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| 1 | Coordinated regulation of apical hook development by gibberellins and ethylene in etiolated Arabidopsis seedlings显示文摘当在土壤发芽时,当通过土壤耸出时,黑暗成年的 Arabidopsis 幼苗开发一个顶端的钩,它保护子叶和顶端的 meristematic 纸巾。几荷尔蒙被报导清楚地调制这个过程。以前的研究证明了乙烯和赤霉素(气体) 并列地调整钩发展,尽管内在的分子的机制大部分是未知的。当 paclobutrazol 镇压了时,这里,我们显示出提高的那 GA 3 ethylene-overexpression 和 EIN3-overexpression (EIN3ox ) 导致了钩弯曲,并且 della 异种展出了夸大的钩弯曲,它要求了发信号的未经触动的乙烯小径。基因学习表明那提高 GA 的钩开发依赖于无钩 1 (HLS1 ) ,调停的一个中央管理者多重发信号小径的输入在顶端的钩开发期间。我们进一步发现那 GA 3 导致(并且 DELLA 蛋白质镇压了) 在乙烯感觉迟钝的 3/EIN3-LIKE 的 HLS1 表示 1 (EIN3/EIL1 ) 依赖举止, EIN3/EIL1 由此激活 HLS1 抄写由对它的倡导者直接有约束力。另外, DELLA 蛋白质被发现与 EIN3/EIL1 的 DNA 有约束力的领域交往并且镇压 EIN3/EIL1-regulated HLS1 表示。有 naphthylphthalamic 酸的处理,一个极的植物生长素运输禁止者,镇压 EIN3ox 线的组成地夸大的钩弯曲和 della 异种,支持那植物生长素在钩开发乙烯和 GA 小径下游地工作。一起拿,我们的结果作为联系 DELLA 的抄写因素的一个新类识别 EIN3/EIL1 并且证明 GA 由经由 EIN3/EIL1 函数的 derepression 导致 HLS1 的表达式部分与乙烯在合作支持顶端的钩形成。 | Fengying An Xing Zhang Ziqiang Zhu Yusi Ji Wenrong He Zhiqiang Jiang Mingzhe Li Hongwei Guo | 2012 | Cell Research2012，22，5： | 34 |
| 2 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 3 | In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L显示文摘 | Chong ZHANG Shuang-shuang ZHOU Lin-yi FENGI Da-yong ZHANG Neng-ming LIN Li-huang ZHANG Jian-ping PAN Jun-bo WANG Jie LI | 2013 | Acta Pharmacologica Sinica2013，34，2： | 9 |
| 4 | DELLA proteins interact with FLC to repress flowering transition显示文摘Flowering is a highly orchestrated and extremely ct critical process in a plant's life cycle. Previous study has ademonstrated that SUPPRESSOR OF OVEREXPRESSION OF pCONSTANS 1(SOC1) and FLOWERING LOCUS T(FT) integrate m-I the gibberellic acid(GA) signaling pathway and vernalization higpathway in regulating flowering time, but detailed molecular Hmechanisms remain largely unclear. In GA signaling pathway,DELLA proteins are a group of master transcriptional regulators, while in vernalization pathway FLOWERING LOCUS C(FLC) is a core transcriptional repressor that down-regulates the expression of SOC1 and FT. Here, we report that DELLA proteins interact with FLC in vitro and in vivo, and the LHRI domains of DELLAs and the C-terminus of MADS domain of FLC are required for these interactions.Phenotypic and gene expression analysis showed that mutation of FLC reduces while over-expression of FLC enhances the GA response in the flowering process. Further,DELLA-FLC interactions promote the repression ability of FLC on its target genes. In summary, these findings report that the interaction between MADS box transcription factor FLC and GRAS domain regulator DELLAs may integrate various signaling inputs in flowering time control, and shed new light on the regulatory mechanism both for FLC and DELLAs in regulating gene expression. | Mingzhe Li Fengying An Wenyang Li Mengdi Ma Ying Feng Xing Zhang Hongwei Guo | 2016 | Journal of Integrative Plant Biology2016，58，7： | 7 |
