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| 1 | Interactions between central nervous system and peripheral metabolic organs显示文摘According to Descartes,minds and bodies are distinct kinds of “substance”,and they cannot have causal interactions.However,in neuroscience,the two-way interaction between the brain and peripheral organs is an emerging field of research.Several lines of evidence highlight the importance of such interactions.For example,the peripheral metabolic systems are overwhelmingly regulated by the mind(brain),and anxiety and depression greatly affect the functioning of these systems.Also,psychological stress can cause a variety of physical symptoms,such as bone loss.Moreover,the gut microbiota appears to play a key role in neuropsychiatric and neurodegenerative diseases.Mechanistically,as the command center of the body,the brain can regulate our internal organs and glands through the autonomic nervous system and neuroendocrine system,although it is generally considered to be outside the realm of voluntary control.The autonomic nervous system itself can be further subdivided into the sympathetic and parasympathetic systems.The sympathetic division functions a bit like the accelerator pedal on a car,and the parasympathetic division functions as the brake.The high center of the autonomic nervous system and the neuroendocrine system is the hypothalamus,which contains several subnuclei that control several basic physiological functions,such as the digestion of food and regulation of body temperature.Also,numerous peripheral signals contribute to the regulation of brain functions.Gastrointestinal(GI) hormones,insulin,and leptin are transported into the brain,where they regulate innate behaviors such as feeding,and they are also involved in emotional and cognitive functions.The brain can recognize peripheral inflammatory cytokines and induce a transient syndrome called sick behavior(SB),characterized by fatigue,reduced physical and social activity,and cognitive impairment.In summary,knowledge of the biological basis of the interactions between the central nervous system and peripheral organs will promote the full understanding of how our body works and the rational treatment of disorders.Thus,we summarize current development in our understanding of five types of central-peripheral interactions,including neural control of adipose tissues,energy expenditure,bone metabolism,feeding involving the brain-gut axis and gut microbiota.These interactions are essential for maintaining vital bodily functions,which result in homeostasis,i.e.,a natural balance in the body’s systems. | Wenwen Zeng Fan Yang Wei L.Shen Cheng Zhan Peng Zheng Ji Hu | 2022 | Science China(Life Sciences)2022，65，10： | 5 |
| 2 | 查看详情显示文摘 | N.Bao L.Shen G.Srinivasan K.Yanagisawa and A.Gupta | | 0，，23： | 1 |
| 3 | Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus显示文摘Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. | Fang Luo Yuling Mu Cuicui Gao Yan Xiao Qian Zhou Yiqing Yang Xinyan Ni Wei L.Shen Jiajun Yang | 2019 | Journal of Genetics and Genomics2019，46，1： | 1 |
| 4 | Interleukin‐17 exacerbates hepatic steatosis and inflammation in non‐alcoholic fatty liver disease显示文摘 | Y.Tang Z.Bian L.Zhao Y.Liu S.Liang Q.Wang X.Han Y.Peng X.Chen L.Shen D.Qiu Z.Li X.Ma | 2011 | Clinical & Experimental Immunology2011，，2： | 1 |
| 5 | Interleukin‐17 exacerbates hepatic steatosis and inflammation in non‐alcoholic fatty liver disease显示文摘 | Y.Tang Z.Bian L.Zhao Y.Liu S.Liang Q.Wang X.Han Y.Peng X.Chen L.Shen D.Qiu Z.Li X.Ma | 2011 | Clinical & Experimental Immunology2011，，： | 1 |
| 6 | 查看详情显示文摘 | Z.Guo W.Zhu L.Shen | | 0，，： | 1 |
| 7 | A New Fe‐based Bulk Glassy Alloy with Outstanding Mechanical Properties显示文摘 | A.Inoue B.?L.Shen | 2004 | Adv Mater (鈥?)2004，，23： | 1 |
| 8 | Neurocircuitry of Predatory Hunting显示文摘Predatory hunting is an important type of innate behavior evolutionarily conserved across the animal king-dom.It is typically composed of a set of sequential actions,including prey search,pursuit,attack,and consumption.This behavior is subject to control by the nervous system.Early studies used toads as a model to probe the neuroethology of hunting,which led to the proposal of a sensory-triggered release mechanism for hunting actions.More recent stud-ies have used genetically-trackable zebrafish and rodents and have made breakthrough discoveries in the neuroethol-ogy and neurocircuits underlying this behavior.Here,we review the sophisticated neurocircuitry involved in hunting and summarize the detailed mechanism for the circuitry to encode various aspects of hunting neuroethology,including sensory processing,sensorimotor transformation,motivation,and sequential encoding of hunting actions.We also discuss the overlapping brain circuits for hunting and feeding and point out the limitations of current studies.We propose that hunting is an ideal behavioral paradigm in which to study the neuroethology of motivated behaviors,which may shed new light on epidemic disorders,including bingeeating,obesity,and obsessive-compulsive disorders. | Zheng-Dong Zhao Li Zhang Xinkuan Xiang Daesoo Kim Haohong Li Peng Cao Wei L.Shen | 2023 | Neuroscience Bulletin2023，39，5： | 0 |
| 9 | Mechanical properties of Al/a-C nanocomposite thin films synthesized using a plasma focus device显示文摘The Al/a-C nanocomposite thin films are synthesized on Si substrates using a dense plasma focus device with aluminum fitted anode and operating with CH4/Ar admixture.X-ray diffractometer results confirm the formation of metallic crystalline Al phases using different numbers of focus shots.Raman analyses show the formation of D and G peaks for all thin film samples,confirming the presence of a-C in the nanocomposite thin films.The formation of Al/a-C nanocomposite thin films is further confirmed using X-ray photoelectron spectroscopy analysis.The scanning electron microscope results show that the deposited thin films consist of nanoparticles and their agglomerates.The sizes of th agglomerates increase with increasing numbers of focus deposition shots.The nanoindentation results show the variations in hardness and elastic modulus values of nanocomposite thin film with increasing the number of focus shots.Maximum values of hardness and elastic modulus of the composite thin film prepared using 20 focus shots are found to be about 10.7 GPa and 189.2 GPa,respectively. | Z.A.Umar R.S.Rawat R.Ahmad A.K.Kumar Y.Wang T.Hussain Z.Chen L.Shen Z.Zhang | 2014 | Chinese Physics B2014，23，2： | 0 |
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