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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Characterization of biomass-based flash pyrolysis oils显示文摘 | Kai Sioila Eeva Kcoppala Leena Fagerna s | 1998 | BiomassandBioenergy1998，14，2： | 1 |
| 3 | Effect of lameness on sow longevity显示文摘 | Sukumarannair S A Leena A John D | 2009 | Journal of the American Veterinary Medical Association2009，235，： | 1 |
| 4 | A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses显示文摘 | Samuli Ripatti Emmi Tikkanen Marju Orho-Melander Aki S Havulinna Kaisa Silander Amitabh Sharma Candace Guiducci Markus Perola Antti Jula Juha Sinisalo Marja-Liisa Lokki Markku S Nieminen Olle Melander Veikko Salomaa Leena Peltonen Sekar Kathiresan | 2010 | The Lancet . 2010 (9750)2010，，： | 1 |
| 5 | Evaluation of Sur- face Lignin on Cellulose Fibers with XPS显示文摘 | LEENA S J CAMPBELL J M KRISTA K | 1999 | Applied Surface Science1999，14，： | 1 |
| 6 | Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors1 显示文摘 | Leena K S Wiiliam B Pang X Z | 1999 | JPET1999，288，： | 1 |
| 7 | Enhanced in vitro permeation of furosemide loaded into thermally carbonized mesoporous silicon(TCPSi)microparticles显示文摘 | Leena L Jamo S | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，，： | 1 |
| 8 | Epidemiology of osteoarthritis: an update 显示文摘 | Leena S Dipali K Sakeba I | 2006 | Curr Opin Rheum2006，18，2： | 1 |
| 9 | Competence areas of nursing students in Europe 显示文摘 | Satu KU Leena S Mikko S | 2013 | Nurse Educ Today2013，33，6： | 1 |
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| 11 | Competence areas of nursing stu-dents in Europe显示文摘 | Satu KU Leena S Mikko S | 2013 | Nurs Educ Today2013，33，6： | 1 |
| 12 | Modification of hardwood dissolcing pulp with purified trichoderma reesei cellulase显示文摘 | Leena R Matti S | 1996 | Cellulose1996，3，： | 1 |
| 13 | Room temperature efficacious synthesis of diphenylmethane over Fe/A1-MCM-41 catalysts 显示文摘 | MUTHURAJ E LEENA P THIRIPURANTHAGAN S | 2010 | Catalysis Communications2010，11，10： | 1 |
| 14 | Cytomegalovirus increases collagen synthesis in chronic rejection in the louse显示文摘 | Anu S Leena K | 2002 | Nephrol-Dial-Transplant2002，17，5： | 1 |
| 15 | Characterization of biomass-based flash pyrolysis oils显示文摘 | Kai Sipilaè Eeva Kuoppala Leena Fagernaès | 1998 | Biomass and Bioenergy1998，14，2： | 1 |
| 16 | Investigation of water uptake behavior and mechanical properties of superporous hydrogels显示文摘 | Bajpai S K Bajpai M Sharma Leena | | 0，，： | 1 |
| 17 | Invasive solid carcinoma of the breast: a report of two cases显示文摘 | Leena JB Kini RG Amber S | 2013 | J Clin Diagn Res2013，7，6： | 1 |
| 18 | Surface modification of poly (divinylbenzene) microspheres via thiol-ene chemistry and alkyne-azide click reactions显示文摘 | Anja S Goldmann Andreas Walther Leena nebhani | 2009 | Macromolecules2009，42，： | 1 |
| 19 | Peptide-polymer biotherapeutic synthesis on novel cross-linked beads with 'Spatially Tunable' and 'Isolated' functional sites显示文摘 | Jacob M K Leena S Kumar K S | 2008 | Biopolymers2008，90，： | 1 |
| 20 | De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction显示文摘 | Dianna M.Milewicz John R.?stergaard Leena M.Ala‐Kokko NadiaKhan Dorothy K.Grange RobertoMendoza‐Londono Timothy J.Bradley Ann HaskinsOlney LesleyAdès Joseph F.Maher DongchuanGuo L. MaximilianBuja DongKim James C.Hyland Ellen S.Regalado | 2010 | Am J Med Genet2010，，10： | 1 |
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