| 5 | Differentiation of rat iPS cells and ES cells into granulosa cell-like cells in vitro显示文摘早熟的卵巢的失败(POF ) 是卵巢的滤泡的早熟的弄空在 40 岁前描绘的一个卵巢的缺点,代表女不孕的一个主要原因。干细胞为 POF 提供一个潜在的处理的可能性。在这研究,老鼠胚胎的干细胞(转换字符) 和导致的 pluripotent 干细胞(iPSCs ) 与 granulosa 房间(GC ) 是 co 有教养的区分到象 GC 一样房间。放射性免疫测定分析的 estradiol (E2 ) 的水平证明 co 有教养的老鼠 iPSCs 和转换字符的文化上层清液的 E2 集中以一种时间依赖者方式增加了,与有一个相反的趋势的 GC 组相比。刺激滤泡的荷尔蒙受体(FSHR ) 的表示被 immunostaining 证实。这些结果显示了那老鼠 iPSCs,转换字符有效地通过间接 cell-to-cell 接触被导致到象 GC 一样房间。实时聚合酶链反应被执行在 POF 分析标记基因的表示水平,包括 BMP15, FMR1, FSHR, INHA, AMH, NOBOX, FOXO3, EIF2B, FIGLA,和 GDF9。BMP15, FSHR, INHA, AMH, NOBOX,和 GDF9 基因在 iPSCs 和与与不是 co 有教养的房间比较的 GC co 有教养的转换字符是显著地起来调整的。因此,这里,我们表明了一个可得到的方法为 POF 的可能的房间治疗在 vitro 区分老鼠 iPSCs 和转换字符进象 GC 一样房间。 | Juan Zhang Hui Li Zhao Wu XiaoJun Tan Fengying Liu Xianghong Huang Xiaoling Fang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 7 |
| 6 | Perception of people for the risk of Tianwan nuclear power plant显示文摘A questionnaire survey of residents’risk perceptions related to Taiwan nuclear power plant in China was carried out to explore the determining factors that affect individual risk perception.This study proposed to pursue a more comprehensive understanding of factors that affected individual risk perception to nuclear power plants.Covariance structure analysis was conducted using risk perceptions of nuclear power as dependent variable and including interest and knowledge levels of nuclear power,acceptability,benefit perception,trust in nuclear power operation,and trust in government as independent variables.The use of the hypothesis of Elaboration likelihood model(ELM)was also proposed.The results showed that persons with higher levels of interest and knowledge of nuclear power had their own perceptions of risk closely associated with acceptability and potential benefits of nuclear power.In contrast,persons with no interest in and knowledge of nuclear power would have risk perceptions related to their trust in nuclear operation and the government,which partially supported the ELM hypothesis.All these results indicated that the government in China plays an important role in rational risk perceptions,and well-designed communication of risks will help the public to be involved in risk management and improve people’s rational acceptance of risk. | Lei HUANG Jun BI Bing ZHANG Fengying LI Changsheng QU | 2010 | Frontiers of Environmental Science & Engineering2010，4，1： | 6 |
| 7 | The effects of modulation period,modulation ratio,and deposition temperature on microstructure and mechanical properties of ZrB_2/W multilayers显示文摘Monolithic ZrB2,W coatings and ZrB2/W multilayers with different modulation periods and modulation ratios were synthesized by ion beam assisted deposition at room temperature and 400°C.X-ray diffraction (XRD),scanning electron microscopy (SEM),surface profiler,and nanoindention were employed to investigate the influences of the deposition temperature and the modulation period on the growth,textures,interface structure,and mechanical properties of the multilayers.The results indicated that the multilayer with modulation period of 13 nm synthesized at room temperature possessed a higher hardness of 23.8 GPa.Deposition temperature gave a significant contribution to mechanical property enhancement.The 400°C-deposition temperature led to a maximum hardness and elastic modulus value of 32.1 and 399.1 GPa for ZrB2/W multilayer with a modulation period of 6.7 nm.Its critical load increased to 42.8 mN and residual stress decreased to -0.7 GPa.A higher deposition temperature can cause an increase in interfacial atomic mixture and mobility of surface species,which induceds an increase in areal atomic density and dislocation pinning.These results as well as small nanoscale grain sizes should be related to hardness increase. | LIU MengYin,TAN Ming,LIU GuangQing,WANG HaiYuan,XUE FengYing,DENG XiangYun & LI DeJun College of Physics and Electronic Information Science,Tianjin Normal University,Tianjin 300387,China | 2010 | Science China(Technological Sciences)2010，53，9： | 4 |
