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| 1 | microRNAs-powerful repression comes from small RNAs显示文摘microRNAs (miRNAs) encode a novel class of small, non-coding RNAs that regulate gene expression post-trancriptionally. miRNAs comprise one of the major non-coding RNA families, whose diverse bio- logical functions and unusual capacity for gene regulation have attracted enormous interests in the RNA world. Over the past 16 years, genetic, biochemical and computational approaches have greatly shaped the growth of the field, leading to the identification of thousands of miRNA genes in nearly all metazoans. The key molecular machinery for miRNA biogenesis and silencing has been identified, yet the precise biochemical and regulatory mechanisms still remain elusive. However, recent findings have shed new light on how miRNAs are generated and how they function to repress gene expression. miRNAs provide a paradigm for endogenous small RNAs that mediate gene silencing at a genome-wide level. The gene silencing mediated by these small RNAs constitutes a major component of gene regu- lation during various developmental and physiological processes. The accumulating knowledge about their biogenesis and gene silencing mechanism will add a new dimension to our understanding about the complex gene regulatory networks. | MA Cong, LIU YuFei & HE Lin 535 LSA, Division of Cell and Developmental Biology, MCB Department, University of California at Berkeley, Berkeley, CA 94720-3200 | 2009 | Science China(Life Sciences)2009，52，4： | 7 |
| 2 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 3 | Response of the East Asian climate system to water and heat changes of global frozen soil using NCAR CAM model显示文摘在陆地空气热和水保存的条件下面,一套敏感数字实验被设置调查东方亚洲气候系统的反应到全球冻结的土壤变化。这被介绍 supercooled 土壤水过程进社区陆地模型(CLM3.0 ) 做,它被联合了到大气的研究社区空气模型(CAM3.1 ) 的国家中心。结果显示出那:(1 ) 在在 CLM3.0 的土壤冰和土壤水之间的比率被 supercooled 土壤水过程清楚地改变。地面表面温度和土壤温度也被影响。(2 ) 欧亚(包括的东方亚洲人) 气候系统在冻结的土壤区域对热和水的变化敏感。在 1 月,阿留申群岛之土人低海水平压力发行量被加强,在 500 hPa 高堵住的乌拉尔变弱,并且东方亚洲马槽变弱。在 7 月,在阿留申群岛之土人岛区域上的海水平压力显著地被减少;在东方亚洲海洋上有在东方亚洲大陆,和积极异例上的 500 hPa geopotential 高度的否定异例。(3 ) 在 1 月,在东亚上的 850 hPa 风地的南方的部件增加,显示削弱的冬季季风。在 7 月,当在海洋上有逆旋风的异例时,气旋的异例出现在东方亚洲大陆上,加强的东方海岸夏天季风反射。(4 ) 在东亚的夏天降雨显著地变化了,包括南部的 Qinghai 西藏高原,中央长江盆,和东北中国上的实质的降水增加。夏天降雨显著地在华南和海南岛减少了,但是稍微减少了在中央并且北方中国。进一步的分析沿着 30 显示出可观的上面的空气运动吗?? | XIN YuFei WU BingYi BIAN LinGen LIU Ge ZHANG Lin LI Ren | 2012 | Chinese Science Bulletin2012，57，34： | 5 |
| 4 | Mechanistic and therapeutic perspectives for cardiac arrhythmias:beyond ion channels显示文摘Cardiac arrhythmias are among the most common causes of death in the world. Foundational studies established the critical role of ion channel disorders in arrhythmias, yet defects in ion channels themselves, such as mutations, may not account for all arrhythmias. Despite the progress made in recent decades, the antiarrhythmic drugs currently available have limited effectiveness,and the majority of these drugs can have proarrhythmic effects. This review describes novel knowledge on cellular mechanisms that cause cardiac arrhythmias, focuses on the dysfunction of subcellular organelles and intracellular logistics, and discusses potential strategies and challenges for developing novel, safe and effective treatments for arrhythmias. | Yufei Wu Jun Li Liang Xu Li Lin Yi-Han Chen | 2017 | Science China(Life Sciences)2017，60，4： | 4 |
