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| 1 | Insights on the solubilization products after combined alkaline and ultrasonic pre-treatment of sewage sludge显示文摘This work provides insights on the solubilization products after a simultaneous combination of alkaline and ultrasonic(ALK + ULS) pre-treatment of sewage sludge.Soluble chemical oxygen demand(SCOD) increased from 1200 to 11,000 mg/L after such treatment. Organics with molecular weight around 5.6 k Da were solubilized because of the synergistic effect of ultrasound and alkali. Organics with molecular weight larger than300 k Da increased from 7.8% to 60%, 16% and 42.3% after ULS, ALK and ALK + ULS treatment, respectively. Excitation emission matrix fluorescence spectroscopy analysis identified soluble microbial product-like and humic acid-like matters as the main solubilization products. Sludge anaerobic biodegradability was significantly enhanced with the simultaneous application of ALK + ULS pre-treatment. ALK + ULS pre-treatment resulted in 37.8% biodegradability increase compared to the untreated sludge. This value was higher compared to the biodegradability increase induced by individual ALK pre-treatment(5.7%) or individual ULS pre-treatment(20.7%) under the same conditions applied. | Xinbo Tian Chong Wang Antoine Prandota Trzcinski Leonard Lin Wun Jern Ng | 2015 | Journal of Environmental Sciences2015，27，3： | 19 |
| 2 | I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘 | Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han | 2014 | Cellular & Molecular Immunology2014，11，2： | 14 |
| 3 | Controllable Synthesis of Co304 from Nanosize to Microsize with Large-Scale Exposure of Active Crystal Planes and Their Excellent Rate Capability in Supercapacitors Based on the Crystal Plane Effect显示文摘 | Yu Wang Ziyi Zhong Yang Chen Cheng Theng Ng Jianyi Lin | 2011 | Nano Research2011，4，7： | 8 |
| 4 | Purification of melibiose-binding lectins from two cultivars of Chinese black soybeans显示文摘一二聚 50 kDa melibiose 有约束力的 lectin 从大豆(Glycine 最大) 的栽培变种的种子被孤立,叫了小光滑的黑大豆。隔离过程在胶化过滤在 Superdex 75 上跟随的 Q Sepharose, SP Sepharose 和单音的 Q 上包括了离子交换层析。lectin 在所有三离子 exchangers 上被吸附,并且它展出了与大豆 lectin 的相同的一个 N 终端序列。测试的所有糖, melibiose 最 potently 禁止了 lectin 的 hemagglutinating 活动,它在 pH 3-12 和 0-70 ° C 之间是稳定的。lectin 唤起了最大的 mitogenic 反应在大约象反对 A 的一样的臼齿的集中。然而,反应弱得多。大豆 lectin 分别地与 2.82 μM, 2.6 μM 和 4.1 μM 的 IC 50 象乳癌 MCF7 房间和 hepatoma HepG2 房间的增长一样禁止了 HIV-1 反向的 transcriptase 的活动。没有抗真菌的活动。另一 lectin 从称为很少黑大豆的大豆的不同栽培变种被孤立。lectin 除了一个更大的子单元实质上类似于小光滑的黑大豆 lectin 分子的质量(31 kDa ) ,一项更多的有势力 mitogenic 活动和更低的 thermostability。结果显示大豆的不同栽培变种生产不在每个方面是相同的 lectins。 | Peng Lin Xiujuan Ye TB Ng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 7 |
| 5 | Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis显示文摘RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem cells.Altogether, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma Ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2019 | Protein & Cell2019，10，9： | 7 |
| 6 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 7 |
| 7 | Advances in lithium niobate photonics:development status and perspectives显示文摘Lithium niobate(LN)has experienced significant developments during past decades due to its versatile properties,especially its large electro-optic(EO)coefficient.For example,bulk LN-based modulators with high speeds and a superior linearity are widely used in typical fiber-optic communication systems.However,with everincreasing demands for signal transmission capacity,the high power and large size of bulk LN-based devices pose great challenges,especially when one of its counterparts,integrated silicon photonics,has experienced dramatic developments in recent decades.Not long ago,high-quality thin-film LN on insulator(LNOI)became commercially available,which has paved the way for integrated LN photonics and opened a hot research area of LN photonics devices.LNOI allows a large refractive index contrast,thus light can be confined within a more compact structure.Together with other properties of LN,such as nonlinear/acousto-optic/pyroelectric