| 8 | Interdecadal variation of East Asian summer monsoon and drought/flood distribution over eastern China in the last 159 years显示文摘在东方中国和夏天上基于 90 个气象的车站的干旱 / 洪水等级在 18502008 期间平均海平面的压力(SLP ) 并且 BPCCA 统计方法,在干旱 / 洪水等级之间的联合关系和东方亚洲夏天 SLP 被分析。与在东方中国上的干旱 / 洪水分发的 interdecadal 变化密切相关的东方亚洲夏天季风索引被使用 SLP 的关键区域定义。在最后 159 年里的东方中国上的干旱 / 洪水的分发上的东方亚洲夏天季风的 interdecadal 变化的影响被研究。结果证明有四典型干旱并且在东方中国充满空间分发模式,即在南部的中国的干旱/洪水的分发与另外的区域相反,沿着 Huanghe River-Huaihe 河山谷的干旱/洪水的分发与长江山谷和它的区域南方相反,沿着长江山谷和 Huaihe 河山谷的干旱/洪水的分发与另外的区域相反,在 easte 的干旱/洪水的分发在夏天的 SLP 的主要分发模式是 SLP 的力量在亚洲大陆和韦斯特太平洋是相反的。它在东方中国和在这篇论文被定义的东方亚洲夏天季风的 interdecadal 变化上有在干旱 / 洪水分发模式的 interdecadal 变化之间的靠近的关系,但是关联不是稳定的,它在 interdecadal 阶段的变化有重要差别。当东方亚洲夏天季风更强壮时(更弱) ,长江山谷的区域北方更产生干旱(洪水) ,长江山谷和它的区域南方在 1920 年代前更产生洪水(干旱) ;当东方亚洲夏天季风更强壮时(更弱) ,长江山谷的区域北方是容易的洪水(干旱) ,长江山谷和它的区域南方在 1920 年代以后对干旱(洪水) 敏感。能比由使用最后 5060 年的数据由使用更长的时期的数据得到富有得多的结果,这被显示。在在在东方中国的东方亚洲夏天季风和干旱 / 洪水分布之间的 interdecadal 阶段的差别可以与非线性的反馈被联系,它是为太阳的活动的外来的强迫的东方亚洲夏天季风。 | LI Qian WEI Fengying LI Dongliang | 2011 | Journal of Geographical Sciences2011，21，4： | 4 |
| 9 | Generalized multiresolution structures in reducing subspaces of L^2(R^d)显示文摘In this paper, we introduce the notion of generalized multiresolution structure (GMS) in the set-ting of reducing subspaces of L2(Rd). For a general expansive matrix, we obtain a necessary and sufficient condition for GMS, and prove the existence of GMS in a reducing subspace. Using GMS, we obtain a pyramid decomposition and a frame-like expansion for signals in reducing subspaces. | ZHOU FengYing LI YunZhang | 2013 | Science China Mathematics2013，56，3： | 3 |
| 10 | Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway显示文摘The aberrant changes of fussion/fission-related proteins can trigger mitochondrial dynamics imbalance,which cause mitochondrial dysfunctions and result insulin resistance(IR).However,the relationship between the inner mitochondrial membrane fusion protein optic atrophy 1(Opa1)and hepatic IR as well as the specific molecular mechanisms of signal transduction has not been fully elucidated.In this study,we explore whether abnormalities in the Opa1 cause hepatic IR and whether berberine(BBR)can prevent hepatic IR through the SIRT1/Opa1 signalling pathway.High-fat diet(HFD)-fed mice and db/db mice are used as animal models to study hepatic IR in vivo.IR,morphological changes,and mitochondrial injury of the liver are examined to explore the effects of BBR.SIRT1/Opa1 protein expression is determined to confirm whether the signalling pathway is damaged in the model animals and is involved in BBR treatment-mediated mitigation of hepatic IR.A palmitate(PA)-induced hepatocyte IR model is established in HepG2 cells in vitro.Opa1 silencing and SIRT1 overexpression are induced to verify whether Opa1 deficiency causes hepatocyte IR and whether SIRT1 improves this