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| 1 | Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China显示文摘 | Hu Peilei Bai Liqiong Liu Fengping Ou Xichao Zhang Zhiying Yi Songlin Chen Zhongnan Gong Daofang Liu Binbin Guo Jingwei Tan Yunhong | 2014 | Chinese Medical Journal2014，，21： | 24 |
| 2 | A Novel Rice bHLH Transcription Factor, DTD, Acts Coordinately with TDR in Controlling Tapetum Function and Pollen Development显示文摘Dear Editor, Male reproductive development is an essential biological process for flowering plants and crucial for crop seed production.Formation of the male reproductive organ,the anther,involves a number of developmental events,including stamen meristem specification,generation of sporogenous cells and their differentiation into microspore mother cells (MMCs),meiosis,microspore (pollen) maturation,and pollination (Ma,2005).The formation of microspores and their development into mature pollen grains require cooperative interactions between gametophytic (microspores) and sporophytic (anther wall) cells,with the innermost cell layer,the tapetum,playing the most crucial role (Ma,2005).Tapetal cells undergo degeneration by programmed cell death (PCD). | Chonghui Ji Heying Li Libin Chen Min Xie Fengping Wang Yuanling Chen Yao-Guang Liu | 2013 | Molecular Plant2013，6，5： | 14 |
| 3 | STAT3 associates with vacuolar H^+-ATPase and regulates cytosolic and lysosomal pH显示文摘 | Bin Liu Johan Palmfeldt Lin Lin Alexandria Colaco Knut K. B, Clemmensen Jinrong Huang Fengping Xu Xin Liu Kenji Maeda Yonglun Luo Marja Jaattela | 2018 | Cell Research2018，28，10： | 5 |
| 4 | Noise-like pulse generation from a thulium-doped fiber laser using nonlinear polarization rotation with different net anomalous dispersion显示文摘A mode-locked thulium-doped fiber laser(TDFL) based on nonlinear polarization rotation(NPR) with different net anomalous dispersion is demonstrated. When the cavity dispersion is-1.425 ps^2, the noise-like(NL) pulse with coherence spike width of 406 fs and pulse energy of 12.342 nJ is generated at a center wavelength of 2003.2 nm with 3 dB spectral bandwidth of 23.20 nm. In the experimental period of 400 min, the 3 dB spectral bandwidth variation, the output power fluctuation, and the central wavelength shift are less than 0.06 nm, 0.04 d B, and0.4 nm, respectively, indicating that the NPR-based TDFL operating in the NL regime holds good long-term stability. | Shuo Liu Fengping Yan Yang Li Luna Zhang Zhuoya Bai Hong Zhou Yafei Hou | 2016 | Photonics Research2016，4，6： | 5 |
| 5 | Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma显示文摘Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.However,the mechanism of C3 a/C4 a in osteoclasts MM patients remains unclear.Methods:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in vitro.RNA-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway inhibitors.Results:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the control.There was no difference between the C4 a and control groups.RNA-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling pathway.The relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control group.The activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibitor(EMD638683).Conclusions:C3 a activated osteoclasts by regulating the PI3 K/PDK1/SGK3 pathways in MM patients,which was reduced using a SGK inhibitor.Overall,our results identified potential therapeutic targets and strategies for MBD patients。 | Fengjuan Jiang Hui Liu Fengping Peng Zhaoyun Liu Kai Ding Jia Song Lijuan Li Jin Chen Qing Shao Siyang Yan Kim De Veirman Karin Vanderkerken Rong Fu | 2021 | Cancer Biology & Medicine2021，18，3： | 3 |
| 6 | UV illumination enhanced desorption of oxygen molecules from monolayer MoS2 surface显示文摘The oxygen adsorption can drastically alter the electronic properties of the two-dimensional(2D)materials,which is usually dificult to be removed.In this work,we report the ultraviolet(UV)ilumination induced desorption of the O2 molecules from the monolayer MoS2 surface by using the atmosphere dependent transport measurement,Kelvin probe microscopy,photoluminescence spectroscopy and X-ray photoelectron spectroscopy.Obvious increasing of the conductivity,rising of the Fermi level,and red shift of the photoluminescence peaks of the MoS2 were observed after the UV ilumination in vacuum,indicating the elimination of the depletion effect from the oxygen adsorption.Such parameter changes can be reversibly recovered by the subsequent O2 exposure.Furthermore,obvious decreasing of the oxygen concentration after the UV ilumination was also observed by X-ray photoelectron spectroscopy.Thus the UV induced O2 photodesorption effect is evidenced.The photo-excited charge transfer mechanism is proposed to account for the photodesorption effect.These results provide a nondestructive way to clean the MoS2 surface and manipulate the performance of the MoS2 based devices. | Yuhang Wang Zhiquan He Jinbing Zhang Hao Liu Xubo Lai Boyang Liu Yibao Chen Fengping Wang Liuwan Zhang | 2020 | Nano Research2020，13，2： | 3 |
