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| 1 | shRNA targeting HDGF suppressed cell growth and invasion of squamous cell lung cancer显示文摘导出 Hepatoma 的生长因素(HDGF ) ,有 mitogenic 的原子蛋白质和 angiogenic 活动,被报导了主要涉及 tumorigenesis 和非小的房间肺癌症的前进。在这研究, HDGF 表示被 specific-shRNA 与在肺指向 HDGF 的 lentivirus 表示向量击倒有鳞的房间癌 520 房间。shRNA 击倒的 HDGF 在 vitro 并且在由 MTT,板克隆和移植肿瘤模型试金显示了的 vivo 显著地压制了房间增长。另外, HDGF 的组合式的表达式也禁止了出现在 transwell 和 Boyden 实验的房间移植和侵略。因为参予有鳞的房间肺癌症的致病的 oncogene,和 HDGF 可以是为非小的房间肺癌症的一个关键治疗学的目标,我们断定 HDGF 行动。 | Jie Meng Wei Xie Liming Cao Chengping Hu Zhiyuan Zhen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 19 |
| 2 | A carbon-oxygen-bridged ladder-type building block for efficient donor and acceptor materials used in organic solar cells显示文摘A carbon-oxygen-bridged ladder-type donor unit(CO5) was invented and prepared via an ‘‘intramolecular demethanolization cyclization' approach. Its single crystal structure indicates enhanced planarity compared with the carbon-bridged analogue indacenodithiophene(IDT). Owing to the stronger electron-donating capability of CO5 than IDT, CO5-based donor and acceptor materials show narrower bandgaps. A donor-acceptor(D-A) copolymer donor(PCO5TPD) and an A-D-A nonfullerene acceptor(CO5IC) demonstrated higher performance than IDT-based counterparts, PIDTTPD and IDTIC, respectively. The better performance of CO5-based materials results from their stronger light-harvesting capability and higher charge-carrier mobilities. | Zuo Xiao Fan Liu Xinjian Geng Jianqi Zhang Shizhe Wang Yujun Xie Zhen Li Huai Yang Yongbo Yuan Liming Ding | 2017 | Science Bulletin2017，62，19： | 16 |
| 3 | Study on the morphology, crystalline structure and thermal properties of yam starch acetates with different degrees of substitution显示文摘This study was carried out to understand and establish the changes in physicochemical properties of starch extracted from Chinese yam (Dioscorea opposita Thunb.) after acetylation. Yam starch acetates with different degrees of substitution (DS) were prepared by the reaction of yam starch with glacial acetic acid/acetic anhydride using sulfuric acid as the catalyst. Their formation was confirmed by the presence of the carbonyl signal around 1750 cm-1 in the Fourier transform infrared (FT-IR) spectra. The thermal behavior of the native starch and starch acetate were investigated using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results reveal that the starch acetates are more thermally stable than the native starch. The starch esters showed 50% weight loss at tem- peratures from 328℃ to 372 ℃ , while the native starch underwent 50% weight loss at 325℃ . The glass transition temperature (Tg) of the starch decreased from 273℃ to 226℃. The X-ray diffraction (XRD) patterns could be classified as typical of the C-type for yam starch. X-ray diffraction also showed the loss of the ordered C-type starch crystalline structure and the degree of crystallinity of starch de- creased from 36.10% to 10.96% with the increasing DS. The scanning electron microscopy (SEM) sug- gested that the most of the starch granules disintegrated with many visible fragments with the in- creasing DS. | WANG Xu GAO WenYuan ZHANG LiMing XIAO PeiGen YAO LiPing LIU Yi LI KeFeng XIE WeiGuang | 2008 | Science China Chemistry2008，51，9： | 11 |
| 4 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 5 | Bisphosphonate-based nanocomposite hydrogels for biomedical applications显示文摘Nanocomposite hydrogels consist of polymeric network embedded with functional nanoparticles or nanostructures,which not only contribute to the enhanced mechanical properties but also exhibit the bioactivities for regulating cell behavior.Bisphosphonates(BPs)are capable of coordinating with various metal ions and modulating bone homeostasis.Thanks to the inherent dynamic properties of metal–ligand coordination bonds,BPbased nanocomposite hydrogels possess tunable mechanical properties,highly dynamic structures,and the capability to mediate controlled release of encapsulated therapeutic agents,thereby making them highly versatile for various biomedical applications.This review presents the comprehensive overview of recent developments in BP-based nanocomposite hydrogels with an emphasis on the properties of embedded nanoparticles(NPs)and interactions between hydrogel network and NPs.Furthermore,various challenges in the biomedical applications of these hydrogels are discussed to provide an outlook of potential clinical translation. | Weihao Yuan Zhuo Li Xian Xie Zhi-Yong Zhang Liming Bian | 2020 | Bioactive Materials2020，5，4： | 7 |
