|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | Current status of severe fever with thrombocytopenia syndrome in China显示文摘Severe fever with thrombocytopenia syndrome(SFTS) is an emerging infectious disease caused by SFTS virus(SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we summarize the recent cases and general properties of SFTS, focusing on the epidemiology, genetic diversity,clinical features, and diagnostics of SFTSV in China. From 2010 to October 2016, SFTS cases were reported in 23 provinces of China, with increased numbers yearly. Infection and death cases are mainly found in central China, where the Haemaphysalis longicornis ticks are spread. The national average mortality rate of SFTS infection was 5.3%, with higher risk to elder people. The main epidemic period was from May to July, with a peak in May. Thus, SFTS reminds a significant public health problem, and development of prophylactic vaccines and effective antiviral drugs will be highly needed. | Jianbo Zhan Qin Wang Jing Cheng Bing Hu Jing Li Faxian Zhan Yi Song Deyin Guo | 2017 | Virologica Sinica2017，32，1： | 71 |
| 3 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 4 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 5 | Super Hybrid Rice Breeding in China:Achievements and Prospects显示文摘 | Shi-Hua Cheng Li-Yong Cao Jie-Yun Zhuang Shen-Guang Chen Xiao-Deng Zhan Ye-Yang Fan De-Feng Zhu Shao-Kai Min | 2007 | Journal of Integrative Plant Biology2007，49，6： | 38 |
| 6 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 7 | The regulatory role of AT 1 receptor on activated HSCs in hepat,c fibrogenesis,effects of RAS inhibitors on hepatic fibrosis induced by CCl_4显示文摘AIM To assess the effect of ACE inhibitor andAng Ⅱ type Ⅰ(AT1)receptor antagonist inpreventing hepatic fibrosis caused by CCl4administration in rats;to investigate whether ornot there are expression of AT 1 receptors onhepatic stellate cells;and to observe the effectof Ang Ⅱ on proliferation and ECM synthesis ofcultured HSCs.METHODS Studies were conducted in maleSprague-Dawley rats.Except for thehepatofibrotic model group and the controlgroup,in three treated groups,either enalapril(5 mg/kg),or Iosartan(10 mg/kg),or enalapril+Iosartan were given to the fibrotic rats bydaily gavage,and saline vehicle was given tomodel and normal control rats.After 6 weeks,liver fibrosis was assessed directly by hepaticmorphometric analysis,which has beenconsidered the gold standard for thequantification of fibrosis.The expressions of AT1 receptors and(α-mooth muscle actin,α-SMA)in liver tissue or isolated hepatic stellate cells(HSCs)were detected by immunohistochemicaltechniques.The effect of Ang Ⅱ on HSCproliferation was determined by MTT method.Effect of Ang Ⅱ on collagen synthesis of HSCswas determined by 3H-proline incorporation.RESULTS Contrasted to the fibrosis in rats ofthe model group,groups of rats treated with either enalapril or Iosartan,or a combination oftwo drugs showed a limited expansion of theinterstitium(4.23±3.70 vs 11.22±4.79,P<0.05),but no difference was observedamong three treated groups(5.38±3.43,4.96±2.96,4.23±2.70,P>0.05).Expression of AT 1receptors was found in fibrotic interstitium offibrotic rats,whereas in normal control rats theywere limited to vasculature only to a very slightdegree.AT 1 receptors were also expressed onactivated HSCs in the culture.At concentrationsfrom 10-9to 10-5mol/L,Ang Ⅱ stimulated HSCproliferation in culture in a dose-dependentmanner.Increasing Ang Ⅱ concentrationsproduced corresponding increases in 3H-prolineincorporation.Differences among groups were significant.CONCLUSION Angiotensin-converting enzyme inhibitors and AT I blocker may slow the progression of hepatic fibrosis; activated HSCs express AT 1 receptors, and Ang Ⅱ can stimulate the proliferation and collagen synthesis of HSCs in a dose-dependent manner; and activation of RAS may be related to hepatic fibrogenesis induced by CCI4. | Hong Shan Wei Han Ming Lu Ding Guo Li Yu Tao Zhan Zhi Rong Wang Xin Huang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，6： | 27 |
