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| 1 | Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities显示文摘Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysaccharides(CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury(ALI) induced by hemorrhagic shock plus lipopolysaccharide(LPS) instillation(two-hit)and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the 'two-hit' ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid(BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidantantioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heatclearing function of H. cordata. | Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 18 |
| 2 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 3 | Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601显示文摘稀释毒力的螺旋体 interrogans serovar Lai 紧张 IPAV 被延长实验室经过从在中国孤立的高度剧毒的祖先的紧张导出。我们学习了 IPAV 的基因变化对病原的 L 经由比较分析使它变为无毒害。interrogans serovar Lai 紧张 56601。IPAV 紧张的完全的染色体顺序决心、使用与作比较,然后修正并且重新注解紧张 56601 的染色体顺序。除了他们的高度类似的 genomic,结构和基因顺序, 33 插入的一个总数, 53 删除和 301 个单个核苷酸的变化(SNV ) 在整个直接影响 101 基因的 IPAV 的染色体被检测,在他们的 5 ′ 的任何一个;在上游的区域或在他们的编码区域以内。在他们之中, 44 功能的基因的多数涉及信号 transduction,压力反应, transmembrane 运输和氮新陈代谢。基于量的液体,层析(LC )-MS/MS 数据揭示了的比较 proteomic 分析在 orthologs 的 1 627 选择的对之中,在 IPAV 的 174 基因拉紧,这是 upregulated,与主要在精力的班上的丰富生产和类脂化合物新陈代谢。相反,在紧张 56601 的 228 基因是 upregulated,与在蛋白质翻译和 DNA 复制 / 修理的范畴充实的多数。 genomic 和 proteomic 途径的联合在批评基因说明了那改变的表情或变化,例如编码 Ser/Thr kinase ,碳饥饿蛋白质 CstA ,夫酸安合成酶,GTP有约束力的蛋白质 BipA , ribonucleotide-diphosphate reductase 和磷酸盐 transporter 的那些,并且在脂蛋白或外部膜蛋白质的翻译侧面的改变是可能的在紧张 IPAV 说明毒力变细。 | Yi Zhong Xiao Chang Xing-Jun Cao Yan Zhang Huajun Zheng Yongzhang Zhu Chengsong Cai Zelin Cui Yunyi Zhang Yuan-Yuan Li Xiu-Gao Jiang Guo-Ping Zhao Shengyue Wang Yixue Li Rong Zeng Xuan Li Xiao-Kui Guo | 2011 | Cell Research2011，21，8： | 10 |
| 4 | Cloning and characterization of three cheB genes in Leptospira interrogans显示文摘活动性和趋化性系统为 leptospires 的毒力是批评的。有在 leptospires 定位的通常认为的趋化性相当或相同的事物的多重拷贝大染色体。从螺旋体 interrogans 紧张 Lai 的 CheB1 和 CheB3 被预言有一个全球象 CheB 一样领域,但是 CheB2 被预言仅仅有一个 C 终端受动器领域。以便验证三通常认为的 cheB 基因的功能,他们被克隆进 pQE31 向量然后分别地,在野类型的 Escherichia coli 紧张 RP437 和 cheB 有缺陷者紧张 RP4972 表示了。聚集的试金的结果和 CheB1 的预言的第三的结构和 L 的 CheB3。interrogans 紧张 Lai 建议一个 N 终端规章的领域的缺席可以是原因之一让 CheB2 的失败补充 E。coli cheB 异种。而且, CheB2 在 leptospires 的相互作用网络完全连接到 CheR1 和 CheR3。一起拿,这些结果显示 CheB2 不能独自工作,并且在某些生理的条件下面,工作可以要求 CheB3 和 CheR1。趋化性基因相当或相同的事物的多重拷贝的存在建议了那 L。interrogans 紧张 Lai 可能有一条更复杂的化学感应的小径。 | Ke Dong Qingtian Li Chang Liu Yunyi Zhang Guoping Zhao Xiaokui Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 5 |
| 5 | Visible light-driven photocatalysis of W,N co-doped TiO_2显示文摘W,N co-doped TiO_2 nanoparticles were synthesized by a sol-gel method.The prepared samples were characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FE-SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS) and diffuse reflectance spectrophotometry(DRS).The results showed that the codoped photocatalysts were essentially uniform spherical particles with the smallest particle size of22.5 nm.Compared to un-doped TiO_2,N-TiO_2 and P-25,the absorption edge of the W,N co-doped TiO_2shifted to longer wavelength and its photocatalytic activity for degradation of methyl orange(MO) under Xe-lamp(350 W) was higher. | Xue Li Yunyi Liu Pengfei Yang Yongchao Shi | 2013 | Particuology2013，11，6： | 4 |
