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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome显示文摘瞄准:与 Klinefelter 的症候群(KFS ) 在 azoospermic 病人学习 Y 微删除的出现。方法:血和精液样品与 KFS 从 azoospermic 病人被收集(n = 14 ) 并且证明富饶的人的一个控制组(n = 13 ) 。精液分析根据世界卫生组织被做() 指南。血样品为 karyotyping,荧光灯的原位杂交(鱼) 和由放射性免疫测定刺激荷尔蒙(FSH ) 的血浆滤泡的测量被处理。决定 Y 微删除, 16 顺序的聚合酶链反应(PCR ) 标注了地点(圣) ,三基因(DFFRY, XKRY 和 RBM1Y ) 在孤立的 genomic DNA 上被执行。阴囊的好针渴望细胞学(FNAC ) 在选择情况中被做。结果:跨越一个 and AZFb 部位与 KFS 在 14 个 azoospermic 病人中的四个被发现的精子缺乏因素(AZF ) 的 Y 微删除。染色质组型和鱼分析表明显示出 Y 微删除的四个盒子,三个盒子有一 47, XXY/46, XY 染色体的模式和一个盒子有一 46, XY/47, XXY/48, XXXY/48, XXYY 染色体的模式。有 Y 微删除的一件样品的阴囊的 FNAC 揭示了形态学的 Sertoli 房间唯一的类型。然而,没有 Y 微删除在任何 13 个肥沃的人被观察。有 KFS 的所有病人提高了血浆 FSH 层次。结论:有 KFS 的病人可以怀有 Y 微删除并且为这些屏蔽应该是他们的诊断病情的检查的部分,特别地在那些考虑帮助了繁殖技术。 | Anurag Mitra Rima Dada Rajeev Kumar Narmada Prasad Gupta Kiran Kucheria Satish Kumar Gupta | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 3 | Genotyping-by-sequencing of pear (Pyrus spp.) accessions unravels novel patterns of genetic diversity and selection footprints显示文摘Understanding of genetic diversity and marker-trait relationships in pears(Pyrus spp.)forms an important part of gene conservation and cultivar breeding.Accessions of Asian and European pear species,and interspecific hybrids were planted in a common garden experiment.Genotyping-by-sequencing(GBS)was used to genotype 214 accessions,which were also phenotyped for fruit quality traits.A combination of selection scans and association analyses were used to identify signatures of selection.Patterns of genetic diversity,population structure and introgression were also investigated.About 15000 high-quality SNP markers were identified from the GBS data,of which 25%and 11%harboured private alleles for European and Asian species,respectively.Bayesian clustering analysis suggested negligible gene flow,resulting in highly significant population differentiation(Fst=0.45)between Asian and European pears.Interspecific hybrids displayed an average of 55%and 45%introgression from their Asian and European ancestors,respectively.Phenotypic(firmness,acidity,shape and so on)variation between accessions was significantly associated with genetic differentiation.Allele frequencies at large-effect SNP loci were significantly different between genetic groups,suggesting footprints of directional selection.Selection scan analyses identified over 20 outlier SNP loci with substantial statistical support,likely to be subject to directional selection or closely linked to loci under selection. | Satish Kumar Chris Kirk Cecilia Deng Claudia Wiedow Mareike Knaebel Lester Brewer | 2017 | Horticulture Research2017，4，1： | 8 |