dysfunction.BBR treatment and SIRT1 silencing are employed to confirm that BBR can prevent hepatic IR by activating the SIRT1/Opa1 signalling pathway.Western blot analysis and JC-1 fluorescent staining results show that Opa1 deficiency causes an imbalance in mitochondrial fusion/fission and impairs insulin signalling in HepG2 cells.SIRT1 and BBR overexpression ameliorates PA-induced IR,increases Opa1,and improves mitochondrial function.SIRT1 silencing partly reverses the effects of BBR on HepG2 cells.SIRT1 and Opa1 expressions are downregulated in the animal models.BBR attenuates hepatic IR and enhances SIRT1/Opa1 signalling in db/db mice.In summary,Opa1 silencing-mediated mitochondrial fusion/fission imbalance could lead to hepatocyte IR.BBR may improve hepatic IR by regulating the SIRT1/Opa1 signalling pathway,and thus,it may be used to treat type-2 diabetes. | Jia Xu Yining Zhang Zhiyi Yu Yueqi Guan Yuqian Lv Meishuang Zhang Ming Zhang Li Chen Xiaoyan Lv Fengying Guan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 3 |
| 11 | Adaptive segmentation based on multi-classification model for dermoscopy images显示文摘 | Fengying XIE Yefen WU Yang LI Zhiguo JIANG Rusong MENG | 2015 | Frontiers of Computer Science2015，9，5： | 2 |
| 12 | Formamidinium Lead Bromide (FAPbBr_3) Perovskite Microcrystals for Sensitive and Fast Photodetectors显示文摘Because of the good thermal stability and superior carrier transport characteristics of formamidinium lead trihalide perovskite HC(NH_2)_2 PbX_3(FAPbX_3), it has been considered to be a better optoelectronic material than conventional CH_3NH_3-PbX_3(MAPbX_3). Herein, we fabricated a FAPbBr_3 microcrystal-based photodetector that exhibited a good responsivity of 4000 A W-1 and external quantum efficiency up to 106% under one-photon excitation, corresponding to the detectivity greater than 1014 Jones. The responsivity is two orders of magnitude higher than that of previously reported formamidinium perovskite photodetectors. Furthermore, the FAPbBr_3 photodetector's responsivity to two-photon absorption with an 800-nm excitation source can reach 0.07 A W^(-1), which is four orders of magnitude higher than that of its MAPbBr_3 counterparts. The response time of this photodetector is less than 1 ms.This study provides solid evidence that FAPbBr_3 can be an excellent candidate for highly sensitive and fast photodetectors. | Fengying Zhang Bin Yang Kaibo Zheng Songqiu Yang Yajuan Li Weiqiao Deng Rongxing He | 2018 | Nano-Micro Letters2018，10，3： | 2 |
| 13 | Adenine Phosphoribosyl Transferase 1 is a Key Enzyme Catalyzing Cytokinin Conversion from Nucleobases to Nucleotides in Arabidopsis显示文摘在植物,细胞激动素包括细胞激动素生合成,互变现象, inactivation,和降级,新陈代谢的进程在细胞激动素动态平衡和植物开发的规定起关键作用。嘌呤新陈代谢的酶被暗示了在以前的工作催化细胞激动素互变现象。在这研究,我们报导腺嘌 Phosphoribosyl Transferase 1 (APT1 ) 是高剂量的细胞激动素抵抗的异种的原因的基因。APT1 从免费的底催化细胞激动素变换到核苷酸,并且在 Arabidopsis 腺嘌 Phosphoribosyl Transferase 家庭的五个成员之中是机能上地占优势的。在工厂的 APT1 活动的损失导致细胞激动素底的过量累积,因此唤起无数调整细胞激动素的回答例如推迟的叶老朽, anthocyanin 累积,和下游的基因表示。因此,我们的学习把 APT1 定义为由 phosphoribosylation 参予细胞激动素 inactivation 的关键新陈代谢的酶。 | Xinyan Zhang Yutao Chen Xin Lin Xinyu Hong Ying Zhu Wenyang Li Wenrong He Fengying An Hongwei Guo | 2013 | Molecular Plant2013，6，5： | 2 |
