efficiency of 45%is achieved. | Ziqing Zhao Wei Liu Fubai Li Qinhao Fan Zhi Wang | 2020 | Automotive Innovation2020，3，4： | 1 |
| 16 | Mining intrinsic information of convalescent patients after suffering coronavirus disease 2019 in Wuhan显示文摘OBJECTIVE:To summarize the potential characteristics of convalescent patients with coronavirus disease 2019(COVID-19)in China based on emerging clinical tongue data and guide the treatment and recovery of COVID-19 patients from the perspective of Traditional Chinese Medicine tongue diagnosis.METHODS:In this study,we developed and validated radiomics-based and lab-based methods as a novel approach to provide individualized pretreatment evaluation by analyzing different features to mine the orderliness behind tongue data of convalescent patients.In addition,this study analyzed the tongue features of convalescent patients from clinical tongue qualitative values,including thick and thin,fur,peeling,fat and lean,tooth marks and cracked,and greasy and putrid fur.RESULTS:We included 2164 tongue images in total(34%from day 0,35.4%from day 14 and 30.6%from day 28)from convalescent patients.The significance results are shown as follows.Firstly,as the recovery time prolongs,the L average values of tongue and coat decrease from 60.21 to 57.18 and from 60.06 to 57.03 respectively.Secondly,the decrease of abnormality rate of tongue coat,included greasy tongue fur,putrid fur,teeth-mark,thick-thin fur,are of significant statistical difference(P<0.05).Thirdly,the average value of gray-level cooccurrence matrices increases from 0.173 to 0.194,the average value of entropy increases from 0.606 to 0.665,the average value of inverse difference normalized decrease from 0.981 to 0.979,and the average value of dissimilarity decrease from 0.1576 to 0.1828.The details of other radiomics features are describe in results section.CONCLUSIONS:Our experiment shows that patients in different recovery periods have a relationship with quantitative values of tongue images,including L color space of the tongue and coat radiomics features analysis.This relationship can help clinical doctors master the recovery and health of patients as soon as possible and improve their understanding of the potential mechanisms underlying the dynamic changes and mechanisms underlying COVID-19. | YAN Shixing LüYi LIU Ziqing REN Meng HE Haiyang XIAO Li GUO Feng PENG Miao LI Xiaoxia WANG Yong XU Xi YANG Tao SHAO Zuoyu HUANG Jingjing XIAO Mingzhong | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 1 |
| 17 | Criticality of networks with long-range connections显示文摘The formation of giant clusters,namely the percolation phase transition,is one of the most widely studied critical phenomena on networks.The critical behaviors of percolation in oneand two-dimensional lattices have been given in the book[1].For d-dimensional lattices,the critical exponents of percolation change with d until the upper critical dimension du=6,above which they are independent of d and become meanfield like.It is also well known that the critical | ZiQing Yang MaoXin Liu XiaoSong Chen | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 0 |
| 18 | Brain circuits for retching-like behavior显示文摘Nausea and vomiting are important defensive responses to cope with pathogens and toxins that invade the body.The nucleus of the solitary tract(NTS)is important for initiating these responses.However,the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses.Here,we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that may be involved in these defensive responses.Among these,we identified Calbindin1-positive(Calb1^(+))NTS neurons that are molecularly distinct from Tac1^(+)neurons.These Calb1^(+)neurons are critical for nausea and retching induced by cereulide;an emetic toxin secreted by Bacillus Cereus.Strikingly,we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1^(+)NTS neurons,a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A.Together,our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior.These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins. | Lifang Huo Zhimin Ye Meiling Liu Ziqing He Meizhu Huang Dapeng Li Qian Wu Qian Wang Xiaoqun Wang Peng Cao Ji Dong Congping Shang | 2024 | National Science Review2024，11，1： | 0 |
| 19 | Acetic Acid Assistant Hydrogenation of Graphene Sheets with Ferromagnetism显示文摘 | SUN Qiushi WANG Xiaofeng LI Benxian WU Yunpeng ZHANG Ziqing ZHANG Xinyang ZHAO Xudong LIU Xiaoyang | 2018 | Chemical Research in Chinese Universities2018，34，3： | 0 |
| 20 | Negative Magnetism in Perovskite Manganites Gd1-xSrxMnO3(0.1 ≤x≤0.3)显示文摘 | ZHANG Yingnan LI Junjia ZHANG Ziqing LIU Fuyang ZHAO Xudong LIU Xiaoyang | 2015 | Chemical Research in Chinese Universities2015，31，5： | 0 |
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