| 8 | Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction: A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study显示文摘 | Ying Zheng Guang-Yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song Wang Gui-Hua Jian Xu-Sheng Liu Yu-Ning Liu Zhao-Hui Ni Jing-Ai Fang Han-Lu Ding Wang Guo Ya-Ni He Li-Hua Wang Ya-Ping Wang Hong-Tao Yang Zhi-Ming Ye Ren-Huan YU Li-Juan Zhao Wen-Hua Zhou Wen-Ge Li Hui-Juan Mao Yong-Li Zhan Zhao Hu Chen Yao Ri-Bao Wei Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，20： | 21 |
| 9 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 10 | Effect of renin-angiotensin-aldosterone system gene polymorphisms on blood pressure response to antihypertensive treatment显示文摘背景 renin-angiotensin-aldosterone 系统(RAAS ) 为必要高血压的发展是重要的,并且许多 antihypertensive 药指向它。这研究被承担决定在 renin-angiotensin-aldosterone 系统的多型性是否与血压(BP ) 有关是对在有必要高血压的 54 个病人收到了的中国汉种族 population.Methods 的利尿的治疗的反应 hydrochlorothiazide (12.5 mg,从前每日) 作为为四个星期的 monotherapy。在 RAAS 基因的七多型性是由基因薄片技术的 genotyped。在在血压的这些多型性和变化之间的关系在 4 星期的 treatment.Results 以后被观察有 -6G 等位基因显示出的 angiotensinogen (AGT ) 的病人在心脏舒张的 BP (P= 0.025 ) 和吝啬的 BP (P=0.039 ) 的更大的减小比那些带的 AA 遗传型。病人带醛固酮 synthase (CYP11B2 ) CC 遗传型比那些带的 CT 和 TT 遗传型展出了更大的 BP 减小(收缩 BP:P= 0.030;心脏舒张的 BP:P= 0.026;意味着 BP:P=0.003 ) 。另外,有 CYP11B2 CC 遗传型和血管收缩素变换酶(王牌)的联合的病人 D 等位基因可能与二基因( P= 0.007 )的任何另外的 genotypic 联合比那些有收缩 BP 的更显著的减小 .Conclusions AGT-6G 等位基因,有王牌 D 等位基因的 CYP11B2 -344CC 遗传型和它的联合与对 hydrochlorothiazide 治疗的 BP 反应被联系。更大的研究被保证验证这发现。 | JIANG Xiao SHENG Hai-hui LIN Gang LI Jian LU Xin-zheng CHENG Yun-lin HUANG Jun XIAO Hua-sheng ZHAN Yi-yang | 2007 | Chinese Medical Journal2007，，9： | 17 |
| 11 | Expressions of type I collagen, α2 integrin and β1 integrin in sclera of guinea pig with defocus myopia and inhibitory effects of bFGF on the formation of myopia显示文摘AIM:To investigate the expressions of type I collagen, α2 integrin and β1 integrin in the posterior sclera of guinea pigs with defocus myopia and whether basic fibroblast growth factor (bFGF) injection inhibits the formation and development of myopia by upregulating the expression of type I collagen, α2 integrin and β1 integrin. METHODS:After 14 days of treatment, the refractive state and axial length were measured and the levels of type I collagen, α2 integrin and β1 integrin were assayed in the posterior sclerae of groups of guinea pigs that wore a monocular-7D polymethylmethacrylate (PMMA) lens or had -7D lens wear followed by the peribulbar injection of Phosphate Buffer Solution (PBS) or bFGF. The untreated fellow eye served as a control. Guinea pigs with no treatment served as normal group. ·RESULTS:The results showed that 14 days of monocular defocus increased axial eye length and refraction, while bFGF delivery inhibited them markedly. Further, it was also found that the monocular-7D lens could decrease the levels of type I collagen, α2 integrin and β1 integrin expressions, while, unlike PBS, bFGF increased them significantly in comparison to contralateral control eyes and normal eyes. CONCLUSION:bFGF can prevent the formation anddevelopment of defocus myopia by upregulating the expressions of type I collagen, α2 integrin and β1 integrin. Taken together, our results demonstrate that bFGF promotes sclera remodeling to prevent myopia in guinea pigs. | Xiao-Dan Tian Yong-Xia Cheng Gui-Bo Liu Su-Fen Guo Chun-Lei Fan Li-Hui Zhan Yan-Chun Xu | 2013 | International Journal of Ophthalmology(English edition)2013，6，1： | 16 |
