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440篇 您的检索式:作者名="LIN Ju"
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1LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer显示文摘Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate energy metabolism in cancer.However,lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present.In this review,we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes,transcription factors,and other proteins involved in metabolic pathways.In addition,we discuss the mechanisms through which these interactions contribute to tumor initiation and progression,and the key roles and clinical significance of functional lncRNAs.We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.Yue-Tao Tan Jin-Fei Lin Ting Li Jia-Jun Li Rui-Hua Xu Huai-Qiang Ju 2021Cancer Communications2021,41,2:92
2Clinical diagnostic performance of the simultaneous amplification and testing methods for detection of the Mycobacterium tuberculosis complex for smear-negative or sputum-scarce pulmonary tuberculosis in China显示文摘Fan Lin Zhang Qing Cheng Liping Liu Zhibing Ji Xiaobing Cui Zhenling Ju Jingliang Xiao Heping 2014Chinese Medical Journal2014,,10:19
3Spectra response from macromolecular structure evolution of tectonically deformed coal of different deformation mechanisms显示文摘Coals with different deformation mechanisms(brittle deformation,brittle-ductile deformation,and ductile deformation) repre-sent different ways in macromolecular structure evolution based on the metamorphism.The evolution of coal structure could affect the occurrence condition of coalbed methane(CBM) because the nanopore structure affected by macromolecular struc-ture is the most important reservoir for CBM.This paper analyzes the evolutions and mechanisms of structure and functional group of tectonically deformed coals(TDCs) collected from Huainan-Huaibei coalfield using X-ray diffraction(XRD),Raman spectroscopy,and Fourier Transform Infrared(FTIR) spectroscopy methods.The results show that the macromolecular struc-ture evolutions of TDC are different from the primary structure coal as a result of the different metamorphic grade and defor-mation mechanisms.The different deformation mechanisms variously affect the process of functional group and polyconden-sation of macromolecular structure.Furthermore,the tectonic deformation leads to secondary structural defects and reduces the structure stability of TDC.The coupled evolution on stacking and extension caused by the changes of secondary structural de-fects results from different deformation mechanisms.We consider that the changes of chemical structure and secondary struc-tural defects are the primary reasons for the various structure evolutions of TDC compared with primary structure coal.LI XiaoShi JU YiWen HOU QuanLin LIN Hong 2012Science China Earth Sciences2012,55,8:18
4Association of Estrogen Receptor I Genetic Polymorphisms with Recurrent Spontaneous Abortion Risk显示文摘Xun-Qiang Yin Hong-Mei Ju Qiang Guo Lin Zhao Xiao-Xiao Zhu Ran Wei Zhen Zhang Yun-Hong Zhang Bin Wang Xia Li 2018Chinese Medical Journal2018,,15:18
5Environmental changes reflected by n-alkanes of lake core in Nam Co on the Tibetan Plateau since 8.4 kaB.P.显示文摘The n-alkanes are extracted from NMLC-1 core that was drilled in the Nam Co, central Tibet. They are measured by using Gas Chromatography and Mass Spectrometry (GC/MS) for componential and quantitative analyses. According to the constructed depth-age model, the component and concentration of n-alkanes, together with total organic carbon (TOC), total nitrogen (TN) and carbonate are used to elu- cidate palaeoenvironmental changes of Nam Co during the past 8.4 ka. The results indicate that Holo- cene environment performs three stages in the lake area. In the stage of 8.4―6.7 kaB.P., it was warmer while precipitation slightly increased. This stage was ended by an obvious cold/dry event. During 6.7― 5.8 kaB.P., temperature increased rapidly and reached its maximum values at about 6.0 kaB.P. The environments were warm/wet optimum for the blooming of terrestrial plants and submerged aquatic plants. After that, temperature decreased continuously and showed the lowest values at about 3.0 kaB.P. From 2.9 kaB.P. to the present, temperature rose again but alternated with cold and warm. The lake area tended to be dry after 1.4 kaB.P. During 600―400 aB.P., the environmental feature was the reflection of 'Little Ice Age'.LIN Xiao ZHU LiPing WANG Yong WANG JunBo XIE ManPing JU JianTing Roland MAUSBACHER Antje SCHWALB 2008Chinese Science Bulletin2008,53,19:14
