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| 1 | Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage显示文摘Intracerebral hemorrhage(ICH)is a stroke subtype caused by spontaneous rupture of small vessels and bleeding into the brain parenchyma,resulting in cell death and sensorimotor deficits.Despite the greater prevalence of the ischemic form of stroke(87%),ICH has the highest mortality rate of all stroke subtypes.The striatum is the most affected structure in hemorrhagic stroke(35–70%),followed by cere- | Juliana Dalibor Neves Régis Gemerasca Mestriner Carlos Alexandre Netto | 2018 | Neural Regeneration Research2018，13，1： | 3 |
| 2 | Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats显示文摘Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury(SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein(GFAP) and S100 calcium-binding protein B(S100B)(astrocytic reactivity classical markers) and global histone H4 acetylation levels. Sixty-one male Wistar rats(aged ~3 months) were divided into the following groups: sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases(first phase: no changes in the 6, 24 and 48 hours post-SCI groups; second phase: increased levels in the 72 hours post-SCI group; and a third phase: return to levels similar to control in the 7 days post-SCI group). Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury. | Mayara Ferraz de Menezes Fabricio Nicola Ivy Reichert Vital da Silva Adriana Vizuete Viviane Rostirola Eisner Leder Leal Xavier Carlos Alberto Saraiva Goncalves Carlos Alexandre Netto Regis Gemerasca Mestriner | 2018 | Neural Regeneration Research2018，13，11： | 2 |
| 3 | Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia显示文摘 | Fabrício Sim?o Aline Matté Aline S. Pagnussat Carlos Alexandre Netto Christianne G. Salbego | 2012 | Neurochemistry International2012，，5： | 1 |
| 4 | Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat显示文摘 | Daniel Lavinsky Nice Sarmento Arterni Matilde Achaval Carlos Alexandre Netto | 2006 | Graefe’s Archive for Clinical and Experimental Ophthalmology2006，，2： | 1 |
| 5 | Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat显示文摘 | évelin Vicente Daniel Degerone Liana Bohn Francisco Scornavaca Alexandre Pimentel Marina C. Leite Alessandra Swarowsky Letícia Rodrigues Patrícia Nardin Lucia Maria Vieira de Almeida Carmem Gottfried Diogo Onofre Souza Carlos Alexandre Netto Carlos Albert | 2008 | Brain Research2008，，： | 1 |
| 6 | Agmatine induces anxiolysis in the elevated plus maze task in adult rats显示文摘 | Daniel Lavinsky Nice Sarmento Arteni Carlos Alexandre Netto | 2003 | Behav Brain Res2003，141，1： | 1 |
| 7 | Early enriched housing results in partial recovery of memory deficits in female, but not in male, rats after neonatal hypoxia–ischemia显示文摘 | Lenir Orlandi Pereira Atahualpa Cauê Paim Strapasson Patrícia Machado Nabinger Matilde Achaval Carlos Alexandre Netto | 2008 | Brain Research2008，，： | 1 |
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