effects,various kinds of high-performance integrated LN devices can be demonstrated.A comprehensive summary of advances in LN photonics is provided.As LN photonics has experienced several decades of development,our review includes some of the typical bulk LN devices as well as recently developed thin film LN devices.In this way,readers may be inspired by a complete picture of the evolution of this technology.We first introduce the basic material properties of LN and several key processing technologies for fabricating photonics devices.After that,various kinds of functional devices based on different effects are summarized.Finally,we give a short summary and perspective of LN photonics.We hope this review can give readers more insight into recent advances in LN photonics and contribute to the further development of LN related research. | Guanyu Chen Nanxi Li Jun Da Ng Hong-Lin Lin Yanyan Zhou Yuan Hsing Fu Lennon Yao Ting Lee Yu Yu Ai-Qun Liu Aaron J.Danner | 2022 | Advanced Photonics2022，4，3： | 6 |
| 8 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
| 9 | Impact of ozone assisted ultrasonication pre-treatment on anaerobic digestibility of sewage sludge显示文摘Impact of ultrasonication(ULS) and ultrasonication–ozonation(ULS-Ozone) pre-treatment on the anaerobic digestibility of sewage sludge was investigated with semi-continuous anaerobic reactors at solid retention time(SRT) of 10 and 20 days. The control, ULS and ULS-Ozone reactors produced 256, 309 and 348 m L biogas/g CODfedand the volatile solid(VS) removals were 35.6%, 38.3% and 42.1%, respectively at SRT of 10 days. At SRT of20 days, the biogas yields reached 313, 337 and 393 m L biogas/g CODfedand the VS removal rates were 37.3%, 40.9% and 45.3% in the control, ULS and ULS-Ozone reactors, respectively.ULS-Ozone pre-treatment increased the residual organic amount in the digested sludge.These soluble residual organics were found to contain macromolecules with molecular weights(MW) larger than 500 k Da and smaller polymeric products with MW around 19.4and 7.7 k Da. These compounds were further characterized to be humic acid-like substances with fluorescent spectroscopy analysis. | Xinbo Tian Antoine Prandota Trzcinski Li Leonard Lin Wun Jern Ng | 2015 | Journal of Environmental Sciences2015，27，7： | 5 |
| 10 | Prokaryotical expression of structural and non-structural proteins of hepatitis G virus显示文摘AIM To study the epitope distribution of hepatitis G virus (HGV) and to seek for the potential recombinant antigens for the development of HGV diagnositic reagents.METHODS Fourteen clones encompassing HGV gene fragments from core to NS3 and NS5 were constructed using prokaryotic expression vector pRSET and (or)pGEX. and expressed in E. coli. Western blotting and ELISA were used to detect the immunoreactivity of these recombinant proteins.``RESULTS One clone with HGV fragment from core to El(Gl). one from E2 (G31), three from NS3 (G6, G61, G7),one from NS5B (G821) and one chimeric fragment from NS3and NS5B (G61 821) could be expressed well and showed obvious immunoreactivity by Western blotting.One clone with I-KGV framment from NS5B (G82) was also well expressed, but could not show immunoreactivity by Western blotting. No obvious expression was found in the other six clones. All the expressed recombinant proteins were in inclusion body form, except the protein G61 which could be expressed in soluble form. Further purified recombinant proteins Gl, G,31, G61, G821 and G61 821were detected in indirected ELISA as coating antigen respectively. Only recombinant Gl could still show immunoreactivity, and the other four recombinant proteins failed to react to the HGV antibody positive sera.Western blotting results indicated that the immunoactivity of these four recombinant proteins were lost during purification.``CONCLUSION Core to El, E2. NS3 and NS5 fragment of HGV contain antigenic epitopes, which could be produced in prokaryotically expressed recombinant proteins. A high. yield recombinant protein (Gl) located in HGV core to E1 could remain its epitope after purification, which showed the potential that G1 could be used as a coating antigen to develop an ELISA kit for HGV specific antibody diagnosis. | Ning-Shao Xia~1 Hai-Jie Yang~1 Jun Zhang~1 Chang-Qing Lin~1 Ying-Bin Wang~1 Juan Wang~1 Mei-Yun Zhan~2 MH Ng~3 1 Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering,Xiamen University,Xiamen 361005,Fujian Province,China2 Institute of Virology,Chinese Academy of Preventive Medicine Beijing 100052,China3 Department of Microbiology,Hoog Kong University,Hongkong,China | 2001 | World Journal of Gastroenterology2001，7，5： | 4 |