| 4 | Higher frequency of Yq microdeletions in sperm DNA as compared to DNA isolated from blood显示文摘瞄准:决定删除的 Yq 微删除频率和 loci 是否在不同胚胎学的起源的二纸巾(血和精子) 是类似的。方法:现在的学习包括了 52 个不肥沃的 oligozoospermic 盒子。在每种情况中, DNA 从血和精子被孤立,微删除分析从 genomic DNA 被做的聚合酶链反应(PCR ) 从两个孤立纸巾。PCR 产品在 1.8% 统帅玫瑰胶化上被分析。发现否定的 PCR 扩大被重复至少三次证实一个给定的标记的删除。结果:仅仅 1 个盒子在血 DNA 怀有微删除,而 4 个盒子在精子 DNA 怀有微删除。结论:Yq 微删除的频率作为与血相比在细菌房间是更高的。为帮助繁殖生产技术(艺术) 作为不肥沃的夫妇的多数抉择, Yq 微删除从细菌房间屏蔽是重要的理解不孕的基因基础,提供全面建议和大多数改编治疗学给不肥沃的夫妇。 | Rima Dada Rakesh Kumar M. B. Shamsi Rajeev Kumar Kiran Kucheria Raj K. Sharma Satish K. Gupta Narmada P. Gupta | 2007 | Asian Journal of Andrology2007，9，5： | 6 |
| 5 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 6 | Comparative study of multiple cancellous screws versus sliding hip screws in femoral neck fractures of young adults显示文摘 | Mayank Gupta Rajendra Kumar Arya Satish Kumar Vijay Kumar Jain Skand Sinha Ananta Kumar Naik | 2016 | Chinese Journal of Traumatology2016，19，4： | 5 |
| 7 | Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population显示文摘这研究试图与长期的 periodontitis 调查在 glycated 血红素和糖尿病的复杂并发症之间的连接。有类型 2 糖尿病和长期的 periodontitis (CP ) 的 207 个病人的一个总数根据吝啬的比萨(牙齿周围的煽动的表面区域) 的 tertiles 被划分作为低、中间、高的比萨组得分。同时,一组 67 个牙齿周围地健康的个人(PH ) 被招募。包括对探查深度(PPD ) 的完整嘴的评价,在探查,临床的附件水平和匾上流血获得的牙齿周围的考试是坚定的。血分析为 glycated 血红素(HbA1c ) 被执行, fasting 血浆葡萄糖(FPG ) , 2 h 驿站 parandial 葡萄糖(PPG ) 。在 PH 的个人比 CP 组组织有的显著地更好的 glycemic 控制。在变化的单程的分析之上,有增加的比萨的题目有显著地更高的 HbA1c 层次, retinopathy 和 nephropathy (P < 0.05 ) 。在好久控制以后,性,身体团索引( BMI ),社会经济的地位( SES ),糖尿病和 periodontitis 的家庭历史,糖尿病的持续时间,在 mm2 的吝啬的比萨, PPD 4-6 公里(%)和 PPD 7 公里(%)在回归模型为提高的 HbA1c 作为重要预言者出现了( P < 0.05 )。逻辑回归分析表明那比萨与有 retinopathy 和神经病(机会比率) 的更高的风险被联系。在我们的学习,在有 periodontitis 的 glycemic 控制和糖尿病的复杂并发症之间的协会被观察。 | Palka Kaur Khanuja Satish Chander Narula Rajesh Rajputt Rajinder Kumar Sharma Shikha Tewari | 2017 | Frontiers of Medicine2017，11，1： | 4 |
| 8 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 9 | Turbocharging introgression breeding of perennial fruit crops:a case study on apple显示文摘The allelic diversity of primitive germplasm of fruit crops provides a useful resource for introgressing novel genes to meet consumer preferences and environmental challenges.Pre-breeding facilitates the identification of novel genetic variation in the primitive germplasm and expedite its utilisation in cultivar breeding programmes.Several generations of pre-breeding could be required to minimise linkage drag from the donor parent and to maximise the genomic content of the recipient parent.In this study we investigated the potential of genomic