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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | Role of live microbial feed supplements with reference to anaerobic fungi in ruminant productivity: A review显示文摘To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials(DFM) for improved animal performance in terms of growth or productivity. This becomes all the more essential in a situation, where a number of the residues of antibiotics and/or other growth stimulants reach in milk and meat with a number of associated potential risks for the consumers. Hence, in the absence of growth stimulants, a positive manipulation of the rumen microbial ecosystem to enhance the feedstuff utilization for improved production efficiency by ruminants has become of much interest to the researchers and entrepreneurs. A few genera of live microbes(i.e., bacteria, fungi and yeasts in different types of formulations from paste to powder) are infrequently used as DFM for the domestic ruminants. These DFM products are live microbial feed supplements containing naturally occurring microbes in the rumen. Among different DFM possibilities, anaerobic rumen fungi(ARF) based additives have been found to improve ruminant productivity consistently during feeding trials. Administration of ARF during the few trials conducted, led to the increased weight gain, milk production, and total tract digestibility of feed components in ruminants. Anaerobic fungi in the rumen display very strong cell-wall degrading cellulolytic and xylanolytic activities through rhizoid development, resulting in the physical disruption of feed structure paving the way for bacterial action. Significant improvements in the fiber digestibility were found to coincide with increases in ARF in the rumen indicating their role. Most of the researches based on DFM have indicated a positive response in nutrient digestion and methane reducing potential during in vivo and/or in vitro supplementation of ARF as DFM. Therefore, DFM especially ARF will gain popularity but it is necessary that all the strains are thoroughly studied for their beneficial properties to have a confirmed ‘generally regarded as safe' status for ruminants. | Anil K Puniya Abdelfattah Z M Salem Sanjay Kumar Sumit S Dagar Gareth W Griffith Monica Puniya Sreenivas R Ravella Nikhil Kumar Tejpal Dhewa Ravinder Kumar | 2015 | Journal of Integrative Agriculture2015，14，3： | 17 |
| 3 | 硅肥对蔗地土壤性状、甘蔗叶片营养及产量的影响(英文)显示文摘【目的】在大棚条件下进行甘蔗硅肥施用量研究,阐明硅肥对甘蔗生长、营养以及土壤特性等的影响。【方法】以新台糖22号为试验材料,以每桶26gN+1.76gP+20gK为对照,设置T1~T6(20、40、60、80、120and150g/桶)6个不同硅肥用量,研究不同施硅水平对甘蔗的影响。【结果】硅肥处理的甘蔗+1叶N、P、Ca、Mg、Si含量较对照有一定提高,其中120g/桶处理的甘蔗+1叶含硅量比对照增加92%。不同施硅水平对甘蔗土壤理化性状具有显著影响,SOM和有效P较对照显著降低,120g/桶处理的有效Si含量较对照增加137%,150g/桶处理的交换性Ca和Mg分别较对照增加117.9%和86.0%,pH均有一定提高。硅肥处理对甘蔗株高和产量增加有显著影响,对甘蔗干物质和产糖量的提高也有促进作用,但不显著。【结论】硅肥对甘蔗生产以及土壤理化性状具有一定正效应,可结合常规施肥进一步推广从而提高甘蔗生产。 | 黄海荣 徐林 BOKHTIAR S M MANOJ Kumar Srivastav 李杨瑞 杨丽涛 | 2011 | 南方农业学报2011，42，7： | 8 |
| 4 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 5 | Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn F.Muell显示文摘Objective:To evaluate the aldose reductase inhibitory(ARI)activity of different fractions of Hybanthus enneaspermus for potential use in diabetic cataract.Methods:Total phenol and flavonoid content of different fractions was determined.ARI activity of different fractions in rat lens was investigated in vitro.Results:The results showed significant level of phenolic and flavonoid content in ethyl acetate fraction[total phenol(212.15±0.79 mg/g),total flavonoid(39.11±2.27mg/g)]and aqueous fraction[total phenol(140.62±0.57mg/g),total