| 5 | The TAK1-JNK cascade is required for IRF3 function in the innate immune response显示文摘干扰素规章的因素(IRF ) 3 在病毒或细菌的侵略期间为 chemokines 和 cytokines 的 transcriptional 正式就职是批评的。kinases 坦克有约束力的 kinase (TBK ) 1 并且 Ikappa B kinase (IKK ) 蔚罐头 phosphorylate IRF3 和玩的 C 终端部分在 IRF3 激活的重要角色。在这研究,我们显示出那另外一个 kinase, c-Jun-NH2-terminal kinase (JNK ) ,它的 N 终端丝氨酸上的 phosphorylates IRF3 173 残余,和 TAK1 能经由 JNK 刺激 IRF3 phosphorylation。没有影响 C 终端 phosphorylation, JNK 特定的禁止者 SP600125 禁止 N 终端 phosphorylation。另外, lipopolysaccharide (LPS ) 上的调停 IRF3 的基因表情或 polyinosinic-cytidylic 酸(polyI : C ) 处理被 SP600125 严重地损害,以及为 IRF3 激活的记者基因试金。进一步证实的 TAK1 击倒这些观察。有趣地,组成的活跃 IRF3 (5D ) 能被 SP600125 禁止;JNK1 罐头 synergize IRF3 (5D ) 的行动,然而并非 S173A-IRF3 (5D ) 变异。更重要地, polyI : 没能戏剧性地导致变异的 S173A 和 SP600125 的 phosphorylation 的 C 废除了被 polyI 刺激的 IRF3 phosphorylation 和 dimerization : C。因此,这研究证明 TAK1-JNK 串联为 IRF3 功能被要求,除了 TBK1/IKK 蔚,揭开为激活 mitogen 的蛋白质(地图) 的新机制调整天生的免疫的 kinase。 | Bianhong Zhang Meng Li Liang Chen Kai Yang Yufei Shan Lianhui Zhu Shaogang Sun Lin Li Chen Wang | 2009 | Cell Research2009，19，4： | 4 |
| 6 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 7 | A core-shell structured COYID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity显示文摘Although inoculation of COVID-19 vaccines has rolled out globally,there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries.Here,we report on the development of a highly efficacious mRNA vaccine,SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex(LPP)nanoparticles.SWOT 23 is easy to produce using a large-scale microfluidics-based apparatus.The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability,and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration.Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123,represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2,but also a panel of variants including D614G and N501Y variants.In addition,SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge.Taken together,SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. | Ren Yang Yao Deng Baoying Huang Lei Huang Ang Lin Yuhua Li Wenling Wang Jingjing Liu Shuaiyao Lu Zhenzhen Zhan Yufei Wang Ruhan A Wen Wang Peihua Niu Li Zhao Shiqiang Li Xiaopin Ma Luyao Zhang Yujian Zhang Weiguo Yao Xingjie Liang Jincun Zhao Zhongmin Liu Xiaozhong Peng Hangwen Li Wenjie Tan | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 3 |
| 8 | Highly-efficient thermoelectric-driven light-emitting diodes based on colloidal quantum dots显示文摘Driven by sub-bandgap electric work and Peltier heat,thermoelectric-driven light-emitting diodes(TED-LEDs)not only offer much enhanced power-conversion-efficiency but also eliminate the waste heat generated during the operation of LEDs.However,costeffective and high-efficiency TED-LEDs are not readily accessible for the epitaxially grown III-V LEDs due to the high chip cost and efficiency droop at low-medium brightness(current densities).Here we show that electroluminescence of colloidal quantum dots(QDs)LEDs(QLEDs)circumvents the deficiencies faced by conventional LEDs.The optimal red-emitting device fabricated by cost-effective solution processing technics exhibits external-and internal-power-conversion-efficiency of 21.5%and 93.5%at 100 cd/m^(2),suited for high-efficiency solid-state lighting and high-resolution display.At this brightness,the electric driving voltage(V)of 1.89 V is lower than the photon voltage(Vp=hv/q=1.96 V,q being the elemental charge).With typical Vp=1.96 V,electroluminescence can be detected with the driving voltage as low as 1.0-1.2 V.Luminance of the thermoelectric-driven QLEDs(TED-QLEDs)remains ideally diffusion-dominated with the driving voltage lower than~1.5 V,and further improvement on charge transport is expected to extend the linear ideality to all practical driving voltages. | Xing Lin Xingliang Dai Zikang Ye Yufei Shu Zixuan Song Xiaogang Peng | 2022 | Nano Research2022，15，10： | 2 |
