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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 3 | Controlled release from poly(phosphoester)matrices显示文摘 | Dahiyat BI Richards M Leong KW | 1995 | J Controlled Release1995，33，1： | 1 |
| 4 | A security model for distributed product data management system显示文摘 | K K Leong K M Yu W B Lee | 2003 | Computers in Industry2003，50，： | 1 |
| 5 | Suppressive subtraction Libraries to Identify interferon-inducible genes in fish显示文摘 | Alonso M Leong J A | 2002 | Mar Biotechnol2002，4，1： | 1 |
| 6 | Dual-polarized slotcoupled planar antenna with wide bandwidth显示文摘 | GAO S LI L LEONG M YEO T | 2003 | IEEE Transactions on Antennas Propagat2003，51，： | 1 |
| 7 | Modeling of shell and tube heat recovery exchanger operated with nanofluid based coolants显示文摘 | Leong K Y Saidur R Mahlia T M I | 2012 | International Journal of Heat and Mass Transfer2012，55，4： | 1 |
| 8 | Application of flexible printed circuit board (FPCB) in personal computer motherboards: Focusing on mechanical performance 显示文摘 | LEONG W ABDULLAH M KHOR C | 2012 | Microelectronics Reliability2012，52，4： | 1 |
| 9 | Infiltration effects on stability of a residual soil slope显示文摘 | GASMO J M RAHARDJO H LEONG E C | 2000 | Computers and Geotechnics2000，26，2： | 1 |
| 10 | Jellyfish as food显示文摘 | Hsieh Y-H P Leong F M Rudloe | 2001 | Hydrobiologia2001，451，： | 1 |
| 11 | Depletion of langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘 | MATTHEWS K LEONG C M BAXTER L | 2003 | J Virol2003，77，： | 1 |
| 12 | Genome organization of Magnaporthe grisea: integration of genetic maps, clustering of transposable elements and identification of genome duplications and rearrangments显示文摘 | Nitta N Farman M L Leong S A | 1997 | Theor Appl Genet1997，95，： | 1 |
| 13 | Infiltration Effects on Stability of a Residual Soil Slope显示文摘 | Gasmo J M Rahardjo H Leong E C | 2000 | Computers and Geote Chanics2000，26，2： | 1 |
| 14 | A new two-step gradient method for large-scale unconstrained optimization显示文摘 | Farid M Leong W J Hassan M A | 2010 | Computers and Mathematics with Applications2010，22，9： | 1 |
| 15 | Angiogenesis inhibitors in the treatment of epithelial ovarian cancer 显示文摘 | Hart ES Wakabayashi M Leong L | 2013 | Curr Treat Options Oncol2013，14，1： | 1 |
| 16 | Effect of pyridostigmine (Mestinon) on human platelet aggregation显示文摘 | Leong CF Aini-Ardena M Cheong SK | | 0，，01： | 1 |
| 17 | Infiltration effects on stability of a residual soil slope显示文摘 | CASMO J M RAHARDJO H LEONG E C | 2000 | Computers & Geotechnics2000，26，： | 1 |
| 18 | Elastoplastic model for unsaturated soil with incorporation of the soil-water characteristic curve 显示文摘 | THU T M RAHARDJO H LEONG E C | 2007 | Canadian Geotechnicai Journal2007，44，1： | 1 |
| 19 | Comput显示文摘 | Leong P M Morgenthaler S Random W | 1995 | Applic1995，102，12： | 1 |
| 20 | Comparison of the Mechanical Properties and Interracial Interactions Between Talc, Kaolin, and Calcium Carbonate Filled Polypropylene Composites显示文摘 | Leong Y W Bakar M B Mohd Z A | 2004 | Journal of Applied Polymer Science2004，91，5： | 1 |
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