| 6 | Fabrication of niobium doped titanate nanoflakes with enhanced visible-light-driven photocatalytic activity for efficient ibuprofen degradation显示文摘In this study,a novel class of niobium(Nb) doped titanate nanoflakes(TNFs) are fabricated through a onestep hydrothermal method.Nb doping affects the curving of titanate nanosheet,leading to the formation of nanoflake structure.In addition,Nb5+ filled in the interlayers of [TiO6] alters the light adsorption property of pristine titanate.The band gap of Nb-TNFs is narrowed to 2.85 eV,while neat titanate nano tubes(TNTs) is 3.4 eV.The enhanced visible light adsorption significantly enhances the visible-lightdriven activity of Nb-TNFs for ibuprofen(IBP) degradation.The pseudo-first order kinetics constant for Nb-TNFs is calculated to be 1.04 h^-1,while no obvious removal is observed for TNTs.Photo-generated holes(h^+) and hydroxyl radicals(·OH) are responsible for IBP degradation.The photocatalytic activity of Nb-TNFs depends on pH condition,and the optimal pH value is found to be 5.In addition,Nb-TNFs exhibited superior photo-stability during the reuse cycles.The results demonstrated Nb-TNFs are very promising in photocatalytic water purification. | Wen Liu Wei Zhang Mushi Liu Penghui Du Chenyuan Dang Jialiang Liang Yunyi Li | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 7 | Heavy ion micro-beam study of single-event transient(SET) in Si Ge heterjunction bipolar transistor显示文摘Silicon-germainum heterojunction bipolar transistor(Si Ge HBT)has been demonstrated to be suitable in extreme environment because of its superior temperature characteristics which can operate from 43 K to 400 K[1].In addition,outstanding hardness to both total ionizing dose(TID)radiation and displacement damage make Si Ge HBT technology particularly attractive for | Jinxin ZHANG Hongxia GUO Fengqi ZHANG Chaohui HE Pei LI Yunyi YAN Hui WANG Linxia ZHANG | 2017 | Science China(Information Sciences)2017，60，12： | 2 |
| 8 | Catalytic Hydrogenation of Acetic Acid to Acetaldehyde: Synergistic Effect of Bifunctional Co/Ce-Fe Oxide Solid Solution Catalysts显示文摘The large-scale industrial production of acetic acid (HAc) from carbonylation of methanol has enabled intense research interest from direct hydrogenation of HAc to acetaldehyde (AA).Herein,a series of cerium-iron oxide solid solution supported metallic cobalt catalysts were prepared by modified sol-gel method and were applied in gas-phase hydrogenation of HAc to AA.A synergistic effect between the hydrogenation metal cobalt and Ce-Fe oxide solid solution is revealed.Specifically,oxygen vacancies provide the active sites for adsorption of HAc,while highly uniformly dispersed metallic Co adsorbs H2 and activates the reduction of HAc into AA.Moreover,the metallic Co can also assist the cyclical conversion between Fe3+/Fe2+ and Ce3+/Ce4+ on the surface of Ce1.xFexO2-δ supports.The unique effect substantially enhances the ability of the support material to rapidly capture oxygen atoms from HAc.It is found that the catalyst of 5% Co/Ce0.8Fe0.2O2-δ with the highest concentration of oxygen vacancy presents the best catalytic performance (i.e.acetaldehyde yield reaches 49.9%) under the optimal reaction conditions (i.e.623 K and H2 flow rate =10 mL/min).This work indicates that the Co/Ce-Fe oxide solid solution catalyst can be potentially used for the selective hydrogenation from HAc to AA.The synergy between the metallic Co and Ce1-xFexO2-δ revealed can be extended to the design of other composite catalysts. | Naixu Li Qi Zhang Rehana Bibi Quanhao Shen Richard Ngulube Yunyi Liu Jiancheng Zhou | 2019 | Chinese Journal of Chemistry2019，37，7： | 2 |