| 6 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 7 | Quantitative study of protein coronas on gold nano- particles with different surface modifications显示文摘 | Menghua Cui Renxiao Liu Zhaoyi Deng Guanglu Ge Ying Liu Liming Xie | 2014 | Nano Research2014，7，3： | 6 |
| 8 | Mussel‑Inspired Redox‑Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics显示文摘Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles(CP NPs),while endowing the CP NPs with redox activity and biocompatibility.This is a universal strategy applicable for a series of CPs,including polyaniline,polypyrrole,and poly(3,4-ethylenedioxythiophene).The catechol/quinone contained sulfonated lignin(LS)was doped into various CPs to form CP/LS NPs with hydrophilicity,conductivity,and redox activity.These CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term adhesiveness.The CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network,forming a well-connected electric path.The hydrogel exhibits long-term adhesiveness,which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS NPs.This conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics. | Donglin Gan Tao Shuai Xiao Wang Ziqiang Huang Fuzeng Ren Liming Fang Kefeng Wang Chaoming Xie Xiong Lu | 2020 | Nano-Micro Letters2020，12，12： | 4 |
| 9 | Building Osteogenic Microenvironments with a Double-Network Composite Hydrogel for Bone Repair显示文摘The critical factor determining the in vivo effect of bone repair materials is the microenvironment,which greatly depends on their abilities to promote vascularization and bone formation.However,implant materials are far from ideal candidates for guiding bone regeneration due to their deficient angiogenic and osteogenic microenvironments.Herein,a double-network composite hydrogel combining vascular endothelial growth factor(VEGF)-mimetic peptide with hydroxyapatite(HA)precursor was developed to build an osteogenic microenvironment for bone repair.The hydrogel was prepared by mixing acrylatedβ-cyclodextrins and octacalcium phosphate(OCP),an HA precursor,with gelatin solution,followed by ultraviolet photo-crosslinking.To improve the angiogenic potential of the hydrogel,QK,a VEGF-mimicking peptide,was loaded in acrylatedβ-cyclodextrins.The QK-loaded hydrogel promoted tube formation of human umbilical vein endothelial cells and upregulated the expression of angiogenesis-related genes,such as Flt1,Kdr,and VEGF,in bone marrow mesenchymal stem cells.Moreover,QK could recruit bone marrow mesenchymal stem cells.Furthermore,OCP in the composite hydrogel could be transformed into HA and release calcium ions facilitating bone regeneration.The double-network composite hydrogel integrated QK and OCP showed obvious osteoinductive activity.The results of animal experiments showed that the composite hydrogel enhanced bone regeneration in skull defects of rats,due to perfect synergistic effects of QK and OCP on vascularized bone regeneration.In summary,improving the angiogenic and osteogenic microenvironments by our double-network composite hydrogel shows promising prospects for bone repair. | Jiaying Li Jinjin Ma Qian Feng En Xie Qingchen Meng Wenmiao Shu Junxi Wu Liming Bian Fengxuan Han Bin Li | 2023 | Research2023，，3： | 3 |