| 14 | Effects of berberine on glucose metabolism in vitro显示文摘 | Jun Yin Renming Hu Mingdao Chen Jinfeng Tang Fengying Li Ying Yang Jialun Chen | 2002 | Metabolism2002，，11： | 2 |
| 15 | High pressure effects on the crystal structure andelectric conductivity of perovskite like (Ca/Sr)_2CuO_2Cl_2 compounds显示文摘The crystal structure stability as well as electric conductance of (Sr/Ca)_2CuO_2Cl_2 compound with K_2NiF_4 structure was investigated up to 31 GPa using diamond anvil technique. It seems that (Sr/Ca)_2CuO_2Cl_2 is quite stable under pressure but with obvious anisotropic compressibility. The equation of state (EOS) obtained shows relative large bulk modulus. | LIU QingQing WANG FuRen LI FengYing CHEN LiangChen YU RiCheng JIN ChangQing LI YanChun LIU Jing | 2008 | Chinese Science Bulletin2008，53，18： | 2 |
| 16 | Numerical Study on Seasonal Transportation of the Suspended Sediments in the Modern Yellow River Mouth Effected by the Artificial Water and Sediment Regulation显示文摘Since 2002, an artificial water and sediment regulation(AWSR) has been carried out, which largely reduced water and sediment discharged from the Yellow River into the Bohai Sea. Although the sediment transport in the Yellow River Mouth(YRM) has been observed and modeled intensively since AWSR, but preferentially for the non-storm conditions. In this study, a three-dimensional current-wave-sediment coupled model, DHI-MIKE numerical model, was used to examine the seasonal suspended-sediment transport in the YRM after the AWSR. Results show that the seasonal distribution of suspended-sediments in the YRM is dominated by wind and wave rather than river input. The major transport pathway of suspended-sediments is from the western Laizhou Bay to the Bohai Strait during the winter monsoon, especially in storm events. In addition, about 66% of the river sediments deposit within 30 km of the YRM, which is smaller than previous estimations. It suggests that the YRM has been eroded in recent decades. | WANG Nan QIAO Lulu LI Guangxue ZHONG Yi SONG Dehai DING Dong GAO Fei JI Fengying | 2019 | Journal of Ocean University of China2019，18，1： | 2 |
| 17 | Advances of supercritical fluid chromatography in lipid profiling显示文摘Supercritical fluid chromatography(SFC) meets with great favor due to its high efficiency, low organic solvent consumption, and the specialty for the identification of the isomeric species. This review describes the advances of SFC in targeted and untargeted lipid profiling. The advancement of the SFC instruments and the stationary phases are summarized. Typical applications of SFC to the targeted and untargeted lipid profiling are discussed in detail. Moreover, the perspectives of SFC in the lipid profiling are also proposed. As a useful and promising tool for investigating lipids in vitro and in vivo, SFC will predictably obtain further development. | Yang Yang Yanshan Liang Jina Yang Fengying Ye Ting Zhou Gongke Li | 2019 | Journal of Pharmaceutical Analysis2019，9，1： | 2 |