| 9 | Enhanced catalytic efficiency in quercetin - 4 - glucoside hydrolysis of Thermotoga mariti- ma β- glucosidase A by site -directed mutagenesis显示文摘 | Sun Huihui Xue Yemin Lin Yufei | 2014 | Journal of Agricultural and Food Chemistry2014，62，28： | 1 |
| 10 | Characteristic and properties of nano-SiO2-AI2OJEP-PU composite显示文摘 | Yufei Chen Caiwei Lin Liping WANG Zuoyu Wu | 2013 | Electrical Insualation and Dielectric Phenomena2013，，： | 1 |
| 11 | Joint Power and Duty-Cycle Design Using Alternating Optimization Algorithm under Energy Harvesting Architectures显示文摘In the emerging sixth generation(6G)communication network,energy harvesting(EH)is a promising technology to achieve the unlimited energy supply and hence makes the wireless communication systems self-sustainable in terms of energy.However,in practice,the efficiency of energy harvesting is often low due to the limited device capability.In this paper,we formulate three types of different EH architectures,i.e.,the harvest-use architecture,the harvest-store-use architecture,and the harvest-use-store architecture from the perspective of energy storage efficiency.We propose resource allocation schemes to jointly design the sensor power and duty-cycle via an alternating optimization algorithm under the above EH architectures,in both simultaneous and non-simultaneous harvesting and utilization models,aiming at achieving a higher throughput and energy efficiency.Non-ideal circuit power is also considered.Numerical results show that our proposed schemes under EH architectures outperform the existing classic continuous transmission schemes. | Tong Wang Xiang Yang Feng Deng Lin Gao Yufei Jiang Zhihua Yang | 2020 | China Communications2020，17，12： | 1 |
| 12 | In-situ constructing visible light CdS/Cd-MOF photocatalyst with enhanced photodegradation of methylene blue显示文摘Based on high specific surface area,high porosity of metal-organic frameworks(MOFs)and excellent vis-ible light response of CdS,the CdS/Cd-MOF nanocomposites were constructed by in-situ sulfurization to form CdS using Cd-MOF as precursor and the CdS loading was controlled by the dose of thioac-etamide.Under the irradiation of simulated sunlight,the degradation rate of methylene blue(MB)by 10mg MOF/CdS-6(mass ratio of MOF to thioacetamide is 6:1)was 91.9%in 100min,which was higher than that of pure Cd-MOF(62.3%)and pure CdS(67.5%).This is attributed to the larger specific surface area of the composite catalysts,which provides more active sites.Meanwhile,the loading of CdS obvi-ously broadens the light response range of Cd-MOF and improves the utilization of visible light.The Mott-Schottky model experiment shows that the formed type-Ⅱheterojunction between Cd-MOF and CdS can effectively inhibit the recombination of photogenerated electrons and holes.Meanwhile,the photocurrent intensity of MOF/CdS-6 is 8 times and 2.5 times of that of pure Cd-MOF and CdS.In addi-tion,MOF/CdS-6 showed good photocatalytic performance after five cycles,showing excellent stability and reusability. | Cheng Jing Yufei Zhang Junjie Zheng Shengsong Ge Jing Lin Duo Pan Nithesh Naik Zhanhu Guo | 2022 | Particuology2022，20，10： | 1 |
| 13 | Clustering uncertain data based on probability distribution similarity显示文摘 | Jiang Bin Pei Jian Tao Yufei Lin Xuemin | | 0，，： | 1 |
| 14 | Development and cross-species transferability of 23 microsatellite markers from the vulnerable Chinese Egret ( Egretta eulophotes ) using 454 sequencing显示文摘 | Yufei Dai Xiaoping Zhou Wenzhen Fang Qingxian Lin Xiaolin Chen | 2013 | Conservation Genetics Resources2013，，： | 1 |