selection(GS)as a tool for rapid background selection of parents for the successive generation.A diverse set of 274 accessions was genotyped using random-tag genotyping-by-sequencing,and phenotyped for eight fruit quality traits.The relationship between‘own phenotypes’of 274 accessions and their general combining ability(GCA)was also examined.Trait heritability influenced the strength of correspondence between own phenotype and the GCA.The average(across eight traits)accuracy of predicting own phenotype was 0.70,and the correlations between genomic-predicted own phenotype and GCA were similar to the observed correlations.Our results suggest that genome-assisted parental selection(GAPS)is a credible alternative to phenotypic parental selection,so could help reduce the generation interval to allow faster accumulation of favourable alleles from donor and recipient parents. | Satish Kumar Elena Hilario Cecilia HDeng Claire Molloy | 2020 | Horticulture Research2020，7，1： | 3 |
| 10 | Statistical Modeling Studies of Iron Recovery from Red Mud Using Thermal Plasma显示文摘Optimization studies of plasma smelting of red mud were carried out. Reduction of the dried red mud fines was done in an extended arc plasma reactor to recover the pig iron. Lime grit and low ash metallurgical (LAM) coke were used as the flux and reductant, respectively. 2level factorial design was used to study the influence of all parameters on the responses. Response surface modeling was done with the data obtained from statistically designed experiments. Metal recovery at optimum parameters was found to be 79.52%. | Swagat S. RATH Archana PANY K. JAYASANKAR Ajit K. MITRA C. SATISH KUMAR Partha S. MUKHERJEE Barada K. MISHRA | 2013 | Plasma Science and Technology2013，15，5： | 2 |
| 11 | 中国实生和无性系苹果砧木及其杂交后代矮化基因型分子鉴定显示文摘【目的】利用已开发的矮化性状分子标记(Dw1/Dw2)筛选中国实生和自育无性系苹果砧木,探明各个砧木品种的矮化基因型,为苹果砧木育种工作中亲本选择及矮化分子辅助育种提供帮助。【方法】以不同地区采集的24份中国实生和自育的无性系苹果砧木、147份新疆野苹果(李2-3)בM9’和345份山荆子(野1-2)בM9’杂交后代单株的叶片DNA为模板,以矮化砧木‘M9’‘M116’和‘MM106’为对照,利用已经开发的Dw1和Dw2矮化标记的SSR引物进行PCR扩增,然后用毛细管电泳检测PCR产物,分析确定各个样品的矮化基因型。【结果】在24份中国苹果砧木中鉴定出8份携带Dw1矮化基因,5份携带Dw2矮化基因,3个自育杂交品种同时携带Dw1和Dw2矮化基因;新疆野苹果(李2-3)בM9’组合的147个杂种实生苗中有48株携带Dw1矮化基因,14株同时携带Dw1和Dw2基因,山荆子(野1-2)בM9’的345个杂交后代中仅有11个单株携带Dw1基因型,其余单株均不携带任一矮化基因。【结论】试验中检测的八棱海棠(房2-3)、山荆子(野1-2)和平邑甜茶(野2-22)等中国常用实生砧木均不携带Dw1或Dw2基因,仅新疆野苹果(李2-3)中含有Dw2矮化基因;中国自育的杂交砧木品种中,以‘M9’等矮化品种为亲本的后代大多携带Dw1或Dw2;双亲都含有矮化基因的杂交组合后代能获得更多的携带矮化基因的单株。 | 张恒涛 BUS Vincent G.M. 张亚茹 王欢 王美丽 BOWATTE Deepa GARDINER Susan E. CHAGNE David KIRK Chris KUMAR Satish 王大江 张瑞萍 周喆 YAO Jia-Long 阎振立 | 2020 | 果树学报2020，37，12： | 2 |