flavonoid(26.07±1.49 mg/g)]as compared with the chloroform fraction[total phenol(68.56±0.51mg/g),total flavonoid(13.41±0.82mg/g)]and petrolium ether fraction[total phenol(36.68±0.43mg/g),total flavonoid(11.55±1.06mg/g)].There was a significant difference in the ARI activity of each fraction,and it was found to be the highest in ethyl acetate fraction[IC_(50)(49.26±1.76μg/mL)]followed by aqueous extract[IC_(50)(70.83±2.82μg/mL)]and it was least in the petroleum ether fraction[IC_(50)(118.89±0.71μg/mL)].Chloroform fraction showed moderate activity[IC_(50)(98.52±1.80μg/mL)].Conclusions:Different fractions showed significanct amount of ARI activity,where in ethyl acetate fraction it was found to be maximum which may be due to its high phenolic and flavonoid content.The extract after further evaluation may be used in the treatment of diabetic cataract. | Patel DK Kumar R Kumar M Sairarn K Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 6 | Ordered Intermetallics显示文摘 | E P George M Yamaguchi K S Kumar C T Liu | 1994 | Annual Review of Materials Science1994，，： | 2 |
| 7 | MEGA4:Molecular Evolutionary Genetics Analysis(MEGA)software version 4.0显示文摘 | Tamura K Dudley J Nei M Kumar S | | 0，，： | 2 |
| 8 | Nanocrystalline TiO2 studied by optical, FTIR and X-ray photoelectron spectroscopy: correlation to presence of surface states 显示文摘 | Madhu Kumar P Badrinarayanan S Sastry M | 2000 | Thin Solid Films2000，358，12： | 2 |
| 9 | Effect of the hydrophilic size on the structural phases of aqueous nonionic Gemini surfactant solutions显示文摘 | Nieh M P Kumar S K Fernando R H | 2004 | Langmuir2004，20，21： | 1 |
| 10 | Genetic variants of platelet glycoprotein receptors and risk of stroke in young women 显示文摘 | Reiner A P Kumar P M Schwartz S M | 2000 | Stroke2000，31，7： | 1 |
| 11 | MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment显示文摘 | Kumar S Tamura K Nei M | 2004 | Brief Bioinform2004，，5： | 1 |
| 12 | MEGA3:Integrated soft-ware for molecular evolutionary genetics analysis and se-quence alignment显示文摘 | KUMAR S TAMURA K NEI M | 2004 | Bioinformatics2004，5，： | 1 |
| 13 | MEGA3: an integrated software for molecular evolutionarygenetics analysis and sequence alignment 显示文摘 | KUMAR S TAMURA K NEI M | 2004 | Brief Bioinform2004，25，： | 1 |
| 14 | Effects of vitamin Cand E on PCB(Aroclor 1245)induced oxidative stress,andro-gen binding protein and lactate in rat Sertoli cells显示文摘 | Kumar J S Banudevi S Sharmila M | 2004 | ReprodToxicol2004，19，2： | 1 |
| 15 | Review on TiC Reinforced Steel Composites 显示文摘 | Parashivamurthy K I KUMAR R K SEETHARAMU S HANDRASEKHARAIAH M N | 2001 | Journal of Materials Science2001，，36： | 1 |
| 16 | Limonoids from the seeds of Azadirachta indica 显示文摘 | Kumar C Srinivas M Yakkundi S | 1996 | Phytohemistry1996，43，： | 1 |
| 17 | Computer Simulation of Transport Processes During Injection Mold-Filling and Optimization of the Molding Conditions显示文摘 | Kumar A Ghoshdastidar P S Muju M K | 2002 | Journal of Materials Processing Technology2002，120，3： | 1 |
| 18 | Physiological concentration of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-grouth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells显示文摘 | Slevein M Kumar S He X | 1999 | Int J Cancer1999，82，3： | 1 |
| 19 | MEGA:abiologist-centric software for evolutionary analysis ofDNA and protein sequences显示文摘 | KUMAR S NEI M DUDLEY J | 2008 | Brief Bioinform2008，9，4： | 1 |
| 20 | Integrated software for molec'ular evo- lutionary genetics analysis and sequence alignment 显示文摘 | Kumar S Tamura K Nei M | 2004 | Briefings in BioinfiJrnmtics2004，5，： | 1 |
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