| 15 | Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study显示文摘 | Zhou Zhiguang Xiang Yufei Ji Linong Jia Weiping Ning Guang Huang Gan Yang Lin Lin Jian Liu Zhenqi Hagopian William A Leslie R David | 2013 | Diabetes2013，，2： | 1 |
| 16 | Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts显示文摘一个单个哺乳动物的抄本通常编码一蛋白质,但是 GNAS (G 蛋白质伪 - 子单元) 的抄本包含二个读物框架并且生产二在结构上无关的蛋白质, XL 伪 s 和 ALEX。没有其它证实象 GNAS 一样双编码的抄本迄今为止被报导了,尽管许多如此的候选人基因被生物信息学分析预言了。在这研究,我们构造了一系列向量测试二个蛋白质产品怎么在 vitro 从一个单个抄本被翻译。ORF (开的读框架) 的长度,第一 8 月的位置和 Kozak 主题被发现是重要因素。这些因素,以及 55-bp NMD (调停胡说八道的 mRNA 腐烂) 规则,为候选人在生物信息学搜索被使用双编码的抄本。分别地, 1307, 750 和 474 个 two-ORF-containing 抄本的一个总数分别地, 170, 89 和 70 哪个被发现是潜在的双编码的抄本在人,老鼠和老鼠被发现。大多数抄本在种类之中显示出低保存。有趣地,双编码的抄本显著地从锌手指蛋白质家庭为抄本被充实,它通常是涉及抄写过程的规定的 DNA 有约束力的蛋白质。 | Heng Xu Ping Wang Yujie Fu Yufang Zheng Quan Tang Lizhen Si Jin You Zhenguo Zhang Yufei Zhu Li Zhou Zejun Wei Bin Lin Landian Hu Xiangyin Kong | 2010 | Cell Research2010，20，4： | 1 |
| 17 | Enzymatic conversion of Baicalin into Baicalein byβ-glucuronidase encapsulated in biomimetic core-shell structured hybrid capsules显示文摘 | Zhang Yufei Wu Hong Li Lin | 2009 | J Mol Catal B Enzyme2009，57，14： | 1 |
| 18 | SARS-CoV-2 promote autophagy to suppress type I interferon response显示文摘Dear Editor,The outbreak of SARS-CoV-2 leads global epidemic with high morbidity and mortality.However,the pathophysiology of this deadly virus is complex and largely unknown.Autophagy is a highly conserved homeostatic process that allows cells to recycle their components.Several studies provided evidence that human coronavirus infections are closely related to various cellular aspects associated with autophagy.1 Autophagy may play a crucial role in the SARS-CoV-2 viral lifecycle. | Xianfeng Hui Linliang Zhang Lei Cao Kun Huang Ya Zhao Yufei Zhang Xi Chen Xian Lin Mingzhou Chen Meilin Jin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 1 |
| 19 | Distributed Skyline Retrieval with Low Bandwidth Consumption显示文摘 | Zhu Lin Tao Yufei Zhou Yonggeng | 2009 | IEEE Transactions on Knowledge and Data Engineering2009，21，3： | 1 |
| 20 | Determination of mechanical parameters for jointed rock masses显示文摘Combining with empirical method, laboratory test and numerical simulation, a comprehensive system was presented to determine the mechanical parameters of jointed rock masses. The system has the following four functions: (1) Based on the field investigation of joints, the system can consider rock mass structures, by using network simulation technology. (2) Rock samples are conducted by numerical simulation with the input engineering mechanical parameters of rocks and joints obtained from laboratory tests. (3) The whole stress-strain curve of jointed rock masses under certain normal stress can be plotted from numerical simulation, and then the shear strength parameters of jointed rock masses can be obtained from the whole stress-strain curves under different normal stresses. (4) The statistical values of mechanical parameters of jointed rock masses can be determined according to numerical simulation. Based on the statistical values, combining with engineering experiences and geological investigations, the comprehensive mechanical parameters of jointed rock masses can be achieved finally. Several cases are presented to prove the engineering feasibility and suitability of this system. | Xiaogang Wang Yufei Zhao Xingchao Lin China | 2011 | Journal of Rock Mechanics and Geotechnical Engineering2011，3，S1： | 1 |
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