| 11 | Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells显示文摘 | Stephanie Ma Kwok–Wah Chan Liang Hu Terence Kin–Wah Lee Jana Yim–Hung Wo Irene Oi–Lin Ng Bo–Jian Zheng Xin–Yuan Guan | 2007 | Gastroenterology2007，，7： | 4 |
| 12 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion. | Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 13 | Alkali and Silane Treatments towards Exemplary Mechanical Properties of Kenaf and Pineapple Leaf Fibre-reinforced Composites显示文摘Following the contemporary research trend of exploring the potential of eco-friendly natural fibres,this work studies the effects of alkali and silane treatments,with varying concentrations,on the mechanical characterization of composites reinforced with kenaf and pineapple leaf fibre(PALF).Kenaf-and PALF-based composites were fabricated through the heat compression method.Their mechanical characterization was then performed to evaluate the tensile,flexural and impact properties.The findings concluded that chemical treatments indeed enhanced the mechanical properties of composite materials.5%NaOH and 3%silane treatments can respectively provide the optimum mechanical properties to the kenaf fibre and PALF reinforced composites.Chemical treatment results evidenced that silane-treated composites exhibit higher mechanical properties compared to the NaOH-treated composites.When comparing the mechanical properties of kenaf-and PALF-reinforced polypropylene composites,the overall results show that composites based on PALF have superior mechanical properties. | Ng Lin Feng Sivakumar Dhar Malingam Nadlene Razali Sivarao Subramonian | 2020 | Journal of Bionic Engineering2020，17，2： | 3 |
| 14 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 3 |
| 15 | A review of computational tools for design and reconstruction of metabolic pathways显示文摘Metabolic pathways reflect an organism's chemical repertoire and hence their elucidation and design have been a primary goal in metabolic engineering.Various computational methods have been developed to design novel metabolic pathways while taking into account several prerequisites such as pathway stoichiometry,thermodynamics,host compatibility,and enzyme availability.The choice of the method is often determined by the nature of the metabolites of interest and preferred host organism,along with computational complexity and availability of software tools.In this paper,we review different computational approaches used to design metabolic pathways based on the reaction network representation of the database(i.e.,graph or stoichiometric matrix)and the search algorithm(i.e.,graph search,flux balance analysis,or retrosynthetic search).We also put forth a systematic workflow that can be implemented in projects requiring pathway design and highlight current limitations and obstacles in computational pathway design. | Lin Wang Satyakam Dash Chiam Yu Ng Costas D.Maranas | 2017 | Synthetic and Systems Biotechnology2017，2，4： | 3 |
