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| 1 | 在 colorectal 癌症的地岬发信号小径,变化和他们的角色显示文摘 Two of the main cellular pathways in which the RAS protein operates are the mitogen-activated protein kinases (MAPK) and phosphoinositide-3 kinase (PI3K) pathways. In a normal cell, these are important in controlling several functions, such as cell growth and survival. It becomes self-evident that these events will be disrupted in a malignant cell with a deregulated MAPK or PI3K pathway. Mutations in genes involved in these pathways and interacting with RAS, as well as RAS itself will be discussed. The second part of this review concentrates on how crucial RAS signaling is in colorectal cancer progression, with references to treatment response and prognosis when RAS or other related mutations are present. | Kypros Zenonos Katy Kyprianou | 2013 | World Journal of Gastrointestinal Oncology2013，5，5： | 8 |
| 2 | Seismic fragility assessment of existing sub-standard low strength reinforced concrete structures显示文摘An analytical seismic fragility assessment framework is presented for the existing low strength reinforced concrete structures more common in the building stock of the developing countries.For realistic modelling of such substandard structures,low strength concrete stress-strain and bond-slip capacity models are included in calibrating material models.Key capacity parameters are generated stochastically to produce building population and cyclic pushover analysis is carried out to capture inelastic behaviour.Secant period values are evaluated corresponding to each displacement step on the capacity curves and used as seismic demand.A modified capacity demand diagram method is adopted for the degrading structures,which is further used to evaluate peak ground acceleration from back analysis considering each point on the capacity curve as performance point.For developing fragility curves,the mean values of peak ground acceleration are evaluated corresponding to each performance point on the series of capacity curves.A suitable probability distribution function is adopted for the secant period scatter at different mean peak ground acceleration values and probability of exceedance of limit states is evaluated.A suitable regression function is used for developing fragility curves and regression coefficients are proposed for different confidence levels.Fragility curves are presented for a low rise pre-seismic code reinforced concrete structure typical of developing countries. | Sohaib Ahmad Nicolas Kyriakides Kypros Pilakoutas Kyriacos Neocleous Qaiser uz Zaman | 2015 | Earthquake Engineering and Engineering Vibration2015，14，3： | 3 |
| 3 | Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses显示文摘 | Fatima Crispi Edgar Hernandez-Andrade Maurice M.A.L. Pelsers Walter Plasencia Jesus Andres Benavides-Serralde Elisenda Eixarch Ferdinand Le Noble Asif Ahmed Jan F.C. Glatz Kypros H. Nicolaides Eduard Gratacos | 2008 | American Journal of Obstetrics and Gynecology2008，，3： | 1 |
| 4 | Topology optimization for the seismic design of truss-like structures显示文摘 | Iman Hajirasouliha Kypros Pilakoutas Hassan Moghaddam | 2011 | Computers and Structures2011，，7： | 1 |
| 5 | Maternal plasma soluble fms‐like tyrosine kinase‐1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia显示文摘 | RanjitAkolekar Jaderde Cruz Jean‐MichelFoidart CarineMunaut Kypros H.Nicolaides | 2010 | Diagn2010，，3： | 1 |
