|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells显示文摘声音的刺猬(嘘) 小径在正常胚胎开始和 carcinogenesis 起一个关键作用,但是它在与 5 氟尿嘧啶(5-FU ) 对待的癌症房间的功能仍然保持未知。我们检验了表明小径基因的嘘的一个子集的表示,包括嘘, SMO, PTC1,苏(Fu ) 和在人的 hepatocellular 癌(HCC ) 的臀部房间线, Hep3BandHepG2,由反向的抄写聚合酶链反应与 5-FU 对待。用尝试平底锅蓝色分析, 3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazoliumbromide 试金和终端 deoxynucleotidyl 调停 transferase 的 digoxigenin-dUTP 刻痕结束标记试金,我们也检测了源于表示向量与 5-FU 治疗相结合的 pCS2-Glil 的 transfection 的 Hep3B 房间的 apoptosis。房间的活动性被擦伤创伤闭合试金检测。在 5-FU 对待的 Hep3B 房间的 PTC1 蛋白质的细胞的地点也是的表示和潜水艇由西方的污点分析和免疫调查了荧光灯的显微镜学。结果显示在送信人 RNA 和蛋白质层次的嘘小径目标分子的表示在与 5-FU 对待的 Hep3B 房间是显然下面调整的。过去图形用户界面的表示恢复房间生存能力并且到某程度,移植能力由 5-FU 禁止了。而且, 5-FU 处理影响潜水艇 PTC1 蛋白质的细胞的本地化,在嘘发信号的一个关键成员小径。我们的数据证明表明小径活动的嘘的下面规定在激活刺猬的 HCC 房间线涉及 5-FU-induced apoptosis 和活动性的抑制。这暗示表明小径禁止者和 5-FU-based 化疗的嘘的联合可能对 HCC 代表更有希望的策略。 | Qiyu Wang Shuhong Huang Ling Yang Ling Zhao Yuxia Yin Zhongzhen Liu Zheyu Chen Hongwei Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 10 |
| 2 | Direct observation of ultrafast plasmonic hot electron transfer in the strong coupling regime显示文摘Achieving strong coupling between plasmonic oscillators can significantly modulate their intrinsic optical properties.Here,we report the direct observation of ultrafast plasmonic hot electron transfer from an Au grating array to an MoS_(2) monolayer in the strong coupling regime between localized surface plasmons(LSPs)and surface plasmon polaritons(SPPs).By means of femtosecond pump-probe spectroscopy,the measured hot electron transfer time is approximately 40 fs with a maximum external quantum yield of 1.65%.Our results suggest that strong coupling between LSPs and SPPs has synergetic effects on the generation of plasmonic hot carriers,where SPPs with a unique nonradiative feature can act as an‘energy recycle bin’to reuse the radiative energy of LSPs and contribute to hot carrier generation.Coherent energy exchange between plasmonic modes in the strong coupling regime can further enhance the vertical electric field and promote the transfer of hot electrons between the Au grating and the MoS_(2) monolayer.Our proposed plasmonic strong coupling configuration overcomes the challenge associated with utilizing hot carriers and is instructive in terms of improving the performance of plasmonic opto-electronic devices. | Hangyong Shan Ying Yu Xingli Wang Yang Luo Shuai Zu Bowen Du Tianyang Han Bowen Li Yu Li Jiarui Wu Feng Lin Kebin Shi Beng Kang Tay Zheng Liu Xing Zhu Zheyu Fang | 2019 | Light(Science & Applications)2019，8，1： | 7 |
| 3 | Numerical investigation of dynamic stall suppression of rotor airfoil via improved co-flow jet显示文摘The decrease in aerodynamic performance caused by the shock-induced dynamic stall of an advancing blade and the dynamic stall of a retreating blade at low speed and high angles of attack limits the flight speed of a helicopter.However,little research has been carried on the flow control methods employed to suppress both the dynamic stall induced by a shock wave and the dynamic stall occurring at high angles of attack.The dynamic stall suppression of a rotor airfoil by Co-Flow Jet(CFJ)is numerically investigated in this work.The flowfield of the airfoil is simulated by solving Reynolds Averaged Navier-Stokes equations based on the sliding mesh technique.Firstly,to improve the effect of a traditional CFJ on suppressing rotor airfoil shock-induced dynamic stall,an improved CFJ—a CFJ-sloping slot is proposed.Research shows that the CFJsloping slot suppresses the shock-induced dynamic stall more effectively than a traditional CFJ.Moreover,the improved CFJ can also suppress the dynamic stall of rotor airfoil at low speed and high angles of attack.The improved CFJ proposed in this paper is an effective flow control method that simultaneously suppresses the dynamic stall of the advancing and retreating blades.The mechanism of the improved CFJ in suppressing the dynamic stall of the rotor airfoil is studied,and a comparison is made between the improved CFJ and the traditional CFJ in terms of dynamic stall suppression at high and low speed.Finally,the effect of improved CFJ parameters(the jet momentum coefficient,the position of the injection/suction slot,and the size of the injection/suction slot)on shock-induced dynamic stall suppression is analyzed. | Jiaqi LIU Rongqian CHEN Yancheng YOU Zheyu SHI | 2022 | Chinese Journal of Aeronautics2022，35，3： | 3 |