| 10 | Phase Engineering of Two-Dimensional Transition Metal Dichalcogenides显示文摘Transition metal dichalcogenides(TMDs)possess a large number of two-dime nsional(2D)materials with novel physical and chemical properties and hold great potential applications in electronic devices,optical devices as well as catalysts.TMDs usually have poly-phases,such as 2H,3R and 1T.Chemical and physical properties,including electrical conductivity,superconductivity,magnetism and catalytic activity,are different for different phases of TMDs.Therefore,great efforts have been made to obtain a specific pure phase of 2D TMD materials.Here,we review the recent phase engineering research for 2D TMDs,including ion insertion,alying,temperature,defects,strain and electric field. | Ziyue Qian Liying Jiao Liming Xie | 2020 | Chinese Journal of Chemistry2020，38，7： | 3 |
| 11 | Adjusting energy level alignment between HTL and CsPbI_(2)Br to improve solar cell efficiency显示文摘Lead halide perovskites are at the forefront of optoelectronic materials due to their high absorption coefficient,tunable bandgap,long carrier diffusion length,and small exciton binding energy[1−3],yielding high-performance optoelectronic devices. | Zihan Zhang Jia Li Zhimin Fang Haipeng Xie Yongbo Yuan Chuantian Zuo Liming Ding Bin Yang | 2021 | Journal of Semiconductors2021，42，3： | 3 |
| 12 | Multifractal Analysis of Geochemical Stream Sediment Data in Bange Region, Northern Tibet显示文摘The aim of this study is to quantify the geochemical elements distribution patterns analyzed from stream sediment data and then to delineate favorable areas for mineral exploration. A total of 7 270 stream sediment samples were collected from four subareas and 37 rock(ore) chip samples from five different locations in the Bange region, northern Tibet(China). The multifractal spectra of 12 elements including Au, Ag, As, Cu, Mo, Pb, Zn, W, Sn, Bi, Sb and Hg are represented by the method of moments, and characterized by five quantitative multifractal parameters. The results show that the multifractality for Cu and Bi in the Gongma area is much stronger than those in other subareas. Both the asymmetry index of multifractal spectra and the variance coefficients of Cu and Bi in this area are the highest, which imply that the distribution pattern of Cu and Bi in the Gongma area is the most heterogeneous. These multifractal parameters indicate that the Gongma area is the most favorable for prospecting Cu and Bi. The results obtained by the method of moments are in agreement with petrochemical analysis and field observation. It is suggested that multifractal analysis can be used as an effective tool to evaluate the ore-forming potential in the study area and to provide new approaches for geochemical exploration. | Xianzhong Ke Shuyun Xie Youye Zheng Salah Fadlallah Awadelseid Shunbao Gao Liming Tian | 2015 | Journal of Earth Science2015，26，3： | 3 |
| 13 | Fluid inclusions and oil charge history in the reservoirs of the Yongjin oilfield in central Junggar Basin显示文摘In the Yongjin oilfield of southern Junggar Basin, many wells have been drilled to produce industrial oils. Based on the analysis of fluid inclusions in the reservoirs, in combination with the geological and thermal evolution, the charge history in this area has been studied. The results indicate that the Jurassic Formation and Cretaceous Formation reservoirs contain abundant oil and gas inclusions, and four types of fluid inclusions have been distinguished. According to the homogenization temperatures of the fluid inclusions, the hydrocarbons charged the Cretaceous Formation for two periods, one ranges from the Late Cretaceous period to the Eogene period, and the other ranges from the Neocene period to the present. The oil filling history is correlated with the oil source correlation analysis, which is controlled by the movement of the Che-Mo plaeo uplift. Overall, oil accumulation is characterized by the superposition of two sets of source rocks for two stages in the Shawan depression. | Xie Guanbao Qin Liming Zhang Zhihuan Li Wenhao | 2013 | Chinese Journal Of Geochemistry2013，32，1： | 2 |
