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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study显示文摘Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis. | Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu | 2019 | Science China(Life Sciences)2019，62，12： | 16 |
| 3 | 显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2007 | Progress in Organic Coatings2007，59，： | 1 |
| 4 | Effect of the hard seg-ment on the properties of UV curable waterborne blocked polyure-thanes显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2008 | Journal of Polymer Research2008，15，1： | 1 |
| 5 | A new UV curable waterborne polyurethane: Effect of C = C content on the film properties显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2006 | Progress in Organic Coatings2006，55，： | 1 |
| 6 | Effect of the hard segment on the properties of UV curable waterborne blocked polyurethanes显示文摘 | Chenyan Bai Xingyuan Zhang Jiabing Dai | 2008 | Journal of Polymer Research2008，15，： | 1 |
| 7 | Effect of thehard segment on the properties of UV curable waterborneblocked polyurethanes显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2008 | J Polym Res2008，15，： | 1 |
| 8 | 显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2008 | J Coat Technol Res2008，5，2： | 1 |
| 9 | Effect of the hard segment on the properties of UV curable waterborne blocked polyurethanes显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2008 | Journal of Polymer Research2008，15，： | 1 |
| 10 | A new UV curable waterborne polyurethane:Effect of C=C content on the film properties显示文摘 | BAI Chenyan ZHANG Xingyuan DAI Jiabing | 2006 | Progress in Organic Coatings2006，55，3： | 1 |
| 11 | Synthesis and characterization of PDMS modified UV-curable waterborne polyurethane dispersions for soft tact layers显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2007 | Progress in Organic Coatings2007，60，1： | 1 |
| 12 | Water resistance of the membranes for UV curable waterborne polyurethane dispersions显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2007 | Progress in Organic Coatings2007，59，： | 1 |
| 13 | 显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2008 | Journal of Polymer Research2008，15，： | 1 |
| 14 | Water resistance of the membranes for UV curable waterborne polyurethane dispersions显示文摘 | Chenyan Bai Xingyuan Zhang Jiabing Dai | | 0，，： | 1 |
| 15 | A new UV curable water borne polyurethane:Effect of C=C content on the film properties显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing etal | 2006 | Progress in Organic Coatings2006，55，3： | 1 |
| 16 | Effect of the hard segment on the properties of UV curable waterborne blocked polyurethanes显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2008 | Journal of Polymer Research2008，15，1： | 1 |
| 17 | Water resistance of the membranes for UV curablewaterborne polyurethane dispersions显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2007 | Progressin Organic Coatings2007，59，4： | 1 |
| 18 | Anew core-shell type fluorinated acrylic and siliconatedpolyurethane hybrid emulsion显示文摘 | Dai Jiabing Zhang Xingyuan Chao Jing Bai Chenyan | 2007 | Journal of CoatingsTechnology and Research2007，4，3： | 1 |
| 19 | Synthesis and surface properties of polyurethane modified by polysiloxane显示文摘 | Linlin Feng Xingyuan Zhang Jiabing Dai Zhen Ge Jing Chao Chenyan Bai | 2008 | Frontiers of Chemistry in China2008，，1： | 1 |
| 20 | A new UV curable waterborne polyurethane: effect of C=C content on the film properties 显示文摘 | Bai Chenyan Zhang Xingyuan Dai Jiabing | 2006 | Progress in Organic Coatings2006，55，3： | 1 |
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