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| 1 | New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders显示文摘The applicability of stable gut hormones for the treatment of obesity-related diabetes is now undisputable. This is based predominantly on prominent and sustained glucoselowering actions, plus evidence that these peptides can augment insulin secretion and pancreatic islet function over time. This review highlights the therapeutic potential of glucagon-like peptide-1(GLP-1), glucose-dependent insulinotropic polypeptide(GIP), oxyntomodulin(OXM) and cholecystokinin(CCK) for obesity-related diabetes.Stable GLP-1 mimetics have already been successfully adopted into the diabetic clinic, whereas GIP, CCK and OXM molecules offer promise as potential new classes of antidiabetic drugs. Moreover, recent studies have shown improved therapeutic effects following simultaneous modulation of multiple receptor signalling pathways by combination therapy or use of dual/triple agonist peptides. However, timing and composition of injections may be important to permit interludes of beta-cell rest. The review also addresses the possible perils of incretin based drugs for treatment of prediabetes. Finally, the unanticipated utility of stable gut peptides as effective treatments for complications of diabetes, bone disorders, cognitive impairment and cardiovascular dysfunction is considered. | Nigel Irwin Peter R Flatt | 2015 | World Journal of Diabetes2015，6，15： | 4 |
| 2 | Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice显示文摘 | S. K. Swanston-Flatt C. Day C. J. Bailey P. R. Flatt | 1990 | Diabetologia1990，，8： | 3 |
| 3 | Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells显示文摘AIM: To explore the bioactivity of an ethanolic extract of Schizandra arisanensis (SA-Et) and isolated constituents against interleukin-1 β and interferon-γ-mediated β cell death and abolition of insulin secretion. METHODS: By employing BRIN-BD11 cells, the effects of SA-Et administration on cytokine-mediated cell death and abolition of insulin secretion were evaluated by a viability assay, cell cycle analysis, and insulin assay. The associated gene and protein expressions were also measured. In addition, the bioactivities of several peak compounds collected from the SA-Et were tested against cytokine-mediated β cell death.RESULTS: Our Results revealed that SA-Et dose-dependently ameliorated cytokine-mediated β cell death and apoptosis. Instead of suppressing inducible nitric oxide synthase/nitric oxide cascade or p38MAPK activity, suppression of stress-activated protein kinase/c-Jun NH2-terminal kinase activity appeared to be the target for SA-Et against the cytokine mix. In addition, SA-Et provided some insulinotropic effects which re-activated the abolished insulin exocytosis in cytokine-treated BRIN-BD11 cells. Finally, schiarisanrin A and B isolated from the SA-Et showed a dose-dependent protective effect against cytokine-mediated β cell death. CONCLUSION: This is the first report on SA-Et ameliorating cytokine-mediated β cell death and dysfunction via anti-apoptotic and insulinotropic actions. | Yi-Shin Hsu Yao-Haur Kuo Hui-Ling Cheng Peter R Flatt Hui-Kang Liu | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 4 | The effects of traditional antidiabetic plants on in vitro glucose diffusion显示文摘 | A.M Gallagher P.R Flatt G Duffy Y.H.A Abdel-Wahab | 2003 | Nutrition Research2003，，3： | 2 |
| 5 | Effects of ketone body infusion on hypoglyeemic reaetion in post absorptive dogs显示文摘 | Flatt J P Blackburn G L Randers G | 1974 | Metabolism1974，23，： | 1 |
| 6 | Effect of dietary fat content on the inci- dence of obesity among ad libitum fed mice 显示文摘 | Salmon D M J P Flatt | 1985 | Int J Obes1985，9，6： | 1 |
| 7 | Salt Damage in Porous Materials: How High Super Saturations are Generated显示文摘 | Flatt R J | 2002 | Journal of Crystal Growth2002，242，34： | 1 |
| 8 | Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity显示文摘 | Pierce JP Stefanick ML Flatt SW | | 0，，17： | 1 |
| 9 | Concrete: An eco material that needs to be improved 显示文摘 | FLATT R J ROUSSEL N CHEESEMAN C R | 2012 | J Eur Ceram Soe2012，32，11： | 1 |
| 10 | Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL)Study显示文摘 | Jacobs ET Thomson CA Flatt SW ctal | 2011 | The American journal of clinical nutrition2011，93，1： | 1 |
| 11 | Compa-rison between ADCP and transmissometer measurements of suspended sedment concentration显示文摘 | HOLDAWAY G P THORNE P D FLATT D | | 0，，19： | 1 |
| 12 | Dietary factors affecting development of the ruminant stomach显示文摘 | Warner R G Flatt W P Loosli J K | 1956 | J Agr Food Chem1956，4，： | 1 |
| 13 | Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes 显示文摘 | Green B D Flatt P R Bailey C J | 2006 | Diabetes Vasc Dis Res2006，3，3： | 1 |
| 14 | Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the famesoid X receptor (FXR) 显示文摘 | Flatt B Martin R Wang TL | 2009 | J Med Chem2009，52，： | 1 |
| 15 | Greater survival after breastcancer in physically active women with high vegetable-fruit intakeregardless of obesity显示文摘 | Pierce JP Stefanick ML Flatt SW | 2007 | J Clin Oncol2007，25，17： | 1 |
| 16 | Tumor necrosis factor stimulates amylin secretion but inhibits insulin from islet β-cells by independent pathways显示文摘 | Ding X Z Flatt P R Adrian T E | 1996 | Regulatory Peptides1996，64，3： | 1 |
| 17 | Failure of dietary fat intake to promote fat oxidation: a factor favoring the development of obesity显示文摘 | Schulz Y Flatt JP Jèquier E | 1989 | Am J Clin Nutr1989，50，： | 1 |
| 18 | Greater survival afterbreast cancer in physically active women with high vegetable-fruit intake regardless of obesity 显示文摘 | Pierce JP Stefanick ML Flatt SW | 2007 | J Clin Oncol2007，25，17： | 1 |
| 19 | Engineering cultured insulin-secreting pancreatic B-cell lines显示文摘 | McClenaghan NH Flatt PR | | 0，，01： | 1 |
| 20 | Four weeks administration of Limglufide improves memory and learning as well as glycaenic con trol in rricewith high fat dietary-induced obesity and insulin resistance显示文摘 | Porter DW Kerr M Flatt PR | | 0，，10： | 1 |
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