| 7 | Mechanisms of carbon storage and the coupled carbon, nitrogen and sulfur cycles in regional seas in response to global change显示文摘1.Great challenges in scientific frontiers of marine carbon storage in the scenario of global change The marine carbon cycle is influenced by anthropogenic activities,affecting global climate change and casting a significant impact on ecosystems.However,the complex spatiotemporal process of the marine carbon cycle results in the uncertainty in the estimation of marine carbon budget。 | XIE ShuCheng CHEN JianFang WANG FengPing XUN LuYing TANG Kai ZHAI WeiDong LIU JiHua MA WenTao | 2017 | Science China Earth Sciences2017，60，5： | 3 |
| 8 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 9 | SNP-based linkage mapping for validation of adult plant stripe rust resistance QTL in common wheat cultivar Chakwal 86显示文摘Wheat crops in China are constantly challenged by stripe rust. Deployment of cultivars with diverse resistances is the best strategy to control the disease. A recombinant inbred line(RIL) population derived from a cross between the resistant cultivar Chakwal 86 and susceptible landrace Mingxian 169 was studied in multiple environments to examine the underlying genetics and to identify quantitative trait loci(QTL) for stripe rust resistance.One hundred and twenty-eight RILs were genotyped with wheat 35 K SNP array and a genome-wide linkage map with 1480 polymorphic SNP markers, or bins, was constructed.Two major QTL on chromosomes 1BL and 3BS, and one minor QTL on 6BS had significant effects in reducing stripe rust severity. The QTL were validated using composite interval mapping(CIM) and inclusive composite interval mapping(ICIM). These methods explained59.0%–74.1% of the phenotype variation in disease response. The QTL on chromosome 1 BL was confirmed to be Yr29/Lr46 and the one on 3BS was the resistance allele identified in CIMMYT germplasm but was not Yr30/Sr2. The QTL on 6BS probably corresponded to previously known QTL. RILs with combined QTL were more resistant than those with single or no QTL. Kompetitive allele-specific PCR(KASP) assays for the QTL with largest effect QTL on chromosome 3BS were performed on a subset of RILs and 150 unrelated wheat lines. The QTL on 3BS with its linked KASP markers can be used in marker-assisted selection to improve stripe rust resistance in breeding programs. | Qingdong Zeng Jianhui Wu Shuo Huang Fengping Yuan Shengjie Liu Qilin Wang Jingmei Mu Shizhou Yu Li Chen Dejun Han Zhensheng Kang | 2019 | The Crop Journal2019，7，2： | 2 |
| 10 | Molecular diversity of Thermococcales isolated from Guaymas Basin hydrothermal vents显示文摘Members of Thermococcales are organoheterotrophic hyperthermophilic anaerobes consisting of three genera, Thermococcus, Pyrococcus, and Palaeococcus, among which Thermococcus are the most frequently isolated. In this study, a variety of Thermococcales strains were isolated from the Guaymas Basin hydrothermal vents under different temperatures and pressures. Based on their 16S rRNA gene sequences, all the strains isolated from 85 C or 95 C enrichment cultures at ambient pressure were classified as Thermococcus, while strains isolated from 108 C-30 MPa enrichment cultures belonged to Pyrococcus. The combination of high pressure and high temperature for enrichment was shown to be an efficient method for isolating Pyrococcus strains. Through selecting and analyzing with multiple molecular phylogenetic markers, the isolated Thermococcales strains were found quite diversified including several putative novel species. This demonstrates a vast genetic reservoir of Thermoccoccales in the deep-sea hydrothermal vents, and a fast evolving of the Thermococcales species adapting to the fast changing environment. | LIU Lupeng WANG Fengping XU Jun XIAO Xiang | 2013 | Acta Oceanologica Sinica2013，32，6： | 2 |