6High-security-level multi-dimensional optical storage medium:nanostructured glass embedded with LiGa_(5)O_(8):Mn^(2+) with photostimulated luminescence显示文摘The launch of the big data era puts forward challenges for information preservation technology,both in storage capacity and security.Herein,a brand new optical storage medium,transparent glass ceramic(TGC)embedded with photostimulated LiGa5O8:Mn2+nanocrystals,capable of achieving bit-by-bit optical data write-in and read-out in a photon trapping/detrapping mode,is developed.The highly ordered nanostructure enables light–matter interaction with high encoding/decoding resolution and low bit error rate.Importantly,going beyond traditional 2D optical storage,the high transparency of the studied bulk medium makes 3D volumetric optical data storage(ODS)possible,which brings about the merits of expanded storage capacity and improved information security.Demonstration application confirmed the erasable-rewritable 3D storage of binary data and display items in TGC with intensity/wavelength multiplexing.The present work highlights a great leap in photostimulated material for ODS application and hopefully stimulates the development of new multi-dimensional ODS media.Shisheng Lin Hang Lin Chonggeng Ma Yao Cheng Sizhe Ye Fulin Lin Renfu Li Ju Xu Yuansheng Wang 2020Light(Science & Applications)2020,9,1:12
7Effect of NDC80 in human hepatocellular carcinoma显示文摘AIM To investigate the role of nuclear division cycle(NDC)80in human hepatocellular carcinogenesis.METHODS NDC80 gene expression was analyzed by real-time reverse transcription polymerase chain reaction in 47paired hepatocellular carcinoma(HCC)and adjacent tissues.The HCC cell line SMMC-7721 was transfected with lentivirus to silence endogenous NDC80 gene expression,which was confirmed by real-time polymerase chain reaction and western blotting.The effects of NDC80silencing on SMMC-7721 cell proliferation were evaluated by Cellomics Array Scan VTI imaging.Cell cycle analysis and apoptosis were detected with flow cytometry.Colony formation was assessed by fluorescence microscopy.RESULTS NDC80 expression levels in HCC tissues were significantly higher than those in the adjacent tissues.Functional studies demonstrated that NDC80 silencing significantly reduced SMMC-7721 cell proliferation and colony formation.Knockdown of NDC80 resulted in increased apoptosis and cell cycle arrest at S-phase.NDC80 contributed to HCC progression by reducing apoptosis and overcoming cell cycle arrest. CONCLUSION Elevated expression of NDC80 may play a role in promoting the development of HCC.Lin-Ling Ju Lin Chen Jun-Hong Li Yi-Fan Wang Ru-Jian Lu Zhao-Lian Bian Jian-Guo Shao 2017World Journal of Gastroenterology2017,23,20:12
8Heterogeneous oxidation of cyclohexanone catalyzed by TS-1:Combined experimental and DFT studies显示文摘Changjiu Xia Long Ju Yi Zhao Hongyi Xu Bin Zhu Feifei Gao Min Lin Zhenyu Dai Xiaodong Zou Xingtian Shu 2015催化学报2015,36,6:11
9First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level.XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua 2014Science China(Physics,Mechanics & Astronomy)2014,57,11:10
10PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented.CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua 2014Science China(Physics,Mechanics & Astronomy)2014,57,8:9
11Large-scale real-world radio signal recognition with deep learning显示文摘In the past ten years, many high-quality datasets have been released to support the rapid development of deep learning in the fields of computer vision, voice, and natural language processing. Nowadays, deep learning has become a key research component of the Sixth-Generation wireless systems(6G) with numerous regulatory and defense applications. In order to facilitate the application of deep learning in radio signal recognition, in this work, a large-scale real-world radio signal dataset is created based on a special aeronautical monitoring system-Automatic Dependent Surveillance-Broadcast(ADS-B). This paper makes two main contributions. First, an automatic data collection and labeling system is designed to capture over-the-air ADS-B signals in the open and real-world scenario without human participation. Through data cleaning and sorting, a high-quality dataset of ADS-B signals is created for radio signal recognition. Second, we conduct an in-depth study on the performance of deep learning models using the new dataset, as well as comparison with a recognition benchmark using machine learning and deep learning methods.Finally, we conclude this paper with a discussion of open problems in this area.Ya TU Yun LIN Haoran ZHA Ju ZHANG Yu WANG Guan GUI Shiwen MAO 2022Chinese Journal of Aeronautics2022,35,9:9