| 9 | Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides显示文摘Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall function of the complement system. The main objective of our study was to develop a specific enzyme-linked immunosorbent assay(ELISA) as an alternative method to assess the anti-complement activity, particularly against the lectin pathway. By using respective coating substrates against different activation pathways, followed by capturing the stable C3c fragments, our ELISA method can be used to screen complement inhibitors against the classical pathway and the lectin pathway. The inhibitory effect of suramin on the classical pathway, as measured by our hemolytic assay is consistent with previous reports. Further assessment of suramin and Bupleurum polysaccharides against the lectin pathway showed a good reproducibility of the method. Comparison of the lectin pathway IC50 between Bupleurum smithii var. parvifolium polysaccharides(1.055 mg/mL) and Bupleurum chinense polysaccharides(0.98 mg/mL) showed that, similar to the classical and alterative pathway, these two Bupleurum polysaccharides had comparable anti-complementary properties against the lectin pathway. The results demonstrate that the described ELISA assay can compensate for the shortcomings of the hemolytic assay in lectin pathway. | Mulu Wu Hong Li Yunyi Zhang Daofeng Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 1 |
| 10 | Sesamin induces melanogenesis by microphthalmia-associated transcription factor and tyrosinase up-regulation via cAMP signaling pathway显示文摘在这研究,我们证实了那芝麻明,从芝麻种子和油孤立的活跃 lignan,是新奇晒黑皮的混合物。黑素内容和 tyrosinase 活动被芝麻明在 B16 黑瘤房间以一种剂量依赖者方式增加。tyrosinase 的 mRNA 和蛋白质层次也与芝麻明在处理以后被提高。西方的污点分析揭示了导致并且支撑联系 microphthalmia 的抄写因素(MITF ) 的起来规定的那芝麻明。芝麻明能激活营地反应元素(CRE ) 有约束力的蛋白质(CREB ) ,但是它没在 p38 的 phosphorylation 上有效果激活 mitogen 的蛋白质 kinase (MAPK ) 或 Akt。而且,芝麻明经由一条营地依赖者小径激活蛋白质 kinase A (PKA ) 。与这些结果一致,黑素合成的调停芝麻明的增加被 H-89 显著地减少,一个 PKA 禁止者,然而并非由 SB203580,一个 p38 MAPK 禁止者或由 LY294002,一个 phosphatidylinositol-3-kinase (PI3K ) 禁止者。CREB 的调停芝麻明的 phosphorylation 和 MITF 和 tyrosinase 表示的正式就职被 H-89 也禁止。这些调查结果显示那芝麻明能经由 MITF 和 tyrosinase 的起来规定在 B16 房间刺激 melanogenesis,接着,它由于营地发信号的激活。 | Zequn Jiang Shasha Li Yunyi Liu Pengyi Deng Jianguo Huang Guangyuan He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 1 |
| 11 | The relationship between air gap sizes and clothing heat transfer performance显示文摘 | Jun Li Zhaohua Zhang Yunyi Wang | 2013 | The Journal of the Textile Institute2013，104，12： | 1 |
| 12 | Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans显示文摘螺旋体 interrogans 染色体编码 cheR 基因的二个拷贝,他们中的每能为 Escherichia coli cheR 0 异种 RP1254 的聚集的有缺点的显型补充到某些程度,当他们的也的在表示上禁止趋化性的野类型的 E 聚集时。coli 紧张, RP437。因此, CheR1 和 CheR2 应该忍受 methyltransferase 活动,尽管 CheR1 有仅仅而不是位于 2 螺旋的断然控告的脸的二保存基本氨基酸残余。当象 CheR2 的 Lys48 和 Arg55 一样的这残余被变异时,任何一个 CheRs 都不能维持上述的互补功能,建议他们考虑到类似于 E 的接受甲基的趋化性蛋白质的关键角色。coli。由 microarray 试金示威了,在 L 的 cheR1 的表情。在 28 点有教养的 | Yunyi Zhang Ke Dong Lingbing Zeng Qingtian Li Chang Liu Jin Wang Xiaokui Guo Guo-Ping Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 1 |
| 13 | Study on skin sensitive difference of human body sections under clothing--Multiple analysis of skin surface temperature changes显示文摘 | LI Jun ZHANG Weiyuan WANG Yunyi | 2002 | Journal of Donghong University2002，28，3： | 1 |
| 14 | The thickness effect of Bi 3.25 La 0.75 Ti 3 O 12 buffer layer in PbZr 0.58 Ti 0.42 O 3 /Bi 3.25 La 0.75 Ti 3 O 12 (PZT/BLT) multilayered ferroelectric thin films显示文摘 | Jianjun Li Ping Li Guojun Zhang Jun Yu Yunyi Wu Xinyi Wen | 2011 | Thin Solid Films2011，，18： | 1 |