| 16 | Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients显示文摘Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease burden.We aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan criteria.Methods:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria.Meta-analyses and meta-regression were conducted using random-effects models.Results:We screened 2,278 studies and included 35 studies with 18,421 patients.LR was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)studies.In uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to LT.Survival between LR and LT were similar in uninodular disease.The risk of recurrence after LR is threefold that of LT. | Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 17 | Tapering-induced enhancement of light extraction efficiency of nanowire deep ultraviolet LED by theoretical simulations显示文摘A nanowire(NW) structure provides an alternative scheme for deep ultraviolet light emitting diodes(DUV-LEDs)that promises high material quality and better light extraction efficiency(LEE). In this report, we investigate the influence of the tapering angle of closely packed Al Ga N NWs, which is found to exist naturally in molecular beam epitaxy(MBE) grown NW structures, on the LEE of NW DUV-LEDs. It is observed that, by having a small tapering angle, the vertical extraction is greatly enhanced for both transverse magnetic(TM) and transverse electric(TE) polarizations. Most notably, the vertical extraction of TM emission increased from 4.8% to 24.3%,which makes the LEE reasonably large to achieve high-performance DUV-LEDs. This is because the breaking of symmetry in the vertical direction changes the propagation of the light significantly to allow more coupling into radiation modes. Finally, we introduce errors to the NW positions to show the advantages of the tapered NW structures can be projected to random closely packed NW arrays. The results obtained in this paper can provide guidelines for designing efficient NW DUV-LEDs. | RONGHUI LIN SERGIO VALDES GALAN HAIDING SUN YANGRUI HU MOHD SHARIZAL ALIAS BILAL JANJUA TIEN KHEE NG BOON S.OOI XIAOHANG LI | 2018 | Photonics Research2018，6，5： | 3 |
| 18 | Anti-hypercholesterolemic effect of kenaf(Hibiscus cannabinus L.)seed on high-fat diet Sprague dawley rats显示文摘Objective:To determine? the anlihypercholesterolemic effects of kenaf seed samples and compare with the commercial hypocholesterolemic drug on serum lipids profiles and malondialdehyde(MDA) level in the rat.Methods:Kenaf seed oil(KSO),microencapsulated kenaf seed oil(MKSO),kenaf seed extract(KSE) and defatted kenaf seed meal(DKSM) were prepared and phytocHemicals screening on these samples were done prior in viro study.Phenolic compounds in KSF.were quantified using high performance liquid chromatography.There were 40(divided in eight diet groups of 5) male Sprague dawley rats adapted lo normal standard diet or hypercholesterolemic diet(HD) with or without the treatment of these kenaf samples for 32 days.Results:All the kenaf samples exhibited to contain most of the major phytocliemicals.KSE possessed gallic acid,tannic acid,catechin.benzaldehyde.benzoic acid,syringic acid,sinapic acid,ferulic acid,naringin acid,and protocatechuic acid.The significant higher(P<0.05) serum total cholesterol,low density lipoprotein cholesterol and MDA levels in HD group without treatment than the normal control group suggested the hypercholesterolemia was induced by the Incorporation of cholesterol into diet.KSE exhibited higher cholesterol-lowering properties due to the significant lower(P<0.05)in serum triglycerides,total cholesterol and MDA levels.KSF showed the highest efficiency of cholesterol-lowering activity,followed by KSO.MKSO and DKSM.Conclusions:DKSM.MKSO.KSO and KSE appeared lo have comparable anti-hypercholesterolemic effect with the commercial hypocholesterolemic drug.Hence,kenaf seed could be used as an alternative natural source lo replace the synthetic hypocholosterolemic drugs. | Ng Shy Kai Tee Ai Nee Elaine Lai Chia Ling Tan Chin Ping Long Kamariah Nyam Kar Lin | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，1： | 2 |
| 19 | Multidetector-Row Computed Tomography (CT) of Blunt Pancreatic Injuries: Can Contrast-Enhanced Multiphasic CT Detect Pancreatic Duct Injuries?显示文摘 | Yon-Cheong Wong Li-Jen Wang Jen-Feng Fang Being-Chuan Lin Chip-Jin Ng Ray-Jade Chen | 2008 | The Journal of Trauma: Injury, Infection, and Critical Care2008，，3： | 2 |
| 20 | Current Management of Nasopharyngeal Cancer显示文摘 | Anne W.M. Lee Jin C. Lin Wai T. Ng | 2012 | Seminars in Radiation Oncology2012，，3： | 2 |
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