12The spatial distribution and sedimentary processes of organic matter in surface sediments of Nam Co,Central Tibetan Plateau显示文摘In this study,67 surface sediment samples collected from Nam Co in central Tibet were analyzed for total carbon,total organic carbon and total nitrogen,and 51 of these samples were also analyzed for n-alkanes.The origin and spatial distribution of organic matter were then investigated using these proxies,and the control factors responsible for the spatial distribution patterns and paleolimnological significance were discussed.The results indicated that the origin of organic matter in surface sediment of Nam Co is consistent with the sources of n-alkanes,which were primarily submerged plants,followed by terrestrial plants,and then aquatic algae and bacteria.The organic matter in surface sediments of the lake showed typical spatial variability.Because of the great influence of underwater topography,river inputs and water quality,the spatial distribution of organic matter is enriched from the source to the deposit center.This spatial variability of organic matter in the lake indicates that the sediments in different areas have different sensitivities to environmental changes,which is important to reconstruction of paleoenvironments and paleoclimate using lake sediment cores.WANG Yong ZHU LiPing WANG JunBo JU JianTing LIN Xiao 2012Chinese Science Bulletin2012,57,36:9
13Composition, spatial distribution, and environmental significance of water ions in Pumayum Co catchment, southern Tibet显示文摘主要阳离子(Mg2+ , Ca2+ , Na+ ,和 K+) 和阴离子的化学(HCO3 ? , SO4 2 ? ,并且 Cl ?) 在普麦乌姆湖的水里,公司和它的流入河被学习,在各种各样的流入河和湖之中揭示明显的离子的差别。湖水的化学类型是 Mg2+-Ca2+-HCO3 ?-SO4 2+ ,但是主要流入河的主要离子是 Ca2+-Mg2+-HCO3 ? 。在 Jiaqu 河的湖入口,主要流入河,有在深度以内的水化学的重要变化不到 2 m。然而,它在湖的另外的区域是几乎同类的。与水化学和湖水的氧同位素的分发的证据,因此,一个结论能被构画出那条 Jiaqu 河在沉没三角洲上在水的 hydrochemistry 上有不同效果,而这为另外的河不是事实。吉布斯阴谋表明负责控制湖水的化学作文的主导的机制是在排水区域捱过的岩石。离子比率和第三的阴谋进一步探索了控制集水的水化学的主要过程,即,捱过的碳酸盐,捱过的黄铁矿,并且硅酸盐捱过。在河水和湖水之间的不同 hydrochemistry 特征可以源于 CaCO3 降水。调查结果将在湖在 paleolimnological 研究有益于碳酸盐的环境意义的解释。ZHU Liping JU Jianting WANG Yong XIE Manping WANG Junbo PENG Ping ZHEN Xiaolin LIN Xiao 2010Journal of Geographical Sciences2010,20,1:9
14Spraying printing of liquid metal electronics on various clothes to compose wearable functional device显示文摘Liquid metal printing is emerging as an important tool for making wearable electronics. However, very limited academic efforts were made to fulfill such an increasing need. This paper is dedicated to present relatively complete theoretical and experimental characterizations for liquid metal spraying printing towards developing wearable electronic textile. The practical conditions of liquid metal droplets in the spraying printing process such as the jet velocity, the size distribution of droplets and their evenness degree, the morphology of droplets and their unrolling areas after impacting the substrate are quantified. The dominating factors, including the oxidation of liquid metal and the pressure force on cloth substrate during the impacting process, which ensure liquid metal firmly adhere to the cloth, are clarified. Further, various clothes are comparatively investigated to test their capabilities in printing liquid metal conductors, where the resistance difference can be over thousand-fold. In addition to interpreting the basic mechanisms and performances of the spraying printing, two programmable flexible circuits with specifically designed functions such as blinking LED lighting and wireless infrared temperature measurement via current manufacture technology were also demonstrated and evaluated for their washable ability. With the realization of wearable modules via liquid metal printing technology, it can be expected that flexible functional devices on cloth fabricated quickly and directly would witness more broad applications in the coming time.GUI Han TAN SiCong WANG Qian YU Yang LIU FuJun LIN Ju LIU Jing 2017Science China(Technological Sciences)2017,60,2:8
15Stress-induced CsPbBr3 nanocrystallization on glass surface:Unexpected mechanoluminescence and applications显示文摘In this work,we discovered an unexpected mechanoluminescence (ML) phenomena occurring when transforming amorphous into crystalline,due to the stress-induced precipitation of CsPbBr3 perovskite nanocrystals on glass surface.It is revealed that,unlike the conventional thermal-induced phase transformation mechanism,the breakage of bonding of glass network provides the energy for nucleation and growth,and the shear stress avoids the long-range migration of structural units for crystallization.Such unique ML phenomenon enables the visualization of dynamical force that is inaccessible by common strategy,and so,opens up some novel applications,such as the pressure-sensitive 'glassy pencil' to learn people's writing habits,and the pb^2+-detection with good sensitivity and selectivity.These findings not only demonstrate an effective route for the preparation of perovskite materials in a green,time-saving,low cost,and scalable way,enrich the knowledge of glass crystallization mechanism,but also exploit a useful avenue to quantitatively visualize the dynamical force.Xiaoqiang Xiang Hang Lin Renfu Li Yao Cheng Qingming Huang Ju Xu Congyong Wang Xueyuan Chen Yuansheng Wang 2019Nano Research2019,12,5:8
