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| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | Almost sure limit theorems under minimal conditions显示文摘 | ISTVAN B ENDRE C LAJOS H | 1998 | Statistics & Probability Letters1998，37，1： | 1 |
| 4 | Multiuser detection assisted time-and frequency-domain spread muiticarrier code-division multiple-access显示文摘 | Yang Lieliang Hua Wei Lajos H | 2006 | IEEE Transactions on Vehicular Technology2006，55，1： | 1 |
| 5 | High affinity binding of paclitaxel to human serum albumin显示文摘 | Krisztina P Jozsef M Lajos H | 2001 | Eur J Biochem2001，268，： | 1 |
| 6 | Comparative study of Turbo decoding techniques:anoverview显示文摘 | Lajos H | 2000 | IEEE Tran-sactions on Vehicular Technology2000，49，6： | 1 |
| 7 | Extreme value theory for stochastic integrals of Legendre polynomials 显示文摘 | Alexander A Lajos H B Marie H | 2009 | Journal of Multivariate Analysis2009，100，3： | 1 |
| 8 | A Conmptive Study of Turbo Decoding Techniques: An Overview显示文摘 | JASON P LAJOS H | 2000 | IEEE Trans on VEH TECHNOL2000，49，6： | 1 |
| 9 | Adaptive modulation techniques for duplex OFDM transmission 显示文摘 | Thomas K Lajos H | 2000 | IEEE Transactions on Vehicular Technology2000，49，5： | 1 |
| 10 | A Turbo- coded burst- by- burst adaptive wide- band speech transceiver显示文摘 | KELLER T MATTHIA M LAJOS H | 2000 | IEEE JSAC2000，18，11： | 1 |
| 11 | Space-Time Codes and Concatenated Channel Codes for Wireless Communications显示文摘 | T H Liew Lajos Hanzo | 2002 | Proceedings of The IEEE2002，90，2： | 1 |
| 12 | Preparation of New Imidacloprid Analogues 显示文摘 | LAJOS N GABOR H IMRE K | 2001 | Heterocycles2001，55，： | 1 |
| 13 | Comparison of the resonance Raman spectra of carbon monoxy and oxyhemoglobin and myoglobin:similarities and differences in heme electron distribution显示文摘 | Lajos R Irving S David H P | 1975 | Biochemistry1975，14，2： | 1 |
| 14 | Space-Time Codes and Concatenated Channel Codes for Wireless Communications 显示文摘 | Liew T H Hanzo Lajos | 2002 | Proceedings of the IEEE2002，90，2： | 1 |
| 15 | The logarithmic average of sample extremes is asymptotically normal显示文摘 | ISTV/N B LAJOS H | 2001 | Stochastic Processes and Their Applications2001，91，1： | 1 |
| 16 | Adaptive multicarrier modulation:a convenient framework for time-frequency processing in wireless communications显示文摘 | HOMAS K LAJOS H | 2000 | IEEE Proceedings2000，88，61： | 1 |
| 17 | Reduced complenty In-phase Quadrature-phase M-QAM turbo equalization using iterafive channel estimation 显示文摘 | Bee L Yeap Choong H Wong Lajos Hanzo | 2003 | IEEE Transactions on Wireless Communications2003，2，1： | 1 |
| 18 | Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae显示文摘 | Lajos H Carlos A Torres R | 2004 | Mol Cell Biol2004，24，10： | 1 |
| 19 | Adaptive multicarrier modulation: a convenient framework for time-frequency processing in wireless communications 显示文摘 | Thomas K Lajos H | 2000 | IEEE Proceedings2000，88，5： | 1 |
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