| 12 | Relationship between enteric microecologic dysbiosis and bacterial translocation in acute necrotizing pancreatitis显示文摘RelationshipbetweenentericmicroecologicdysbiosisandbacterialtranslocationinacutenecrotizingpancreatitisWUChengTang,LIZhanL... | WU Cheng Tang, LI Zhan Liang and XIONG De Xin | 1998 | World Journal of Gastroenterology1998，4，3： | 16 |
| 13 | The ceramide pathway is involved in the survival, apoptosis and exosome functions of human multiple myeloma cells in vitro显示文摘多重骨髓瘤(公里) 被恶意的血浆房间和倔强的同种细胞的增长描绘到传统的治疗。exosomes 涉及 modulating,这被显示出前进和通过 microRNAs (米尔) 的癌症的转移。Ceramide 是 sphingolipid 的一种类型;exosomal 分泌物的 ceramide 小径被显示了影响癌症房间的 apoptosis。但是在公里房间功能, exosome 功能和米尔规定的这条小径的角色仍然保持未知。在这研究,我们显示出那 C6 ceramide (外长的 ceramide 补充, 1.25-40 mol/L ) dose-dependently 禁止了增长并且在人的公里 OPM2 房间线支持了 apoptosis,它与提高的 caspase 3/9 和 PARP 劈开被联系。我们也发现 C6 ceramide (5-20 mol/L ) dose-dependently 刺激了 exosome 分泌物并且增加了肿瘤镇压的米尔的 exosomal 层次(米尔 202,米尔 16,米尔 29b 和米尔 15a ) 。笔记,从 C6 对待 ceramide 的 OPM2 房间的 exosomes 能影响接受者 OPM2 房间的增长和 apoptosis,它与增加的肿瘤镇压的 exosomal 米尔相关。相反, GW4869 (一个 ceramide 禁止者, 5-20 mol/L ) 在公里 exosomes 在公里功能, exosome 分泌物和米尔层次的规定上施加了相反的效果。然而,从对待 GW4869 的 OPM2 房间的 exosomes 没在这些米尔和指向的 OPM2 房间的幸存上有效果。一起拿,我们的调查结果表明 ceramide 小径调制公里幸存,可能直接经由 caspase 小径并且间接地经由 exosomal 米尔机制。 | Qian CHENG Xin LI Yue WANG Min DONG Feng-huang ZHAN Jing LIU | 2018 | Acta Pharmacologica Sinica2018，39，4： | 15 |
| 14 | Early-Mid Ordovician brachiopod diversification in South China显示文摘Affected by paleogeographic position, paleoclimatic condition and depositional environments, the increase of the Early-Mid Ordovician brachiopod diversity of South China commenced at the beginning of the Ordovician (early Tremadoc), accelerated from the Tetra- graptus approximatus Biozone (base of Arenig), and reached its first acme in the Didymograptus eobifidus Biozone (mid early Arenig) when the number of brachiopod genera was over 7 times as great as that at the start of the Ordovician. This was the first radiation in the history of brachiopod macroevolution in South China, which occurred nearly 5 graptolitic biozones earlier than the global trend of the great Ordovician biodiversification (in the lower part of the Undulograptus austrodentatus Biozone). It is also characterized by (1) the origination or first occurrences of some major groups, such as the punctate dalmanelloids and the pseudopunctate stro- phomenoids including Plectambonitoidea (cardinal process simple or absent) and Stro- phomenoidea (cardinal process bilobed) in South China; (2) niche expansion, particularly in the first occupation of deeper water benthic regimes by the Euorthisina-Nocturnellia Association developed at Houping, Chengkou, northern Chongqing; and (3) the differentiation of brachiopod faunas under different environmental conditions. The gradual and increasing separation from Gondwana may have been one of the factors responsible for the radiation in South China. | ZHAN Renbin, RONG Jiayu, CHENG Jinhui & CHEN Pengfei Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing 210008, China | 2005 | Science China Earth Sciences2005，48，5： | 14 |