16Photocatalytic degradation of organic pollutants by MOFs based materials:A review显示文摘Metal-organic frameworks(MOFs)are currently popular porous materials with research and application value in various fields.Aiming at the application of MOFs in photocatalysis,this paper mainly reviews the main synthesis methods of MOFs and the latest research progress of MOFs-based photocatalysts to degrade organic pollutants in water,such as organic dyes,pharmaceuticals and personal care products,and other organic pollutants.The main characteristics of different synthesis methods of MOFs,the main design strategies of MOFs-based photocatalysts,and the excellent performance of photocatalytic degradation of organic pollutants are summarized.At the end of this paper,the practical application of MOFs,the current limitations of MOFs,the synthesis methods of MOFs,and the future development trend of MOFs photocatalysts are explained.Tianliang Xia Yingchao Lin Weizun Li Meiting Ju 2021Chinese Chemical Letters2021,32,10:8
17A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling显示文摘Long noncoding RNAs(lncRNAs)are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.Liquid–liquid phase separation(LLPS)occurs in a wide range of biological processes,while its role in signal transduction remains largely undeciphered.In this study,we uncovered a lipid-associated lncRNA,small nucleolar RNA host gene 9(SNHG9)as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1(LATS1)and inhibiting the Hippo pathway.Mechanistically,SNHG9 and its associated phosphatidic acids(PA)interact with the C-terminal domain of LATS1,promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation.Loss of SNHG9 suppresses xenograft breast tumor growth.Clinically,expression of SNHG9 positively correlates with YAP activity and breast cancer progression.Taken together,our results uncover a novel regulatory role of a tumor-promoting lncRNA(i.e.,SNHG9)in signal transduction and cancer development by facilitating the LLPS of a signaling kinase(i.e.,LATS1).Rui-Hua Li Tian Tian Qi-Wei Ge Xin-Yu He Cheng-Yu Shi Jun-Hong Li Zhen Zhang Fang-Zhou Liu Ling-Jie Sang Zuo-Zhen Yang Ya-Zhuo Liu Yan Xiong Qingfeng Yan Xu Li Huai-Qiang Ju Jian Liu Liang-Jing Wang Jian-Zhong Shao Wenqi Wang Tianhua Zhou Aifu Lin 2021Cell Research2021,31,10:6
18Robust superhydrophobic polyurethane sponge functionalized with perfluorinated graphene oxide for efficient immiscible oil/water mixture, stable emulsion separation and crude oil dehydration显示文摘In recent years, graphene oxide(GO), prepared by the modified Hummers’ method, and its derivatives have become a focus of research owing to their outstanding physical and chemical properties and low cost. Drawing inspiration from the mussel protein,a facile and environmentally-friendly method was employed to fabricate superhydrophobic/superoleophilic reduced graphene oxide(rGO) derivative. The preparation comprises two steps: coating GO nanosheets with polydopamine(PDA) and subsequent reaction with 1H,1H,2H,2H-perfluorodecanethiol. Due to the excellent adhesive ability of PDA, the resulting f PDA modified rGO nanosheets(rGO-f PDA) were firmly immobilized onto polyurethane(PU) sponge skeleton by a simple drop-coating method. The as-prepared rGO-f PDA functionalized sponge exhibited superhydrophobic behavior with a water contact angle of 162°±2°, high organic adsorption capacity, recyclability and stable oil/water separation behavior under different acidic/alkaline conditions. Due to its facile fabrication technique and outstanding properties, the superhydrophobic-superoleophilic PU-rGOf PDA sponge holds great promise as an oil adsorbent for cleaning up large-scale pollution of oil and organic solvents, and dehydrating crude oil.CAO Ning GUO JingYu BOUKHERROUB Rabah SHAO QingGuo ZANG XiaoBei LI Jin LIN XueQiang JU Hong LIU EnYang ZHOU ChaoFan LI HuiPing 2019Science China(Technological Sciences)2019,62,9:6
19Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2.HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou 2019Science China(Physics,Mechanics & Astronomy)2019,62,3:6
20Yang-tonifying traditional Chinese medicinal plants and their potential phytoandrogenic activity显示文摘The concept of phytoandrogens, plants that contain androgens or those that stimulate androgenic activity in men, is relatively new. In traditional Chinese medicine a number of phytoandrogens are classified in medicinal plant restoratives for reinforcing yang, and they find their application in the treatment of the kidney yang deficiency diseases. In this review, the phytoandrogens used in traditional Chinese medicine are listed, and their proven applications in the treatment of kidney yang deficiency diseases, such as sexual disorders, cancer, and obesity and associated metabolic syndromes are presented. As a background, the mechanism of action of androgens, their synthesis and metabolism, the interrelations of androgens and estrogens, as well as the state of art methods to detect and analyze these hormonal activities in medicinal plants are discussed.Munyangaju Jose Edouard MIAO Lin FAN Guan-Wei Barnabas Bessem Orang Ojong ZHEN Hu ZHANG Ju GAO Xiu-Mei ZHU Yan 2014Chinese Journal of Natural Medicines2014,12,5:5
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