| 15 | Experimental evidence of the thickness- and electric-field-dependent topological phase transitions intopological crystalline insulator SnTe(111) thin films显示文摘Using in situ angle-resolved photoemission spectroscopy, we systematicallystudied molecular-beam-epitaxy-grown topological crystalline insulator SnTe(111 )thin films with varied thicknesses and substrate conditions. An oscillation in theband gap size with an increase in thickness was observed to depend on theelectric field perpendicular to the films. The observations are consistent withthe theoretically predicted thickness- and electric-field-dependent topologicalphase transitions between the normal insulator and the quantum spin Hallinsulator phases in SnTe(111) films and demonstrate them to be an excellentand electrically tunable quantum spin Hall system. | Yan Gong Kejing Zhu Zhe Li Yunyi Zang Xiao Feng Ding Zhang Canli Song Lili Wang Wei Li Xi Chen Xu-Cun Ma Qi-Kun Xue Yong Xu Ke He | 2018 | Nano Research2018，11，11： | 1 |
| 16 | Tractor path tracking control based on binocular vision显示文摘In the process of field operation management,determining how to accurately realize crop row identification and path tracking control is an essential part of tractor automatic navigation.According to the linear operation in the process of cotton field management,the tractor path tracking control system was designed based on binocular vision and the pure pursuit model.A new crop row detection method based on the Census transform and the PID control algorithm with dead zone were used.First,the upper computer software was developed by C++with the functions of parameter setting and image acquisition and processing.Second,an automatic steering controller was developed based on microprocessor MC9S12XS128 of Freescale.The control program was developed based on modular design using CodeWarrior during development of the PID-based automatic steering control strategy.Finally,a field experiment platform of tractor path tracking control was built,and field experiments under the actual cotton were conducted.The optimal visibility distance was determined by several previous experiments.When the tractor tracks the path with the optimal visibility distance in the growth environment of actual cotton crops,the mean absolute deviation of course angle was 0.95°,and the standard deviation was 1.26°;the mean absolute deviation of lateral position was 4.00 cm,and the standard deviation was 4.97 cm;the mean absolute deviation of front wheel angle was 2.99°,and the standard deviation was 3.67°.The experimental results show that(1)the crop row detection method based on Census transform can identify the crop line and plan the navigation path well,and(2)the tractor path tracking control system based on binocular vision has good stability and high control precision;thus,the control systemcan realize the automatic path tracking control of cotton line operation and meets the agricultural requirements of cotton field operation management. | Shuo Zhang Yunyi Wang Zhongxiang Zhu Zhen Li Yuefeng Du Enrong Mao | 2018 | Information Processing in Agriculture2018，5，4： | 1 |
| 17 | A high temperature,high density drilling fluid with sepiolite显示文摘 | Wang Song Mei Yunyi Li Shulian | 1998 | Journal of JiangHan Petroleum Institute1998，20，1： | 1 |
| 18 | Recent progress and future perspectives of flexible metal‐air batteries显示文摘With the rapid development of wearable and intelligent flexible electronic devices(FEDs),the demand for flexible energy storage/conversion devices(ESCDs)has also increased.Rechargeable flexible metal‐air batteries(MABs)are expected to be one of the most ideal ESCDs due to their high theoretical energy density,cost advantage,and strong deformation adaptability.With the improvement of the device design,material assemblies,and manufacturing technology,the research on the electrochemical performance of flexible MABs has made significant progress.However,achieving the high mechanical flexibility,high safety,and wearable comfortability required by FEDs while maintaining the high