| 6 | Bond behavior of fiber reinforced polymer bars under direct pullout conditions 显示文摘 | Zenon Achillides Kypros Pilakoutas | 2004 | Journal of Composites for Construction2004，8，2： | 1 |
| 7 | Compressive Behavior of Concrete Actively Confined by Metal Strips, Part B : Analysis 显示文摘 | Hasan Moghaddam Maysam Samadi Kypros Pilakoutas | 2010 | Materials and Structures2010，43，10： | 1 |
| 8 | Bond behavior of fiber reinforced polymer bars under direct pullout conditions 显示文摘 | Achillides Zenon Pilakoutas Kypros | 2004 | Journal of Composites for Construction2004，8，2： | 1 |
| 9 | RC Column Strengthening by Lateral Pre-Tensioning of FRP 显示文摘 | Ali A Mortazavi Kypros Pilakoutas Ki Sang Son | 2003 | Construction and Building Materials2003，17，： | 1 |
| 10 | Bond Behavior of Fiber Reinforced Polymer Bars under Direct Pullout Conditions显示文摘 | ZENON ACHILLIDES KYPROS PILAKOUTAS | 2004 | Journal of Composites for construction2004，，： | 1 |
| 11 | 加快大型数据中心服务的可重构结构显示文摘数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个实例都由嵌入48台机器的半机架6×8二维环面高端Stratix V FPGA组成。每台服务器中都放置了一个FPGA,可以通过PCIe来访问,并用成对的10 Gb SAS电缆直接连接到其他FPGA。在本文中,我们描述了这种结构在1,632台服务器组(bed)的中等规模的部署,并测量了其在加快Bing搜索引擎方面的功效。我们描述了系统的要求和架构,详细介绍了关键技术挑战,以及使系统在出现故障情况下保持鲁棒性所需的解决方案,还有根据排名候选文档测量的系统性能、功率和弹性。在高负载时,一定范围内的可重构结构提高了每台服务器固定延迟分布的吞吐量排名95%——或在保持等效吞吐量时,减少29%的尾延迟。 | Andrew Putnam Adrian M.Caulfield Eric S.Chung Derek Chiou Kypros Constantinide John Demme Hadi Esmaeilzadeh Jeremy Fowers Gopi Prashanth Gopal Jan Gray Michael Haselman Scott Hauck Stephen Heil Amir Hormati Joo-Young Kim Sitaram Lanka James Larus Eric Peterson Simon Pope Aaron Smith Jason Thong Phillip Yi Xiao Doug Burger | 2015 | 中国集成电路2015，24，1： | 1 |
| 12 | Strength and deformability of waste tyre rubber-filled reinforced concrete columns显示文摘 | Ki Sang Son Iman Hajirasouliha Kypros Pilakoutas | 2011 | Construction and Building Materials2011，25，1： | 1 |
| 13 | First-Trimester Prediction of Hypertensive Disorders in Pregnancy显示文摘 | Leona C.Y. Poon Nikos A. Kametas Nerea Maiz Ranjit Akolekar Kypros H. Nicolaides | 2009 | Hypertension2009，，5： | 1 |
| 14 | Temporal regulation of the expression of syncytin ( HERV-W ), maternally imprinted PEG10 and SGCE in human placenta 显示文摘 | Alan S Aris P Kypros N | 2003 | BiolReprod2003，69，1： | 1 |
| 15 | Relationship between the fetal circulation and pituitary thyroid function显示文摘 | Thorpe JG Kypros HN Osalinde R | 1991 | British Journal of Obstetrics and Gynecology1991，98，11： | 1 |
| 16 | First-Trimester Prediction of Hypertensive Disorders in Pregnancy显示文摘 | Leona C.Y. Poon Nikos A. Kametas Nerea Maiz Ranjit Akolekar Kypros H. Nicolaides | 2009 | Hypertension2009，，5： | 1 |
| 17 | Low levels of maternal serum PAPP‐A in the first trimester and the risk of pre‐eclampsia显示文摘 | KevinSpencer Nicholas J.Cowans Kypros H.Nicolaides | 2008 | Prenat Diagn2008，，1： | 1 |
| 18 | Prediction of pregnancy complications by first‐trimester maternal serum PAPP‐A and free β‐hCG and with second‐trimester uterine artery Doppler显示文摘 | KevinSpencer Christina K. H.Yu Nicholas J.Cowans ChinezeOtigbah Kypros H.Nicolaides | 2005 | Prenat Diagn2005，，10： | 1 |
| 19 | Optimized realtime quantitative PCR measurement of male fetal DNA in maternal plasma显示文摘 | BERNHARD Z AHMAD E KYPROS N | 2005 | Clinical Chemistry2005，51，9： | 1 |
| 20 | Integrated ultrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free β‐hCG and PAPP‐A at 11 to 14 weeks显示文摘 | SimonaCicero RenuBindra GeorgiosRembouskos KevinSpencer Kypros H.Nicolaides | 2003 | Prenat Diagn2003，，4： | 1 |
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