| 18 | Cy5.5-MSA-G250 nanoparticles(CMGNPs)induce M1 polarity of RAW264. 7 macrophage cells via TLR4-dependent manner显示文摘Cy5.5-MSA-G250 nanoparticles(CMGNPs)had been proved to have unique advantages for cancer treatment,including excellent photothermal performance,tumor cell-selective cytotoxicity,direct visualization,and good biocompatibility.However,to cellular systems,the CMGNPs are considered as fo reign invaders,and the effect of CMGNPs on immunity system is still unknown.Therefore,more efforts are needed to understand the role of CMGNPs on the immunity system.In this study,we attempted to screen the pro-inflammatory responses on RAW264.7 macrophages after treated with the CMGNPs.In vitro experiments clearly showed that CMGNPs not only enhances phagocytosis capacity of RAW264.7 cells,but also promotes Ml polarization,associated with changes in cell morphology and increased expression of inflammatory cytokines.This ability to induce Ml polarization may be beneficial to CMGNPs to achieve better anticancer effects in clinical trials.Moreover,the observed Ml macrophages’ polarization triggered by CMGNPs can be abolished after adding TLR4 inhibitor,CLI095,suggesting that TLR4 is involved in CMGNP-induced inflammation. | Zhuoxuan Lu Lingfeng Xu Nongyue He Fengying Huang Tiefeng Xu Li Li Yanwei Zhang Liming Zhang | 2019 | Chinese Chemical Letters2019，30，6： | 2 |
| 19 | Efficacy of ICIs on patients with oncogene-driven non-small cell lung cancer:a retrospective study显示文摘Aim:The objective of our study was to assess the efficacy of immune checkpoint inhibitors(ICIs)on patients with non-small-cell lung cancer(NSCLC)harboring oncogenic alterations.Methods:We retrospectively enrolled patients with advanced non-squamous NSCLC who were treated with anti-PD-1-based monotherapy or combined immunotherapy.Major characteristics including PD-L1 expression,treatment,and survival were analyzed.Results:In total,309 non-squamous NSCLC patients with a median age of 61 years(range 20-88 years)including 70.9%male were retrospectively enrolled.The molecular alterations involved epidermal growth factor receptor(EGFR)(n=81),V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)(n=31),anaplastic lymphoma kinase(ALK)(n=1),human epidermal growth factor receptor 2(HER2)(n=12),V-raf murine sarcoma viral oncogene homolog(BRAF)(n=2),rearranged during transfection(n=4),and c-ros oncogene 1(ROS1)(n=3).In the EGFR subset,the ORR was 30.9%(n=81)and PFS was significantly shorter than WT group(median PFS:5.7 months vs.7.1 months;P=0.0061).In subgroup analyses,ICI combined therapy was significantly correlated with a longer PFS compared with ICI monotherapy(median PFS:7.7 months vs.4.7 months;P=0.0112).In KRAS patients,ORR was 51.6%(n=31).No significant difference was found in subgroup analyses.The ORR and PFS were 16.7%(n=12)and 28.6%(n=7),7.8 months and 9.0 months for HER2 and EGFR Exon20 insertion patients,respectively.Three ROS1 patients were enrolled with a PFS of 16.0,34.2,and 45.0 months individually,and one ALK patient with PFS of 4.4 months was identified.No response was found in two BRAF patients.Conclusion:ICI-based combination therapy can bring benefit to patients with EGFR-mutant NSCLC.ICI-based combination therapy could be considered for patients with ROS1 rearrangement,HER2 mutation and EGFR Exon20 insertion NSCLC. | Xiaojin Guo He Du Jiayu Li Menghang Yang Anweng Xiong Haiping Zhang Fengying Wu | 2022 | Cancer Drug Resistance2022，5，1： | 2 |
| 20 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
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