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| 1 | Accuracy of training blood volume quantifi cation using a visual estimation tool显示文摘BACKGROUND:We investigated whether the use of a specially designed visual estimation tool may improve accuracy in quantifying blood volumes related to surface spreading.METHODS:A prospective,paired-control,single-blinded experimental study was performed at a medical university.Anesthesiologists and emergency medical personnel estimated various blood volumes on surfaces with varying absorptivity(carpet,towel,polyvinyl chloride,wooden fl ooring)in an experimental setting.We assessed the sensitivity of training blood volume quantifi cation using a self-designed visual estimation tool by comparing the accuracy of visual blood volume estimations before and after practical training with the tool.RESULTS:A total of 352 estimations by 44 participants were evaluated.Accurate estimations improved significantly from pre-training to post-training(P<0.05).The sensitivity of blood volume quantifi cation was 33.0%after training with the visual estimation tool.Estimations did not depend on age,profession,gender or years of the estimator’s professional experience.CONCLUSIONS:Training with a visual estimation tool by professional rescuers can improve the estimation accuracy of blood volumes spread on surfaces with varying absorptivity. | Janett Kreutziger Philip Puchner Stefan Schmid Wolfgang Mayer Harald Prossliner Wolfgang Lederer | 2021 | World Journal of Emergency Medicine2021，12，3： | 5 |
| 2 | Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats显示文摘Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury(SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein(GFAP) and S100 calcium-binding protein B(S100B)(astrocytic reactivity classical markers) and global histone H4 acetylation levels. Sixty-one male Wistar rats(aged ~3 months) were divided into the following groups: sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases(first phase: no changes in the 6, 24 and 48 hours post-SCI groups; second phase: increased levels in the 72 hours post-SCI group; and a third phase: return to levels similar to control in the 7 days post-SCI group). Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury. | Mayara Ferraz de Menezes Fabricio Nicola Ivy Reichert Vital da Silva Adriana Vizuete Viviane Rostirola Eisner Leder Leal Xavier Carlos Alberto Saraiva Goncalves Carlos Alexandre Netto Regis Gemerasca Mestriner | 2018 | Neural Regeneration Research2018，13，11： | 2 |
| 3 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 4 | Formin Binding Proteins Bear WWP/WW Domains that Bind Proline-rich Peptides and Functionally Resemble SH3 Domains显示文摘 | CHAN D BEDFORD C LEDER P | 1996 | EMBO J1996，15，5： | 1 |
| 5 | Computed tomography of renal lymphoma显示文摘 | Cohan RH Dunnick NR Leder RA | 1990 | J Comput Assist Tomogr1990，14，： | 1 |
| 6 | PSA bounce phenomenon after transperineal interstitial permanent prostate brachytherapy for localized prostate cancer显示文摘 | Morita M Lederer JL Fukagai T | 2004 | Nippon Hinyokika Gakkai Zasshi2004，5，3： | 1 |
| 7 | Compression CT urography: a comparison with IVU in the opacification of the collecting system and ureter显示文摘 | Heneghan JP Kim DH Leder RA | 2001 | J Comput Assist Tomogr2001，25，3： | 1 |
| 8 | A viral movement protein prevents spread of the gene silencing signal in Nicotiana benthamiana显示文摘 | VOINNET O LEDERER C BAULCOMBE D C | 2000 | Cell2000，103，： | 1 |
| 9 | Neostigmine injected 5 minutes after low-dose rocuronium accelerates the recovery of neuromuscular function显示文摘 | Lederer W Reiner T Khuenl-Brady KS | | 0，，06： | 1 |
| 10 | Fiberoptic endoscopic documen-tation of the high incidence of aspiration following extubation incritically ill trauma patients 显示文摘 | Leder SB?Cohn SM Moller BA | 1998 | Dysphagia1998，134，： | 1 |
| 11 | Clinical utility of the 3- ounce water swallow test显示文摘 | Suiter DM Leder SI3 | 2008 | Dysphagia2008，23，3： | 1 |
| 12 | 显示文摘 | Pattengale PK Kuo A | 1986 | Cell1986，45，4： | 1 |
| 13 | Information systems project management: an agency theory interpretation显示文摘 | Mahaney C Robert Lederer L Albert | 2003 | The Journal of Systems and Software2003，68，： | 1 |
| 14 | Enhancement of capsid gene expression:preparing the human papillomavirus type 16 major structural gene L1 for DNA vaccination purposes显示文摘 | Leder C Kleinschmidt J A Wiethe C | 2001 | J Virol2001，75，： | 1 |
| 15 | Cloning and expression of an inwardly rectifying ATP-rgulated potassium channel 显示文摘 | Ho K Nichols C Lederer J | 1993 | Nature1993，362，： | 1 |
| 16 | Guidelines for Strategic Information Planning 显示文摘 | Lederer A L Sethi V | 1991 | Journal of Business Strategy1991，12，6： | 1 |
| 17 | Significance of working conditions on burnout in anesthetists显示文摘 | Lederer W Kinzl JF Trefalt E | 2006 | Acta Anaesthesiol Scand2006，50，1： | 1 |
| 18 | Wide-field retinal imaging in the management of noninfectious posterior uveitis 显示文摘 | Campbell JP Leder HA Sepah YJ | 2012 | Am J Ophthalmol2012，154，5： | 1 |
| 19 | Beta-catenin is a downstream el- lector of Wnt mediated tumorigenesis in the mammary gland显示文摘 | Michaelson JS Leder P | 2001 | Oncogene2001，20，37： | 1 |
| 20 | Regulatory fit effects on perceived fiscal exchange and tax compli- ance显示文摘 | Susanne Leder Lucia Mannetti Erik Htilzl Erich Kirehler | 2010 | Journal of Socio-Economics2010，39，4： | 1 |
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