| 4 | Phonon scattering and exciton localization: molding exciton flux in two dimensional disorder energy landscape显示文摘Two dimensional excitonic devices are of great potential to overcome the dilemma of response time and integration in current generation of electron or/and photon based systems.The ultrashort diffusion length of exciton arising from ultrafast relaxation and low carrier mobility greatly discounts the performance of excitonic devices.Phonon scattering and exciton localization are crucial to understand the modulation of exciton flux in two dimensional disorder energy landscape,which still remain elusive.Here,we report an optimized scheme for exciton diffusion and relaxation dominated by phonon scattering and disorder potentials in WSe2 monolayers.The effective diffusion coefficient is enhanced by>200%at 280 K.The excitons tend to be localized by disorder potentials accompanied by the steadily weakening of phonon scattering when temperature drops to 260 K,and the onset of exciton localization brings forward as decreasing temperature.These findings identify that phonon scattering and disorder potentials are of great importance for long-range exciton diffusion and thermal management in exciton based systems,and lay a firm foundation for the development of functional excitonic devices. | Pengfei Qi Yang Luo Beibei Shi Wei Li Donglin Liu Liheng Zheng Zhixin Liu Yanglong Hou Zheyu Fang | 2021 | eLight2021，1，1： | 3 |
| 5 | Nanomaterials toward the treatment of Alzheimer's disease:Recent advances and future trends显示文摘Alzheimer’s disease(AD)is a progressive and fatal neurodegenerative condition and the most prevalent cause of dementia.This disease is characterized by progressive cognitive impairment.The prevalence of AD is currently affecting more than 35 million people and is rising worldwide.No efficient therapy is currently available due to low drug potency and a number of various obstacles to delivery.Recent nanotechnological advancements have the potential to offer promising therapeutic options.Progress on nanomaterials as well as their applications in biomedicine is receiving increasing attention,especially the advantages of nanomaterial-based drug delivery systems.The aim of this review is to comprehensively summarize the latest developments in nanomaterial-based strategies for AD treatment,including nanoparticles,liposomes and other options for the delivery of therapeutic compounds and scaffolds for cell delivery strategies.Future research directions are also proposed.We hope this review can provide important information to guide the future development of nanomaterials in AD treatment. | Huihui Zeng Yujie Qi Zheyu Zhang Chuntai Liu Weijun Peng Yi Zhang | 2021 | Chinese Chemical Letters2021，32，6： | 2 |
| 6 | Conformance control by a microgel in a multi-layered heterogeneous reservoir during CO_(2) enhanced oil recovery process显示文摘Injecting CO_(2)into the underground for oil displacement and shortage is an important technique for carbon capture,utilization and storage(CCUS).One of the main problems during the CO_(2)injection is the channeling plugging.Finding an effective method for the gas channeling plugging is a critical issue in the CO_(2)EOR process.In this work,an acid-resistance microgel named dispersed particle gel(DPG)was characterized and its stability was tested in the CO_(2)environment.The microgel size selection strategies for the homogeneous and heterogeneous reservoirs were respectively investigated using the single core flooding and three parallel core flooding experiments.Moreover,the comparison of microgel alternate CO_(2)(MAC)injection and water alternate CO_(2)(WAC)injection in the dual core flooding experiments were presented for the investigation of the role of microgel on the conformance control in CO_(2)flooding process.The results have shown that the microgel featured with ANH and CAN groups can keep its morphology after aging 7 days in the CO_(2)environment.Where,the small microgel with unobstructed migration and large microgel with good plugging efficiency for the high permeability zone were respectively featured with the higher recovery factor in homogeneous and heterogeneous conditions,which indicate they are preferred used for the oil displacement and conformance control.Compared to WAC injection,MAC injection had a higher incremental recovery factor of 12.4%.It suggests the acid-resistance microgel would be a good candidate for the conformance control during CO_(2)flooding process. | Zheyu Liu Jian Zhang Xianjie Li Chunming Xu Xin Chen Bo Zhang Guang Zhao Han Zhang Yiqiang Li | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 2 |
| 7 | Helically Grooved Gold Nanoarrows: Controlled Fabrication, Superhelix, and Transcribed Chiroptical Switching显示文摘Plasmonic chiroptical materials,coupled by chirality and surface plasmons,have been attracting great interest due to their potential applications,such as photonics,chiral recognition,asymmetric catalysis and biosensing.Herein,we constructed a new chiral plasmonic nanostructure—helically grooved gold nanoarrows(HeliGNAs)by introducing L-/Dcysteine(L-/D-Cys)during the growth of the gold nanoarrows(GNAs).The variation of the concentration of L-/D-Cys leads to the HeliGNAs with a tunable plasmonic circular dichroism(PCD). | Song Wang Liheng Zheng Wenjie Chen Lukang Ji Li Zhang Wensheng Lu Zheyu Fang Fucheng Guo Limin Qi Minghua Liu | 2021 | CCS Chemistry2021，3，9： | 2 |
