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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 3 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 4 | Less invasive technique for mitral valve surgery 显示文摘 | Carpentier A Cho PW Berrebi A d'Attellis N Austin CB Couetil JP Lajos P | 1998 | J Thorac Cardiovasc Surg1998，115，4： | 1 |
| 5 | Fuzzy model-based predictive control by instantaneous linearization显示文摘 | JANOS A LAJOS N FERENC S | 2001 | Fuzzy Sets and Systems2001，120，1： | 1 |
| 6 | Matrix Metalloproteinase-9 Expression in the Normal Mucosa–Adenoma–Dysplasia–Adenocarcinoma Sequence of the Colon显示文摘 | László Herszényi Ferenc Sipos Orsolya Galamb Norbert Solymosi István Hritz Pál Miheller Lajos Berczi Béla Molnár Zsolt Tulassay | 2008 | Pathology & Oncology Research2008，，1： | 1 |
| 7 | Proximal tubular transport and urinary excretion of sodium after renal denervation in sodium depleted rats显示文摘 | Gábor Szénási Pál Benesáth Lajos Takács Bozena Asztalos Mária Vedres | 1985 | Pflügers Archiv European Journal of Physiology1985，，2： | 1 |
| 8 | Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer:The superiority of minimally invasive surgery显示文摘BACKGROUND Previous meta-analyses,with many limitations,have described the beneficial nature of minimal invasive procedures.AIM To compare all modalities of esophagectomies to each other from the results of randomized controlled trials(RCTs)in a network meta-analysis(NMA).METHODS We conducted a systematic search of the MEDLINE,EMBASE,Reference Citation Analysis(http://gffzzb1f9d057b5954674snpq99wb9oko96669.ffgz.tsg.suse.edu.cn/)and CENTRAL databases to identify RCTs according to the following population,intervention,control,outcome(commonly known as PICO):P:Patients with resectable esophageal cancer;I/C:Transthoracic,transhiatal,minimally invasive(thoracolaparoscopic),hybrid,and robot-assisted esophagectomy;O:Survival,total adverse events,adverse events in subgroups,length of hospital stay,and blood loss.We used the Bayesian approach and the random effects model.We presented the geometry of the network,results with probabilistic statements,estimated intervention effects and their 95% confidence interval(CI),and the surface under the cumulative ranking curve to rank the interventions.RESULTS We included 11 studies in our analysis.We found a significant difference in postoperative pulmonary infection,which favored the minimally invasive intervention compared to transthoracic surgery(risk ratio 0.49;95%CI:0.23 to 0.99).The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery(mean difference-85 min;95%CI:-150 to-29),hybrid intervention(mean difference-98 min;95%CI:-190 to-9.4),minimally invasive technique(mean difference-130 min;95%CI:-210 to-50),and robot-assisted esophagectomy(mean difference-150 min;95%CI:-240 to-53).Other comparisons did not yield significant differences.CONCLUSION Based on our results,the implication of minimally invasive esophagectomy should be favored. | Lajos Szakó Dávid Németh Nelli Farkas Szabolcs Kiss Réka Zsuzsa Domotor Marie Anne Engh Péter Hegyi Balint Eross András Papp | 2022 | World Journal of Gastroenterology2022，28，30： | 1 |
| 9 | Marketing Margins and Price ransmission on the Hungarian Pork Meat Market显示文摘 | Lajos Zoltán Bakucs Imre Fert | | 0，，02： | 1 |
| 10 | PPAR3, in immunity and inflam- mation : cell types and diseases 显示文摘 | LAJOS S DANIEL T LASZLO N | 2007 | Biochimicaet Biophysica Acta2007，1771，： | 1 |
| 11 | Multicentric plasmocytic Castleman’s disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection – a possible relationship显示文摘 | á dá m Fazakas Má rta Csire Gy? rgy Berencsi á gota Szepesi Andrá s Matolcsy Lajos Jakab Istvá n kará di Judit Vá rkonyi | 2009 | Leukemia & Lymphoma2009，，： | 1 |
| 12 | Detection of phosphine : new aspects of the phosphorus cycle in the hydrosphere显示文摘 | István Dévai Lajos Felfldy Ilona Wittner | 1988 | Nature1988，333，26： | 1 |
| 13 | Comparison of separation performances of novel β -cyclodextrin-based chiral stationary phases in high-performance liquid chromatographic enantioseparation显示文摘 | Gábor Varga Gábor Fodor István Ilisz Julianna Szemán Júlia Visy Lajos Szente Antal Péter | 2012 | Journal of Pharmaceutical and Biomedical Analysis2012，，： | 1 |
| 14 | Preparation of New Imidacloprid Analogues 显示文摘 | LAJOS N GABOR H IMRE K | 2001 | Heterocycles2001，55，： | 1 |
| 15 | The logarithmic average of sample extremes is asymptotically normal显示文摘 | ISTV/N B LAJOS H | 2001 | Stochastic Processes and Their Applications2001，91，1： | 1 |
| 16 | Novel application of an in situ radiotracer method for the study of the formation of surface adlayers in the course of Cr(Ⅵ) reduction on a gold electrode显示文摘 | Kálmán V Imre S Lajos G | 2002 | Journal of Electroanalytical Chemistry2002，，： | 1 |
| 17 | PPARγ in immunity and inflammation: cell types and diseases 显示文摘 | Lajos S Daniel T Laszlo N | 2007 | Biochimicaet Biophysica Acta2007，1771，： | 1 |
| 18 | Effects of pentoxifylline and pentosan polysulphate combination therapy on diabetic neuropathy in type 2 diabetes mellitus显示文摘 | Boglárka Laczy Judit Cseh Márton Mohás Lajos Markó Mónika Tamaskó Tamás K?szegi Gerg? A. Molnár Zoltán Wagner László Wagner István Wittmann | 2009 | Acta Diabetologica2009，，2： | 1 |
| 19 | Xenon chloride ultraviolet B laser is more effective in treating psoriasis and in inducing T cell apoptosis than narrow-band ultraviolet B显示文摘 | Zoltán Novák Béla Bónis Eszter Baltás Imre Ocsovszki Ferenc Ignácz Attila Dobozy Lajos Kemény | 2002 | Journal of Photochemistry & Photobiology, B: Biology2002，，1： | 1 |
| 20 | Systematic study of structural,transport,and magnetic properties of Ni52+xMn26-xAl22(1≤x≤5)melt-spun ribbons显示文摘 | SAURABH K S VIJAY K S LAJOS K VLADIMIR V KHOVAYLO V RYOUSUKE K MAKOTO N RATNAMALA C | 2011 | Journal of Applied Physics2011，109，08： | 1 |
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