| 11 | Responses of marine-derived Trichoderma fungi to seawater and their potential antagonistic behaviour显示文摘To explore the metabolic responses of marine-derived Trichoderma fungi to environmental stresses, the survivability, metabolism, and antagonism of ten marine isolates have been examined. Their survival in both freshwater and seawater indicates them to be facultative marine fungi, but they are more adaptable to marine environment. Most of them feature strain-specific and positive metabolic responses to seawater, which also usually result in the higher proportions of heteroatom-bearing and unsaturated units in mycelial constituents. Seawater factors can promote many strains to produce bioactive metabolites, including plant pathogen- and marine phytoplankton-inhibitory and marine animal-toxic ones, but the eff ects of NaCl are often weak or negative. The inhibition of marine phytoplankton corresponds to the intracellular accumulation of heteroatom-bearing and unsaturated units under seawater condition, and the varied toxicities to marine animals further signify the divergences of lipophilic exudates under diff erent conditions. The results may contribute to further understanding and mining the structural diversity and biological activity of secondary metabolites from marine-derived Trichoderma fungi. | SONG Yinping MIAO Fengping LIU Xianghong JI Naiyun | 2019 | Journal of Oceanology and Limnology2019，37，2： | 2 |
| 12 | Comparison of Lipid Levels, Hyperlipidemia Prevalence and Its Risk Factors between Guangxi Hei Yi Zhuang and Han Populations显示文摘 | Yin Ruixing Chen Yuming Pan Shangling He Fengping Liu Tangwei Yang Dezhai Wu Jinzhen Yao Limei Lin Weixiong Li Rongshan Huang Jiandong | 2006 | Archives of Medical Research2006，，6： | 1 |
| 13 | Theoretical prediction of the Kovat's retention index for oxygen-containing organic compounds using novel topological indices显示文摘 | Fengping Liu Yizeng Liang Chenzhong Cao Neng Zhou | 2007 | Analytica Chimica Acta2007，594，： | 1 |
| 14 | TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat显示文摘Grain development is a crucial determinant of yield and quality in bread wheat(Triticum aestivum L.).However,the regulatory mechanisms underlying wheat grain development remain elusive.Here we report how Ta MADS29 interacts with Ta NF-YB1 to synergistically regulate early grain development in bread wheat.The tamads29 mutants generated by CRISPR/Cas9 exhibited severe grain filling deficiency,coupled with excessive accumulation of reactive oxygen species(ROS)and abnormal programmed cell death that occurred in early developing grains,while overexpression of Ta MADS29 increased grain width and1,000-kernel weight.Further analysis revealed that Ta MADS29 interacted directly with Ta NF-YB1;null mutation in Ta NF-YB1caused grain developmental deficiency similar to tamads29 mutants.The regulatory complex composed of Ta MADS29 and Ta NF-YB1 exercises its possible function that inhibits the excessive accumulation of ROS by regulating the genes involved in chloroplast development and photosynthesis in early developing wheat grains and prevents nucellar projection degradation and endosperm cell death,facilitating transportation of nutrients into the endosperm and wholly filling of developing grains.Collectively,our work not only discloses the molecular mechanism of MADS-box and NF-Y TFs in facilitating bread wheat grain development,but also indicates that caryopsis chloroplast might be a central regulator of grain development rather than merely a photosynthesis organelle.More importantly,our work offers an innovative way to breed high-yield wheat cultivars by controlling the ROS level in developing grains. | Guoyu Liu Runqi Zhang Sen Li Rehmat Ullah Fengping Yang Zihao Wang Weilong Guo Mingshan You Baoyun Li Chaojie Xie Liangsheng Wang Jie Liu Zhongfu Ni Qixin Sun Rongqi Liang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 15 | Prediction of adolescent subjective well being: A machine learning approach显示文摘Background Subjective well-being(SWB),also known as happiness,plays an important role in evaluating both mental and physical health.Adolescents deserve specific attention because they are under a great variety of stresses and are at risk for mental disorders during adulthood.Aim The present paper aims to predict undergraduate students1 SWB by machine learning method.Methods Gradient Boosting Classifier which was an innovative yet validated machine learning approach was used to analyse data from 10518 Chinese adolescents.The online survey included 298 factors such as depression and personality.Quality control procedure was used to minimise biases due to online survey reports.We applied feature selection to achieve the balance between optimal prediction and result interpretation.Results The top 20 happiness risks and protective factors were finally brought into the predicting model.Approximately 90%individuals'SWB can be predicted correctly,and the sensitivity and specificity were about 92%and 90%,respectively.Conclusions This result identifies at-risk individuals according to new characteristics and established the foundation for adolescent prevention strategies. | Naixin Zhang Chuanxin Liu Zhixuan Chen Lin An Decheng Ren Fan Yuan Ruixue Yuan Lei Ji Yan Bi Zhenming Guo Gaini Ma Fei Xu Fengping Yang Liping Zhu Gabirel Robert Yifeng Xu Lin He Bo Bai Tao Yu Guang He | 2019 | General Psychiatry2019，32，5： | 1 |