| 8 | Design and completion of a desktop virtual physics laboratory显示文摘 | LIU ZHEYU | | 0，，04： | 1 |
| 9 | Effects of Emodin on Ca 2+ Signal Transduction of Smooth Muscle Cells in Multiple Organ Dysfunction Syndrome显示文摘 | Chen Zheyu Q.I. Qinghui Liu Lixin M.A. Tao Jian Xu Liang Zhang Yan Lunan | 2006 | Journal of Surgical Research2006，，1： | 1 |
| 10 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 11 | Positive effects of applying endophytic bacteria in eggplant-Sedum intercropping system on Cd phytoremediation and vegetable production in cadmium polluted greenhouse显示文摘The combination of intercropping and phytoremediation in the remediation of cadmium contaminated soil is an emerging model in recent years,but the results of previous studies are inconsistent.In the field experiment,eggplant was intercropped with hyperaccumula-tor Sedum alfredii Hance(inoculated or not inoculated with endophytic bacteria)to study the effects of intercropping on vegetable safety production,phytoremediation efficiency of hyperaccumulator and variation of soil available nutrients.The results showed that the in-tercropping treatment had a negative effect on the growth of eggplant and Sedum,but en-dophyte SaMR12 alleviated the inhibition of intercropping on plant growth.Intercropping treatment increases the Cd concentration in edible part of eggplant to 1.34 mg/kg compared with eggplant monoculture(1.19 mg/kg).While the application of SaMR12 reduces the Cd concentration of eggplant fruit to 0.95 mg/kg and significantly promotes the Cd uptake by Sedum.What's more surprising is that compared with eggplant monocropping,the con-tent of soil available nitrogen,phosphorus and potassium in the treatment of intercropping with inoculated Sedum increased significantly.And according to the correlation analysis of various indexes of plants and soil,the Cd content of eggplant is negatively correlated with the available phosphorus and potassium in the soil,while the Cd content of Sedum is positively correlated with it,which suggested that the application of phosphorus and potas-sium fertilizers in this experimental site was beneficial to reduce Cd content in eggplant and improve Cd phytoextraction of Sedum.Therefore,in the daily production of moderately Cd-contaminated soil,intercropping eggplant with Sedum inoculated with endophytic bacteria is an excellent Phytoextraction Coupled with Agro-safe-production(PCA)pattern. | Luyao Ma Lukuan Huang Qizhen Liu Shunan Xu Zheyu Wen Shuai Qin Tingqiang Li Ying Feng | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 12 | Chiral detection of biomolecules based on reinforcement learning显示文摘Chirality plays an important role in biological processes,and enantiomers often possess similar physical properties and different physiologic functions.In recent years,chiral detection of enantiomers become a popular topic.Plasmonic metasurfaces enhance weak inherent chiral effects of biomolecules,so they are used in chiral detection.Artificial intelligence algorithm makes a lot of contribution to many aspects of nanophotonics.Here,we propose a nanostructure design method based on reinforcement learning and devise chiral nanostructures to distinguish enantiomers.The algorithm finds out the metallic nanostructures with a sharp peak in circular dichroism spectra and emphasizes the frequency shifts caused by nearfield interaction of nanostructures and biomolecules.Our work inspires universal and efficient machine-learning methods for nanophotonic design. | Yuxiang Chen Fengyu Zhang Zhibo Dang Xiao He Chunxiong Luo Zhengchang Liu Pu Peng Yuchen Dai Yijing Huang Yu Li Zheyu Fang | 2023 | Opto-Electronic Science2023，2，1： | 1 |
| 13 | Long non-coding RNA BACE1-AS plays an oncogenic role in hepatocellular carcinoma cells through miR-214-3p/APLN axis显示文摘BACE1 antisense RNA (BACE1-AS) is implicated in promoting cell proliferation in different types of tumors. However, the function and mechanism of BACE1-AS in hepatocellular carcinoma (HCC) are still unclear. In the present study, we found that the relative expression of BACE1-AS in HCC cell lines, HCC tissues, and serum samples of HCC patients was significantly increased, and its high expression was correlated with the poor prognosis of HCC patients. In addition, overexpression of BACE1 promoted HCC cell proliferation, cell cycle progression, migration, and invasion, but inhibited cell apoptosis, while knockdown of BACE1 exerted the opposite role. Furthermore, BACE1-AS sponged miR-214-3p and inhibited its expression, thus promoting Apelin (APLN) expression. Overexpression or knockdown of miR-214-3p could partially reverse the abnormal proliferation, cell cycle progression, migration, invasion, and apoptosis caused by overexpression or knockdown of BACE1. These findings suggest that the BACE1-AS/miR-214-3p/APLN axis is a novel signaling pathway that facilitates HCC. | Qing Tian Xiaodong Yan Long Yang Zirong Liu Zheyue Yuan Yamin Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 0 |
