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您的检索式：作者名="Congping Shang"
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| 1 | Brain circuits for retching-like behavior显示文摘Nausea and vomiting are important defensive responses to cope with pathogens and toxins that invade the body.The nucleus of the solitary tract(NTS)is important for initiating these responses.However,the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses.Here,we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that may be involved in these defensive responses.Among these,we identified Calbindin1-positive(Calb1^(+))NTS neurons that are molecularly distinct from Tac1^(+)neurons.These Calb1^(+)neurons are critical for nausea and retching induced by cereulide;an emetic toxin secreted by Bacillus Cereus.Strikingly,we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1^(+)NTS neurons,a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A.Together,our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior.These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins. | Lifang Huo Zhimin Ye Meiling Liu Ziqing He Meizhu Huang Dapeng Li Qian Wu Qian Wang Xiaoqun Wang Peng Cao Ji Dong Congping Shang | 2024 | National Science Review2024，11，1： | 0 |
| 2 | Watermelon domestication was shaped by stepwise selection and regulation of the metabolome显示文摘Although crop domestication has greatly aided human civilization,the sequential domestication and regulation of most quality traits remain poorly understood.Here,we report the stepwise selection and regulation of major fruit quality traits that occurred during watermelon evolution.The levels of fruit cucurbitacins and flavonoids were negatively selected during speciation,whereas sugar and carotenoid contents were positively selected during domestication.Interestingly,fruit malic acid and citric acid showed the opposite selection trends during the improvement.We identified a novel gene cluster(CGC1,cucurbitacin gene cluster on chromosome 1)containing both regulatory and structural genes involved in cucurbitacin biosynthesis,which revealed a cascade of transcriptional regulation operating mechanisms.In the CGC1,an allele caused a single nucleotide change in Cl ERF1 binding sites(GCC-box)in the promoter of Cl Bh1,which resulted in reduced expression of Cl Bh1 and inhibition of cucurbitacin synthesis in cultivated watermelon.Functional analysis revealed that a rare insertion of 244 amino acids,which arose in C.amarus and became fixed in sweet watermelon,in Cl OSC(oxidosqualene cyclase)was critical for the negative selection of cucurbitacins during watermelon evolution.This research provides an important resource for metabolomics-assisted breeding in watermelon and for exploring metabolic pathway regulation mechanisms. | Pingli Yuan Congping Xu Nan He Xuqiang Lu Xingping Zhang Jianli Shang Hongju Zhu Chengsheng Gong Hanhui Kuang Tang Tang Yong Xu Shuangwu Ma Dexi Sun Weiqin Zhang Muhammad J.Umer Jian Shi Alisdair R.Fernie Wenge Liu Jie Luo | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 3 | 社交学习时嗅觉记忆中僧帽细胞依赖胰岛素样生长因子的突触可塑性显示文摘工作与资助文章简介在食物偏好的社交传递(STFP)中,小鼠能对社交伙伴带来的食物气味形成长时程记忆。传统观点认为,记忆的形成和维持发生在海马和大脑皮层。课题组应用分子遗传学和膜片钳电生理技术,发现小鼠的社交学习记忆依赖于嗅觉神经元释放的类胰岛素生长因子(IGF1)。 | Zhihui Liu Zijun Chen Congping Shang Fei Yan Yingchao Shi Jiajing Zhang Baole Qu Hailin Han Yanying Wang Dapeng Li Thomas C.Südhof 曹鹏 | 2018 | 科学新闻2018，0，4： | 0 |
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