| 15 | Study of parachute inflation process using fluid–structure interaction method显示文摘A direct numerical modeling method for parachute is proposed firstly, and a model for the star-shaped folded parachute with detailed structures is established. The simplified arbitrary Lagrangian–Eulerian fluid–structure interaction(SALE/FSI) method is used to simulate the inflation process of a folded parachute, and the flow field calculation is mainly based on operator splitting technique. By using this method, the dynamic variations of related parameters such as flow field and structure are obtained, and the load jump appearing at the end of initial inflation stage is captured. Numerical results including opening load, drag characteristics, swinging angle, etc. are well consistent with wind tunnel tests. In addition, this coupled method can get more space–time detailed information such as geometry shape, structure, motion, and flow field. Compared with previous inflation time method, this method is a completely theoretical analysis approach without relying on empirical coefficients, which can provide a reference for material selection, performance optimization during parachute design. | Yu Li Cheng Han Zhan Ya'nan Li Shaoteng | 2014 | Chinese Journal of Aeronautics2014，27，2： | 13 |
| 16 | Principal aspects of the Ordovician biotic radiation显示文摘The Ordovician radiation is among the major bioevents in earth history that have drawn great attention from geologists all over the world, and there have been hundreds of publications treating various aspects of this radiation. The study of the event involves a broad spectrum of research fields and concerns many scientific questions. Many opinions and hypotheses have been proposed on the triggering and controlling factors of the radiation. Herein the authors critically review the study of the Ordovician radiation and dissect four principal aspects by synthesizing the studies over the past years: (1) relationships of the radiation to fossil clades, ecotypes, and environments, such as water depth, latitude, and climate; (2) the ecological structure and food webs of Ordovician marine organisms; (3) fossil records and true biodiversities; and (4) likely triggering and controlling factors of the Ordovician radiation. The authors also recommend approaches to furthering studies of these aspects. | ZHANG YuanDong,ZHAN RenBin,FAN JunXuan,CHENG JunFeng & LIU Xiao LPS, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China | 2010 | Science China Earth Sciences2010，53，3： | 13 |
| 17 | 桂枝加龙骨牡蛎汤加味对心肾不交型早泄瘦素、5-羟色胺影响及疗效研究显示文摘目的:探讨桂枝加龙骨牡蛎汤加味对心肾不交型早泄瘦素、5-羟色胺影响及疗效。方法:将72例心肾不交型早泄患者,随机分为桂枝加龙骨牡蛎汤加味组(A组)24例、金锁固精丸组(B组)24例、曲唑酮组(C组)24例。三组分别用药,疗程为4周,停药后4周随访。比较三组治疗效果,比较三组治疗前及治疗后8周的平均阴道内射精潜伏期(IELT)以及早泄诊断量表(PEDT)中的各项指标情况,比较三组治疗前后的血清瘦素(Lpetin)及5-羟色胺(5-HT)水平,并比较三组治疗期间的不良反应情况。结果:A组治疗后IELT平均值增加了4.28 min,B组、C组平均增加了1.15及1.22 min,组间比较差异有统计学意义(P<0.05),治疗后A组射精控制能力及配偶性生活满意度均较治疗前显著升高,且A组治疗后明显优于B、C组(P<0.05),治疗后三组Leptin及5-HT均较治疗前显著改善,且治疗后A组明显优于B、C组,组间比较差异有统计学意义(P<0.05)。结论:桂枝加龙骨牡蛎汤应用于治疗心肾不交型早泄能够显著降低血清瘦素并提高5-HT水平,起到良好的治疗效果,且安全性较高。 | 程宛钧 张敏建 史亚磊 危椠罡 邓日森 潘旭东 陈蓉艳 CHENG Biaojian ZHAN Huashen ZENG Zhicheng | 2017 | 中国性科学2017，26，11： | 10 |
| 18 | Traditional Chinese medicine “Qing Yi Tang” alleviates oxygen free radical injury in acute necrotizing pancreatitis显示文摘TraditionalChinesemedicine“QingYiTang”aleviatesoxygenfreeradicalinjuryinacutenecrotizingpancreatitisLIZhanLiang1,WUChengTan... | LI ZhanLiang1, WU ChengTang2, LU LianRong, ZHU XiaoFeng and XIONG DeXinKeywords pancreatitis/therapy Qing Yi Tang free radicals superoxide dismutase/analysis malonyldiadehyde/analysis | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 19 | Dissecting the Genetic Basis of Grain Shape and Chalkiness Traits in Hybrid Rice Using Multiple Collaborative Populations显示文摘 | Junyi Gong Jiashun Miao Yan Zhao Qiang Zhao Qi Feng Qilin Zhan Benyi Cheng Junhui Xia Xuehui Huang Shihua Yang Bin Han | 2017 | Molecular Plant2017，10，10： | 8 |
| 20 | Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial显示文摘Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. | Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen | 2021 | Journal of Integrative Medicine2021，19，2： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员