| 14 | Self-design of arbitrary polarization-control waveplates via deep neural networks显示文摘The manipulation of polarization states beyond the optical limit presents advantages in various applications.Considerable progress has been made in the design of meta-waveplates for on-demand polarization transformation,realized by numerical simulations and parameter sweep methodologies.However,due to the limited freedom in these classical strategies,particular challenges arise from the emerging requirement for multiplex optical devices and multidimensional manipulation of light,which urge for a large number of different nanostructures with great polarization control capability.Here,we demonstrate a set of self-designed arbitrary wave plates with a high polarization conversion efficiency.We combine Bayesian optimization and deep neural networks to design perfect halfand quarter-waveplates based on metallic nanostructures,which experimentally demonstrate excellent polarization control functionalities with the conversion ratios of 85%and 90%.More broadly,we develop a comprehensive wave plate database consisting of various metallic nanostructures with high polarization conversion efficiency,accompanying a flexible tuning of phase shifts(0-2π)and group delays(0-10 fs),and construct an achromatic metalens based on this database.Owing to the versatility and excellent performance,our self-designed wave plates can promote the performance of multiplexed broadband metasurfaces and find potential applications in compact optical devices and polarization division multiplexing optical communications. | ZHENGCHANG LIU ZHIBO DANG ZHIXIN LIU YU LI XIAO HE YUCHEN DAI YUXIANG CHEN PU PENG ZHEYU FANG | 2023 | Photonics Research2023，11，5： | 0 |
| 15 | Field distribution of the Z_(2)topological edge state revealed by cathodoluminescence nanoscopy显示文摘Photonic topological insulators with robust boundary states can enable great applications for optical communication and quantum emission,such as unidirectional waveguide and single-mode laser.However,because of the diffraction limit of light,the physical insight of topological resonance remains unexplored in detail,like the dark line that exists with the crys-talline symmetry-protected topological edge state.Here,we experimentally observe the dark line of the Z_(2)photonic topo-logical insulator in the visible range by photoluminescence and specify its location by cathodoluminescence characteriza-tion,and elucidate its mechanism with the p-d orbital electromagnetic field distribution which calculated by numerical sim-ulation.Our investigation provides a deeper understanding of Z_(2)topological edge states and may have great signific-ance to the design of future on-chip topological devices. | Xiao He Donglin Liu Hongfei Wang Liheng Zheng Bo Xu Biye Xie Meiling Jiang Zhixin Liu Jin Zhang Minghui Lu Zheyu Fang | 2022 | Opto-Electronic Advances2022，5，4： | 0 |
| 16 | A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling显示文摘Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in prophylaxis,calling for the need for drug improvement.Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms.The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments,providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies.A total of 128 sequences were obtained after sequencing 196 memory B cells,and 42 sequences were left after merging extremely similar ones and discarding incomplete ones,followed by homology modeling of the antibody variable region.Thirteen candidate sequences were expressed,of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants.The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication. | Zheyue Wang Qi Tang Bende Liu Wenqing Zhang Yufeng Chen Ningfei Ji Yan Peng Xiaohui Yang Daixun Cui Weiyu Kong Xiaojun Tang Tingting Yang Mingshun Zhang Xinxia Chang Jin Zhu Mao Huang Zhenqing Feng | 2023 | The Journal of Biomedical Research2023，37，3： | 0 |
| 17 | A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling显示文摘 | Zheyue Wang Qi Tang Bende Liu Wenqing Zhang Yufeng Chen Ningfei Ji Yan Peng Xiaohui Yang Daixun Cui Weiyu Kong Xiaojun Tang Tingting Yang Mingshun Zhang Xinxia Chang Jin Zhu Mao Huang Zhenqing Feng | 2023 | The Journal of Biomedical Research2023，37，3： | 0 |