| 16 | Dual-wavelength single-longitudinal-mode Tm-doped fiber laser using PM-CMFBG显示文摘 | Yan Fengping Peng Wanjing Liu Shuo | 2015 | IEEE Photon Technol Lett2015，27，9： | 1 |
| 17 | Burn patients’ experience of pain management: A qualitative study显示文摘 | Li Yuxiang Zhou Lingjun Tang Lu Liu Mengjie Ming Xing Shen Fengping Cui Jing Meng Xianli Zhao Jijun | 2011 | Burns2011，，2： | 1 |
| 18 | Theoretical prediction of the Kovat's retention index for oxygen-containing organic compounds using novel topological indices显示文摘 | Fengping Liu Yizeng Liang Chenzhong Cao Neng Zhou | 2007 | Analytica Chimica Acta2007，594，： | 1 |
| 19 | Structural and physical properties of permalloy thin films prepared by DC magnetron sputtering at different substrate temperature显示文摘Permalloy Ni8oFe20 films have been grown on thermal oxidized Si (111) wafers by magnetron sputtering at well-controlled substrate temperatures of 300, 500, 640 and 780 K in 0.65 Pa argon pressure. The base pressure was about 1×10^-4 Pa. The deposition rate was about 5 nm/min for all the films. The structure of the films was studied using X-ray dif-fraction, scanning electron microscopy and atomic force microscopy. The composition of the films was analyzed using scanning Auger microprobe. The resistance and magnetoresistance of the films were measured using four-point probe tech-nique. The results show that the content of oxygen in the films decreases gradually with raising substrate temperature. In addition, the surface morphology of the films presents notable change with the increasing of the substrate temperature; the residual gases and defects decrease and the grains have coalesced evidently, and then the grains have grown up obviously and the texture of (111) orientation develops gradually in the growing film. As a result, the resistivity reduces apparently and magnetoresistance ratio increases markedly with raising substrate temperature. | WANG Fengping, WU Ping, QIU Hong, PAN Liqing, LIU Huanping, TIAN Yue, and LUO Sheng | 2004 | Rare Metals2004，23，1： | 1 |
| 20 | Algicidal activities of secondary metabolites of marine macroalgal-derived endophytic fungi显示文摘Red tide occurrs frequently and causes signi?cant damage to the environment and human health. As a result, development of new effcient and environment friendly red-tide microalgae inhibitors has gained increasing attention in recent times. Algicolous endophytic fungi with unique habitats are promising sources for active agents owing to their abundant secondary metabolites and distinguished activities. In this study, the algicidal activities of 49 marine macroalgal-derived endophytic fungi against phytoplankton Alexandrium tamarense, Prorocentrum donghaiense, Heterosigma akashiwo, and Chattonella marina were examined using 96-well microplate. Four fungal strains, including Aspergillus wentii(pt-1), A. ustus(cf-42),and A. versicolor(dl-29, pt-20), exhibited potent algicidal activities. A total of 32 pure compounds isolated from these fungi were noted to possess dif ferent degrees of algicidal activities. Of those, 11 compounds comprising ?ve anthraquinones, two terpenoids, and four steroids showed high 24-h inhibition rates for the four red tide algae, with 24 h EC_(50) values ranging from 0.01 to 14.29 μg/mL. Among them, compound1(1,5-dihydroxy-3-methoxy-7-methylanthraquinone) presented the strongest activity against H. akashiwo,and could decrease its chlorophyll a(Chl a) and superoxide dismutase contents and increase the soluble protein, malondialdehyde, and peroxidase contents. These results suggested that the identi?ed anti-algal compound might inhibit the growth of red tide algae by weakening photosynthesis(reducing Chl a content),destroying cell membrane, and damaging the antioxidant system. | MIAO Fengping ZUO Jincheng LIU Xianghong JI Naiyun | 2019 | Journal of Oceanology and Limnology2019，37，1： | 1 |
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