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| 1 | Free radicals and ocular disease显示文摘 | ANDERSON R E KRETZER F L RAPP L M | 1994 | Adv Exp Med Biol1994，366，： | 1 |
| 2 | Influence of stem design on the primary stability of megaprostheses of the proximal femur显示文摘 | Stefan Kinkel Jan Dennis Graage Jan Philippe Kretzer Eike Jakubowitz Jan Nadorf | 2013 | International Orthopaedics2013，，10： | 1 |
| 3 | Compliance with handwashing and barrier precautions显示文摘 | Larson E Kretzer EK | 1995 | J Hosp Infect1995，30，： | 1 |
| 4 | Acute intracranial subdural hematoma fol owing a lumbar CSF leak caused by spine surgery显示文摘 | Sciubba DM Kretzer RM Wang PP | | 0，，1976： | 1 |
| 5 | Mesoscopic nonuniformity of wafer-annealed semi-insulating InP显示文摘 | G. Hirt D. Wolf B. Hoffmann U. Kretzer G. Kühnel A. Woitech D. Zemke G. Müller | 1996 | Journal of Electronic Materials1996，，3： | 1 |
| 6 | A 12-Year Experience of Bipolar Steroid-Eluting Epicardial Pacing Leads in Children显示文摘 | Maren Tomaske Bart Gerritse Leo Kretzers Rene Pretre Ali Dodge-Khatami Mariette Rahn Urs Bauersfeld | 2008 | The Annals of Thoracic Surgery2008，，5： | 1 |
| 7 | Chile's Next Generation Pension Reform显示文摘 | Barbara E kretzer | 2008 | Social Security Bulletin2008，，2： | 1 |
| 8 | A noncompeti- tive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor alpha显示文摘 | Kretzer NM Cherian MT Mao CJ | 2010 | J Biol Chem2010，285，41： | 1 |
| 9 | Translaminar screw fixation in the upper thoracic spine显示文摘 | Kretzer RM Sciubba DM Bagley CA | | 0，，06： | 1 |
| 10 | Evalution of an amikacin load-ing dose for nosocomial infections in very low birth weight infants显示文摘 | Berger A Kretzer V’Gludovatz P | 2004 | Acta Paediatr2004，93，3： | 1 |
| 11 | From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution显示文摘Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction.Lipid mediators orchestrate both the initiation and resolution of inflammation.Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are unknown.Starting from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase subdomains.We identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 synthase-1.Leukotriene production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 macrophages.The shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell infiltration.In summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles. | Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 12 | A computed tomography-based morphometric study of thoracic pedicle anatomy in a random United States trauma population显示文摘 | Kretzer RM Chaput C Sciubba DM | | 0，，： | 1 |
| 13 | A 12-Year Experi- ence of Bipolar Steroid-Eluting Epicardial Pacing Leads in Children 显示文摘 | Tomaske M Gerritse B Kretzers L | 2008 | Ann Thorac Surg2008，85，： | 1 |
| 14 | Visual acuity correlates with severity of retinopathy of prematurity in untreated infants weighing 750g or less at birth显示文摘 | Mintz-Hittner HA Prager TC Kretzer FL | | 0，，： | 1 |
| 15 | Wear analysi s of unieondylar mobile bearing and fixed bearingknee systems:A knee simulator study显示文摘 | Kretzer JP Jakubowitz E Reinders J | 2010 | Acta Biomater2010，29，： | 1 |
| 16 | Intraviteous bevacizumab as anti-vascular endothelial growth factor therapy of retinopathy of prematurity: a morpho- logic study显示文摘 | Kong L Mintz-Hittner HA Penland RL Kretzer FL Ch~vez-Bar- rios P | 2008 | Arch Ophthalmol2008，126，8： | 1 |
| 17 | Transeatherter intervention in the neonate with congenital heart disease 显示文摘 | Kretzer J | 2001 | Clin Perinatol2001，28，1： | 1 |
| 18 | Compliance with handwashing and barrier precautions显示文摘 | Larson E Kretzer EK | 1995 | J Hosp Infect1995，，30： | 1 |
| 19 | Loosening detection of the femoral component of hip prostheses with extracorporeal shockwaves: A pilot study显示文摘 | Johannes S. Rieger Sebastian Jaeger Jan Philippe Kretzer Rüdiger Rupp Rudi G. Bitsch | 2014 | Medical Engineering and Physics2014，，： | 1 |
| 20 | Free radicals and ocular disease显示文摘 | Anderson R E Kretzer F L RAPP L M | | 0，，： | 1 |
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