| 18 | Factors Controlling Organic Matter Enrichment in Alkaline Lacustrine Source Rocks:A Case Study of the Late Paleozoic Fengcheng Formation in the Junggar Basin,NW China显示文摘The late Paleozoic Fengcheng Formation shale(LPF shale)in the Junggar Basin,NW China,is the oldest alkaline source rock discovered in the world,providing a unique perspective with which to explore organic matter(OM)enrichment in alkaline lake environments.Combined with the organic carbon isotope profile and paleoenvironmental proxies,this study reveals that the LPF shale was deposited in an arid climate with high salinity and a strong reducing environment,accompanied by frequent volcanic activity.High TOC values are concentrated in two intervals with frequent fluctuations in OM types.A negative excursion due to changes in sedimentary OM source is found in the δ^(13)C_(org) profile.The excursion corresponds to the OM enrichment interval and is accompanied by abnormally high values of Sr/Ba and Sr/Cu.This implies that the extreme arid climate has led to high salinity,resulting in strong reducibility and changes in paleontological assemblages,which in turn controlled the differential enrichment of OM.The Fengcheng Fm.high-quality source rocks are the result of the combined action of climatic events,volcanism,high-salinity water environment and superior hydrocarbon-generating organisms.The results provide new insights into the formation conditions of terrestrial alkaline high-quality source rocks and the factors controlling alkaline OM enrichment. | HUANG Renda JIANG Fujie HU Tao CHEN Di HUANG Liliang LIU Zheyu WANG Xiaohao ZHANG Chenxi LU Jiahao WU Yuping | 2023 | Acta Geologica Sinica(English Edition)2023，97，6： | 0 |
| 19 | Microscopic experiment on efficient construction of underground gas storages converted from water-invaded gas reservoirs显示文摘Based on the microfluidic technology,a microscopic visualization model was used to simulate the gas injection process in the initial construction stage and the bottom water invasion/gas injection process in the cyclical injection-production stage of the underground gas storage(UGS)rebuilt from water-invaded gas reservoirs.Through analysis of the gas-liquid contact stabilization mechanism,flow and occurrence,the optimal control method for lifecycle efficient operation of UGS was explored.The results show that in the initial construction stage of UGS,the action of gravity should be fully utilized by regulating the gas injection rate,so as to ensure the macroscopically stable migration of the gas-liquid contact,and greatly improve the gas sweeping capacity,providing a large pore space for gas storage in the subsequent cyclical injection-production stage.In the cyclical injection-production stage of UGS,a constant gas storage and production rate leads to a low pore space utilization.Gradually increasing the gas storage and production rate,that is,transitioning from small volume to large volume,can continuously break the hydraulic equilibrium of the remaining fluid in the porous media,which then expands the pore space and flow channels.This is conducive to the expansion of UGS capacity and efficiency for purpose of peak shaving and supply guarantee. | JIANG Tongwen QI Huan WANG Zhengmao LI Yiqiang WANG Jinfang LIU Zheyu CAO Jinxin | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
| 20 | Add-on plasmonic patch as a universal fluorescence enhancer显示文摘Fluorescence-based techniques are the cornerstone of modern biomedical optics,with applications ranging from bioimaging at various scales(organelle to organism)to detection and quantification of a wide variety of biological species of interest.However,the weakness of the fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image,detect,and quantify biological species with low abundance.Here,we report a simple and universal method based on a flexible and conformal elastomeric film with adsorbed plasmonic nanostructures,which we term a“plasmonic patch,”that provides large(up to 100-fold)and uniform fluorescence enhancement on a variety of surfaces through simple transfer of the plasmonic patch to the surface.We demonstrate the applications of the plasmonic patch in improving the sensitivity and limit of detection(by more than 100 times)of fluorescence-based immunoassays implemented in microtiter plates and in microarray format.The novel fluorescence enhancement approach presented here represents a disease,biomarker,and application agnostic ubiquitously applicable fundamental and enabling technology to immediately improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner,without changing the original procedures of the existing techniques. | Jingyi Luan Jeremiah J.Morrissey Zheyu Wang Hamed Gholami Derami Keng-Ku Liu Sisi Cao Qisheng Jiang Congzhou Wang Evan D.Kharasch Rajesh R.Naik Srikanth Singamaneni | 2018 | Light(Science & Applications)2018，7，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员