| 12 | BISAP评分与Ranson评分和CT严重指数预测印度急性胰腺炎患者并发症发生率和病死率的比较研究显示文摘目的:本研究通过印度中东部地区一家三甲医院,前瞻性评估急性胰腺炎严重度床边指数(BISAP)评分预测急性胰腺炎患者病死率及疾病进展中间指标的准确性,从而为贫困人群提供一个经济、有效的预后预测方法。方法:2012-2014年间我们中心连续收治的119例急性胰腺炎患者纳入研究。起病24 h内对所有病例进行BISAP评分,同时也进行Ranson评分和CT严重指数(CTSI)评估。采用趋势和判别分析来对这三种评分系统对病死率的预测价值进行评价。通过受试者操作特征(ROC)曲线评估这三种评分系统对急性胰腺炎患者病死率及疾病进展中间指标(器官衰竭和胰腺坏死)的预测情况。结果:119例入组病例中42例(35.2%)出现器官衰竭,定义为重症急性胰腺炎,47例(39.5%)发生胰腺坏死,12例(10.1%)死亡。BISAP评分预测重症急性胰腺炎、胰腺坏死和死亡的曲线下面积(AUC)分别为0.962、0.934和0.846。Ranson评分预测重症急性胰腺炎(AUC 0.956)和死亡(AUC 0.841)的准确性稍低于BISAP评分。CTSI在预测胰腺坏死方面的准确性最高,AUC为0.958。以≥3分作为截点,BISAP评分预测病死率的敏感性和特异性分别为100%和69.2%。结论:BISAP评分简单实用,在急性胰腺炎起病24 h内即可鉴别出高危死亡风险及高危疾病进展风险的患者。这种风险分层方法可用以提高临床诊治,并有助于临床研究中的病例入组。 | Jitin Yadav Sanjay Kumar Yadav Satish Kumar Ranjan George Baxla Dipendra Kumar Sinha Pankaj Bodra Ram Chandra Besra Babu Mani Baski Om Prakash Abhinav Anand | 2016 | Gastroenterology Report2016，4，3： | 2 |
| 13 | Amine loaded zeolites for carbon dioxide capture: Amine loading and adsorption studies显示文摘 | Ravikrishna Chatti Amit K. Bansiwal Jayashri A. Thote Vivek Kumar Pravin Jadhav Satish K. Lokhande Rajesh B. Biniwale Nitin K. Labhsetwar Sadhana S. Rayalu | 2009 | Microporous and Mesoporous Materials2009，，1： | 2 |
| 14 | Microscopic polymer cups by electrospinning显示文摘 | Jing Liu Satish Kumar | 2005 | Polymer2005，46，： | 1 |
| 15 | Land Application of Sugar Beet By-products: Effects on Runoff and Percolating Water Ouality显示文摘 | Kumar Kuldip Rosen Carl J Satish C Gupta | 2009 | Journal of environmental quality2009，38，1： | 1 |
| 16 | LNG:An eco -friendly cryogenic fuel for sustainable development 显示文摘 | Satish Kumar Hyouk - Tae Kwon Kwang - Ho Choi | 2011 | Applied Energy2011，88，12： | 1 |
| 17 | Studies on the Genotoxicity of Endosulfan in Different Tissues of Fresh Water Fish Mystus vittatus Using the Comet Assay显示文摘 | Shilpi Sharma N. S. Nagpure Ravindra Kumar Sanjay Pandey Satish K. Srivastava Poonam J. Singh P. K. Mathur | 2007 | Archives of Environmental Contamination and Toxicology2007，，4： | 1 |
| 18 | The role of friction stir welding tool on material flow and weld formation显示文摘 | KUMAR K SATISH KAILAS V | 2008 | Materials Science and Engineering A2008，485，： | 1 |
| 19 | On the Re-strictor Design Parameter of Hybrid Journal Bearing forOptimum Rotor Dynamic Coefficients显示文摘 | Kumar Vijay Sharma Satish C Jain S C | 2006 | TribologyInternational2006，39，4： | 1 |
| 20 | A low-cost noneontact capacitance-type level transducer for a conducting liquid 显示文摘 | Satish Chandra Bera Jayanta Kumar Ray Subrata Chattopadhyay | 2006 | IEEE Transactions on Instrumentation and Measurement2006，55，3： | 1 |
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