performance of flexible MABs are still a daunting challenge.In this review,flexible Zn‐air and Li‐air batteries are mainly exemplified to describe the most recent progress and challenges of flexible MABs.We start with an overview of the structure and configuration of the flexible MABs and discuss their impact on battery performance and function.Then it focuses on the research progress of flexible metal anodes,gel polymer electrolytes,and air cathodes.Finally,the main challenges and future research perspectives involving flexible MABs for FEDs are proposed. | Tingzhen Li Xinwen Peng Peng Cui Ge Shi Wu Yang Zehong Chen Yongfa Huang Yongkang Chen Jinyuan Peng Ren Zou Xiaoyan Zeng Jian Yu Jianyun Gan Zhiyuan Mu Yuling Chen Jiaming Zeng Juan Liu Yunyi Yang Yujia Wei Jun Lu | 2021 | SmartMat2021，2，4： | 1 |
| 19 | Physical mechanism of field modulation effects in ion implanted edge termination of vertical GaN Schottky barrier diodes显示文摘In this study,the physical properties of F ion-implanted GaN were thoroughly studied,and the related electric-field modulation mechanisms in ion-implanted edge termination were revealed.Transmission electron microscopy re.sults indicate that the ion-implanted region maintains a single-crystal structure even with the implantation of high-energy F ions,indicating that the high resistivity of the edge termination region is not induced by amorphization.Alternately,ion implantation-induced deep levels could compensate the electrons and lead to a highly resistive layer In addition to the bulk ffect,the direct bombardment of high-energy F ions resulted in a rough and nitrogen-deficient surface,which was confirmed via atomic force microscopy(AFM)and X-ray photoelectron spectroscopy,The implanted surface with a large density of nitrogen vacancies can accommodate electrons,and it is more conductive than the bulk in the implanted region,which is validated via spreading resistance profiling and conductive AFM measurements.Under reverse bias,the implanted surface can spread the potential in the lateral direction,whereas the acceptor traps capture electrons acting as space charges,shifting the peak electric field into the bulk region in the vertical direction.As a result,the Schottky barrier diode terminated with high-energy F ion-implanted regions exhibits a breakdown voltage of over 1.2 kv. | Ruiyuan Yin Chiachia Li Bin Zhang Jinyan Wang Yunyi Fu Cheng P.Wen Yilong Hao Bo Shen Maojun Wang | 2022 | Fundamental Research2022，2，4： | 1 |
| 20 | Dynamic changes of wound-related miRNAs after application of autologous platelet-rich gel in diabetic wounds显示文摘To the Editor:Diabetic chronic cutaneous ulcers(DCUs)are among the most common and serious complications of diabetes mellitus.Diabetic foot ulcers are the most common type of DCU and are now considered a global epidemic.[1]The clinical prevention and treatment of DCUs are critical and have remained challenging for clinicians.With the exploration of topical treatment methods,autologous platelet-rich gel(APG)is regarded as an adjuvant therapy to promote wound healing,and it has been widely used for wound repair.[2]Some microRNAs that play a critical role in the whole wound healing process have been found in wound tissues,which we call wound-related miRNAs(wr-miRNAs).However,few studies have explored the dynamic changes of wr-miRNAs during APG treatment.Our study aimed to evaluate the efficacy of APG in treating diabetic wounds and explore the dynamic changes of wr-miRNAs during wound healing. | Yan Li Yujie Liang Yunyi Gao Dawei Chen Xingwu Ran | 2022 | Chinese Medical Journal2022，135，21： | 0 |
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