| 14 | Quantitative deconvolution of autocorrelations and cross correlations from two-dimensional lifetime decay maps in fluorescence lifetime correlation spectroscopy显示文摘Fluorescence correlation spectroscopy(FCS) is a widely used method for measuring molecular diffusion and chemical kinetics. However, when a mixture of fluorescent species is taken into account, the conventional FCS method has limitations in extracting autocorrelations for different species and cross correlations between different species. Recently developed fluorescence lifetime correlation spectroscopy(FLCS) based on time-tagged time-resolved(TTTR) photon recording, which can record the global and micro arrival time for each individual photon, has been used to discriminate different species according to fluorescence lifetime. Here, based on two-dimensional lifetime decay maps constructed from TTTR photon stream, we have developed a quantitative lifetime-deconvolution FCS model(LDFCS) to extract precise chemical rates for chemical conversions in multi-species systems. The key point of LDFCS model is separation of different species according to the global distribution of fluorescence lifetime and then deconvolution of autocorrelations and cross-correlations from the two-dimensional lifetime decay maps constructed by the micro arrival times of photon pairs at each delay time. | Shanshan Gao Menghua Cui Ruiru Li Ling Liang Ying Liu Liming Xie | 2017 | Science Bulletin2017，62，1： | 2 |
| 15 | Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing显示文摘Complex oxides with tunable structures have many fascinating properties,though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach.Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic(1-x)BiTi(1-y)/2FeyMg(1-y)/2O3–(x)CaTiO3(BTFM–CTO)solid solution in large area,confirming its ferroelectricity at the atomic scale with strong spontaneous polarization.Careful compositional tuning leads to a bulk magnetization of 0.07±0.035μB/Fe at room temperature,enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0×10^-7 s/m.This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film,making it possible to explore a much wider space of composition,phase,and structure that can be easily scaled up for industrial applications. | Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li | 2020 | National Science Review2020，7，1： | 2 |
| 16 | An industrial solution to light-induced degradation of crystalline silicon solar cells显示文摘硼氧缺点能基于做硼的水晶的硅(c-Si ) 引起商业太阳能电池的严肃的导致光的降级(盖) ,它在也照明劝诱的过量搬运人的注射下面被形成或使用前面的偏爱。在这贡献,我们证明了硼氧缺点的钝化过程能被为太阳能电池的大数量使用前面的偏爱导致,它比轻照明是更多经济。我们使用了这策略触发太阳能电池和使钝化的 emitter 和尾部联系的铝背表面地(Al-BSF )(PERC ) 的批的钝化进程太阳能电池。两种对待的太阳能电池在效率显示出高稳定性并且在房间温度在进一步的照明下面受不了很小的盖。这种技术具有为为工业制造的 c-Si 太阳能电池的盖的抑制的意义。 | Meng XIE Changrui REN Liming FU Xiaodong QIU Xuegong YU Deren YANG | 2017 | Frontiers in Energy2017，11，1： | 2 |
| 17 | Surface-deformation monitoring in the permafrost regions over the Tibetan Plateau,using Sentinel-1 data显示文摘Differential Interferometric Synthetic Aperture Radar(D-In SAR) has been widely used to measure surface deformation over the Tibetan Plateau. However, the accuracy and applicability of the D-In SAR method are not well estimated due to the lack of in-situ validation. In this paper, we mapped the seasonal and long-term displacement of Tanggula(TGL) and Liangdaohe(LDH) permafrost regions with a stack of Sentinel-1 acquisitions using the Small Baseline Subset In SAR(SBAS-In SAR) method. In the TGL region, with its dry soils and sparse vegetation, the In SAR-derived surface-deformation trend was consistent with ground-based leveling results; long-term changes of the active layer showed a settlement rate of around 1 to 3 mm/a due to the melting of ground ice, indicating a degrading permafrost in this area. Around half of the deformation was picked up on monitoring, in contrast with in-situ measurements in LDH, implying that the D-In SAR method remarkably underestimated the surface-deformation. This phenomenon may be induced by the large soil-water content, high vegetation coverage, or a combination of these two factors in this region. This study demonstrates that surface deformation could be mapped accurately for a specific region with Sentinel-1 C-band data, such as in the TGL region.Moreover, although the D-In SAR technology provides an efficient solution for broad surface-deformation monitoring in permafrost regions, it shows a poor performance in the region with high soil-water content and dense vegetation coverage. | ZhenMing Wu Lin Zhao Lin Liu Rui Zhu ZeShen Gao YongPing Qiao LiMing Tian HuaYun Zhou MeiZhen Xie | 2018 | Research in Cold and Arid Regions2018，10，2： | 2 |
