|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 3 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 4 | Comparative analysis of genetic diversity among Indian populations of Scirpophaga incertulas by ISSR-PCR and RAPD-PCR显示文摘 | Kumar L S Sawant A S Gupta V S | 2001 | Biochem Genet2001，39，： | 1 |
| 5 | Assessing Reseller Performance from the Perspective of the Supplier显示文摘 | KUMAR N STERN L W ACHROL R S | 1992 | Journal of Marketing Research1992，29，5： | 1 |
| 6 | Changes in soil nutrient content and enzymatic activity under conventional and zero-tillage practices in an Indian sandy clay loam soil 显示文摘 | MINA B L SAHA S KUMAR N | 2008 | Nutrient cycling in Agroecosystems2008，82，： | 1 |
| 7 | Development of low- cost media for the culture of mosquito larvicides Bacillus sphaerlcus and Bacillus thuringiensis serovar Israelensis显示文摘 | POOPATHI S KUMAR K A KABILANL L | 2002 | World Journal of Microbiology & Biotechnology2002，18，： | 1 |
| 8 | HIPI and HIPlr stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains显示文摘 | Hyun T S Rao D S Saint-Dic D Michael L E Kumar P D Bradley S V Mizukami I F | | 0，，14： | 1 |
| 9 | Intensification of nicotinic acid separation using organophosphorous solvating extractants by reactive extraction 显示文摘 | KUMAR S WASEWAR K L BABU B V | 2008 | Chem Eng Technol2008，31，11： | 1 |
| 10 | Subcutaneous panniculitis like T cell lymphoma is a tumor of cytotoxic T lymphocytes显示文摘 | Kumar S Krenacs L Medeiros J | 1998 | Hum Pathol1998，29，4： | 1 |
| 11 | Modelling of Corex Process for Optimisation of OperatiOnal Parameters显示文摘 | Prachethan Kumar P Garg L M Gupta S S | 2006 | Ironmaking and Steelmaking2006，33，1： | 1 |
| 12 | A comparimn of histopathology findings of ovarian tissue inadvertently excised with endomctrioma and other kinds of bellign ovarian cyst in patients undergoing laparoscopy vetches lap roomy显示文摘 | Alborzi S Fbrouginia L Kumar P V | 2012 | Fertil Seril2012，92，6： | 1 |
| 13 | Fabric de- fect detection based on GLCM and Gabor filter: A com- parison 显示文摘 | RAHEJA J L KUMAR S CHAUDHARY A | 2013 | Optik-International Journal for Light and Electron Optics2013，124，23： | 1 |
| 14 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus显示文摘 | Floyd J L Smith K P Kumar S H | 2010 | Antimicrob Agents Chemother2010，54，12： | 1 |
| 15 | A classification of unruptured middle cerebral artery bifurcation aneurysms that can help in choice of clipping technique显示文摘 | Kumar M V Karagiozov K L Chen L Imizu S Yoneda M Watabe T | 2007 | Minim Invasive Neurosurg2007，50，： | 1 |
| 16 | Calcified splenic metastasis from gastric carcinoma显示文摘 | Williams L Kumar A Aggarwal S | 1995 | Abdom Imaging1995，20，： | 1 |
| 17 | The processing, properties and structures of carbon fibers显示文摘 | Minus L M Kumar S | 2005 | JOM Journal of the Minerals Metals and Materi- als Society2005，57，2： | 1 |
| 18 | Design and fabrication of an automated technique: measurement of spontaneous polarization in two new schiff'base ferroelectric liquid crystals 显示文摘 | Madhu Mohan M L N Goud B V S Kumar P A | 1999 | Materials Research Bulletin1999，34，1415： | 1 |
| 19 | Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes显示文摘 | Ceriello A kumar S Piconi L | 2007 | Diabetes Care2007，30，3： | 1 |
| 20 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员