| 18 | Local electrical charac terization of t wo-dimensional mat erials with functional atomic force microscopy显示文摘Research about two-dimensional (2D) materials is growing exponentially across various scientific and engineering disciplines due to the wealth of unusual physical phenomena that occur when charge transport is confined to a plane. The applications of 2D materials are highly affected by the electrical properties of these mat erials, including curren t dist ribution, surface pot ential, dielectric response, conductivity, perm计tivity, and piezoelectric response. Hence, it is very crucial to characterize these properties at the nanoscale. The Atomic Force Microscopy (AFM)-based techniques are powerful tools that can simultaneously characterize morphology and electrical properties of 2D materials with high spatial resolution, thus being more and more extensively used in this research field. Here, the principles of these AFM techniques are reviewed in detail. After that, their representative applications are further demonstrated in the local characterization of various 2D materials? elcctrical properties. | Sabir Hussain Kunqi Xu Shili Ye Le Lei Xinmeng Liu Rui Xu Liming Xie Zhihai Cheng | 2019 | Frontiers of physics2019，14，3： | 2 |
| 19 | High performance inkjet-printed QLEDs with 18.3% EQE: improving interfacial contact by novel halogen-free binary solvent system显示文摘Poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt(4,4′-(N-(4-butylphenyl))](TFB),one of the most popular and widely used hole-transport layer(HTL)materials,has been successfully applied in high performance spin-coated quantum dots-based light-emitting diodes(QLEDs)due to its suitable energy level and high mobility.However,there are still many challenging issues in inkjet-printed QLED devices when using TFB as HTL.TFB normally suffers from the interlayer mixing and erosion,and low surface energy against the good film formation.Here,a novel environment-friendly binary solvent system was established for formulating quantum dot(QD)inks,which is based on mixing halogen-free alkane solvents of decalin and n-tridecane.The optimum volume ratio for the mixture of decalin and n-tridecane was found to be 7:3,at which a stable ink jetting flow and coffee-ring free QD films could be formed.To research the influence of substrate surface on the formation of inkjet-printed QD films,TFB was annealed at different temperatures,and the optimum annealing temperature was found to enable high quality inkjet-printed QD film.Inkjet-printed red QLED was ultimately manufactured.A maximum 18.3%of external quantum efficiency(EQE)was achieved,reaching 93%of the spin-coated QLED,which is the best reported high efficiency inkjet-printed red QLEDs to date.In addition,the inkjet-printed QLED achieved similar T75 operational lifetime(27 h)as compared to the spin-coated reference QLED(28 h)at 2,000 cd·m−2.This work demonstrated that the novel orthogonal halogen-free alkane co-solvents can improve the interfacial contact and facilitate high-performance inkjet printing QLEDs with high EQE and stability. | Ming Chen Liming Xie Changting Wei Yuan-Qiu-Qiang Yi Xiaolian Chen Jian Yang Jinyong Zhuang Fushan Li Wenming Su Zheng Cui | 2021 | Nano Research2021，14，11： | 2 |
| 20 | Preparation of superhydrophobic silica film on Mg–Nd–Zn–Zr magnesium alloy with enhanced corrosion resistance by combining micro-arc oxidation and sol–gel method显示文摘 | Shaohua Wang Xingwu Guo Yijun Xie Lihua Liu Haiyan Yang Rongyu Zhu Jia Gong Liming Peng Wenjiang Ding | 2012 | Surface & Coatings Technology2012，，： | 2 |
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